A Double‐Blind, Randomized, Placebo‐Controlled Trial of Macrolide in the Treatment of Chronic Rhinosinusitis

No abstract is available for this paper.

• Publication year

  2006

• Venue

  The Laryngoscope

• Publication date

  2006-02-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/01.mlg.0000191560.53555.08PMID 16467702
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Challenge‐induced plasma exudation and mucinous secretion in human airways

  2005cited by this paper
• Australian norms for a quantitative olfactory function test.

  2004cited by this paper
• Effects of subinhibitory concentrations of macrolide antibiotics on Pseudomonas aeruginosa.

  2004cited by this paper
• Evaluation of the Medical and Surgical Treatment Of Chronic Rhinosinusitis: A Prospective, Randomised, Controlled Trial

  2004cited by this paper
• Outcomes assessment.

  2002cited by this paper
• Clarithromycin and Prednisolone Inhibit Cytokine Production in Chronic Rhinosinusitis

  2002cited by this paper
• Mode of action of long-term low-dose macrolide therapy for chronic sinusitis in the light of neutrophil recruitment.

  2002cited by this paper
• One-Year Low-Dose Erythromycin Treatment of Persistent Chronic Sinusitis after Sinus Surgery: Clinical Outcome and Effects on Mucociliary Parameters and Nasal Nitric Oxide

  2002cited by this paper
• Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds

  2000cited by this paper
• Prognostic Factors of Chronic Rhinosinusitis under Long-Term Low-Dose Macrolide Therapy

  2000cited by this paper
• Effects of Clarithromycin on Cultured Human Nasal Epithelial Cells and Fibroblasts

  2000cited by this paper
• Effects of erythromycin on human peripheral neutrophil apoptosis

  1999cited by this paper
• Outcomes Assessment

  1997cited by this paper
• Staging for Rhinosinusitis

  1997cited by this paper
• Adult Rhinosinusitis Defined

  1997cited by this paper
• Efficacy of long-term administration of clarithromycin in the treatment of intractable chronic sinusitis.

  1996cited by this paper
• Staging in rhinosinusitus.

  1993cited by this paper

• Personalized Management of Chronic Rhinosinusitis in the Context of Immune Deficiency

  2026cites this paper
• Efficacy of Long-Term Low-Dose Macrolide Therapy in Preventing Early Recurrence of Nasal Polyps after Endoscopic Sinus Surgery

  2026cites this paper
• Diagnostik und medikamentöse Therapie der chronischen Rhinosinusitis

  2025cites this paper
• Endoscopic sinus surgery versus macrolides in chronic rhinosinusitis: redefining clinical priorities.

  2025cites this paper
• [The diagnosis and treatment progress of olfaction disorders in chronic rhinosinusitis].

  2025cites this paper
• Medications and new therapies for chronic rhinosinusitis: a narrative review

  2025cites this paper
• Efficacy and safety of azithromycin in treating sinusitis patients: a systematic review and meta-analysis of randomized controlled trails

  2025cites this paper
• Clinical Practice Guideline: Adult Sinusitis Update

  2025cites this paper
• Chronic Rhinosinusitis from the Perspective of Traditional Chinese Medicine: Pathological Mechanisms, Integrated Treatment Strategies of TCM and Western Medicine, and Collaborative Pathways

  2025cites this paper
• Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

  2025cites this paper
• Endotypes of Chronic Rhinosinusitis: A Clinical Perspective

  2025cites this paper
• The clinical effectiveness of clarithromycin versus endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial.

  2025cites this paper
• Clinical Practice Guideline: Surgical Management of Chronic Rhinosinusitis

  2025cites this paper
• Chronic rhinosinusitis with and without nasal polyps: the state-of-the-art of current treatment strategies and future developments

  2025cites this paper
• Effect of Clarithromycin Combined With Oxymetazoline Hydrochloride Spray on Olfactory Function and Inflammatory Factors in Patients With Acute Exacerbations of Chronic Rhinosinusitis

  2025cites this paper
• Clinical Significance of Endotypes of Asian Chronic Rhinosinusitis: A Review and Expert Commentary

  2025cites this paper
• Antibiotic-Induced Immunosuppression—A Focus on Cellular Immunity

  2024cites this paper
• Update on the Role of the Microbiome in Chronic Rhinosinusitis

  2024cites this paper
• The role of macrolides in chronic rhinosinusitis and nasal polyps

  2024cites this paper
• Outcome measures for chronic rhinosinusitis with nasal polyps.

