Translational Mini‐Review Series on Complement Factor H: Structural and functional correlations for factor H

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Clinical and Experimental Immunology

• Publication date

  2007-12-07

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1365-2249.2007.03553.xPMID 18081691PMCID PMC2276926
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Secondary Structure

  2010cited by this paper
• The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells.

  2007cited by this paper
• Y402H Polymorphism of Complement Factor H Affects Binding Affinity to C-Reactive Protein1

  2007cited by this paper
• Complement factor H.

  2007cited by this paper
• Structural basis for complement factor H–linked age-related macular degeneration

  2007cited by this paper
• Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains

  2007cited by this paper
• STRUCTURE SHOWS GLYCOSAMINOGLYCAN- AND PROTEIN-RECOGNITION SITE IN FACTOR H IS PERTURBED BY AGE-RELATED MACULAR DEGENERATION-LINKED SNP

  2007cited by this paper
• Solution of the Structure

  2007cited by this paper
• Structure Shows That a Glycosaminoglycan and Protein Recognition Site in Factor H Is Perturbed by Age-related Macular Degeneration-linked Single Nucleotide Polymorphism*

  2007cited by this paper
• Mutation in factor H (Y402H) associated with age related macular degeneration (AMD) results in reduced binding activities

  2007cited by this paper
• Biochemical analysis of a common human polymorphism associated with age-related macular degeneration.

  2007cited by this paper
• The Factor H Variant Associated with Age-related Macular Degeneration (His-384) and the Non-disease-associated Form Bind Differentially to C-reactive Protein, Fibromodulin, DNA, and Necrotic Cells*

  2007cited by this paper
• Binding of factor H to C-reactive protein occurs only when the latter has undergone non-physiologic denaturation

  2007cited by this paper
• Atypical haemolytic uraemic syndrome.

  2006cited by this paper
• Critical Role of the C-Terminal Domains of Factor H in Regulating Complement Activation at Cell Surfaces1

  2006cited by this paper
• Disease-associated Sequence Variations Congregate in a Polyanion Recognition Patch on Human Factor H Revealed in Three-dimensional Structure*

  2006cited by this paper
• Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II).

  2006cited by this paper
• The C‐terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein

  2006cited by this paper
• De novo gene conversion in the RCA gene cluster (1q32) causes mutations in complement factor H associated with atypical hemolytic uremic syndrome

  2006cited by this paper
• Localization of the third heparin-binding site in the human complement regulator factor H1.

  2006cited by this paper
• Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid

  2006cited by this paper
• Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome.

  2006cited by this paper
• His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form*

  2006cited by this paper
• Structure of complement factor H carboxyl‐terminus reveals molecular basis of atypical haemolytic uremic syndrome

  2006cited by this paper
• Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)

  2005cited by this paper
• Complement Control Protein Modules in the Regulators of Complement Activation

  2005cited by this paper
• A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration.

  2005cited by this paper
• The Extracellular Matrix and Inflammation

  2005cited by this paper
• Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site.

  2005cited by this paper
• Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions.

  2005cited by this paper
• Exploring the charge space of protein–protein association: A proteomic study

  2005cited by this paper
• Large-scale modelling as a route to multiple surface comparisons of the CCP module family.

  2005cited by this paper
• The Extracellular Matrix and Inflammation FIBROMODULIN ACTIVATES THE CLASSICAL PATHWAY OF COMPLEMENT BY DIRECTLY BINDING C1q *

  2005cited by this paper
• Functional analysis in serum from atypical Hemolytic Uremic Syndrome patients reveals impaired protection of host cells associated with mutations in factor H.

  2004cited by this paper
• Complement Resistance of Borrelia burgdorferi Correlates with the Expression of BbCRASP-1, a Novel Linear Plasmid-encoded Surface Protein That Interacts with Human Factor H and FHL-1 and Is Unrelated to Erp Proteins*

  2004cited by this paper
• Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome.

