Mice Deficient in LRG-47 Display Enhanced Susceptibility to Trypanosoma cruzi Infection Associated with Defective Hemopoiesis and Intracellular Control of Parasite Growth

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Immunology

• Publication date

  2005-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.175.12.8165PMID 16339555
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes1

  2006cited by this paper
• Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of Bim of cell death.

  2006cited by this paper
• CD8 T Cells, Like CD4 T Cells, Are Triggered by Multivalent Engagement of TCRs by MHC-Peptide Ligands but Not by Monovalent Engagement1

  2006cited by this paper
• Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help.

  2006cited by this paper
• Integrin αIIbβ3 induces the adhesion and activation of mast cells through interaction with fibrinogen.

  2006cited by this paper
• Anti-Inflammatory Effect of Lactobacillus casei on Shigella-Infected Human Intestinal Epithelial Cells1

  2006cited by this paper
• Thymocyte Negative Selection Is Mediated by Protein Kinase C- and Ca2+-Dependent Transcriptional Induction of Bim1

  2006cited by this paper
• Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth.

  2006cited by this paper
• Tec Kinases Itk and Rlk Are Required for CD8+ T Cell Responses to Virus Infection Independent of Their Role in CD4+ T Cell Help1

  2006cited by this paper
• Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.

  2006cited by this paper
• Ly9 (CD229)-Deficient Mice Exhibit T Cell Defects yet Do Not Share Several Phenotypic Characteristics Associated with SLAM- and SAP-Deficient Mice1

  2006cited by this paper
• p47 GTPases Regulate Toxoplasma gondii Survival in Activated Macrophages

  2005cited by this paper
• Loss of New Chemokine CXCL14 in Tumor Tissue Is Associated with Low Infiltration by Dendritic Cells (DC), while Restoration of Human CXCL14 Expression in Tumor Cells Causes Attraction of DC Both In Vitro and In Vivo1

  2005cited by this paper
• RNA interference of VCP/p97 increases Mallory body formation.

  2005cited by this paper
• Immune control of phagosomal bacteria by p47 GTPases.

  2005influential reference
• Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.

  2004cited by this paper
• IL-21 Induces the Functional Maturation of Murine NK Cells 1

  2004cited by this paper
• p47 GTPases: regulators of immunity to intracellular pathogens

  2004influential reference
• Lysosomal Fusion Is Essential for the Retention of Trypanosoma cruzi Inside Host Cells

  2004cited by this paper
• Involvement of nitric oxide (NO) and TNF‐α in the oxidative stress associated with anemia in experimental Trypanosoma cruzi infection

  2004cited by this paper
• Interferon-gamma: an overview of signals, mechanisms and functions.

  2004cited by this paper
• Mechanisms Regulating the Positioning of Mouse p47 Resistance GTPases LRG-47 and IIGP1 on Cellular Membranes: Retargeting to Plasma Membrane Induced by Phagocytosis1

  2004cited by this paper
• Innate and Acquired Immunity in the Pathogenesis of Chagas Disease

  2004cited by this paper
• Inducible Nitric Oxide Synthase Is Not Essential for Control of Trypanosoma cruzi Infection in Mice

  2004cited by this paper
• Interferon- : an overview of signals, mechanisms and functions

  2004cited by this paper
• IFN-inducible GTPases and immunity to intracellular pathogens.

  2004cited by this paper
• Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif.

  2004cited by this paper
• Mice Deficient in LRG-47 Display Increased Susceptibility to Mycobacterial Infection Associated with the Induction of Lymphopenia

  2004influential reference
• Involvement of nitric oxide (NO) and TNF-alpha in the oxidative stress associated with anemia in experimental Trypanosoma cruzi infection.

  2004cited by this paper
• Interferon‐γ: an overview of signals, mechanisms and functions

  2004cited by this paper
• Impaired Production of Proinflammatory Cytokines and Host Resistance to Acute Infection with Trypanosoma cruzi in Mice Lacking Functional Myeloid Differentiation Factor 881

  2004cited by this paper
• Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

  2003cited by this paper
• Absence of Interferon-γ–Inducible Gene IGTP Does Not Significantly Alter the Development of Chagasic Cardiomyopathy in Mice Infected with Trypanosoma cruzi (Brazil Strain)

  2003cited by this paper
• Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR.

  2003cited by this paper
• Immune control of tuberculosis by IFN-gamma-inducible LRG-47.

