Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Metallomics

• Publication date

  2011-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1039/c0mt00064gPMID 21210060PMCID PMC3172965
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Probing the biology of Alzheimer's disease in mice.

  2010cited by this paper
• Gene–Environment Interactions in Parkinson's Disease: The Importance of Animal Modeling

  2010cited by this paper
• Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells.

  2010cited by this paper
• Molecular mechanisms of neurodegeneration in Alzheimer's disease.

  2010cited by this paper
• Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans

  2010cited by this paper
• Environmental Exposure, Obesity, and Parkinson’s Disease: Lessons from Fat and Old Worms

  2010cited by this paper
• A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments

  2010cited by this paper
• Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans.

  2010cited by this paper
• VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.

  2010cited by this paper
• Alzheimer disease.

  2010cited by this paper
• SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity.

  2010cited by this paper
• Hormetic effect of methylmercury on Caenorhabditis elegans.

  2010cited by this paper
• Metals, oxidative stress and neurodegenerative disorders

  2010cited by this paper
• Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers.

  2010cited by this paper
• The transition metals copper and iron in neurodegenerative diseases.

  2010cited by this paper
• Global microRNA Expression Profiling of Caenorhabditis elegans Parkinson's Disease Models

  2010cited by this paper
• Inhibition of mitochondrial fusion by α‐synuclein is rescued by PINK1, Parkin and DJ‐1

  2010cited by this paper
• Exposure to Lead and Mercury in Young Larvae Induces More Severe Deficits in Neuronal Survival and Synaptic Function than in Adult Nematodes

  2009cited by this paper
• A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau.

  2009cited by this paper
• Genetics of Alzheimer's disease: recent advances

  2009cited by this paper
• Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

  2009cited by this paper
• Combined Extracellular Matrix Cross-linking Activity of the Peroxidase MLT-7 and the Dual Oxidase BLI-3 Is Critical for Post-embryonic Viability in Caenorhabditis elegans*

  2009cited by this paper
• α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

  2009cited by this paper
• Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

  2009cited by this paper
• Caenorhabditits elegans LRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth*

  2009cited by this paper
• Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in Caenorhabditis elegans.

  2009cited by this paper
• Alzheimer's disease, metal ions and metal homeostatic therapy.

  2009cited by this paper
• Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α‐synuclein complex by Hip

  2009cited by this paper
• Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

  2009cited by this paper
• The Caenorhabditis elegans Aβ1–42 Model of Alzheimer Disease Predominantly Expresses Aβ3–42*

  2009cited by this paper
• The Divalent Metal Transporter Homologues SMF-1/2 Mediate Dopamine Neuron Sensitivity in Caenorhabditis elegans Models of Manganism and Parkinson Disease*

  2009cited by this paper
• Characterization of the effects of methylmercury on Caenorhabditis elegans.

  2009cited by this paper
• Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration.

  2009cited by this paper
• SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans

  2009cited by this paper
• Copper and Zinc Binding to Amyloid‐β: Coordination, Dynamics, Aggregation, Reactivity and Metal‐Ion Transfer

  2009cited by this paper
• A Pathogenesis Assay Using Saccharomycescerevisiae and Caenorhabditiselegans Reveals Novel Roles for Yeast AP-1, Yap1, and Host Dual Oxidase BLI-3 in Fungal Pathogenesis

  2009cited by this paper
• Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease.

  2009cited by this paper
• Metal Ion Physiopathology in Neurodegenerative Disorders

  2009cited by this paper
• Divalent metal transporter 1 is involved in amyloid precursor protein processing and Aβ generation

  2009cited by this paper
• Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease

  2008cited by this paper
• Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

  2008cited by this paper
• The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans.

  2008cited by this paper
• Manganese transport in eukaryotes: the role of DMT1.

  2008cited by this paper
• Use of non-mammalian alternative models for neurotoxicological study.

  2008cited by this paper
• Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau

  2007cited by this paper
• Gene-environment interactions in Parkinson's disease.

  2007cited by this paper
• Age-associated increases of α-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

  2007cited by this paper
• Manganese: recent advances in understanding its transport and neurotoxicity.

  2007cited by this paper
• LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins.

  2007cited by this paper
• Manganese neurotoxicity: a focus on the neonate.

