The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?

Interstitial fibrosis is the common endpoint of end-stage chronic kidney disease (CKD) leading to kidney failure. The clinical course of many renal diseases, and thereby of CKD, is highly variable. One of the major challenges in deciding which treatment approach is best suited for a patient but also in the development of new treatments is the lack of markers able to identify and stratify patients with stable versus progressive disease. At the moment renal biopsy is the only means of diagnosing renal interstitial fibrosis. Novel biomarkers should improve diagnosis of a disease, estimate its prognosis and assess the response to treatment, all in a non-invasive manner. Existing markers of CKD do not fully and specifically address these requirements and in particular do not specifically reflect renal fibrosis. The aim of this review is to give an insight of the involvement of the extracellular matrix (ECM) proteins in kidney diseases and as a source of potential novel biomarkers of renal fibrosis. In particular the use of the protein fingerprint technology, that identifies neo-epitopes of ECM proteins generated by proteolytic cleavage by proteases or other post-translational modifications, might identify such novel biomarkers of renal fibrosis.

• Publication year

  2014

• Venue

  Fibrogenesis & Tissue Repair

• Publication date

  2014-03-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/1755-1536-7-4PMID 24678881PMCID 3986639
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue Diseases Possibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure

  2013cited by this paper
• ABC of Kidney Disease. 2nd Edition

  2013cited by this paper
• Therapy for Fibrotic Diseases: Nearing the Starting Line

  2013cited by this paper
• Associations of Urinary Levels of Kidney Injury Molecule 1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) With Kidney Function Decline in the Multi-Ethnic Study of Atherosclerosis (MESA)

  2013cited by this paper
• A MMP derived versican neo-epitope is elevated in plasma from patients with atherosclerotic heart disease.

  2013cited by this paper
• Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases

  2013cited by this paper
• Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis—a serological evaluation

  2013cited by this paper
• Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis

  2013cited by this paper
• Association of Systemic Collagen Type IV Formation with Survival among Patients Undergoing Hemodialysis

  2013cited by this paper
• Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

  2013cited by this paper
• Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats

  2013cited by this paper
• Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy

  2013cited by this paper
• Magnetic Resonance Elastography Noninvasively Detects In Vivo Renal Medullary Fibrosis Secondary to Swine Renal Artery Stenosis

  2013cited by this paper
• ABC of Kidney Disease

  2013cited by this paper
• Biomarkers for incident CKD: a new framework for interpreting the literature

  2013cited by this paper
• Plasminogen activator inhibitor-1 in kidney pathology (Review).

  2013cited by this paper
• Quantification of “end products” of tissue destruction in inflammation may reflect convergence of cytokine and signaling pathways – implications for modern clinical chemistry

  2013cited by this paper
• Kidney injury molecule‐1: More than just an injury marker of tubular epithelial cells?

  2013influential reference
• Origin and function of myofibroblasts in kidney fibrosis

  2013cited by this paper
• Matrix metalloproteinases in kidney homeostasis and diseases.

  2012cited by this paper
• Transmembrane collagen XVII is a novel component of the glomerular filtration barrier

  2012influential reference
• Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA).

  2012cited by this paper
• Renal interstitial hyaluronan: functional aspects during normal and pathological conditions.

  2012cited by this paper
• ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis.

  2012cited by this paper
• Enzyme‐linked immunosorbent serum assay specific for the 7S domain of Collagen Type IV (P4NP 7S): A marker related to the extracellular matrix remodeling during liver fibrogenesis

  2012cited by this paper
• The renal (myo-)fibroblast: a heterogeneous group of cells.

  2012cited by this paper
• Renal interstitial fibrosis: mechanisms and evaluation

  2012cited by this paper
• Urine proteome of autosomal dominant polycystic kidney disease patients

  2012cited by this paper
• Elevated Plasma Levels of Endostatin Are Associated with Chronic Kidney Disease

  2012cited by this paper
• Glomerular basement membrane and related glomerular disease.