  2024cites this paper
• The Role of Nasal Microbiota and Sensitivity in Patients With Chronic Rhinosinusitis at a Rural Tertiary Care Hospital

  2024cites this paper
• Treatment Outcome Post Endoscopic Sinus Surgery(ESS) in Patients with Chronic Rhinosinusitis (CRS)

  2024cites this paper
• Schwierig zu behandelnde chronische Rhinosinusitis – wenn die Standardtherapie nicht wirkt und Biologika nicht zur Verfügung stehen

  2024cites this paper
• Common Drug Interactions in ENT: A Review of Antibiotics in Sinusitis

  2023cites this paper
• Pathophysiological features of chronic IgE-mediated rhinosinusitis of bacterial etiology

  2023cites this paper
• Effectiveness of keigairengyoto in patients with chronic rhinosinusitis after endoscopic sinus surgery

  2023cites this paper
• The Mechanism of Action and Clinical Efficacy of Low-Dose Long-Term Macrolide Therapy in Chronic Rhinosinusitis

  2023influential citation
• Treatment Strategy of Uncontrolled Chronic Rhinosinusitis with Nasal Polyps: A Review of Recent Evidence

  2023cites this paper
• A novel inflammatory endotype diagnostic model based on cytokines in chronic rhinosinusitis with nasal polyps

  2023cites this paper
• The inflammatory microenvironment of nasal polyps in patients with chronic rhinosinusitis and the relationship of this microenvironment with the nasal microbiome.

  2023cites this paper
• Predictive factors for identifying macrolide responder in treating chronic rhinosinusitis

  2023cites this paper
• Targeting Epithelium Dysfunction and Impaired Nasal Biofilms to Treat Immunological, Functional, and Structural Abnormalities of Chronic Rhinosinusitis

  2023cites this paper
• Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial

  2022cites this paper
• Exploring the role of antibiotics and steroids in managing respiratory diseases

  2022cites this paper
• Upper airway microbiome transplantation for patients with chronic rhinosinusitis

  2022cites this paper
• Unified Airway Disease: Medical Management.

  2022cites this paper
• Immunological mechanisms and treatable traits of chronic rhinosinusitis in Asia: A narrative review

  2022cites this paper
• A pilot randomised controlled trial of oral doxycycline after endoscopic sinus surgery and its effects on the sinonasal microbiome

  2022cites this paper
• Perspectives in Therapy of Chronic Rhinosinusitis

  2022cites this paper
• Current and emerging treatment modalities for bacterial rhinosinusitis in adults: a comprehensive review

  2022cites this paper
• Immunomodulatory Effects of Macrolides Considering Evidence from Human and Veterinary Medicine

  2022cites this paper
• Endotypes of Asian chronic rhinosinusitis with nasal polyps: A narrative review

  2022cites this paper
• Is there a Role for Antibiotics in the Treatment of Chronic Rhinosinusitis?

  2022influential citation
• Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review.

  2022cites this paper
• International consensus statement on allergy and rhinology: Olfaction

  2022cites this paper
• Current evaluation and management of patients with chronic rhinosinusitis and nasal polyps

  2022cites this paper
• Current Insight into Treatment of Chronic Rhinosinusitis: Phenotypes, Endotypes and Implications for Targeted Therapeutics.

  2022cites this paper
• Review of international questionnaires assessing quality of life in acute and chronic rhinosinusitis

  2021cites this paper
• Endotypes of chronic rhinosinusitis: Relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches

  2021cites this paper
• Precision Medicine in Chronic Rhinosinusitis: Where Does Allergy Fit In?

  2021cites this paper
• Long-term, low-dose macrolide antibiotic treatment in pediatric chronic airway diseases

  2021cites this paper
• Safety review of current systemic treatments for severe chronic rhinosinusitis with nasal polyps and future directions

  2021cites this paper
• Predictive factors for identifying macrolide responder in treating chronic rhinosinusitis.

  2021cites this paper
• Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Chronic Rhinitis and Chronic Rhinosinusitis

  2021cites this paper
• Sinonasal and gastrointestinal bacterial composition and abundance are stable after 1 week of once‐daily oral antibiotic treatment for chronic rhinosinusitis

  2021cites this paper
• Efficacy and Safety of Long-Term Low-Dose Clarithromycin in Patients With Refractory Chronic Sinusitis After Endoscopic Sinus Surgery: A Prospective Clinical Trial

  2021cites this paper
• Revisiting Asian chronic rhinosinusitis in the era of type 2 biologics

  2021cites this paper
• [Management strategies for chronic rhinosinusitis with nasal polyps in adults].