  2007cited by this paper
• APL-1, a Caenorhabditis elegans protein related to the human β-amyloid precursor protein, is essential for viability

  2007cited by this paper
• ATP depletion is the major cause of MPP+ induced dopamine neuronal death and worm lethality in α-synuclein transgenic C. elegans

  2007cited by this paper
• Caenorhabditis elegans as a Model System for Parkinson’s Disease

  2007cited by this paper
• Finding function in novel targets: C. elegans as a model organism

  2006cited by this paper
• Role of Iron in Neurodegenerative Disorders

  2006cited by this paper
• C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease.

  2006cited by this paper
• Dopamine Signaling Architecture in Caenorhabditis elegans

  2006cited by this paper
• Methylmercury: Recent Advances in the Understanding of Its Neurotoxicity

  2005cited by this paper
• Trace metal regulation of neuronal apoptosis: from genes to behavior.

  2005cited by this paper
• Similar Patterns of Mitochondrial Vulnerability and Rescue Induced by Genetic Modification of α-Synuclein, Parkin, and DJ-1 in Caenorhabditis elegans*

  2005cited by this paper
• The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

  2005cited by this paper
• Pathways of chaperone-mediated protein folding in the cytosol

  2004cited by this paper
• Parkinson's disease

  2004cited by this paper
• Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor.

  2004cited by this paper
• Manganese Neurotoxicity

  2004cited by this paper
• Parkin genetics: one model for Parkinson's disease.

  2004cited by this paper
• Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy

  2003cited by this paper
• Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

  2003cited by this paper
• The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration.

  2003cited by this paper
• Parkinson's Disease Mechanisms and Models

  2003cited by this paper
• Alzheimer disease in the US population: prevalence estimates using the 2000 census.

  2003cited by this paper
• Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase.

  2002cited by this paper
• Contrasting, Species-Dependent Modulation of Copper-Mediated Neurotoxicity by the Alzheimer's Disease Amyloid Precursor Protein

  2002cited by this paper
• Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

  2002cited by this paper
• Age-Environment and Gene-Environment Interactions in the Pathogenesis of Parkinson's Disease

  2002cited by this paper
• Overexpression of Alzheimer's Disease Amyloid-β Opposes the Age-dependent Elevations of Brain Copper and Iron*

  2002cited by this paper
• Enhancement of Oxidative Damage to Cultured Cells and Caenorhabditis elegans by Mitochondrial Electron Transport Inhibitors

  2001cited by this paper
• Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada.

  2001cited by this paper
• Dopamine signaling in Caenorhabditis elegans-potential for parkinsonism research.

  2001cited by this paper
• A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes.

  2000cited by this paper
• Presenilin is required for proper morphology and function of neurons in C. elegans

  2000cited by this paper
• New order from neurological disorders

  1999cited by this paper
• The iron transporter DMT1.

  1999cited by this paper
• Quality of life and parkinson's disease: Translation and validation of the US Parkinson's Disease Questionnaire (PDQ-39)

  1999cited by this paper
• Distinct Mechanisms Underlie Neurotoxin-Mediated Cell Death in Cultured Dopaminergic Neurons

  1999cited by this paper
• Using Caenorhabditis elegans to study vesicular transport.

  1998cited by this paper
• Copper, iron and zinc in Alzheimer's disease senile plaques.

  1998cited by this paper
• Epidemiology versus genetics in parkinson's disease: Progress in resolving an age‐old debate

  1998cited by this paper
• The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

  1996cited by this paper
• Differential changes in neurochemical markers of striatal dopamine nerve terminals in idiopathic Parkinson's disease

  1996cited by this paper
• A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans

  1995cited by this paper
• Genetic and pharmacological analysis of neurotransmitters controlling egg laying in C. elegans

  1995cited by this paper
• The beta A4 amyloid precursor protein binding to copper.

  1994cited by this paper
• The βA4 amyloid precursor protein binding to copper

  1994cited by this paper
• apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.

  1993cited by this paper
• Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia. The Royal Kings and Queens Parkinson's Disease Research Group.

  1992cited by this paper
• Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia

  1992cited by this paper
• Mercury and monomethylmercury: present and future concerns.

  1991cited by this paper
• The embryonic cell lineage of the nematode Caenorhabditis elegans.

  1983cited by this paper
• Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.

  1977cited by this paper

• Invitro anti-biofilm activity and the artificial chaperone activity of quinoline-based ionic liquids.

  2024cites this paper
• Evaluation of a battery of biotests to improve waste ecotoxicity assessment (HP 14), using incineration bottom ash as a case study.