  2012influential reference
• Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation

  2012influential reference
• Hereditary ADAMTS 13 deficiency presenting as recurrent acute kidney injury

  2012cited by this paper
• UPDATE ON FIBROBLAST GROWTH FACTOR 23 IN CHRONIC KIDNEY DISEASE

  2012cited by this paper
• Serological Investigation of the Collagen Degradation Profile of Patients with Chronic Obstructive Pulmonary Disease or Idiopathic Pulmonary Fibrosis

  2012influential reference
• Urinary Matrix Metalloproteinase Activity in Diabetic Kidney Disease: A Potential Marker of Disease Progression

  2012cited by this paper
• Increased Renal Versican Expression Is Associated with Progression of Chronic Kidney Disease

  2012cited by this paper
• Biomarkers in chronic kidney disease: a review.

  2011influential reference
• Cellular and molecular mechanisms of renal fibrosis

  2011cited by this paper
• FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis.

  2011cited by this paper
• Measurement of CO3-610, a Potential Liver Biomarker Derived from Matrix Metalloproteinase-9 Degradation of Collagen Type III, in a Rat Model of Reversible Carbon-Tetrachloride-Induced Fibrosis

  2011cited by this paper
• Chronic kidney disease growth factors in renal fibrosis

  2011cited by this paper
• Assessment of proteolytic degradation of the basement membrane: a fragment of type IV collagen as a biochemical marker for liver fibrosis

  2011cited by this paper
• Renal interstitial fibrosis: a critical evaluation of the origin of myofibroblasts.

  2011cited by this paper
• Role of Glomerular Proteoglycans in IgA Nephropathy

  2011influential reference
• Extracellular matrix degradation and remodeling in development and disease.

  2011cited by this paper
• Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease.

  2011cited by this paper
• The peroxisome proliferator-activated receptor-α agonist, BAY PP1, attenuates renal fibrosis in rats.

  2011cited by this paper
• MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay

  2011cited by this paper
• Measurement of matrix metalloproteinase 9-mediated Collagen type III degradation fragment as a marker of skin fibrosis

  2011cited by this paper
• Increased total cytokeratin-18 serum and urine levels in chronic kidney disease.

  2011cited by this paper
• Small leucine-rich proteoglycans in kidney disease.

  2011cited by this paper
• Association of urinary type IV collagen with GFR decline in young patients with type 1 diabetes.

  2011influential reference
• Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis.

  2011cited by this paper
• Protein fingerprints - relying on and understanding the information of serological protein measurements.

  2011cited by this paper
• Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non‐neoplastic diseases

  2010cited by this paper
• Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases.

  2010cited by this paper
• Renal fibrosis: novel insights into mechanisms and therapeutic targets

  2010cited by this paper
• The extracellular matrix at a glance

  2010cited by this paper
• Urinary Type IV Collagen in Nondiabetic Kidney Disease

  2010cited by this paper
• Early urinary markers of diabetic kidney disease: a nested case-control study from the Diabetes Control and Complications Trial (DCCT).

  2010cited by this paper
• The extracellular matrix in development and morphogenesis: a dynamic view.

  2010cited by this paper
• Laminin alpha4-null mutant mice develop chronic kidney disease with persistent overexpression of platelet-derived growth factor.

  2010cited by this paper
• Matrix metalloproteinase‐9‐mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

  2010cited by this paper
• Next-generation biomarkers for detecting kidney toxicity

  2010cited by this paper
• Urinary procollagen III aminoterminal propeptide (PIIINP): a fibrotest for the nephrologist.

  2010cited by this paper
• Association Between Urinary Type IV Collagen Level and Deterioration of Renal Function in Type 2 Diabetic Patients Without Overt Proteinuria

  2010cited by this paper
• Urinary Liver-Type Fatty Acid-Binding Protein Predicts Progression to Nephropathy in Type 1 Diabetic Patients

  2010cited by this paper
• Neutrophil gelatinase-associated lipocalin is a new and sensitive marker of kidney function in chronic kidney disease patients and renal allograft recipients.

