Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Blood

• Publication date

  2007-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD-2007-02-071225PMID 17351108PMCID PMC1890829
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia.

  2007cited by this paper
• Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays.

  2007cited by this paper
• Conserved MicroRNA Characteristics in Mammals

  2006cited by this paper
• The origin of B-cell chronic lymphocytic leukemia.

  2006cited by this paper
• bloodjournal.hematologylibrary.org at PENN STATE UNIVERSITY on March 1, 2013. For personal use

  2006cited by this paper
• A small piece in the cancer puzzle: microRNAs as tumor suppressors and oncogenes

  2006cited by this paper
• Cell-type-specific signatures of microRNAs on target mRNA expression.

  2006cited by this paper
• MicroRNAs and leukemias: how strong is the connection?

  2006cited by this paper
• Autoimmune complications of chronic lymphocytic leukemia.

  2006cited by this paper
• Clinical and laboratory parameters that define clinically relevant B-CLL subgroups.

  2005cited by this paper
• miRBase: microRNA sequences, targets and gene nomenclature

  2005cited by this paper
• miR-15 and miR-16 induce apoptosis by targeting BCL2.

  2005cited by this paper
• Real-time quantification of microRNAs by stem–loop RT–PCR

  2005cited by this paper
• Colocalization of Expansion of the Splenic Marginal Zone Population with Abnormal B Cell Activation and Autoantibody Production in B6 Mice with an Introgressed New Zealand Black Chromosome 13 Interval1

  2005cited by this paper
• A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.

  2005cited by this paper
• Perspectives on familial chronic lymphocytic leukemia: genes and the environment.

  2004cited by this paper
• Clinical staging and prognostic markers in chronic lymphocytic leukemia.

  2004cited by this paper
• A uniform system for microRNA annotation.

  2003cited by this paper
• Embryonic stem cell-specific MicroRNAs.

  2003cited by this paper
• Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma

  2002cited by this paper
• Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

  2002cited by this paper
• Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

  2002cited by this paper
• Bethesda proposals for classification of lymphoid neoplasms in mice.

  2002cited by this paper
• Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene.

  2001cited by this paper
• Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.

  2001cited by this paper
• The combination of chemotherapy and systemic immunotherapy with soluble B7-immunoglobulin G leads to cure of murine leukemia and lymphoma and demonstration of tumor-specific memory responses.

  2001cited by this paper
• Genomic aberrations and survival in chronic lymphocytic leukemia.

  2000cited by this paper
• Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14.

  2000cited by this paper
• Multiplex inheritance of component phenotypes in a murine model of lupus

  1999cited by this paper
• Regulatory role of T cells in a murine model of lymphoproliferative disease.

  1998cited by this paper
• Mapping of a gene for the increased susceptibility of B1 cells to Mott cell formation in murine autoimmune disease.

  1997cited by this paper
• Requirement for increased IL-10 in the development of B-1 lymphoproliferative disease in a murine model of CLL.

  1996cited by this paper
• 介绍New Eng J Med全文光盘

  1996cited by this paper
• Genetics of systemic autoimmunity.

  1996cited by this paper
• Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner.

  1995cited by this paper
• Classification of mouse lymphomas.

  1995cited by this paper
• The natural history of a lymphoproliferative disorder in aged NZB mice.

  1995cited by this paper
• A genetic map of the mouse with 4,006 simple sequence length polymorphisms

  1994cited by this paper
• A cultured malignant B-1 line serves as a model for Richter's syndrome.

  1994cited by this paper
• The NZB mouse as a model for chronic lymphocytic leukemia.

  1992cited by this paper
• Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities.

  1990cited by this paper
• In vivo effects of hyperdiploid Ly-1+ B cells of NZB origin.

  1988cited by this paper
• Genetic Studies in NZB Mice

  1979cited by this paper
• Lymphocytes and lymphocyte functions in systemic lupus erythematosus.

  1979cited by this paper
• Genetic studies in NZB mice. II. Hyperdiploidy in the spleen of NZB mice and their hybrids.

  1979cited by this paper

• Evaluation of current mouse in vivo models and advanced in vitro models for leukaemia research.

  2025cites this paper
• microRNA involvement in human cancer.

  2025influential citation
• miRNA expression based modulation: A new paradigm for the treatment of chronic myeloid leukemia.

  2025cites this paper
• Differential microRNAs Expression during Cancer Development, and Chemoprevention by Natural Compounds: A Comprehensive Review.

  2024cites this paper
• Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions

  2024cites this paper
• CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention

  2024cites this paper
• Role of microRNAs in Chronic Lymphocytic Leukemia

  2023cites this paper
• miRNAs as cornerstones in chronic lymphocytic leukemia pathogenesis and therapeutic resistance- An emphasis on the interaction of signaling pathways.

