VASCULARIZATION OF THE CORNEA OF THE RAT IN RIBOFLAVIN DEFICIENCY, WITH A NOTE ON CORNEAL VASCULARIZATION IN VITAMIN A DEFICIENCY

Vascularization of the cornea of the rat in the absence of antecedent pathology is probably a specific and the most reliable criterion of riboflavin deficiency. Its initiation and repair may be used for testing the biological activity of compounds structurally related to riboflavin. The facts that the invading capillaries are easily visible in the living animal and that the growth and regression of the blood vessels are under dietary control and for a considerable period of time unaccompanied by other pathological reactions, make this method very suitable for the study of problems related to capillary growth. We believe that the best hypothesis in explanation is that the vascularization is a response to asphyxia of the tunica propria.

• Publication year

  1939

• Venue

  Journal of Experimental Medicine

• Publication date

  1939-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.69.1.1PMID 19870829PMCID 2133728
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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