  2009cited by this paper
• The mesangial cell revisited: no cell is an island.

  2009cited by this paper
• Fibrogenesis & Tissue Repair

  2009cited by this paper
• Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane.

  2009influential reference
• Proteoglycans: from structural compounds to signaling molecules

  2009influential reference
• Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease.

  2009influential reference
• Assessment of liver fibrosis by transient elastography in persons with hepatitis C virus infection or HIV-hepatitis C virus coinfection.

  2009cited by this paper
• Urinary peptidome may predict renal function decline in type 1 diabetes and microalbuminuria.

  2009cited by this paper
• Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats.

  2009cited by this paper
• Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

  2009cited by this paper
• Human matrix metalloproteinases: Characteristics and pathologic role in altering mesangial homeostasis

  2008cited by this paper
• Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria.

  2008influential reference
• Urinary proteomics in diabetes and CKD.

  2008cited by this paper
• Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis.

  2008cited by this paper
• Daily pattern of breathing in healthy young men.

  2008cited by this paper
• Renal hyaluronan content during experimental uncontrolled diabetes in rats.

  2008cited by this paper
• Immunopathogenesis of IgAN

  2007influential reference
• Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity.

  2007influential reference
• Tubular kidney injury molecule‐1 (KIM‐1) in human renal disease

  2007influential reference
• PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis.

  2007cited by this paper
• Role of matrix metalloproteinases in renal pathophysiologies.

  2007influential reference
• Complement C5 mediates experimental tubulointerstitial fibrosis.

  2007cited by this paper
• Messenger RNA Expression of Podocyte-Associated Molecules in the Urinary Sediment of Patients with Diabetic Nephropathy

  2007cited by this paper
• Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction.

  2007cited by this paper
• Treatment targets in renal fibrosis.

  2007cited by this paper
• A hypomorphic mutation in the mouse laminin alpha5 gene causes polycystic kidney disease.

  2006cited by this paper
• Structure and function of matrix metalloproteinases and TIMPs.

  2006cited by this paper
• ADAM19 expression in human nephrogenesis and renal disease: associations with clinical and structural deterioration.

  2006cited by this paper
• Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes.

  2006cited by this paper
• Can we rely on blood urea nitrogen as a biomarker to determine when to initiate dialysis?

  2006cited by this paper
• Matrix metalloproteases in aberrant fibrotic tissue remodeling.

  2006cited by this paper
• Modular Activation of Nuclear Factor-κB Transcriptional Programs in Human Diabetic Nephropathy

  2006cited by this paper
• Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome.

  2006cited by this paper

• Diterpenoids from Euphorbia wallichii show anti-renal fibrosis potential with associated inhibition on TGF-β/Smad signaling pathway.

  2026cites this paper
• Gut microbiome- targeted intervention ameliorates structural and transcriptomic changes in the kidney of hindlimb unloaded mouse model

  2026cites this paper
• A rat model of Immunologic and hypertensive kidney injury

  2026cites this paper
• Kidney injury urine biomarker normal ranges in children

  2026cites this paper
• A diálise peritoneal exerce influência na expressão de microRNAS e na resposta pró-inflamatória: resultados de um estudo transversal

  2026cites this paper
• Fibrillin-1 is a novel ligand of the epidermal growth factor receptor promoting mesangial cell activation and glomerulosclerosis.

  2026cites this paper
• Extrusion bioprinting: meeting the promise of human tissue biofabrication?

  2025cites this paper
• Perturbed gut microbiota and serum metabolites are associated with progressive renal fibrosis

  2025cites this paper
• Integrated Transcriptomic and Metabolomic Analysis Reveals the Induction of Anoikis in Renal Proximal Tubular Epithelial Cells by 2,6-Dichloro-1,4-benzoquinone.