  2003cited by this paper
• Structural and functional characterization of factor H mutations associated with atypical hemolytic uremic syndrome.

  2002cited by this paper
• Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H

  2002cited by this paper
• Cutting Edge: Localization of the Host Recognition Functions of Complement Factor H at the Carboxyl-Terminal: Implications for Hemolytic Uremic Syndrome1

  2002cited by this paper
• Complement C3b/C3d and Cell Surface Polyanions Are Recognized by Overlapping Binding Sites on the Most Carboxyl-Terminal Domain of Complement Factor H1

  2002cited by this paper
• Factor H family proteins: on complement, microbes and human diseases.

  2001cited by this paper
• Structure and composition of drusen associated with glomerulonephritis: Implications for the role of complement activation in drusen biogenesis

  2001cited by this paper
• Folded-back solution structure of monomeric factor H of human complement by synchrotron X-ray and neutron scattering, analytical ultracentrifugation and constrained molecular modelling.

  2001cited by this paper
• Structure and flexibility of the multiple domain proteins that regulate complement activation

  2001cited by this paper
• Complement Factor H Is a Serum-binding Protein for Adrenomedullin, and the Resulting Complex Modulates the Bioactivities of Both Partners*

  2001cited by this paper
• Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome.

  2001cited by this paper
• C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response

  2000cited by this paper
• A common site within factor H SCR 7 responsible for binding heparin, C-reactive protein and streptococcal M protein.

  2000cited by this paper
• C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response: Implications for Systemic Autoimmunity

  2000cited by this paper
• Each of the three binding sites on complement factor H interacts with a distinct site on C3b.

  2000cited by this paper
• Regulation of complement activation by C-reactive protein.

  1999cited by this paper
• Identification of the second heparin-binding domain in human complement factor H.

  1998cited by this paper
• M Protein of the Group A StreptococcusBinds to the Seventh Short Consensus Repeat of Human Complement Factor H

  1998cited by this paper
• Age-related increase in activity of specific lysosomal enzymes in the human retinal pigment epithelium.

  1997cited by this paper
• [Uremic syndrome].

  1997cited by this paper
• Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis.

  1996cited by this paper
• Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H.

  1996cited by this paper
• Mapping of the domains required for decay acceleration activity of the human factor H‐like protein 1 and factor H

  1996cited by this paper
• Analysis of the recognition mechanism of the alternative pathway of complement by monoclonal anti‐factor H antibodies: evidence for multiple interactions between H and surface bound C3b

  1996cited by this paper
• Identification of complement regulatory domains in human factor H.

  1995cited by this paper
• Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1.

  1995cited by this paper
• RNA Secondary Structure

  1995cited by this paper
• Regulation of alternative pathway complement activation by glycosaminoglycans: specificity of the polyanion binding site on factor H.

  1994cited by this paper
• Solution structure of a pair of complement modules by nuclear magnetic resonance.

  1993cited by this paper
• Solution structure of the fifth repeat of factor H: a second example of the complement control protein module.

  1992cited by this paper
• Ultrastructures and interactions of complement factors H and I.

  1992cited by this paper
• Three-dimensional structure of a complement control protein module in solution.

  1991cited by this paper
• Secondary structure of a complement control protein module by two-dimensional 1H NMR.

  1991cited by this paper
• Oligomeric domain structure of human complement factor H by X-ray and neutron solution scattering.

  1991cited by this paper
• Localization of the heparin-binding site on complement factor H.

  1991cited by this paper
• Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H.

  1990cited by this paper
• Human complement factor H: An additional gene product of 43kDa isolated from human plasma shows cofactor activity for the cleavage of the third component of complement

  1989cited by this paper
• The complete amino acid sequence of human complement factor H.

  1988cited by this paper
• A study of the structure of human complement component factor H by Fourier transform infrared spectroscopy and secondary structure averaging methods.

