Unstressing intemperate models: how cold stress undermines mouse modeling

Chris Karp discusses the negative impact of cold stress on mouse models of disease.

• Publication year

  2012

• Venue

  Journal of Experimental Medicine

• Publication date

  2012-06-04

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1084/jem.20120988PMID 22665703PMCID 3371737
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of High Ambient Temperature on Fat Metabolism of Pigs

  2014cited by this paper
• Non-canonical alternatives: What a macrophage is 4

  2012cited by this paper
• Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

  2011cited by this paper
• Brown adipose tissue activity controls triglyceride clearance

  2011cited by this paper
• Progress and challenges in translating the biology of atherosclerosis

  2011cited by this paper
• Effect of Temperature on Cystic Fibrosis Lung Disease and Infections: A Replicated Cohort Study

  2011cited by this paper
• Nonshivering thermogenesis and its adequate measurement in metabolic studies

  2011cited by this paper
• Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.

  2010cited by this paper
• The Population Dynamics and Control of Tuberculosis

  2010cited by this paper
• Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

  2010cited by this paper
• Resilience to bacterial infection: difference between species could be due to proteins in serum.

  2010cited by this paper
• Cellular bioenergetics as a target for obesity therapy

  2010cited by this paper
• Murine responses to endotoxin: another dirty little secret?

  2010cited by this paper
• Effects of Cold Stress, Corticosterone and Catecholamines on Phagocytosis in Mice: Differences between Resting and Activated Macrophages

  2010cited by this paper
• UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.

  2009influential reference
• Salmeterol restores secretory functions in cystic fibrosis airway submucosal gland serous cells.

  2009cited by this paper
• The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

  2009cited by this paper
• Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality.

  2008cited by this paper
• Febrile-Range Hyperthermia Augments Neutrophil Accumulation and Enhances Lung Injury in Experimental Gram-Negative Bacterial Pneumonia1

  2005influential reference
• Of Mice and Not Men: Differences between Mouse and Human Immunology

  2004cited by this paper
• Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors.

  2004cited by this paper
• Brown adipose tissue: function and physiological significance.

  2004cited by this paper
• Brown adipose tissue: function and physiological significance.

  2004cited by this paper
• Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold

  2001cited by this paper
• The role of fever in the infected host.

  2000cited by this paper
• Febrile Core Temperature Is Essential for Optimal Host Defense in Bacterial Peritonitis

  2000cited by this paper
• The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system.

  2000influential reference
• Fecal Glucocorticoids: A Noninvasive Method of Measuring Adrenal Activity in Wild and Captive Rodents

  2000cited by this paper
• An antipyretic role for interleukin-10 in LPS fever in mice.

  1999cited by this paper
• Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

  1997cited by this paper
• Temperature Regulation in Laboratory Rodents

  1993influential reference
• Changes in fasting-induced adrenocortical secretion of cold-acclimated rats.

  1990cited by this paper
• Effect of noradrenaline on plasma hormones and metabolites in cold-acclimated rats.

  1988cited by this paper
• Stress- and cold-induced adrenocortical responses in repetitively immobilized or cold-acclimated rats.

  1987cited by this paper
• Relationship between autonomic and behavioral thermoregulation in the mouse.

  1985cited by this paper
• Nonshivering thermogenesis.

  1984influential reference
• Body temperature in normal and endotoxin-treated mice of different ages.

  1981cited by this paper
• Effects of High Ambient Temperature on Various Stages of Rabies Virus Infection in Mice

  1974cited by this paper
• Relationship of low temperature to mouse resistance to infection with Klebsiella pneumoniae.

  1971cited by this paper
• Invasiveness of Salmonella Administered Orally to Cold-Exposed Mice

  1970cited by this paper
• Influence of ambient temperature on excretion of catecholamines and metabolites.

  1969cited by this paper
• Role of environmental temperature and humidity in susceptibility to disease.

  1968cited by this paper
• Effects of environmental temperature on Trypanosoma cruzi infection in mice.

  1967cited by this paper
• Protective effect of elevated temperature on mice infected with Coe virus.

  1966cited by this paper
• ENHANCEMENT OF SALMONELLOSIS AND EMERGENCE OF SECONDARY INFECTION IN MICE EXPOSED TO COLD

  1962cited by this paper
• The effect of environmental temperature on the host-parasite relationship in mice.

  1962cited by this paper
• Catecholamine production and release in exposure and acclimation to cold.

