Statins: a new insight into their mechanisms of action and consequent pleiotropic effects.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Pharmacological Reports

• Publication date

  2007-09-01

• Fields of study

  Medicine

• Identifiers
  PMID 18048949
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Air Force/Texas Coronary Atherosclerosis Prevention Study

  2008cited by this paper
• Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages.

  2007cited by this paper
• Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins

  2007cited by this paper
• Statins and the endothelium.

  2007cited by this paper
• Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin

  2006cited by this paper
• Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits.

  2006cited by this paper
• Statins: another class of antihypertensive agents?

  2006influential reference
• Peroxisome proliferator-activated receptors and the control of fatty acid oxidation in cardiac hypertrophy.

  2006cited by this paper
• Atorvastatin desensitizes β‐adrenergic signaling in cardiac myocytes via reduced isoprenylation of G‐protein γ‐subunits

  2006cited by this paper
• Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.

  2005cited by this paper
• Effects of Atorvastatin on Th polarization in patients with acute myocardial infarction

  2005cited by this paper
• Interaction between simvastatin and metoprolol with respect to cardiac β-adrenoceptor density, catecholamine levels and perioperative catecholamine requirements in cardiac surgery patients

  2005cited by this paper
• Toward immunomodulatory and anti-inflammatory properties of statins.

  2005cited by this paper
• Therapeutic roles of peroxisome proliferator-activated receptor agonists.

  2005cited by this paper
• Atorvastatin reverses age‐related reduction in rat hepatic PPARα and HNF‐4

  2005cited by this paper
• A statin in the treatment of heart failure? Controlled rosuvastatin multinational study in heart failure (CORONA): Study design and baseline characteristics

  2005cited by this paper
• Peroxisome proliferator-activated receptors and cardiovascular remodeling.

  2005cited by this paper
• Angiotensin converting enzyme (ACE) and HydroxyMethylGlutaryl-CoA (HMG-CoA) reductase inhibitors in the forefront of pharmacology of endothelium.

  2005cited by this paper
• Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4.

  2005cited by this paper
• Hypercholesterolemia Stimulates Angiotensin Peptide Synthesis and Contributes to Atherosclerosis Through the AT1A Receptor

  2004cited by this paper
• Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro.

  2004cited by this paper
• Atorvastatin completely inhibits VEGF-induced ACE upregulation in human endothelial cells.

  2004cited by this paper
• Effect of Atorvastatin on Risk of Recurrent Cardiovascular Events After an Acute Coronary Syndrome Associated With High Soluble CD40 Ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study

  2004cited by this paper
• Pravastatin has an additional depressor effect in patients undergoing long-term treatment with antihypertensive drugs.

  2004cited by this paper
• Simvastatin Combined With Ramipril Treatment in Hypercholesterolemic Patients

  2004cited by this paper
• Inflammation, Immunity, and HMG-CoA Reductase Inhibitors: Statins as Antiinflammatory Agents?

  2004cited by this paper
• Association between different lipid-lowering treatment strategies and blood pressure control in the Brisighella Heart Study.

  2004cited by this paper
• Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells.

  2004cited by this paper
• Peroxisome Proliferator-Activated Receptor &agr; Agonists Increase Nitric Oxide Synthase Expression in Vascular Endothelial Cells

  2004cited by this paper
• RHO SIGNALING in vascular diseases.

  2004cited by this paper
• PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats.

  2004cited by this paper
• Antioxidant effects of statins.

  2004cited by this paper
• The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging.

  2004cited by this paper
• Peroxisome proliferator-activated receptor alpha and hypertensive heart disease.

  2004cited by this paper
• Statins as immunomodulatory agents.

  2004influential reference
• Resistant arterial hypertension and hyperlipidemia: atorvastatin, not vitamin C, for blood pressure control.

  2004cited by this paper
• Statins Inhibit &bgr;-Adrenergic Receptor–Stimulated Apoptosis in Adult Rat Ventricular Myocytes via a Rac1-Dependent Mechanism

  2004cited by this paper
• Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development

  2003influential reference
• Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure.

  2003cited by this paper
• Peroxisome Proliferator-Activated Receptor &ggr; Ligands Increase Release of Nitric Oxide From Endothelial Cells

  2003cited by this paper
• &bgr;-Adrenergic Receptor–Stimulated Apoptosis in Cardiac Myocytes Is Mediated by Reactive Oxygen Species/c-Jun NH2-Terminal Kinase–Dependent Activation of the Mitochondrial Pathway

  2003cited by this paper
• Blood pressure reduction with HMG-CoA reductase inhibitors in renal transplant recipients.

  2003cited by this paper
• PPARs of the heart: three is a crowd.

  2003cited by this paper
• Simvastatin Normalizes Autonomic Neural Control in Experimental Heart Failure

  2003cited by this paper
• Small G proteins as novel therapeutic targets in cardiovascular medicine.

  2003influential reference
• Upregulation of CD40-CD40 Ligand (CD154) in Patients With Acute Cerebral Ischemia

  2003cited by this paper
• Peroxisome Proliferator-Activated Receptor-&agr; and Receptor-&ggr; Activators Prevent Cardiac Fibrosis in Mineralocorticoid-Dependent Hypertension

  2003cited by this paper
• Statin inhibits interferon-γ-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells

  2002cited by this paper
• Modulation of inflammatory mediators and PPARgamma and NFkappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro.

