Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Cancer Research

• Publication date

  1981-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 6165465
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. II. Induction of growth.

  1980cited by this paper
• Proliferation of rat liver cells in preneoplastic nodules after stimulation of liver growth by xenobiotic inducers.

  1979cited by this paper
• The effects of dieldrin, diet and other environmental components on enzyme function and tumour incidence in livers of CF-1 mice.

  1979cited by this paper
• Liver tumors and steroid hormones in rats and mice.

  1979cited by this paper
• Early biological markers during liver carcinogenesis.

  1979cited by this paper
• Cell kinetics of hepatocytes during the preneoplastic period of diethylnitrosamine-induced liver carcinogenesis.

  1979cited by this paper
• The effect of estradiol‐17‐phenylpropionate and estradiol benzoate on N‐nitrosomorpholine‐induced liver carcinogenesis in ovariectomized female rats

  1978cited by this paper
• Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3'-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine.

  1978influential reference
• Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine

  1978cited by this paper
• Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.

  1978cited by this paper
• Enhancement by Wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat.

  1978cited by this paper
• Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.

  1978cited by this paper
• Two-Stage Control of Cell Proliferation Induced in Rat Liver by α-Hexachlorocyclohexane

  1977cited by this paper
• Malignant tumors in rats fed nafenopin, a hepatic peroxisome proliferator.

  1977cited by this paper
• Two-stage control of cell proliferation induced in rat liver by alpha-hexachlorocyclohexane.

  1977cited by this paper
• Long‐term administration of ddt or phenobarbital‐na in wistar rats

  1977cited by this paper
• Functional markers and growth behavior of preneoplastic hepatocytes.

  1976cited by this paper
• Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.

  1976cited by this paper
• New principle for the analysis of chemical carcinogenesis

  1976cited by this paper
• Development of hepatocellular carcinomas in rats treated with benzene hexachloride.

  1975cited by this paper
• Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression.

  1975cited by this paper
• Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.

  1975cited by this paper
• Induction of liver growth by xenobiotic compounds and other stimuli.

  1974cited by this paper
• Circadiane Rhythm of Cell Proliferation in Rat Liver: Synchronization by Feeding Habits

  1974cited by this paper
• The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, -BHC and -BHC.

  1973cited by this paper
• Polysome-ribosome dynamics in the acute response of the liver to carcinogens.

  1972cited by this paper
• Growth kinetics of diethylnitrosamine-induced, enzyme-deficient "preneoplastic" liver cell populations in vivo and in vitro.

  1972cited by this paper
• [Histochemical investigations of carcinogenesis in rat liver after continuous application of diethylnitrosamine].

  1969cited by this paper
• [THE ELIMINATION OF ALPHA- AND GAMMA-HEXACHLOROCYCLOHEXANE AND ITS ALTERATION BY ENZYMES OF LIVER MICROSOMES].

  1964cited by this paper

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  2009cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
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  2000cites this paper
• The effect of 1/3 partial hepatectomy on the growth of glutathione S-transferase positive foci.

  1999cites this paper
• Different pathways for mitogenic and enzyme induction signal transduction by cytochrome P450 inducers.

  1999cites this paper
• Effect of fasting/refeeding on the incidence of chemically induced hepatocellular carcinoma in the rat.

  1999cites this paper
• Development of resistance to the mitoinhibitory effects of orotic acid during experimental liver carcinogenesis

  1998cites this paper
• The Progression of Neoplasia, Cell Replication, and Electromagnetic Fields

  1998cites this paper
• Apoptosis in human colorectal tumours: ultrastructure and quantitative studies on tissue localization and association with bak expression

  1998cites this paper
• Inducers of the cytochrome P-450 superfamily as promoters of carcinogenesis.

  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1997cites this paper
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  1996cites this paper
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  1996influential citation
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1995cites this paper
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  1995cites this paper
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  1995cites this paper
• Inhibition of DNA synthesis in primary rat hepatocyte cultures by malachite green: a new liver tumor promoter.

  1995cites this paper
• Biological behavior of prestages of cancer cells: an introduction.

  1995cites this paper
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  1995cites this paper
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  1995cites this paper
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  1994cites this paper
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  1994cites this paper
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  1994cites this paper