  2023cites this paper
• Caenorhabditis elegans as a suitable model to evaluate the toxicity of water from Rolante River, southern Brazil.

  2023cites this paper
• Potential of Ascorbic Acid Supplements to Ameliorate the Deleterious Effects of Hyperuricemia on Albino Wistar Rats’ Hippocampus (Structural and Functional Study)

  2023cites this paper
• The Use and Predictability of C. elegans as an Alternative and Complementary Model in Neurotoxicological Studies: Focus on the Dopaminergic System

  2022cites this paper
• Caenorhabditis elegans as a Model to Study Manganese-Induced Neurotoxicity

  2022cites this paper
• Iron overload and neurodegenerative diseases: What can we learn from Caenorhabditis elegans?

  2022cites this paper
• Chronic di(2-ethylhexyl) phthalate exposure leads to dopaminergic neuron degeneration through mitochondrial dysfunction in C. elegans.

  2022cites this paper
• Application of Fluorescence Microscopy and Behavioral Assays to Demonstrating Neuronal Connectomes and Neurotransmitter Systems in C. elegans.

  2021cites this paper
• Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives.

  2021cites this paper
• Detrimental effects of long-term elevated serum uric acid on cognitive function in rats

  2021cites this paper
• Application of and Behavioral Assays to Demonstrating Neuronal and Neurotransmitter Systems in C. elegans

  2021cites this paper
• Iron oxide nanoparticles in biological systems: Antibacterial and toxicology perspective

  2021cites this paper
• Caenorhabitidis elegans as an animal model in toxicological studies

  2020cites this paper
• C. elegans—An Emerging Model to Study Metal-Induced RAGE-Related Pathologies

  2018cites this paper
• Uptake of TiO2 Nanoparticles into C. elegans Neurons Negatively Affects Axonal Growth and Worm Locomotion Behavior.

  2018cites this paper
• Immune and xenobiotic response crosstalk to chemical exposure by PA01 infection in the nematode Caenorhabditis elegans.

  2018cites this paper
• Neurodegeneration Induced by Metals in Caenorhabditis elegans.

  2017cites this paper
• Metal Biology Associated with Huntington’s Disease

  2017cites this paper
• An enhanced C. elegans based platform for toxicity assessment

  2017cites this paper
• Neurochemistry of lead and manganese.

  2016cites this paper
• Copper Oxide Nanoparticles Impact Several Toxicological Endpoints and Cause Neurodegeneration in Caenorhabditis elegans

  2016cites this paper
• Gene–Environment Interactions in Huntington’s Disease

  2015cites this paper
• Chapter 6 – Use of Caenorhabditis elegans to Model Human Movement Disorders

  2015cites this paper
• Inverse Association Between Serum Uric Acid Levels and Alzheimer’s Disease Risk

  2015cites this paper
• Gene-Environment Interactions Between Manganese Toxicity and Early-Onset Parkinson's Disease Genes

  2015cites this paper
• Iron promotes protein insolubility and aging in C. elegans

  2014cites this paper
• Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease.

  2014cites this paper
• n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and α-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease

  2014cites this paper
• Molecular characterization of the UV-response in Caenorhabditis elegans

  2014cites this paper
• Serum Uric Acid Levels in Patients with Alzheimer's Disease: A Meta-Analysis

  2014cites this paper
• Oxidative Stress Mechanisms Underlying Parkinson’s Disease-Associated Neurodegeneration in C. elegans

  2013cites this paper
• Hydroximic acid derivatives: pleiotropic HSP co-inducers restoring homeostasis and robustness.

  2013cites this paper
• Assaying Environmental Nickel Toxicity Using Model Nematodes

  2013cites this paper
• The multiple faces of calcineurin signaling in Caenorhabditis elegans: Development, behaviour and aging

  2013cites this paper
• C. elegans and Neurodegeneration In Caenorhabditis Elegans: Anatomy, Life Cycles and Biological Functions.

  2012cites this paper
• Protein fractionation and detection for metalloproteomics: challenges and approaches

  2012cites this paper
• Caenorhabditis elegans: An Emerging Model System for Pesticide

  2012cites this paper
• Caenorhabditis elegans: An Emerging Model System for Pesticide Neurotoxicity

  2012cites this paper
• Role of manganese in neurodegenerative diseases.

  2011cites this paper