  2003cited by this paper
• Transgenic Mice Expressing Human Interleukin-10 in the Antigen-Presenting Cell Compartment Show Increased Susceptibility to Infection with Mycobacterium avium Associated with Decreased Macrophage Effector Function and Apoptosis

  2002cited by this paper
• The Function of Gamma Interferon-Inducible GTP-Binding Protein IGTP in Host Resistance to Toxoplasma gondii Is Stat1 Dependent and Requires Expression in Both Hematopoietic and Nonhematopoietic Cellular Compartments

  2002influential reference
• Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure.

  2002cited by this paper
• Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection

  2001influential reference
• Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis

  2001cited by this paper
• Stage-Dependent Role of Nitric Oxide in Control ofTrypanosoma cruzi Infection

  2001cited by this paper
• Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection.

  2001cited by this paper
• Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.

  2000cited by this paper
• Acute Trypanosoma cruzi infection is associated with anemia, thrombocytopenia, leukopenia, and bone marrow hypoplasia: reversal by nifurtimox treatment.

  2000influential reference
• Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP

  2000influential reference
• Gamma Interferon Modulates CD95 (Fas) and CD95 Ligand (Fas-L) Expression and Nitric Oxide-Induced Apoptosis during the Acute Phase ofTrypanosoma cruzi Infection: a Possible Role in Immune Response Control

  1999cited by this paper
• Nitric oxide-induced apoptotic cell death in the acute phase of Trypanosoma cruzi infection in mice.

  1998cited by this paper
• Aplastic Anemia Rescued by Exhaustion of Cytokine-secreting CD8+ T Cells in Persistent Infection with Lymphocytic Choriomeningitis Virus

  1998cited by this paper
• Bone marrow and thymus expression of interferon-gamma results in severe B-cell lineage reduction, T-cell lineage alterations, and hematopoietic progenitor deficiencies.

  1997cited by this paper
• Identification of a Novel GTPase, the Inducibly Expressed GTPase, That Accumulates in Response to Interferon γ*

  1996influential reference
• Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.

  1995cited by this paper
• Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro

  1994cited by this paper
• IFN-gamma abrogates IL-7-dependent proliferation in pre-B cells, coinciding with onset of apoptosis.

  1994cited by this paper
• [Congenital Chagas disease in the city of Salta, Argentina].

  1993cited by this paper
• Modulation of lymphohematopoiesis in long-term cultures by gamma interferon: direct and indirect action on lymphoid and stromal cells.

  1993cited by this paper
• Congenital Chagas' disease in Salta, Argentina

  1993cited by this paper
• Bone marrow hypoplasia and aplasia complicating interferon therapy for chronic myelogenous leukemia

  1992cited by this paper
• Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells.

  1992cited by this paper
• Acute Chagas' disease in non-human primates. 1. Chronology of clinical events, clinical chemistry, ECG, radiology, parasitemia, and immunological parameters in the Cebus apella monkey.

  1988cited by this paper
• Enhanced mononuclear phagocytic activity during Trypanosoma cruzi infection in mice.

  1976cited by this paper

• Comprehensive Analysis of Differences in N6-Methyladenosine RNA Methylation Groups in CVB3-Induced Viral Myocarditis and Identification of the Anti-Apoptotic Role of RBM15B

  2025cites this paper
• The Complexity of Interferon Signaling in Host Defense against Protozoan Parasite Infection

  2023cites this paper
• Sex Influences Age-Related Changes in Natural Antibodies and CD5+ B-1 Cells

  2022cites this paper
• Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis

  2022cites this paper
• How did we get here? Insights into mechanisms of immunity-related GTPase targeting to intracellular pathogens.

  2022cites this paper
• m6A mRNA Methylation Regulates Epithelial Innate Antimicrobial Defense Against Cryptosporidial Infection

  2021cites this paper
• Functional characterization of an immunity-related GTPase gene in immune defense from obscure puffer (Takifugu obscurus).

  2020cites this paper
• Plasticity in Interferon Responses Modulates T-Cell Immunity in Parasitic Infections: Periphery to Thymus

  2020cites this paper
• Could angiotensin-modulating drugs be relevant for the treatment of Trypanosoma cruzi infection? A systematic review of preclinical and clinical evidence

  2019cites this paper
• Bordetella pertussis Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naïve Infection by Driving Hematopoietic Stem and Progenitor Cell Expansion in Mice

  2018cites this paper
• Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection

  2018cites this paper
• Disease Tolerance and Pathogen Resistance Genes May Underlie Trypanosoma cruzi Persistence and Differential Progression to Chagas Disease Cardiomyopathy

  2018cites this paper
• Protective host response to Trypanosoma cruzi and its limitations

  2017cites this paper
• Rapidly progressive course of Trypanosoma cruzi infection in mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene.

