Altered structural connectivity of cortico-striato-pallido-thalamic networks in Gilles de la Tourette syndrome

Y. Worbe,L. Marrakchi-Kacem,S. Lecomte,R. Valabrègue,F. Poupon,P. Guevara,A. Tucholka,J. F. Mangin,M. Vidailhet,S. Lehéricy,A. Hartmann,C. Poupon

Published 2014 in Brain : a journal of neurology

ABSTRACT

See Jackson (doi:10.1093/brain/awu338) for a scientific commentary on this article. The neural substrate of Gilles de la Tourette syndrome is unknown. Worbe et al. use probabilistic tractography to demonstrate widespread structural abnormalities in cortico-striato-pallido-thalamic white matter pathways—likely arising from abnormal brain development—in patients with this syndrome.

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