Linking tumor associated macrophages, inflammation, and intestinal tumorigenesis: Role of MCP‐1

No abstract is available for this paper.

• Publication year

  2012

• Venue

  American Journal of Physiology - Gastrointestinal and Liver Physiology

• Publication date

  2012-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpgi.00252.2012PMID 23019193PMCID PMC3517651
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cancer-related inflammation: common themes and therapeutic opportunities.

  2012cited by this paper
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• c-Myc Is Required for Proper Coronary Vascular Formation via Cell- and Gene-Specific Signaling

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• Intestinal inflammatory cytokine response in relation to tumorigenesis in the Apc(Min/+) mouse.

  2012influential reference
• Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models

  2012cited by this paper
• The hallmarks of cancer

  2012cited by this paper
• Cytotoxic T lymphocyte migration and effector function in the tumor microenvironment.

  2011cited by this paper
• Curcumin's Effect on Intestinal Inflammation and Tumorigenesis in the Apc Min/+ Mouse

  2011cited by this paper
• Monocyte chemoattractant protein-1 modulates invasion and apoptosis of PC-3M prostate cancer cells via regulating expression of VEGF, MMP9 and caspase-3.

  2011cited by this paper
• Monocyte chemoattractant protein-1 blockade inhibits lung cancer tumor growth by altering macrophage phenotype and activating CD8+ cells.

  2011cited by this paper
• Intratumoral macrophage counts correlate with tumor progression in colorectal cancer

  2010cited by this paper
• Mouse models for unraveling the importance of diet in colon cancer prevention.

  2010cited by this paper
• CCL2 blockade augments cancer immunotherapy.

  2010cited by this paper
• Activated macrophages induce metastatic behavior of colon cancer cells.

  2010cited by this paper
• Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice.

  2010cited by this paper
• Tumor-Associated Macrophages (TAM) as Major Players of the Cancer-Related Inflammation

  2010influential reference
• Adoptive Transfer of Tumor-Specific Tc17 Effector T Cells Controls the Growth of B16 Melanoma in Mice

  2010cited by this paper
• Macrophages, innate immunity and cancer: balance, tolerance, and diversity.

  2010cited by this paper
• Loss of transforming growth factor-beta signaling in mammary fibroblasts enhances CCL2 secretion to promote mammary tumor progression through macrophage-dependent and -independent mechanisms.

  2010cited by this paper
• Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer.

  2009cited by this paper
• Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice.

  2009influential reference
• Macrophage-derived IL-1β stimulates Wnt signaling and growth of colon cancer cells; a crosstalk interrupted by vitamin D3

  2009cited by this paper
• The Interaction of a High-Fat Diet and Regular Moderate Intensity Exercise on Intestinal Polyp Development in ApcMin/+ Mice

  2009cited by this paper
• The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6

  2009cited by this paper
• Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane‐ApcMin/+ mouse model of intestinal cancer

  2009cited by this paper
• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation

  2009cited by this paper
• Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients

  2009cited by this paper
• Interleukin-6 and cachexia in ApcMin/+ mice.

  2008cited by this paper
• Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps.

  2008cited by this paper
• Cancer-related inflammation

  2008cited by this paper
• Cancer: Inflaming metastasis

  2008cited by this paper
• Cancer and inflammation: a complex relationship.

  2008cited by this paper
• Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy

  2008cited by this paper
• Immune surveillance of tumors.

  2007cited by this paper
• Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer

  2007influential reference
• Tregs and rethinking cancer immunotherapy.

  2007cited by this paper
• IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice

  2006cited by this paper
• Cancer: Inflammation by remote control

  2005cited by this paper
• Smoldering and polarized inflammation in the initiation and promotion of malignant disease.

  2005cited by this paper
• Cancer and the chemokine network

  2004cited by this paper
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  2003cited by this paper
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• Induction of inflammatory angiogenesis by monocyte chemoattractant protein‐1

  1999cited by this paper
• Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice

  1998cited by this paper
• Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease.

  1996cited by this paper
• [Inflammation and cancer].

  1974cited by this paper

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