  2025cites this paper
• Kidney Fibrosis In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

  2025cites this paper
• [Shenqi Xiezhuo Decoction alleviates renal fibrosis in rats by ameliorating oxidative stress and inflammation through the Rap1/MAPK/FoxO3a signaling pathway].

  2025cites this paper
• Imidazopyrimidine-based Pyruvate Kinase M2 Activator Halts Diabetic Nephropathy Progression via Modulating Epithelial-To-Mesenchymal Transition and Fibrosis.

  2025cites this paper
• Fibrosis markers as prognostic markers of decline in kidney function in patients with neuroendocrine neoplasms undergoing peptide receptor radionuclide therapy

  2025cites this paper
• Association of Urinary Collagen Type III Degradation Product With Kidney Function and Fibrosis in Chronic Kidney Disease Patients

  2025cites this paper
• Preclinical Evaluation of Baicalin for the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis

  2025cites this paper
• Empagliflozin protected kidney function in CKD rat through suppressing hypoxic and fibrotic signalings mediated inflammation and EMT.

  2025cites this paper
• Protecting kidney function: from mechanisms to therapeutic targets and traditional Chinese medicine

  2025cites this paper
• How a kidney microenvironment atlas can advance kidney tissue engineering.

  2025cites this paper
• Peritoneal dialysis influences microRNA expression and pro-inflammatory response: results from a cross-sectional study

  2025cites this paper
• Mesenchymal cell-derived exosomes and miR-29a-3p mitigate renal fibrosis and vascular rarefaction after renal ischemia reperfusion injury

  2025cites this paper
• Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics

  2025cites this paper
• Podocyte specific knockout of the natriuretic peptide clearance receptor is podocyte protective in focal segmental glomerulosclerosis

  2025cites this paper
• Identification of mechanistic CKD biomarkers in a rat SNx kidney fibrosis model by transcriptomics and proteomics detectable in biofluids

  2025cites this paper
• Histopathology of Diabetic Nephropathy: Beyond Glomerular Basement Membrane Thickening

  2025cites this paper
• Reduced glomerular and elevated tubulointerstitial transglutaminase pathway and its inhibition in a rat model of renal warm ischemia: implications for feline chronic kidney disease

  2025cites this paper
• Matrix Metalloproteinases in Ureteropelvic Junction Obstruction: Their Role in Pathogenesis and Their Use as Clinical Markers

  2025cites this paper
• Ketone Bodies in Renal Function and Diabetic Kidney Disease.

  2025cites this paper
• Collagen formation, function and role in kidney disease

  2024cites this paper
• Urtica dioica L. Leaf Extract Dose-Dependently Modulates Oxidative Stress in the Kidney and Exerts Anti-Fibrotic and Anti-Inflammatory Properties by the Molecular Mechanisms Independent of NRF-2 Signalization Mirroring the Effects of Losartan in SHR

  2024cites this paper
• Development of a spontaneous model of renal interstitial fibrosis in NOD/SCID mice: Aging-induced pathogenesis

  2024cites this paper
• Exosomal let‐7b‐5p deriving from parietal epithelial cells attenuate renal fibrosis through suppression of TGFβR1 and ARID3a in obstructive kidney disease

  2024cites this paper
• The Clinical Diagnostic Value of Combined Detection of miR-146a, UAER, and Other Indicators for Early-Stage Type 2 Diabetic Nephropathy

  2024cites this paper
• Attenuation of renal fibrosis in mice due to lack of bombesin receptor‐activated protein homologue

  2024cites this paper
• Complex Pathophysiology of Acute Kidney Injury (AKI) in Aging: Epigenetic Regulation, Matrix Remodeling, and the Healing Effects of H2S

  2024cites this paper
• CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the Lysosomal Degradation of DDX1

  2024cites this paper
• Long-Term Dietary Consumption of Grapes Affects Kidney Health in C57BL/6J Mice

  2024cites this paper
• Fibrosis in Chronic Kidney Disease: Pathophysiology and Therapeutic Targets

