Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  American Journal of Epidemiology

• Publication date

  2004-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/AJE/KWH101PMID 15105181
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Statistical Evaluation of Medical Tests for Classification and Prediction

  2005influential reference
• Re: The central role of receiver operating characteristic (ROC) curves in evaluating tests for the early detection of cancer.

  2005cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• [Odds ratio].

  1997cited by this paper
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