  1988cited by this paper
• Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins

  1987cited by this paper
• Demonstration ofLong Homologous Repeating Domains That Are Composed of the Short Consensus Repeats Characteristicof C3/C4 Binding Proteins

  1987cited by this paper
• Partial characterization of human complement factor H by protein and cDNA sequencing: Homology with other complement and non-complement proteins

  1986cited by this paper
• Murine protein H is comprised of 20 repeating units, 61 amino acids in length.

  1986cited by this paper
• Unusual ultrastructure of complement-component-C4b-binding protein of human complement by synchrotron X-ray scattering and hydrodynamic analysis.

  1986cited by this paper
• Structural and functional studies on C4b-binding protein, a regulatory component of the human complement system

  1985cited by this paper
• Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H.

  1985cited by this paper
• Lysine residues, but not carbohydrates, are required for the regulatory function of H on the amplification C3 convertase of complement.

  1984cited by this paper
• Localization of the complement-component-C3b-binding site and the cofactor activity for factor I in the 38kDa tryptic fragment of factor H.

  1984cited by this paper
• Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b.

  1983cited by this paper
• Circular dichroism studies of human factor H. A regulatory component of the complement system.

  1982cited by this paper
• Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution

  1977cited by this paper
• THE URAEMIC SYNDROME.

  1963cited by this paper
• CHOLESTEROL BODIES IN SOILS: PHYTOSTEROL

  1911cited by this paper
• Visualization of human C 4 b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C 4 b ( protein-protein interaction / protein conformation / C 3 convertase / complement regulation / blood coagulation )

  year unknowncited by this paper
• Study on the structure

  year unknowncited by this paper

• Factor B as a therapeutic target for the treatment of complement-mediated diseases

  2025cites this paper
• Unique target binding by the C-terminal region of FHR1 provides a new perception of aHUS pathology

  2024cites this paper
• Complement factor H in molecular regulation of angiogenesis

  2024cites this paper
• The complement system and diabetic retinopathy.

  2024cites this paper
• PolySialic Acid Nanoparticles Actuate Complement-Factor-H-Mediated Inhibition of the Alternative Complement Pathway: A Safer Potential Therapy for Age-Related Macular Degeneration

  2024influential citation
• SARS-CoV-2: Prediction of critical ionic amino acid mutations

  2024cites this paper
• Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury

  2024cites this paper
• Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.

  2023cites this paper
• Exploring the involvement of the alternative complement pathway in non-infectious uveitis pathogenesis

  2023cites this paper
• The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury

  2023cites this paper
• Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy

  2023cites this paper
• Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi‐protein cascade of the complement system

  2022cites this paper
• Antibody recognition of complement factor H reveals a flexible loop involved in atypical hemolytic uremic syndrome pathogenesis

  2022cites this paper
• Complement and the prothrombotic state.

  2021cites this paper
• Complement Genetic Variants and FH Desialylation in S. pneumoniae-Haemolytic Uraemic Syndrome

  2021cites this paper
• Mutational signatures in GATA3 transcription factor and its DNA binding domain that stimulate breast cancer and HDR syndrome

  2021cites this paper
• Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces

  2021cites this paper
• Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions

  2020cites this paper
• A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes

  2020cites this paper
• A novel complement inhibitor sMAP‐FH targeting both the lectin and alternative complement pathways

  2020cites this paper
• A Systematic Investigation on Complement Pathway Activation in Diabetic Retinopathy

  2020cites this paper
• The Complement System

  2020cites this paper
• Sweet turning bitter: Carbohydrate sensing of complement in host defence and disease

  2020cites this paper
• A unique PRDM13-associated variant in a Georgian Jewish family with probable North Carolina macular dystrophy and the possible contribution of a unique CFH variant

  2020cites this paper
• A systematic investigation on the involvement of complement pathway in diabetic retinopathy

  2019influential citation
• Complement regulation by heparan sulfate and factor H on the endothelial glycocalyx

  2019cites this paper
• Complement factor H family proteins in their non-canonical role as modulators of cellular functions.