  2024cites this paper
• Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease

  2024cites this paper
• Mechanisms of norcantharidin against renal tubulointerstitial fibrosis

  2024cites this paper
• The sclerotic component of metabolic syndrome: Fibroblast activities may be the central common denominator driving organ function loss and death

  2024cites this paper
• Boswellia serrate Gum Resin Mitigates Renal Toxicity: Role of TNF-α, Interleukins, TGF-β, and Lipid Peroxidation

  2024cites this paper
• Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome

  2024cites this paper
• Integration of Urinary Peptidome and Fecal Microbiome to Explore Patient Clustering in Chronic Kidney Disease

  2024cites this paper
• Interpretable machine learning model integrating clinical and elastosonographic features to detect renal fibrosis in Asian patients with chronic kidney disease

  2024cites this paper
• Nontargeted Plasma Proteomic Analysis of Renal Disease and Pulmonary Hypertension in Patients with Sickle Cell Disease.

  2024cites this paper
• MMP-14 Exhibits Greater Expression, Content and Activity Compared to MMP-15 in Human Renal Carcinoma

  2024cites this paper
• Dual amylin and calcitonin receptor agonist treatment reduces biomarkers associated with kidney fibrosis in diabetic rats.

  2023cites this paper
• Exploratory Study Analyzing the Urinary Peptidome of T2DM Patients Suggests Changes in ECM but Also Inflammatory and Metabolic Pathways Following GLP-1R Agonist Treatment

  2023cites this paper
• Biomarkers of the End-Stage Renal Disease Progression: Beyond the GFR

  2023cites this paper
• Is urinary type IV collagen a good marker of early impairment of renal function in childhood cancers survivors?

  2023cites this paper
• Features of the course of type 1 diabetes mellitus and its complications against the background of undifferentiated connective tissue dysplasia

  2023cites this paper
• Interstitial Nephritis: Wherefrom, Wherein, and Whereto.

  2023cites this paper
• Effect of Youthful Blood Environment and Its Key Stem Cell Factor on Renal Interstitial Fibrosis in Elderly Mice

  2023cites this paper
• Fibronectin-targeted FUD and PEGylated FUD peptides for fibrotic diseases.

  2023cites this paper
• Spatially resolved transcriptomic profiling for glomerular and tubulointerstitial gene expression in C3 glomerulopathy

  2023cites this paper
• Identification of Potential Predictive and Diagnostic Urinary Biomarkers for Acute Rejection in Renal Transplant Recipients: A Proteomics Study

  2023cites this paper
• Matrikines in kidney ageing and age-related disease

  2023cites this paper
• Kidney fibrosis: Emerging diagnostic and therapeutic strategies.

  2023cites this paper
• Renal fibrosis in type 2 cardiorenal syndrome: An update on mechanisms and therapeutic opportunities.

  2023cites this paper
• Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis

  2023cites this paper
• Endotrophin as a risk marker of mortality and kidney complications in a type 1 diabetes cohort

  2023cites this paper
• Hypoxia and renal fibrosis.

  2023cites this paper
• Unique Biomarkers of Collagen Type III Remodeling Reflect Different Information Regarding Pathological Kidney Tissue Alterations in Patients with IgA Nephropathy

  2023cites this paper
• Higher Content but No Specific Activity in Gelatinase B (MMP-9) Compared with Gelatinase A (MMP-2) in Human Renal Carcinoma

  2023cites this paper
• Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity.

  2023cites this paper
• Marker for kidney fibrosis is associated with inflammation and deterioration of kidney function in people with type 2 diabetes and microalbuminuria

  2023cites this paper
• Spheroids, organoids and kidneys-on-chips: how complex human cellular models have assisted in the study of kidney disease and renal ciliopathies

  2023cites this paper
• The protective effects of a novel AT2 receptor agonist, β-Pro7Ang III in ischemia-reperfusion kidney injury.

  2023cites this paper
• Is the proximal tubule the focus of tubulointerstitial fibrosis?