  2002cited by this paper
• The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

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• Oxidized Low-Density Lipoprotein Augments and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Limit CD40 and CD40L Expression in Human Vascular Cells

  2002cited by this paper
• Atorvastatin treatment induced peroxisome proliferator-activated receptor alpha expression and decreased plasma nonesterified fatty acids and liver triglyceride in fructose-fed rats.

  2002cited by this paper
• Statins as anti-inflammatory agents.

  2002cited by this paper
• 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase-Independent Inhibition of CD40 Expression by Atorvastatin in Human Endothelial Cells

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• Statin Prevents Tissue Factor Expression in Human Endothelial Cells: Role of Rho/Rho-Kinase and Akt Pathways

  2002cited by this paper
• Rho GTPase signalling pathways in the morphological changes associated with apoptosis

  2002cited by this paper
• Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.

  2002influential reference
• Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension.

  2002cited by this paper
• Ras family genes: An interesting link between cell cycle and cancer

  2002cited by this paper
• Atorvastatin activates PPAR-gamma and attenuates the inflammatory response in human monocytes.

  2002cited by this paper
• Peroxisome proliferator-activated receptor alpha as a genetic determinant of cardiac hypertrophic growth: culprit or innocent bystander?

  2002cited by this paper
• Peroxisome Proliferator-Activated Receptor α as a Genetic Determinant of Cardiac Hypertrophic Growth

  2002cited by this paper
• Fibrate and Statin Synergistically Increase the Transcriptional Activities of PPARα/RXRα and Decrease the Transactivation of NFκB

  2002cited by this paper
• Negative Regulation of Human Fibrinogen Gene Expression by Peroxisome Proliferator-activated Receptor α Agonists via Inhibition of CCAAT Box/Enhancer-binding Protein β*

  2001cited by this paper
• Amelioration of Angiotensin II–Induced Cardiac Injury by a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor

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• Statins Alter Smooth Muscle Cell Accumulation and Collagen Content in Established Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

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• Downregulation of Angiotensin II Type 1 Receptor by Hydrophobic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors in Vascular Smooth Muscle Cells

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• Thrombin Suppresses Endothelial Nitric Oxide Synthase and Upregulates Endothelin-Converting Enzyme-1 Expression by Distinct Pathways: Role of Rho/ROCK and Mitogen-Activated Protein Kinase

  2001cited by this paper
• Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta.

  2001cited by this paper
• Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells.

  2001cited by this paper
• Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I.

  2001cited by this paper
• Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase.

  2001cited by this paper
• The CD40/CD154 receptor/ligand dyadRID="†"ID="†" Review

  2001cited by this paper
• Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events.

  2001cited by this paper
• Increased Expression and Activity of RhoA Are Associated With Increased DNA Synthesis and Reduced p27Kip1 Expression in the Vasculature of Hypertensive Rats

  2001cited by this paper
• An HMG-CoA Reductase Inhibitor, Cerivastatin, Suppresses Growth of Macrophages Expressing Matrix Metalloproteinases and Tissue Factor In Vivo and In Vitro

  2001cited by this paper
• [Statins as Anti-Inflammatory Agents]

  2001influential reference
• Peroxisome Proliferator-Activated Receptor &ggr; Activators Inhibit Cardiac Hypertrophy in Cardiac Myocytes

  2001cited by this paper
• Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.

  2001cited by this paper
• The Transcription Factor NF-κB and the Regulation of Vascular Cell Function

  2000cited by this paper
• Angiotensin II activates nuclear transcription factor kappaB through AT(1) and AT(2) in vascular smooth muscle cells: molecular mechanisms.

  2000cited by this paper
• Regulation of Lipid and Lipoprotein Metabolism by PPAR Activators

  2000cited by this paper
• Expression and function of PPARgamma in rat and human vascular smooth muscle cells.

  2000influential reference
• Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells.

  2000cited by this paper
• Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity*

  2000cited by this paper
• HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells.

  2000cited by this paper
• The transcription factor NF-kappa B and the regulation of vascular cell function.

  2000cited by this paper
• CD154 (CD40 ligand).

  2000cited by this paper
• Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth.

  2000cited by this paper
• Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of MRNA levels for interleukin-1beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPARalpha) in primary endothelial cells.

  2000cited by this paper
• Angiotensin-converting enzyme expression in human carotid artery atherosclerosis.

  2000cited by this paper
• Inhibition of Monocyte Chemotactic Protein-1 Synthesis by Statins

  2000cited by this paper
• Pravastatin: An Antithrombotic Effect Independent of the Cholesterol-lowering Effect

  2000cited by this paper
• Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability.

  2000cited by this paper
• Expression and Function of PPARγ in Rat and Human Vascular Smooth Muscle Cells

  2000cited by this paper
• PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway.

  2000cited by this paper
• Angiotensin AT1 receptor over-expression in hypercholesterolaemia

  2000cited by this paper
• Peroxisome Proliferator-Activated Receptor γ Activators Downregulate Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells

  2000cited by this paper
• Effect of the HMG-CoA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia.

  1999cited by this paper
• Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators.

  1999cited by this paper

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