Detyrosinated (Glu) microtubules are stabilized by an ATP-sensitive plus-end cap.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Cell Science

• Publication date

  2000-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 11058078
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Positioning of the mitotic spindle by a cortical-microtubule capture mechanism.

  2000cited by this paper
• Microtubule Interactions with the Cell Cortex Causing Nuclear Movements in Saccharomyces cerevisiae

  2000cited by this paper
• Molecular linkage underlying microtubule orientation toward cortical sites in yeast.

  2000cited by this paper
• CLIP-170 highlights growing microtubule ends in vivo.

  1999cited by this paper
• A signal transduction pathway involved in microtubule‐mediated cell polarization

  1999cited by this paper
• Formin' the Connection between Microtubules and the Cell Cortex

  1999cited by this paper
• Control of Mitotic Spindle Position by the Saccharomyces cerevisiae Formin Bni1p

  1999cited by this paper
• Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal ends.

  1999cited by this paper
• Kin I kinesins are microtubule-destabilizing enzymes.

  1999cited by this paper
• EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle

  1998cited by this paper
• Targeting, Capture, and Stabilization of Microtubules at Early Focal Adhesions

  1998cited by this paper
• Relationship between microtubule dynamics and lamellipodium formation revealed by direct imaging of microtubules in cells treated with nocodazole or taxol.

  1998cited by this paper
• The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules.

  1998cited by this paper
• Assembly and colchicine binding characteristics of tubulin with maximally tyrosinated and detyrosinated alpha-tubulins.

  1998cited by this paper
• Rho Guanosine Triphosphatase Mediates the Selective Stabilization of Microtubules Induced by Lysophosphatidic Acid

  1998cited by this paper
• Selective Destruction of Stable Microtubules and Axons by Inhibitors of Protein Serine/Threonine Phosphatases in Cultured Human Neurons (NT2N Cells)

  1997cited by this paper
• Kinesin-related KIP3 of Saccharomyces cerevisiae Is Required for a Distinct Step in Nuclear Migration

  1997cited by this paper
• The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration

  1996cited by this paper
• Identification and partial characterization of mitotic centromere- associated kinesin, a kinesin-related protein that associates with centromeres during mitosis

  1995cited by this paper
• Centripetal transport of microtubules in motile cells.

  1995cited by this paper
• Minus-end-directed motion of kinesin–coated microspheres driven by microtubule depolymerization

  1995cited by this paper
• Stable, detyrosinated microtubules function to localize vimentin intermediate filaments in fibroblasts

  1995cited by this paper
• Cellular microtubules heterogeneous in their content of microtubule-associated protein 4 (MAP4).

  1994cited by this paper
• Microtubule dynamics in fish melanophores

  1994cited by this paper
• Microtubule organization and dynamics dependent on microtubule-associated proteins.

  1994cited by this paper
• The binding of a ciliary microtubule plus-end binding protein complex to microtubules is regulated by ciliary protein kinase and phosphatase activities.

  1994cited by this paper
• Protein phosphatase inhibitors induce the selective breakdown of stable microtubules in fibroblasts and epithelial cells.

  1993cited by this paper
• Observation and quantification of individual microtubule behavior in vivo: microtubule dynamics are cell-type specific

  1993cited by this paper
• Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis

  1992cited by this paper
• CENP-E is a putative kinetochore motor that accumulates just before mitosis

  1992cited by this paper
• Stabilization and post‐translational modification of microtubules during cellular morphogenesis

  1991cited by this paper
• Increased microtubule assembly in bovine brain tubulin lacking the type III isotype of beta-tubulin.

  1990cited by this paper
• Localization of cytoplasmic dynein to mitotic spindles and kinetochores

  1990cited by this paper
• Ciliary microtubule capping structures contain a mammalian kinetochore antigen

  1990cited by this paper
• Cytoplasmic dynein is localized to kinetochores during mitosis

  1990cited by this paper
• Detyrosination of alpha tubulin does not stabilize microtubules in vivo [published erratum appears in J Cell Biol 1990 Sep;111(3):1325-6]

  1990cited by this paper
• Enzymes for microtubule-dependent motility.

  1989cited by this paper
• Microtubule dynamics and kinetochore function in mitosis.

  1988cited by this paper
• Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level

  1988cited by this paper
• Inhibition of kinesin-driven microtubule motility by monoclonal antibodies to kinesin heavy chains

  1988cited by this paper
• Assembly and turnover of detyrosinated tubulin in vivo

  1987cited by this paper
• Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends

  1987cited by this paper
• Posttranslational modification and microtubule stability

  1987cited by this paper
• Microtubules containing detyrosinated tubulin are less dynamic.

  1987cited by this paper
• Dynamic and stable populations of microtubules in cells

  1987cited by this paper
• Postpolymerization detyrosination of alpha-tubulin: a mechanism for subcellular differentiation of microtubules

  1987cited by this paper
• Differential turnover of tyrosinated and detyrosinated microtubules.

  1987cited by this paper
• Microtubule arrays in differentiated cells contain elevated levels of a post-translationally modified form of tubulin.