  2023cites this paper
• Effect of tissue fixation on the optical properties of structural components assessed by non-linear microscopy imaging.

  2023cites this paper
• Serum and Urine Biomarkers Related to Kidney Fibrosis Predict Kidney Outcome in Czech Patients with IgA Nephropathy

  2023cites this paper
• TGFβ instructs mTORC2 to activate PKCβII for increased TWIST1 expression in proximal tubular epithelial cell injury

  2023cites this paper
• Markers of end-stage renal disease progression: beyond the GFR

  2023cites this paper
• Diagnostic and prognostic biomarkers for tubulointerstitial fibrosis

  2023cites this paper
• Development of cell-derived matrices for 3D in vitro cancer cell models.

  2023cites this paper
• Unsupervised clustering of venous thromboembolism patients by clinical features at presentation identifies novel endotypes that improve prognostic stratification.

  2023cites this paper
• Randomized Trial of SGLT2 Inhibitor Identifies Target Proteins in Diabetic Kidney Disease

  2023cites this paper
• Human placenta/umbilical cord derivatives in regenerative medicine - Prospects and challenges.

  2023cites this paper
• Urinary proteome of dogs with renal disease secondary to leishmaniosis.

  2022cites this paper
• Poricoic Acid A Inhibits the NF-κB/MAPK Pathway to Alleviate Renal Fibrosis in Rats with Cardiorenal Syndrome

  2022cites this paper
• Lasmiditan Promotes Recovery of Renal Function Through Mitochondrial Biogenesis.

  2022cites this paper
• Effect of crude Ganoderma applanatum polysaccharides as a renoprotective agent against carbon tetrachloride-induced early kidney fibrosis in mice

  2022cites this paper
• The Delivery of the Recombinant Protein Cocktail Identified by Stem Cell-Derived Secretome Analysis Accelerates Kidney Repair After Renal Ischemia-Reperfusion Injury

  2022cites this paper
• Crosstalk between lysine methyltransferase Smyd2 and TGF-β-Smad3 signaling promotes renal fibrosis in autosomal dominant polycystic kidney disease.

  2022cites this paper
• β-Elemene Attenuates Renal Fibrosis in the Unilateral Ureteral Obstruction Model by Inhibition of STAT3 and Smad3 Signaling via Suppressing MyD88 Expression

  2022cites this paper
• Kaempferol inhibits renal fibrosis by suppression of the sonic hedgehog signaling pathway.

  2022cites this paper
• An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model

  2022cites this paper
• An Integrative in silico Study to Discover Key Drivers in Pathogenicity of Focal and Segmental Glomerulosclerosis

  2022cites this paper
• Prostaglandin E2 receptors as therapeutic targets in renal fibrosis

  2022cites this paper
• Densification: Hyaluronan Aggregation in Different Human Organs

  2022cites this paper
• Roles of NAD+ in Acute and Chronic Kidney Diseases

  2022cites this paper
• Silencing of LncRNA KCNQ1OT1 confers an inhibitory effect on renal fibrosis through repressing miR-124-3p activity

  2022cites this paper
• Adverse Effects of fine particulate matter on human kidney functioning: a systematic review

  2022influential citation
• Kidney development and function: ECM cannot be ignored.

  2022cites this paper
• Endotrophin is a risk marker of complications in CANagliflozin cardioVascular Assessment Study (CANVAS): a randomized controlled trial

  2022cites this paper
• Characterization of Glomerular and Tubulointerstitial Proteomes in a Case of Nonsteroidal Anti-Inflammatory Drug–Attributed Acute Kidney Injury

  2022cites this paper
• Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children

  2022cites this paper
• A nomogram based on shear wave elastography for assessment of renal fibrosis in patients with chronic kidney disease

  2022cites this paper
• Cell–Matrix Interactions in Renal Fibrosis

  2022cites this paper
• Association between fibrosis markers and kidney function following peptide receptor radionuclide therapy in patients with neuroendocrine tumours

  2022cites this paper