  1961cited by this paper
• VARIATION IN MORBIDITY AND MORTALITY OF MURINE TYPHUS INFECTION IN MICE WITH CHANGES IN THE ENVIRONMENTAL TEMPERATURE

  1944cited by this paper

• Thermoregulatory adaptations to cold in C3H/HeJ mice are independent of ADRB3 signaling

  2026cites this paper
• Neither rats nor mice have a broad thermoneutral zone: implications for physiological studies

  2026cites this paper
• Adipocyte-specific deletion of gp130 prevents ketogenic diet–induced hepatic steatosis

  2025cites this paper
• Gut microbiota in rheumatoid arthritis: Mechanistic insights, clinical biomarkers, and translational perspectives.

  2025cites this paper
• Impact of thermoneutral acclimation on a murine model of polymicrobial peritonitis

  2025cites this paper
• A minimally invasive thrombotic model to study stroke in awake mice

  2025cites this paper
• Improving bench-to-bedside translation for acute graft-versus-host disease models

  2025cites this paper
• From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy

  2025cites this paper
• Time-Restricted Feeding Extends Healthspan in Female and Lifespan in Male C57BL/6J Mice

  2025cites this paper
• Temperature-dependent differences in mouse gut motility are mediated by stress

  2024influential citation
• Anxiety Disorders: Treatments, Models, and Circuitry Mechanisms.

  2024cites this paper
• Circadian immunity from bench to bedside: a practical guide

  2024cites this paper
• Rearing mice at 22°C programs increased capacity to respond to chronic exposure to cold but not high fat diet

  2023cites this paper
• Unraveling the lost balance: Adrenergic dysfunction in cancer cachexia.

  2023cites this paper
• Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases

  2023cites this paper
• Influence of Housing Temperature and Genetic Diversity on Allogeneic T Cell-Induced Tissue Damage in Mice

  2023cites this paper
• Sex differences in energy metabolism: natural selection, mechanisms and consequences

  2023cites this paper
• Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids

  2023cites this paper
• Immune Features of Disparate Liver Transplant Outcomes in Female Hispanics With Nonalcoholic Steatohepatitis

  2023cites this paper
• Obesity amplifies influenza virus-driven disease severity in male and female mice

  2023cites this paper
• Reduction in Cold Stress in an Innovative Metabolic Cage Housing System Increases Animal Welfare in Laboratory Mice

  2023influential citation
• Effects of thermoneutrality on food intake, body weight, and body composition in a Prader-Willi syndrome mouse model

  2023cites this paper
• Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility

  2022cites this paper
• Cold stress during room temperature housing alters skeletal response to simulated microgravity (hindlimb unloading) in growing female C57BL6 mice.

  2022cites this paper
• Leptin and environmental temperature as determinants of bone marrow adiposity in female mice

  2022cites this paper
• Tumor Temperature: Friend or Foe of Virus-Based Cancer Immunotherapy

  2022cites this paper
• Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans

  2022cites this paper
• How murine models of human disease and immunity are influenced by housing temperature and mild thermal stress

  2022cites this paper
• Animal Models for Autoimmune Hepatitis: Are Current Models Good Enough?

  2022cites this paper
• Skeletal Muscle Uncoupling Proteins in Mice Models of Obesity

  2022cites this paper
• Setting Ambient Temperature Conditions to Optimize Translation of Molecular Work from the Mouse to Human: The "Goldilocks Solution".

  2022cites this paper
• The Immunomodulatory Effects of Social Isolation in Mice are Linked to Temperature Control

  2021cites this paper
• Gene Expression Analysis of Environmental Temperature and High-Fat Diet-Induced Changes in Mouse Supraclavicular Brown Adipose Tissue

  2021cites this paper
• Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner

  2021cites this paper
• Interleukin-10 Attenuates Liver Fibrosis Exacerbated by Thermoneutrality

  2021cites this paper
• A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review

  2021cites this paper
• Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice

  2021cites this paper
• Behavioral thermoregulation in the fasted C57BL/6 mouse.

  2021cites this paper
• Naturalizing mouse models for immunology

  2021cites this paper
• Significance of variation in basal metabolic rate in laboratory mice for translational experiments

  2021cites this paper
• Sepsis therapies: learning from 30 years of failure of translational research to propose new leads

  2020cites this paper
• Infrared Thermography as an Indicator of Heat Loss in Fur-Chewing Chinchillas (Chinchilla Lanigera)

  2020cites this paper
• Impact of Adaptive Thermogenesis in Mice on the Treatment of Obesity

  2020influential citation
• Simulation of Human-Operator Behavior in Solving Intellectual Problems during Control of Technological Processes in Stresses

  2020cites this paper
• Thermoneutrality and Immunity: How Does Cold Stress Affect Disease?

  2020influential citation
• Housing temperature affects the circadian rhythm of hepatic metabolism and clock genes.

