NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nephrology, Dialysis and Transplantation

• Publication date

  2004-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/NDT/GFH207PMID 15280531
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway.

  2002cited by this paper
• Protein Overload-Induced NF-κB Activation in Proximal Tubular Cells Requires H2O2 through a PKC-Dependent Pathway

  2002cited by this paper
• Systemic infusion of angiotensin II into normal rats activates nuclear factor-kappaB and AP-1 in the kidney: role of AT(1) and AT(2) receptors.

  2001cited by this paper
• Systemic Infusion of Angiotensin II into Normal Rats Activates Nuclear Factor-κB and AP-1 in the Kidney : Role of AT1 and AT2 Receptors

  2001cited by this paper
• Transcription factor-kappa B (NF-kappa B) and renal disease.

  2001cited by this paper
• Renin-angiotensin system and renal damage: emerging data on angiotensin II as a proinflammatory mediator.

  2001cited by this paper
• Role of angiotensin II in tubulointerstitial injury.

  2001cited by this paper
• Tubular NF-κB and AP-1 activation in human proteinuric renal disease

  2001influential reference
• Tubular NF-kappaB and AP-1 activation in human proteinuric renal disease.

  2001cited by this paper
• Activation of NF-&kgr;B in Tubular Epithelial Cells of Rats With Intense Proteinuria: Role of Angiotensin II and Endothelin-1

  2001cited by this paper
• Lipoprotein-X stimulates monocyte chemoattractant protein-1 expression in mesangial cells via nuclear factor-kappa B.

  2001cited by this paper
• Overexpression of chemokines, fibrogenic cytokines, and myofibroblasts in human membranous nephropathy.

  2000cited by this paper
• Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy.

  2000influential reference
• Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor kappaB in proximal tubule cells.

  1999cited by this paper
• Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria.

  1999cited by this paper
• Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats.

  1999cited by this paper
• The role of oxidative stress and NF‐κB activation in late diabetic complications

  1999cited by this paper
• Induction of Monocyte Chemoattractant Protein-1 by Albumin Is Mediated by Nuclear Factor κB in Proximal Tubule Cells

  1999cited by this paper
• Insufficient Glycemic Control Increases Nuclear Factor-κB Binding Activity in Peripheral Blood Mononuclear Cells Isolated From Patients With Type 1 Diabetes

  1998cited by this paper
• Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation.

  1998cited by this paper
• In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation.

  1998cited by this paper
• Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.

  1997cited by this paper
• Interaction of IgA with Fc alpha receptors of human mesangial cells activates transcription factor nuclear factor-kappa B and induces expression and synthesis of monocyte chemoattractant protein-1, IL-8, and IFN-inducible protein 10.

  1997cited by this paper
• Nuclear factor-κB

  1997cited by this paper
• AP-1 function and regulation.

  1997cited by this paper

• Senloytics, dasatinib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease

  2026cites this paper
• The Interplay Between Reactive Oxygen Species, Glucose Metabolism and NF-kB in the Pathogenesis of Type 2 Diabetes

  2026cites this paper
• Mechanisms of Inflammation-Fibrosis in Diabetic Nephropathy and Intervention Strategies of Traditional Chinese and Western Medicine

  2026cites this paper
• The emerging endogenous peptide Apelin 13 in diabetes and its related complications: a narrative review.

  2026cites this paper
• Therapeutic Effects of Gallic Acid and Alpha‐Tocopherol on Adenine‐Induced Chronic Kidney Disease in Male Wistar Rats

  2026cites this paper
• Progress in the study of the role of C5a-induced tubular cell senescence in the progression of diabetic kidney disease

  2025cites this paper
• Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

  2025cites this paper
• REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy

  2025cites this paper
• Pericyte specific MDM2 knockout alleviates diabetic nephropathy inflammation in mice

  2025cites this paper
• Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies

  2025cites this paper
• Novel translational mouse models of metabolic dysfunction-associated steatotic liver disease comparable to human MASLD with severe obesity

  2025cites this paper
• Actin cytoskeleton stabilization inhibits NLRP3 inflammasome activation and mitigates renal inflammation and fibrosis in obstructive nephropathy.

  2025cites this paper
• Therapeutic Potential of Cinnamic Acid as an SGLT2 Inhibitor in Mitigating Diabetic Nephropathy in a Rat Model of Type 2 Diabetes

  2025cites this paper
• Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study

  2025cites this paper
• Abelmoschus manihot alleviates insulin resistance in diabetic kidney disease through attenuation of inflammation

  2025cites this paper
• Assessing the Influence of Matcha Green Tea Extract on NF-κB/MAPK Signaling Pathway Activation in Rats: A Study on Irradiation-Induced Acute Hepatic Inflammatory Response

  2025cites this paper
• Mechanism of Yi-Qi-Bu-Shen Recipe for the Treatment of Diabetic Nephropathy Complicated with Cognitive Dysfunction Based on Network Pharmacology and Experimental Validation

  2024cites this paper
• The Role of Mitochondria in Diabetic Kidney Disease and Potential Therapeutic Targets

  2024cites this paper
• Association of systemic immune-inflammation index with all-cause and cardio-cerebrovascular mortality in individuals with diabetic kidney disease: evidence from NHANES 1999-2018

  2024cites this paper
• Sodium Tungstate (NaW) Decreases Inflammation and Renal Fibrosis in Diabetic Nephropathy.

