Cathepsin S and an asparagine‐specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro

No abstract is available for this paper.

• Publication year

  2001

• Venue

  European Journal of Immunology

• Publication date

  2001-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/1521-4141(200112)31:12<3726::AID-IMMU3726>3.0.CO;2-OPMID 11745393
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Emerging roles for cysteine proteases in human biology.

  1997influential reference
• HLA‐DR‐restricted presentation of purified myelin basic protein is independent of intracellular processing

  1997influential reference
• Cloning, Isolation, and Characterization of Mammalian Legumain, an Asparaginyl Endopeptidase*

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• T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

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  1989cited by this paper
• The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B.

  1989cited by this paper
• The sequential limited degradation of bovine myelin basic protein by bovine brain cathepsin D.

  1979cited by this paper

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