  2023cites this paper
• The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers

  2021influential citation
• The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders

  2021cites this paper
• Classical and noncanonical functions of miRNAs in cancers.

  2021cites this paper
• Is miR therapeutic targeting still a miRage?

  2021cites this paper
• Low miR-16 expression induces regulatory CD4+NKG2D+ T cells involved in colorectal cancer progression.

  2021cites this paper
• A Phase 2 Study of PNT2258 for Treatment of Relapsed or Refractory B-Cell Malignancies.

  2021cites this paper
• Deficiency of miR-15a/16 upregulates NKG2D in CD8+ T cells to exacerbate dextran sulfate sodium-induced colitis.

  2021cites this paper
• Transthyretin Suppressed Tumor Progression in Nonsmall Cell Lung Cancer by Inactivating MAPK/ERK Pathway.

  2021cites this paper
• miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+ CD8+ T large granular lymphocyte leukemia

  2021cites this paper
• Advantages and disadvantages of mouse models of chronic lymphocytic leukemia in drug discovery

  2021cites this paper
• Serum microRNA profiles among dioxin exposed veterans with monoclonal gammopathy of undetermined significance

  2020cites this paper
• The role of noncoding RNAs in epithelial cancer

  2020cites this paper
• Combined loss of function of two different loci of miR-15/16 drives the pathogenesis of acute myeloid leukemia

  2020influential citation
• MicroRNA-15a/16/SOX5 axis promotes migration, invasion and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes

  2020cites this paper
• Mouse Models in the Study of Mature B-Cell Malignancies.

  2020cites this paper
• Animal mouse models of acute myeloid leukemia

  2019cites this paper
• Decrypting noncoding RNA interactions, structures, and functional networks

  2019influential citation
• MiR-126 Modulates Angiogenesis in Breast Cancer by Targeting VEGF-A -mRNA

  2019cites this paper
• MicroRNAs in Cutaneous T-Cell Lymphoma: The Future of Therapy.

  2019cites this paper
• Hematologic Malignancy Biomarkers in Proximal Fluids

  2019cites this paper
• Mutational Screening of miR-17-92 Cluster and miR-34a by DNA Sequencing in Childhood High-Grade Brain Tumors

  2019cites this paper
• BCL2-Family Dysregulation in B-Cell Malignancies: From Gene Expression Regulation to a Targeted Therapy Biomarker

  2019cites this paper
• Impact des anomalies moléculaires dans l'histoire naturelle de la leucémie lymphoïde chronique

  2018cites this paper
• Noncoding RNAs in disease

  2018cites this paper
• Genetic Alteration of MicroRNA Affecting Cancer Pathways

  2018cites this paper
• Unlocking new molecular mechanisms and potential therapeutic targets for chronic lymphocytic leukemia

  2017cites this paper
• BCL2 and miR-15/16: from gene discovery to treatment

  2017influential citation
• microRNAs in Cancer Susceptibility

  2017cites this paper
• MicroRNA Dysregulation to Identify Novel Therapeutic Targets.

  2017cites this paper
• Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia: implication for therapy

  2017cites this paper
• Chronic lymphocytic leukaemia

  2017cites this paper
• A mutation in porcine pre-miR-15b alters the biogenesis of MiR-15b\16-1 cluster and strand selection of MiR-15b

  2017cites this paper
• RNA interactome identification by next-generation sequencing (RIINGS) : a novel method for identifying microRNA-RNA interactome in exact correspondence

  2017cites this paper
• THREE Animal Models to Study MicroRNA Function

  2017influential citation
• Single nucleotide polymorphisms and cancer susceptibility

  2017cites this paper
• Animal Models to Study MicroRNA Function

  2017cites this paper
• microRNAs and Acute Myeloid Leukemia Chemoresistance: A Mechanistic Overview

  2017cites this paper
• Interferon regulatory factor 4 attenuates Notch signaling to suppress the development of chronic lymphocytic leukemia

  2016cites this paper
• Modelling chronic lymphocytic leukaemia (CLL) cell : microenvironment interactions in two- and three-dimensional culture systems

  2016cites this paper
• Genetic and epigenetic alterations of microRNAs and implications for human cancers and other diseases

  2016cites this paper
• Defining the role of Interferon Regulatory Factor 4 in Chronic Lymphocytic Leukemia.

  2016influential citation
• Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model

  2016cites this paper
• Small RNAs/Cancer

  2016cites this paper
• Somatic Mutation of the SNP rs11614913 and Its Association with Increased MIR 196A2 Expression in Breast Cancer

  2016cites this paper
• Preclinical modeling of novel therapeutics in chronic lymphocytic leukemia: the tools of the trade.

  2016cites this paper
• Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer.

  2016cites this paper
• Novel mechanisms of regulation of miRNAs in CLL.