  2024cites this paper
• Novel Biomarkers for the diagnosis of diabetic nephropathy

  2024cites this paper
• Phloretamide Protects against Diabetic Kidney Damage and Dysfunction in Diabetic Rats by Attenuating Hyperglycemia and Hyperlipidemia, Suppressing NF-κβ, and Upregulating Nrf2

  2024cites this paper
• Role of inflammation in the progression of diabetic kidney disease

  2024cites this paper
• Polyphenol-Standardized Aphanamixis polystachya Leaf Extract Ameliorates Diabetes, Oxidative Stress, Inflammation, and Fibrosis in Streptozotocin-Induced Diabetic Rats

  2024cites this paper
• In Silico Characterization of Inflammatory and Anti-Inflammatory Modulation in Diabetic Nephropathy: The Construction of a Genetic Panel

  2024cites this paper
• NF‐κB pathway as a molecular target for curcumin in diabetes mellitus treatment: Focusing on oxidative stress and inflammation

  2024cites this paper
• Gastrodin ameliorates diabetic nephropathy by activating the AMPK/Nrf2 pathway

  2024cites this paper
• Nandrolone decanoate induced kidney injury through miRNA-146a targeting IRAK1 and TRAF6 via activation of the NF-κB pathway: The effect of moderate exercise.

  2024cites this paper
• Metabolomics and molecular dynamics unveil the therapeutic potential of epalrestat in diabetic nephropathy.

  2024cites this paper
• Plant-Derived Bioactive Molecules in the Management of Diabetic Neuropathy: Insights and Future Prospects

  2024cites this paper
• Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease.

  2024cites this paper
• Assessing the Inhibitory Potential of Pregnenolone Sulfate on Pentraxin 3 in Diabetic Kidney Disease: A Molecular Docking and Simulation Study

  2024cites this paper
• Involvement of CCL2 in Salivary Gland Response to Hyperosmolar Stress Related to Sjögren’s Syndrome

  2024cites this paper
• Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-κB, NLRP3 inflammasome, and autophagy pathways

  2023cites this paper
• Discovery of PRDM16‐Mediated TRPA1 Induction as the Mechanism for Low Tubulo‐Interstitial Fibrosis in Diabetic Kidney Disease

  2023cites this paper
• Pathophysiology of diabetic kidney disease and autophagy: A review

  2023cites this paper
• Low-dose lipopolysaccharide inducing continuous and obvious increase in urinary protein in hyperglycemic rats and the underlying mechanism

  2023cites this paper
• Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.

  2023cites this paper
• Precision Medicine in Diabetic Kidney Disease: A Narrative Review Framed by Lived Experience

  2023cites this paper
• The roles of gut microbiota and its metabolites in diabetic nephropathy

  2023cites this paper
• Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300

  2023cites this paper
• A delve into the pharmacological targets and biological mechanisms of Paederia foetida Linn.: a rather invaluable traditional medicinal plant

  2023cites this paper
• The beneficial effects of astragaloside IV on ameliorating diabetic kidney disease.

  2023cites this paper
• Investigate the genetic mechanisms of diabetic kidney disease complicated with inflammatory bowel disease through data mining and bioinformatic analysis

  2023cites this paper
• Role of Gut Microbiota, Immune Imbalance, and Allostatic Load in the Occurrence and Development of Diabetic Kidney Disease

  2023cites this paper
• Dysregulated coagulation system links to inflammation in diabetic kidney disease

  2023cites this paper
• CysLTR1 antagonism by montelukast can ameliorate diabetes-induced aortic and testicular inflammation.

  2023cites this paper
• Advances in understanding and treating diabetic kidney disease: focus on tubulointerstitial inflammation mechanisms

  2023cites this paper
• An Investigation into the Effects of Ubiquinone on Inflammation, Diabetic Myopathy and Endotheliopathy, and CBC Parameters in Diabetic Rats

  2023cites this paper
• Effects of antioxidants on diabetic kidney diseases: mechanistic interpretations and clinical assessment

  2023cites this paper
• Platelets in Renal Disease

  2023cites this paper
• Role of Phytochemicals against Diabetic Nephropathy: An Insight into Molecular Receptors

  2023cites this paper
• A Glimpse of Inflammation and Anti-Inflammation Therapy in Diabetic Kidney Disease

  2022cites this paper
• Role of Periostin and Nuclear Factor-κB Interplay in the Development of Diabetic Nephropathy

  2022cites this paper
• Diabetic nephropathy patients show hyper-responsiveness to N6-carboxymethyllysine