  2017cites this paper
• The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion

  2016cites this paper
• Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

  2016cites this paper
• Mice lack of LRG-47 display the attenuated outcome of infection with Schistosoma japonicum

  2016cites this paper
• Bcl‐2 proteins in development, health, and disease of the hematopoietic system

  2016cites this paper
• During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection

  2016cites this paper
• Regulation of Epithelial Turnover by Host-Virome Interactions

  2016influential citation
• IFN-γ-induced macrophage antileishmanial mechanisms in mice: A role for immunity-related GTPases, Irgm1 and Irgm3, in Leishmania donovani infection in the liver.

  2015cites this paper
• Mechanisms of interferon‐beta‐induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: role of immunity‐related GTPase M1

  2015cites this paper
• with fibrinogen. activation of mast cells through interaction induces the adhesion and 3 β IIb α Integrin

  2014cites this paper
• The immunity-related GTPase (IRG) resistance system against intracellular parasites

  2014cites this paper
• Eimeria falciformis infection of mouse cells identifies host determinants of parasite development

  2014cites this paper
• Repeated Exposure to Lutzomyia intermedia Sand Fly Saliva Induces Local Expression of Interferon-Inducible Genes Both at the Site of Injection in Mice and in Human Blood

  2014cites this paper
• Striking the Right Balance Determines TB or Not TB

  2014cites this paper
• Irgm1 (LRG-47), a Regulator of Cell-Autonomous Immunity, Does Not Localize to Mycobacterial or Listerial Phagosomes in IFN-γ–Induced Mouse Cells

  2013cites this paper
• in Macrophages and β Triggers IFN- Pathway Activated by Trypanosomes A Novel IFN Regulatory Factor 3-Dependent

  2013cites this paper
• Eimeria falciformis infection of the mouse caecum identifies opposing roles of IFNγ-regulated host pathways for the parasite development

  2013cites this paper
• Immune-related GTPase Irgm1 exacerbates experimental auto-immune encephalomyelitis by promoting the disruption of blood-brain barrier and blood-cerebrospinal fluid barrier.

  2013cites this paper
• Proinflammatory Cytokine Production and Negatively Regulates TLR4-Triggered The IFN-Inducible GTPase LRG47 (Irgm1)

  2013influential citation
• Murine Chlamydia psittaci Infection Innate Immunity and Inflammation to The p47 GTPases Iigp2 and Irgb10 Regulate

  2013cites this paper
• Oral Exposure to Phytomonas serpens Attenuates Thrombocytopenia and Leukopenia during Acute Infection with Trypanosoma cruzi

  2013cites this paper
• IFN-γ Plays a Unique Role in Protection against Low Virulent Trypanosoma cruzi Strain

  2012cites this paper
• Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke

  2012cites this paper
• Host interferon-γ inducible protein contributes to Brucella survival

  2012cites this paper
• Pathogenesis of Chagas disease: time to move on.

  2012cites this paper
• IL-10 Limits Parasite Burden and Protects against Fatal Myocarditis in a Mouse Model of Trypanosoma cruzi Infection

  2012cites this paper
• Interferon-inducible effector mechanisms in cell-autonomous immunity

  2012cites this paper
• NADPH Phagocyte Oxidase Knockout Mice Control Trypanosoma cruzi Proliferation, but Develop Circulatory Collapse and Succumb to Infection

  2012cites this paper
• The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens

  2011cites this paper
• Selection of TcII Trypanosoma cruzi population following macrophage infection.

  2011cites this paper
• Invasion and intracellular survival by protozoan parasites.

  2011cites this paper
• Epigenetic priming: the target?

  2011cites this paper
• This information is current as Infection Trypanosoma cruzi of against Fatal Myocarditis in a Mouse Model IL-10 Limits Parasite Burden and Protects

  2011cites this paper
• Interferon and PV stem cells.

  2011cites this paper
• Brucella abortus intracellular survival and intercellular trafficking

  2011cites this paper
• Splenectomy Increases Mortality in Murine Trypanosoma cruzi Infection

  2011cites this paper
• Invasion and intracellular survival by protozoan parasites

  2011cites this paper
• Osteoblast-enriched membrane protein IFITM5 regulates the association of CD9 with an FKBP11-CD81-FPRP complex and stimulates expression of interferon-induced genes.

  2011cites this paper
• The innate immune response to Trypanosoma cruzi infection.