  2019cites this paper
• Regulation of regulators: Role of the complement factor H-related proteins.

  2019cites this paper
• A komplementrendszer aktiválódását gátló H-faktor és az FHR molekulák patológiás szerepének vizsgálata

  2019cites this paper
• Self versus Nonself Discrimination by the Soluble Complement Regulators Factor H and FHL-1

  2019cites this paper
• Calcineurin inhibitor-induced endothelial cell injury – A role for complement

  2018influential citation
• The Complement System

  2018cites this paper
• Thrombotic microangiopathy after renal transplantation: Current insights in de novo and recurrent disease

  2018cites this paper
• Ophtalmologie. La dégénérescence maculaire liée à l’âge et la voie du complément : où en est-on en 2017 ?

  2018cites this paper
• Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

  2018influential citation
• Insights into the effects of complement factor H on the assembly and decay of the alternative pathway C3 proconvertase and C3 convertase.

  2017cites this paper
• Complement: A primer for the coming therapeutic revolution.

  2017cites this paper
• The properdin pathway: an “alternative activation pathway” or a “critical amplification loop” for C3 and C5 activation?

  2017cites this paper
• Complement Factor H related proteins and their biological role during bacterial infection

  2017cites this paper
• IMMUNOBIOLOGY Incomplete inhibition by eculizumab : mechanistic evidence for residual C 5 activity during strong complement activation

  2017cites this paper
• Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface–selective regulation of complement activation

  2017cites this paper
• THE ERA OF PLANT BASED MEDICINE- AN OVERVIEW

  2017cites this paper
• Analysis of Linear Antibody Epitopes on Factor H and CFHR1 Using Sera of Patients with Autoimmune Atypical Hemolytic Uremic Syndrome

  2017cites this paper
• Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation.

  2017cites this paper
• Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines

  2017cites this paper
• Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody

  2017cites this paper
• Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system

  2017cites this paper
• electivity of C 3-opsonin targeted complement inhibitors : A distinct dvantage in the protection of erythrocytes from paroxysmal octurnal hemoglobinuria patients

  2016cites this paper
• REGULATION OF COMPLEMENT ACTIVATION ON SURFACES: Towards better understanding of atypical hemolytic uremic syndrome

  2016cites this paper
• The alternative pathway of complement and the thrombotic microangiopathies.

  2016cites this paper
• omplement inhibition in biomaterial-and biosurface-induced hromboinflammation ristina

  2016cites this paper
• Complement related kidney diseases: Recurrence after transplantation

  2016cites this paper
• Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation

  2016cites this paper
• Overview of C3 Glomerulopathy

  2016cites this paper
• Complement Factor H Serum Levels Determine Resistance to Pneumococcal Invasive Disease.

  2016cites this paper
• Mechanisms of Host-Pathogen Protein Complex Formation and Bacterial Immune Evasion of Streptococcus suis Protein Fhb*

  2016cites this paper
• Protection of host cells by complement regulators

  2016cites this paper
• Alternative pathway regulation by factor H modulates Streptococcus pneumoniae induced proinflammatory cytokine responses by decreasing C5a receptor crosstalk.

  2016cites this paper
• Modulation of miR-146a/complement factor H-mediated inflammatory responses in a rat model of temporal lobe epilepsy

  2016cites this paper
• In the perspective of cartilage degradation in inflammatory joint diseases

  2016cites this paper
• The mechanisms of immune complex formation of Fhb 1 S . suis Protein Fhb : The Mechanisms of Host-pathogen Protein Complexes Formation and Bacterial Immune Evasion

  2016cites this paper
• Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients.

  2016cites this paper
• Complement inhibition in biomaterial- and biosurface-induced thromboinflammation

  2016cites this paper
• The Treponema denticola FhbB Protein Is a Dominant Early Antigen That Elicits FhbB Variant-Specific Antibodies That Block Factor H Binding and Cleavage by Dentilisin

  2016cites this paper
• Actividad anti-inflamatoria e inmunomoduladora de los inhibidores solubles del complemento C4BP ß- y factor H

  2016cites this paper
• Biomolecular strategies to modulate the macrophage response to implanted materials.