  2022cites this paper
• Rack1 regulates pro-inflammatory cytokines by NF-κB in diabetic nephropathy

  2022cites this paper
• The Role of Platelets in Diabetic Kidney Disease

  2022cites this paper
• Mitochondrial Contribution to Inflammation in Diabetic Kidney Disease

  2022cites this paper
• Mannose‐binding lectin activates the nuclear factor‐κB and renal inflammation in the progression of diabetic nephropathy

  2022cites this paper
• Selection of experimental models mimicking human pathophysiology for diabetic microvascular complications

  2022cites this paper
• Gold Nanoparticles Supported on Ceria Nanoparticles Modulate Leukocyte–Endothelium Cell Interactions and Inflammation in Type 2 Diabetes

  2022cites this paper
• Targeting inflammation to treat diabetic kidney disease: the road to 2030.

  2022cites this paper
• Prevention of oxidative stress and diseases by antioxidant supplementation.

  2022cites this paper
• Exploring the pathogenesis of diabetic kidney disease by microarray data analysis

  2022cites this paper
• The role of inflammation in cadmium nephrotoxicity: NF-κB comes into view.

  2022cites this paper
• The effect of quercetin on diabetic nephropathy (DN): a systematic review and meta-analysis of animal studies.

  2022cites this paper
• Immune responses in diabetic nephropathy: Pathogenic mechanisms and therapeutic target

  2022cites this paper
• Potential Roles of Anti-Inflammatory Plant-Derived Bioactive Compounds Targeting Inflammation in Microvascular Complications of Diabetes

  2022cites this paper
• Renal Inflammation and Innate Immune Activation Underlie the Transition From Gentamicin-Induced Acute Kidney Injury to Renal Fibrosis

  2021cites this paper
• The role of inflammation in diabetic kidney disease

  2021cites this paper
• CCL24 Protects Renal Function by Controlling Inflammation in Podocytes

  2021cites this paper
• Honokiol: A naturally occurring lignan with pleiotropic bioactivities.

  2021cites this paper
• Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy

  2021cites this paper
• Current Challenges and Future Perspectives of Renal Tubular Dysfunction in Diabetic Kidney Disease

  2021cites this paper
• Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways

  2021influential citation
• Intestinal microbiota and diabetic kidney diseases: the Role of microbiota and derived metabolites inmodulation of renal inflammation and disease progression.

  2021cites this paper
• A look on target-specificity of eutectic systems based on natural bioactive compounds

  2021cites this paper
• Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm

  2021cites this paper
• Immunomodulatory and Mechanistic Considerations of Hibiscus sabdariffa (HS) in Dysfunctional Immune Responses: A Systematic Review

  2021cites this paper
• Kefir reduces nitrosative stress and upregulates Nrf2 in the kidney of diabetic rats

  2021cites this paper
• Therapeutic potential of resveratrol in diabetic nephropathy according to molecular signaling.

  2021cites this paper
• Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

  2021cites this paper
• Icariin ameliorates streptozocin-induced diabetic nephropathy through suppressing the TLR4/NF-κB signal pathway.

  2021cites this paper
• Nephroprotective Effect of Adropinin Against Streptozotocin-Induced Diabetic Nephropathy in Rats: Inflammatory Mechanism and YAP/TAZ Factor

  2021cites this paper
• Urinary sediment CCL5 messenger RNA as a potential prognostic biomarker of diabetic nephropathy

  2021cites this paper
• Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy

  2021cites this paper
• Glomerular basement membrane damage and leaking of structural proteins in among different stages of type 2 diabetes mellitus patients

  2021cites this paper
• Protective Role of Fisetin in STZ Induced Diabetic Nephropathy in Rats

  2021cites this paper
• DDDT_A_294009 589..600

  2021cites this paper
• Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease

  2021influential citation
• Serum adiponectin among di erent stages of type 2 diabetes mellitus patients

  2021cites this paper
• Development of Biomarkers and Molecular Therapy Based on Inflammatory Genes in Diabetic Nephropathy

  2021cites this paper
• Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy

  2020cites this paper
• Pathogenic role of human C-reactive protein in diabetic retinopathy.

  2020cites this paper
• Glucose Induces IL-1α-Dependent Inflammation and Extracellular Matrix Proteins Expression and Deposition in Renal Tubular Epithelial Cells in Diabetic Kidney Disease

  2020cites this paper
• Resveratrol Inhibits Lipopolysaccharide-Induced Extracellular Matrix Accumulation and Inflammation in Rat Glomerular Mesangial Cells by SphK1/S1P2/NF- κ B Pathway Therapy

  2020cites this paper
• The Emerging Role of Innate Immunity in Chronic Kidney Diseases

  2020cites this paper
• Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

  2020cites this paper
• The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy

  2020cites this paper
• TRAF3 Modulation: Novel Mechanism for the Anti-inflammatory Effects of the Vitamin D Receptor Agonist Paricalcitol in Renal Disease.

  2020cites this paper