  2010cites this paper
• The Mouse Resistance Protein Irgm1 (LRG-47): A Regulator or an Effector of Pathogen Defense?

  2010cites this paper
• Cross‐presentation of peptides from intracellular pathogens by MHC class I molecules

  2010cites this paper
• IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection

  2010cites this paper
• Topological journey of parasite-derived antigens for presentation by MHC class I molecules.

  2010cites this paper
• Iron metabolism in trypanosomatids, and its crucial role in infection

  2010cites this paper
• Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer.

  2010cites this paper
• Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

  2010influential citation
• Genetic deficiency of Irgm1 (LRG‐47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells

  2010cites this paper
• Mycobacteria in Crohn’s disease: how innate immune deficiency may result in chronic inflammation

  2010cites this paper
• DNA mimics based on pyrrolidine and hydroxyproline

  2010cites this paper
• [DNA mimics on the base of pyrrolidine and hydroxyproline].

  2010cites this paper
• The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

  2010cites this paper
• Protective Host Response to Parasite and Its Limitations

  2010cites this paper
• Duke University Dissertation Template

  2010cites this paper
• 5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas' disease.

  2009cites this paper
• Contribution à la compréhension des mécanismes moléculaires de résistance de mycobacterium tuberculosis aux agents anti-tuberculeux

  2009cites this paper
• Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6

  2009cites this paper
• IFN-γ-Inducible Irga6 Mediates Host Resistance against Chlamydia trachomatis via Autophagy

  2009cites this paper
• Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease.

  2009cites this paper
• Interferon-inducible immunity-related GTPase Irgm1 regulates IFNγ-dependent host defense, lymphocyte survival and autophagy

  2009cites this paper
• Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance against Trypanosoma cruzi Infection

  2009cites this paper
• Resistance Factor Irgb10-Inducible Host g Restriction by the IFN-Evades Growth Chlamydia muridarum

  2008cites this paper
• SNPping away at the pathogenesis of Crohn's disease.

  2008cites this paper
• Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase Families

  2008cites this paper
• Chlamydia muridarum Evades Growth Restriction by the IFN-γ-Inducible Host Resistance Factor Irgb101

  2008cites this paper
• Immunity-Related GTPases in Cell-autonomous Resistance against Toxoplasma gondii

  2008cites this paper
• Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6

  2008cites this paper
• The IRG proteins: a function in search of a mechanism.

  2008cites this paper
• Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection.

  2008cites this paper
• A Novel IFN Regulatory Factor 3-Dependent Pathway Activated by Trypanosomes Triggers IFN-β in Macrophages and Fibroblasts1

  2008cites this paper
• The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.

  2008cites this paper
• The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death

  2008cites this paper
• Inactive and Active States of the Interferon-inducible Resistance GTPase, Irga6, in Vivo

  2008cites this paper
• Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

  2008cites this paper
• IRG proteins: key mediators of interferon‐regulated host resistance to intracellular pathogens

  2007influential citation
• Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).

  2007cites this paper
• CARD6 Is Interferon Inducible but Not Involved in Nucleotide-Binding Oligomerization Domain Protein Signaling Leading to NF-κB Activation

  2007cites this paper
• The IFN-Inducible GTPase LRG47 (Irgm1) Negatively Regulates TLR4-Triggered Proinflammatory Cytokine Production and Prevents Endotoxemia1

  2007influential citation
• E¡ects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murineTrypanosomacruzi infection

  2007cites this paper
• Biochemical Analysis of Immunity-Related GTPase Irga6 In Vivo and In Vitro. The Role of the Myristoyl Group

  2007cites this paper
• Interferon-induced and Constitutive Expression of Immunity-related GTPases (IRG) in Mouse Tissues

  2007cites this paper
• Evolution and Cellular Resistance Mechanisms of the Immunity-Related GTPases

  2007cites this paper
• Chlamydia psittaci Murine Innate Immunity and Inflammation to Regulate Irgb 10 and Iigp 2 The p 47 GTPases

  2007cites this paper
• Impaired Macrophage Function Underscores Susceptibility to Salmonella in Mice Lacking Irgm1 (LRG-47)1

  2007cites this paper
• The p47 GTPases Iigp2 and Irgb10 Regulate Innate Immunity and Inflammation to Murine Chlamydia psittaci Infection1

  2007cites this paper
• Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families.

  2007cites this paper
• Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes1

  2006cites this paper
• TLR-Dependent Induction of IFN-β Mediates Host Defense against Trypanosoma cruzi1

  2006cites this paper