  1986cited by this paper
• Purification and assay of a 145-kDa protein (STOP145) with microtubule-stabilizing and motility behavior.

  1986cited by this paper
• Heterogeneity among microtubules of the cytoplasmic microtubule complex detected by a monoclonal antibody to alpha tubulin

  1984cited by this paper
• Distinct populations of microtubules: tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo.

  1984cited by this paper
• Rat monoclonal antitubulin antibodies derived by using a new nonsecreting rat cell line

  1982cited by this paper
• Calcium lability of cytoplasmic microtubules and its modulation by microtubule-associated proteins.

  1981cited by this paper
• ATP-dependent regulation of cytoplasmic microtubule disassembly.

  1981cited by this paper
• Taxol stabilizes microtubules in mouse fibroblast cells.

  1980cited by this paper
• COLD‐LABILE AND COLD‐STABLE MICROTUBULES IN THE MITOTIC SPINDLE OF MAMMALIAN CELLS *

  1975cited by this paper

• Cell polarity proteins promote macropinocytosis in response to metabolic stress

  2024cites this paper
• Cell polarity proteins promote macropinocytosis in response to metabolic stress

  2024cites this paper
• Inactivity of Stat3 in sensory and non-sensory cells of the mature cochlea

  2024cites this paper
• Microtubule‐associated proteins and enzymes modifying tubulin

  2023cites this paper
• SCG10 is required for peripheral axon maintenance and regeneration in mice.

  2023cites this paper
• Cellular cartography: Towards an atlas of the neuronal microtubule cytoskeleton

  2023cites this paper
• Microtubule and auditory function - an underestimated connection.

  2022cites this paper
• Manipulation of the Tubulin Code Alters Directional Cell Migration and Ciliogenesis

  2022cites this paper
• Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s disease

  2022cites this paper
• Periodic potential can enormously boost free-particle transport induced by active fluctuations.

  2022cites this paper
• Susceptibility of cytoskeletal-associated proteins for tumor progression

  2021cites this paper
• Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

  2021cites this paper
• α-tubulin tail modifications regulate microtubule stability through selective effector recruitment, not changes in intrinsic polymer dynamics.

  2021cites this paper
• A live-cell marker to visualize the dynamics of stable microtubules throughout the cell cycle

  2021cites this paper
• Role of Mitochondria-Cytoskeleton Interactions in the Regulation of Mitochondrial Structure and Function in Cancer Stem Cells

  2020cites this paper
• Small molecule‐driven SIRT3‐autophagy‐mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes

  2020cites this paper
• Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: an in vitro study

  2019cites this paper
• Coordination of microtubule acetylation and the actin cytoskeleton by formins

  2018cites this paper
• Vangl2 regulates spermatid planar cell polarity through microtubule (MT)-based cytoskeleton in the rat testis

  2018cites this paper
• Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testis

  2018cites this paper
• Asymmetric Tyrosination of Spindle Microtubules Facilitates Selfish Inheritance.

  2018cites this paper
• NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice

  2018cites this paper
• Microtubule Motors in Establishment of Epithelial Cell Polarity.

  2018cites this paper
• Dissecting the role of the tubulin code in mitosis.

  2018cites this paper
• Semi-retentive cytoskeletal fractionation (SERCYF): A novel method for the biochemical analysis of the organization of microtubule and actin cytoskeleton networks.

  2017cites this paper
• Axonal Transport, Parkin, And Α-Synuclein; Novel Therapeutic Targets To Treat Methamphetamine Neurotoxicity

  2017cites this paper
• Basement Membrane Laminin &agr;2 Regulation of BTB Dynamics via Its Effects on F-Actin and Microtubule Cytoskeletons Is Mediated Through mTORC1 Signaling

  2017cites this paper
• An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance

  2017cites this paper
• Zebrafish yolk syncytial nuclei migrate along a dynamic microtubule network

  2017cites this paper
• Formin 1 Regulates Microtubule and F-Actin Organization to Support Spermatid Transport During Spermatogenesis in the Rat Testis.

  2016cites this paper
• An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells

  2016cites this paper
• Loss of CENP-F results in distinct microtubule-related defects without chromosomal abnormalities

  2016influential citation
• Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasion

  2015cites this paper
• Kif4 Interacts with EB1 and Stabilizes Microtubules Downstream of Rho-mDia in Migrating Fibroblasts

  2014cites this paper
• Biological and medical physics, biomedical engineering

  2014cites this paper
• Microtubules and Their Role in Cellular Stress in Cancer

  2014cites this paper
• CKD-516 displays vascular disrupting properties and enhances anti-tumor activity in combination with chemotherapy in a murine tumor model

  2014cites this paper
• Microtubule-targeting agents: a therapeutic strategy in neurodegenerative diseases

  2014cites this paper
• CHAPTER 0 Imaging GTP-BoundTubulin : From Cellular to In Vitro Assembled Microtubules 1

  2013cites this paper
• Autophagy and microtubules – new story, old players

  2013cites this paper
• Structural basis of tubulin tyrosination by tubulin tyrosine ligase

  2013influential citation
• A hypothesis on the origin and evolution of tubulin.