  2016cites this paper
• Alterations in the mir-15a/16-1 Loci Impairs Its Processing and Augments B-1 Expansion in De Novo Mouse Model of Chronic Lymphocytic Leukemia (CLL)

  2016cites this paper
• Associate micro-RNA expression profile with its target MRNA for new trend diagnosis and treatment in cancer

  2015cites this paper
• Monoclonal B-lymphocytosis in patients aged over 90 years is common but not inevitable, and has a prevalence comparable to that in individuals aged 65–90 years

  2015cites this paper
• Sequence Variation in Mature MicroRNA-499 Confers Unfavorable Prognosis of Lung Cancer Patients Treated with Platinum-Based Chemotherapy

  2015cites this paper
• LymphomiRs: microRNAs with regulatory roles in lymphomas

  2015cites this paper
• Mouse Models to Study Obesity Effects on Hematologic Malignancies

  2015cites this paper
• The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients.

  2015cites this paper
• IL-4 Up-Regulates MiR-21 and the MiRNAs Hosted in the CLCN5 Gene in Chronic Lymphocytic Leukemia

  2015cites this paper
• microRNA and Chronic Lymphocytic Leukemia.

  2015cites this paper
• MicroRNAs, cancer and ionizing radiation: Where are we?

  2015cites this paper
• The Role of microRNAs in Cancer

  2015cites this paper
• miRNA-15a/16: as tumor suppressors and more.

  2015cites this paper
• Role of microRNA in chronic lymphocytic leukemia onset and progression

  2015cites this paper
• microRNA-99a is downregulated and promotes proliferation, migration and invasion in non-small cell lung cancer A549 and H1299 cells

  2015cites this paper
• The miRNA Response after Exposure to Particulate Matter: a Potential Epigenetic Mechanism

  2015cites this paper
• R E V I E W T he miRNA Response after Exposure to Particulate Matter: a Potential Epigenetic Mechanism

  2015cites this paper
• The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL

  2015cites this paper
• MicroRNAs, cancer and ionizing radiation: Where are we?

  2015cites this paper
• Recent advances of microRNA-based molecular diagnostics to reduce false-positive lung cancer imaging

  2015cites this paper
• Investigating and reversing T-cell dysfunction in the Eμ-TCL1 mouse model of chronic lymphocytic leukaemia (CLL)

  2015cites this paper
• Micro-RNA Profiling for the Diagnosis and Prognosis of Canine Multicentric Lymphoma

  2015cites this paper
• MicroRNAs in Prostate Cancer: Small RNAs with Big Roles

  2015cites this paper
• Intersection of MicroRNA and gene regulatory networks and their implication in cancer.

  2014cites this paper
• Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53−/− mouse model and primary human leukemia cells

  2014cites this paper
• A new hope: novel therapeutic approaches to treatment of chronic lymphocytic leukaemia with defects in TP53

  2014cites this paper
• Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy.

  2014cites this paper
• MicroRNAs and Blood Cancers

  2014cites this paper
• Human diseases caused by germline and somatic abnormalities in microRNA and microRNA‐related genes

  2014cites this paper
• Role of miR-15/16 in CLL

  2014influential citation
• 1 Sequence variation in mature microRNA-499 confers unfavorable prognosis of lung cancer patients treated with platinum-based chemotherapy

  2014cites this paper
• Small is the New Big - Interplay of Mirnas in Cancer

  2014cites this paper
• MicroRNAs as Drugs and Drug Targets in Cancer

  2014cites this paper
• Mechanisms of Neuroblastoma Cell Growth Inhibition by CARP-1 Functional Mimetics

  2014cites this paper
• The role of miRNAs in cancer: from pathogenesis to therapeutic implications.

  2014cites this paper
• Facts and Speculations on the Onset and Clonal Expansion of Chronic Lymphocytic Leukemia Cells

  2014cites this paper
• MicroRNAome genome: A treasure for cancer diagnosis and therapy

  2014cites this paper
• The Role of MicroRNAs and Ultraconserved Non-Coding RNAs in Cancer

  2014cites this paper
• Defective DROSHA processing contributes to downregulation of MiR-15/-16 in chronic lymphocytic leukemia

  2014cites this paper
• MicroRNAs and Chronic Lymphocytic Leukemia

  2014cites this paper
• Bortezomib-contained chemotherapy and thalidomide combined with CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) play promising roles in plasmablastic lymphoma: a case report and literature review.

  2014cites this paper
• Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

  2014cites this paper
• MicroRNAs in cancer.

  2014influential citation
• MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease?

  2013cites this paper
• miR deregulation in CLL.

  2013cites this paper
• Role of miRNAs in the Pathogenesis of Chronic Lymphocytic Leukemia

  2013cites this paper