  2021cites this paper
• Avaliação prospectiva da claritromicina na rinossinusite crônica com polipose nasossinusal recorrente

  2021cites this paper
• The Role of Macrolides and Doxycycline in Chronic Rhinosinusitis.

  2020cites this paper
• Phenotypes of Chronic Rhinosinusitis.

  2020cites this paper
• Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis

  2020cites this paper
• Phenotypes in Chronic Rhinosinusitis

  2020cites this paper
• Medical Management Strategies in Acute and Chronic Rhinosinusitis.

  2020cites this paper
• Antibiotic Treatment for Chronic Rhinosinusitis: Prescription Patterns and Associations With Patient Outcome and the Sinus Microbiota

  2020cites this paper
• International consensus statement on allergy and rhinology: rhinosinusitis 2021

  2020cites this paper
• Local drug delivery systems for inflammatory diseases: Status quo, challenges, and opportunities.

  2020cites this paper
• The possible anti-inflammatory activity of macrolide antibiotics in male albino rat models

  2020cites this paper
• Use of Nonmedicated Control Substances in Randomized Clinical Trials of Patients With Chronic Rhinosinusitis: A Systematic Review and Single-Arm Meta-analysis.

  2020cites this paper
• ROLE OF MACROLIDES (CLARITHROMYCIN) ON BIOFILMS IN CHRONIC RHINOSINUSITIS

  2020cites this paper
• Azithromycin for chronic eosinophilic rhinosinusitis with nasal polyp: a placebo-controlled trial.

  2020cites this paper
• Azithromycin in viral infections

  2020cites this paper
• Rhinosinusitis update

  2020cites this paper
• Erythromycin reduces nasal inflammation by inhibiting immunoglobulin production, attenuating mucus secretion, and modulating cytokine expression

  2020cites this paper
• Antibiotic eluting sinus stents

  2020cites this paper
• Adult chronic rhinosinusitis

  2020cites this paper
• Roxithromycin inhibits compound 48/80-induced pseudo-allergy via the MrgprX2 pathway both in vitro and in vivo.

  2020cites this paper
• European Position Paper on Rhinosinusitis and Nasal Polyps 2020.

  2020cites this paper
• Injection of Steroid in Nasal Polyps: A Systematic Review

  2020cites this paper
• Low‐dose and long‐term azithromycin significantly decreases Staphylococcus aureus in the microbiome of refractory CRS patients

  2020cites this paper
• Effets rhino sinusiens des biothérapies chez l'asthmatique sévère

  2019influential citation
• Chronic rhinosinusitis

  2019cites this paper
• Rinossinusites: evidências e experiências

  2019cites this paper
• Superantigens and Biofilms in Sinus Diseases

  2019cites this paper
• A 10-Year Follow-Up of a Randomized Prospective Study of 2 Treatments for Chronic Rhinosinusitis Without Nasal Polyps and Investigation of the Impact of Gastroeosophageal Reflux Disease in the Resistance to Treatment

  2019cites this paper
• Neutrophils as a Protagonist and Target in Chronic Rhinosinusitis

  2019cites this paper
• Clarithromycin for the treatment of adult chronic rhinosinusitis: a systematic review and meta‐analysis

  2019cites this paper
• Diagnostik und Therapie von Riechstörungen

  2019cites this paper
• Short‐term outcomes of olfaction in patients with eosinophilic chronic rhinosinusitis after endoscopic sinus surgery and an assessment of prognostic factors

  2019cites this paper
• Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes.

  2019cites this paper
• The effects of erythromycin towards the treatment of persistent rhinosinusitis after functional endoscopic sinus surgery: A randomized, active comparator-controlled study

  2019cites this paper
• Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial

  2019cites this paper
• Unmet Needs in Chronic Upper Respiratory Tract Diseases

  2019cites this paper
• The use of roxithromycin in the treatment of acute bacterial rhinosinusitis

  2019cites this paper
• Antibiotic usage in chronic rhinosinusitis: analysis of national primary care electronic health records.

  2019cites this paper
• Prospective evaluation of clarithromycin in recurrent chronic rhinosinusitis with nasal polyps

  2019cites this paper
• Measuring antibiotic levels and their relationship with the microbiome in chronic rhinosinusitis

  2019cites this paper
• Factors of success of low‐dose macrolides in chronic sinusitis: Systematic review and meta‐analysis

  2019cites this paper
• Optimising Medical Management in CRS

  2019cites this paper
• Measurement of Nasal Nitric Oxide in Chronic Rhinosinusitis and Its Relationship to Patient-Reported Outcome: A Longitudinal Pilot Study

  2019cites this paper