  2013cites this paper
• Centrosome Polarization in T Cells: A Task for Formins

  2013cites this paper
• Imaging GTP-bound tubulin: from cellular to in vitro assembled microtubules.

  2013cites this paper
• [Compartmentalization and plasticity of the microtubule network].

  2013cites this paper
• HDAC6 activity is required for efficient polarization and intracellular transport of organelles in directionally migrating cells

  2013influential citation
• Tubulohelical Membrane Arrays, Annulate Lamellae and Nuclear Pores: Tripartite Membrane Architecture with the Participation of Nucleoporins

  2012cites this paper
• Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1

  2012cites this paper
• An Investigation into the Relationship Between the Activation of AMP Kinase and the Acetylation of Microtubules

  2012cites this paper
• Arsenic trioxide induces depolymerization of microtubules in an acute promyelocytic leukemia cell line

  2012cites this paper
• The ins and outs of tubulin acetylation: more than just a post-translational modification?

  2011cites this paper
• Microtubule tip-interacting proteins: a view from both ends.

  2011cites this paper
• A PAR-1–dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte

  2011cites this paper
• KIF4 regulates midzone length during cytokinesis.

  2011cites this paper
• FORMIN a link between kinetochores and microtubule ends.

  2011cites this paper
• KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC

  2010cites this paper
• An investigation of the Ciliary Protein PKHD1 in Cyst development in liver disease: clues to the pathogenesis of Biliary Atresia

  2010cites this paper
• Post-translational modifications of microtubules

  2010cites this paper
• Antimitotic chemotherapeutics promote adhesive responses in detached and circulating tumor cells

  2010cites this paper
• Tubulohelical membrane arrays: From the initial observation to the elucidation of nanophysical properties and cellular function

  2010cites this paper
• Formins and microtubules.

  2010cites this paper
• Novel Modes of Neural Computation: From Nanowires to Mind

  2009cites this paper
• Glycogen synthase kinase 3 in the world of cell migration

  2009cites this paper
• TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils

  2009cites this paper
• Extracellular Matrix Receptors in Astrogliosis

  2009cites this paper
• Molecular Alterations that Reduce Cortical Containment of Tubulin Microtentacles and their Impact on Breast Tumor Metastasis

  2009cites this paper
• The Post-Translational Modifications of Tubulin

  2008cites this paper
• Cell biology of embryonic migration.

  2008cites this paper
• The formin mDia2 stabilizes microtubules independently of its actin nucleation activity

  2008influential citation
• Submembraneous microtubule cytoskeleton: regulation of ATPases by interaction with acetylated tubulin

  2008cites this paper
• Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions

  2008cites this paper
• Beyond polymer polarity: how the cytoskeleton builds a polarized cell

  2008cites this paper
• Big roles for small GTPases in the control of directed cell movement.

  2007cites this paper
• The Drosophila CLASP homologue, Mast/Orbit regulates the dynamic behaviour of interphase microtubules by promoting the pause state.

  2007cites this paper
• Microtubules and actin filaments "cross-talk" in cell migration : role of the formin mDia and the tumor suppressor APC

  2007cites this paper
• HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions

  2007influential citation
• Preparation and characterization of posttranslationally modified tubulins from Artemia franciscana.

  2007cites this paper
• Adenomatous Polyposis Coli on Microtubule Plus Ends in Cell Extensions Can Promote Microtubule Net Growth with or without EB 1

  2006cites this paper
• Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.

  2006cites this paper
• RhoGTPase signaling in cell polarity and gene regulation.

  2006cites this paper
• Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

  2006cites this paper
• Microtubules in the Cerebral Cortex: Role in Memory and Consciousness

  2006cites this paper
• The formin mDia regulates GSK3beta through novel PKCs to promote microtubule stabilization but not MTOC reorientation in migrating fibroblasts.

  2006influential citation
• Infection with replication-deficient adenovirus induces changes in the dynamic instability of host cell microtubules.

  2006cites this paper
• Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space.

  2006cites this paper
• Regulation of the leading edge motility by PI (4,5)P2-dependent lipid microdomains

  2005cites this paper
• Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin.

  2005cites this paper
• Regulation of microtubules in cell migration.

  2005cites this paper
• Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

  2005cites this paper
• Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer.

  2005cites this paper
• Kinesin is involved in protecting nascent microtubules from disassembly after recovery from nocodazole treatment.

  2005cites this paper
• Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network

  2005cites this paper
• STAT5B-mediated Growth Hormone Signaling Is Organized by Highly Dynamic Microtubules in Hepatic Cells*

  2005cites this paper
• Understanding microtubule dynamics for improved cancer therapy

  2005cites this paper
• Rho Proteins and Microtubules

  2005cites this paper
• Development of the Ocular Lens: The Structure of the Vertebrate Lens

  2004cites this paper
• Transcription factors in early lens development

  2004cites this paper
• Development of the Ocular Lens: Role of Matrix and Cell Adhesion Molecules in Lens Differentiation

  2004cites this paper
• Development of the Ocular Lens: Lens Cell Membranes

  2004cites this paper
• Development of the Ocular Lens: Lens Fiber Differentiation

  2004cites this paper