  2016cites this paper
• Insights into the Effects of Complement Factor H on the Assembly and Decay of the Alternative Pathway C3 Proconvertase and C3 Convertase*

  2016cites this paper
• Complement abnormalities in membranoproliferative glomerulonephritis and C3 glomerulopathy

  2016cites this paper
• The Complement Inhibitor Factor H Generates an Anti-Inflammatory and Tolerogenic State in Monocyte-Derived Dendritic Cells

  2016cites this paper
• Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

  2016cites this paper
• Cell Surface Engineering for Regulation of Immune Reactions in Cell Therapy.

  2015cites this paper
• Electrostatic study of Alanine mutational effects on transcription: application to GATA-3:DNA interaction complex

  2015cites this paper
• The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases.

  2015cites this paper
• Complement Factor H Antibodies from Lung Cancer Patients Induce Complement-Dependent Lysis of Tumor Cells, Suggesting a Novel Immunotherapeutic Strategy

  2015cites this paper
• The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures.

  2015cites this paper
• This information is current as Infection Plasmodium falciparum Blood-Stage Complement Evasion Strategy for Recruitment of Factor H as a Novel

  2015cites this paper
• Creating functional sophistication from simple protein building blocks, exemplified by factor H and the regulators of complement activation.

  2015cites this paper
• Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

  2015cites this paper
• Energetic evaluation of binding modes in the C3d and Factor H (CCP 19‐20) complex

  2015cites this paper
• Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement

  2015cites this paper
• Genetics of atypical haemolytic uraemic syndrome

  2015cites this paper
• More than just immune evasion: Hijacking complement by Plasmodium falciparum.

  2015cites this paper
• Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular Degeneration

  2014cites this paper
• Complement-Related Proteins Control the Flavivirus Infection of Aedes aegypti by Inducing Antimicrobial Peptides

  2014cites this paper
• Genomic aspects of age-related macular degeneration.

  2014cites this paper
• Making sense of the spectrum of glomerular disease associated with complement dysregulation

  2014cites this paper
• Novel Bifunctional Single-Chain Variable Antibody Fragments to Enhance Virolysis by Complement: Generation and Proof-of-Concept

  2014influential citation
• Mechanism and function of complement factor H

  2014cites this paper
• Extra-Renal Manifestations of Complement-Mediated Thrombotic Microangiopathies

  2014cites this paper
• Update on hemolytic uremic syndrome: Diagnostic and therapeutic recommendations.

  2013cites this paper
• Complement factor H-derived short consensus repeat 18–20 enhanced complement-dependent cytotoxicity of ofatumumab on chronic lymphocytic leukemia cells

  2013cites this paper
• Factor H Binds to the Hypervariable Region of Many Streptococcus pyogenes M Proteins but Does Not Promote Phagocytosis Resistance or Acute Virulence

  2013cites this paper
• Reduction of complement factor H binding to CLL cells improves the induction of rituximab-mediated complement-dependent cytotoxicity

  2013cites this paper
• Functional anatomy of complement factor H.

  2013cites this paper
• Defective complement action and control defines disease pathology for retinal and renal disorders and provides a basis for new therapeutic approaches.

  2013cites this paper
• Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

  2013cites this paper
• In Vitro Secretion Deficits are Common Among Human Coagulation Factor XIII Subunit B Missense Mutants: Correlations with Patient Phenotypes and Molecular Models

  2013cites this paper
• Properdin in complement activation and tissue injury.

  2013cites this paper
• A method of purifying intact complement factor H from human plasma.

  2013cites this paper
• Reduction of complement factor H binding to CLL cells improves the induction of rituximab-mediated complement-dependent cytotoxicity

  2013cites this paper