  2020cites this paper
• Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery

  2020cites this paper
• Diet‐induced rodent models of obesity‐related metabolic disorders—A guide to a translational perspective

  2020cites this paper
• Thermoneutral Housing Temperature Improves Survival in a Murine Model of Polymicrobial Peritonitis

  2020cites this paper
• Mouse thermoregulation: Introducing the concept of the thermoneutral point

  2020cites this paper
• Auricular concha eletroacupuncture modulates lipid-lipoprotein metabolism in rats submitted to cold stress

  2020cites this paper
• Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice

  2019cites this paper
• HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.

  2019cites this paper
• The heat is on: A device that reduces cold stress-induced tachycardia in laboratory mice.

  2019cites this paper
• Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice

  2019cites this paper
• Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals.

  2019cites this paper
• Inner sensors of endotoxin - implications for sepsis research and therapy.

  2019cites this paper
• Confounding Factors in the Interpretation of Preclinical Studies

  2019cites this paper
• Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice

  2019cites this paper
• Aquatic Exercise at Thermoneutral Water Temperature Enhances Antitumor Immune Responses

  2019cites this paper
• Affectations in photic and thermic circadian entrainment of the locomotor activity rhythm in obese volcano mouse Neotomodon alstoni

  2019cites this paper
• Housing temperature influences exercise training adaptations in mice

  2019cites this paper
• Comparative proteomic study of liver lipid droplets and mitochondria in mice housed at different temperatures

  2019cites this paper
• Evaporative cooling provides a major metabolic energy sink

  2019cites this paper
• Oxygen and Carbon Dioxid e Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals Graphical

  2019cites this paper
• Incorporating Laboratory Animal Science into Responsible Biomedical Research.

  2019cites this paper
• Individual housing of male C57BL/6J mice after weaning impairs growth and predisposes for obesity

  2019cites this paper
• Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response

  2018cites this paper
• Acute Respiratory Distress Syndrome: Bench‐to‐Bedside Approaches to Improve Drug Development

  2018cites this paper
• Evaluation of potential prebiotics: a review

  2018cites this paper
• Mice selectively bred for high voluntary wheel-running behavior conserve more fat despite increased exercise.

  2018cites this paper
• Title : Modelling physical resilience in ageing mice

  2018cites this paper
• Effects of Rodent Thermoregulation on Animal Models in the Research Environment

  2018cites this paper
• The effects of sucrose on urine collection in metabolic cages

  2018cites this paper
• Low temperature decreases bone mass in mice: Implications for humans.

  2018cites this paper
• Of mice and men – environmental temperature, body temperature, and treatment of obesity

  2018cites this paper
• Home alone: a systematic review and meta‐analysis on the effects of individual housing on body weight, food intake and visceral fat mass in rodents

  2018cites this paper
• Effects of Rodent Thermoregulation on Animal Models in the Research Environment.

  2018cites this paper
• New Approaches to Treat Sepsis: Animal Models «Do Not Work» (Review)

  2018cites this paper
• Growth Hormone and Aging: Updated Review

  2018cites this paper
• Modelling physical resilience in ageing mice

  2018cites this paper
• Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research

  2018cites this paper
• AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

  2018cites this paper
• Metabolic Adaptations of CD4+ T Cells in Inflammatory Disease

  2018cites this paper
• Cold exposure down-regulates immune response pathways in ferret aortic perivascular adipose tissue

  2017cites this paper
• Presentations at conferences

  2017cites this paper
• Thermoneutral housing exacerbates non-alcoholic fatty liver disease in mice and allows for sex-independent disease modeling

  2017cites this paper
• The role of Fyn kinase in CRH regulation of energy homeostasis

  2017cites this paper
• Effects of Nesting Material on Energy Homeostasis in BALB/cAnNCrl, C57BL/6NCrl, and Crl:CD1(ICR) Mice Housed at 20 °C.

  2017cites this paper
• Somatic growth, aging, and longevity

  2017cites this paper
• Warming the mouse to model human diseases

  2017cites this paper
• The Impact of Housing Temperature-Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous System.

  2017cites this paper
• Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology

  2017cites this paper
• Stressed out: providing laboratory animals with behavioral control to reduce the physiological effects of stress

  2017cites this paper
• Ambient temperature modulates the effects of the Prader-Willi syndrome candidate gene Snord116 on energy homeostasis.

  2017cites this paper
• The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.

  2017cites this paper
• Metabolic Response of Visceral White Adipose Tissue of Obese Mice Exposed for 5 Days to Human Room Temperature Compared to Mouse Thermoneutrality

  2017cites this paper
• Effects of Nesting Material on Energy Homeostasis in BALB/cAnNCrl, C57BL/6NCrl, and Crl:CD1(ICR) Mice Housed at 20 °C.

  2017cites this paper
• Establishment and characterization of a novel murine model of pancreatic cancer cachexia

  2017cites this paper
• Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity

  2017cites this paper