Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecular Biology of the Cell

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.E05-05-0465PMID 16221890PMCID PMC1289423
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein.

  2005cited by this paper
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  2004influential reference
• A component of C. elegans meiotic chromosome axes at the interface of homolog alignment, synapsis, nuclear reorganization, and recombination.

  2004cited by this paper
• Subunit interface residues of glutathione S-transferase A1-1 that are important in the monomer-dimer equilibrium.

  2004cited by this paper
• The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions.

  2004cited by this paper
• Mnd1 is required for meiotic interhomolog repair.

  2004cited by this paper
• The importance of genetic recombination for fidelity of chromosome pairing in meiosis.

  2003influential reference
• The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast.

  2003cited by this paper
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• Un ménage à quatre: the molecular biology of chromosome segregation in meiosis.

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• Targeted stimulation of meiotic recombination.

  2002influential reference
• Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

  2002influential reference
• Whence meiosis?

  2001cited by this paper
• Multifaceted physiological response allows yeast to adapt to the loss of the signal recognition particle-dependent protein-targeting pathway.

  2001cited by this paper
• Mechanism and control of meiotic recombination initiation.

  2001influential reference
• The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination.

  2001cited by this paper
• The tandem affinity purification (TAP) method: a general procedure of protein complex purification.

  2001cited by this paper
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  2000influential reference
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Yeast Rad54 Promotes Rad51-dependent Homologous DNA Pairing via ATP Hydrolysis-driven Change in DNA Double Helix Conformation*

  1999cited by this paper
• Red1p, a MEK1-dependent Phosphoprotein That Physically Interacts with Hop1p during Meiosis in Yeast*

  1999influential reference
• High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1‐independent DSB repair pathway

  1999influential reference
• Genetic and morphological approaches for the analysis of meiotic chromosomes in yeast.

  1998cited by this paper
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  1998influential reference
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  1998cited by this paper
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  1998cited by this paper
• Meiotic cells monitor the status of the interhomolog recombination complex.

  1997influential reference
• Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway.

  1997influential reference
• Use of protein A gene fusions for the analysis of structure-function relationship of the transactivator protein C of bacteriophage Mu.

  1997cited by this paper
• The Yeast Red1 Protein Localizes to the Cores of Meiotic Chromosomes

  1997influential reference
• A meiotic recombination checkpoint controlled by mitotic checkpoint genes

  1996cited by this paper
• Double strand breaks at the HIS2 recombination hot spot in Saccharomyces cerevisiae.

  1996cited by this paper
• Analysis of meiotic recombination pathways in the yeast Saccharomyces cerevisiae.

  1996influential reference
• MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.

  1995influential reference
• Zip1-induced changes in synaptonemal complex structure and polycomplex assembly

  1995cited by this paper
• Three‐Dimensional structure of schistosoma japonicum glutathione s‐transferase fused with a six‐amino acid conserved neutralizing epitope of gp41 from hiv

  1994cited by this paper
• Insertional mutations in the yeast HOP1 gene: evidence for multimeric assembly in meiosis.

  1994influential reference
• Meiosis-induced double-strand break sites determined by yeast chromatin structure.

  1994cited by this paper
• Homologous pairing is reduced but not abolished in asynaptic mutants of yeast

  1994cited by this paper
• ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis.

  1993cited by this paper
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  1993cited by this paper
• Mixed segregation and recombination of chromosomes and YACs during single-division meiosis in spo13 strains of Saccharomyces cerevisiae.

  1993cited by this paper
• DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression.

  1992influential reference
• Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae.

  1992influential reference
• Meiotic induction of the yeast HOP1 gene is controlled by positive and negative regulatory sites

  1992cited by this paper
• A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.

  1991cited by this paper
• The HOP1 gene encodes a meiosis-specific component of yeast chromosomes.

  1990cited by this paper
• Meiosis in asynaptic yeast.

  1990influential reference
• Molecular cloning : a laboratory manual. Cold Spring Harbor, NY

  1989cited by this paper
• HOP1: a yeast meiotic pairing gene.

  1989influential reference
• Expression and DNA sequence of RED1, a gene required for meiosis I chromosome segregation in yeast

  1989cited by this paper
• Meiosis in haploid yeast.

  1982cited by this paper
• Recombinationless meiosis in Saccharomyces cerevisiae

  1981influential reference
• Recombination and chromosome segregation during the single division meiosis in SPO12-1 and SPO13-1 diploids.

  1980cited by this paper

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