Is Pain Perception Altered in People With Depression? A Systematic Review and Meta-Analysis of Experimental Pain Research.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Pain

• Publication date

  2016-12-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.jpain.2016.08.007PMID 27589910
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Pain and Depressive Symptoms in Primary Care: Moderating Role of Positive and Negative Affect

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• Depressed Mood Differentially Mediates the Relationship between Pain Intensity and Pain Disability Depending on Pain Duration: A Moderated Mediation Analysis in Chronic Pain Patients

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• Pain perception in major depressive disorder: a neurophysiological case-control study.

  2015cited by this paper
• Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

  2015cited by this paper
• Decreased pain sensitivity among people with schizophrenia: a meta-analysis of experimental pain induction studies

  2015cited by this paper
• Symptoms of Depression and Risk of New Episodes of Low Back Pain: A Systematic Review and Meta‐Analysis

  2015cited by this paper
• Pain and Depression: A Neurobiological Perspective of Their Relationship

  2015cited by this paper
• Neuronal differences between chronic low back pain and depression regarding long‐term habituation to pain

  2014cited by this paper
• The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses

  2014cited by this paper
• Does pain interfere with antidepressant depression treatment response and remission in patients with depression and pain? An evidence-based structured review.

  2014cited by this paper
• Cortisol response to experimental pain in patients with chronic low back pain and patients with major depression.

  2013cited by this paper
• Depression and pain: often together but still a clinical challenge: a review.

  2012cited by this paper
• Pain inhibition is deficient in chronic widespread pain but normal in major depressive disorder.

  2011cited by this paper
• Factor analysis of responses to thermal, electrical, and mechanical painful stimuli supports the importance of multi‐modal pain assessment

  2011cited by this paper
• Differential processing of laser stimuli by Aδ and C fibres in major depression

  2011cited by this paper
• Depression, cytokines and experimental pain: evidence for sex-related association patterns.

  2011cited by this paper
• Pseudohypoalgesia on the Skin: A Novel View on the Paradox of Pain Perception in Depression

  2011cited by this paper
• Effects of Duloxetine Treatment on Brain Response to Painful Stimulation in Major Depressive Disorder

  2010cited by this paper
• Right Anterior Insula Hypoactivity During Anticipation of Homeostatic Shifts in Major Depressive Disorder

  2010cited by this paper
• Increased cold-pain thresholds in major depression.

  2010cited by this paper
• Increased sensitivity to heat pain after sad mood induction in female patients with major depression

  2010cited by this paper
• Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences.

  2010cited by this paper
• Cochrane Handbook for Systematic Reviews of Interventions

  2010cited by this paper
• Sympathetic skin response following painful electrical stimulation is increased in major depression

  2010cited by this paper
• Clinical diagnosis of depression in primary care: a meta-analysis.

  2009cited by this paper
• Depression and Chronic Medical Illness

  2009cited by this paper
• Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement

  2009cited by this paper
• Anxiety sensitivity and pain: Generalisability across noxious stimuli

  2008cited by this paper
• Depression and changed pain perception: Hints for a central disinhibition mechanism

  2008cited by this paper
• Increased Affective Bias Revealed Using Experimental Graded Heat Stimuli in Young Depressed Adults: Evidence of “Emotional Allodynia”

  2008cited by this paper
• Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain.

  2008cited by this paper
• Increased prefrontal activation during pain perception in major depression.

  2007cited by this paper
• Comorbid painful physical symptoms and depression: prevalence, work loss, and help seeking.

  2006cited by this paper
• Studies of pain in human subjects

  2006cited by this paper
• Basic mechanisms of deep somatic pain

  2006cited by this paper
• Peripheral mechanisms of cutaneous nociception

  2006cited by this paper
• Pain perception in major depression depends on pain modality

  2005influential reference
• An Introduction to Metaanalysis

  2005cited by this paper
• Anterior cingulate cortex contributes to the descending facilitatory modulation of pain via dorsal reticular nucleus

  2005cited by this paper
• The link between depression and physical symptoms.

  2004cited by this paper
• Measuring inconsistency in meta-analyses

  2003cited by this paper
• Depression and pain comorbidity: a literature review.

  2003influential reference
• Impact of Depression on Experimental Pain Perception: A Systematic Review of the Literature with Meta-Analysis

  2003cited by this paper
• Pain Thresholds as a Putative Functional Test for Cerebral Laterality in Major Depressive Disorder and Panic Disorder1

  2003cited by this paper
• Increased perception of post-ischemic paresthesias in depressed subjects.

  2003cited by this paper
• Influence of gender and hemispheric lateralization on heat pain perception in major depression.

  2003cited by this paper
• Meta-analysis of observational studies in epidemiology - A proposal for reporting

  2000cited by this paper
• Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group.

  2000cited by this paper
• Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis

  2000cited by this paper
• Pain modulation: expectation, opioid analgesia and virtual pain.

  2000cited by this paper
• Pain demands attention: a cognitive-affective model of the interruptive function of pain.

  1999cited by this paper
• Relationship between clinical pain complaints and pain sensitivity in patients with depression and panic disorder.

  1999cited by this paper
• An international study of the relation between somatic symptoms and depression.

  1999cited by this paper
• Reduced tolerance and cardiovascular response to ischemic pain in minor depression.

  1999cited by this paper
• Textbook of pain

  1999cited by this paper
• Pain threshold is reduced in depression.

  1998cited by this paper
• Bias in meta›analysis detected by a simple, graphical test

  1998cited by this paper
• Bias in meta-analysis detected by a simple, graphical test

  1997cited by this paper
• Impaired attention in depressive states: a non-specific deficit?

  1996cited by this paper
• Pain Sensitivity in Women with Premenstrual Dysphoric Disorder: A Preliminary Report

  1995cited by this paper
• Pain responsivity in major depression and bipolar disorder.

  1995cited by this paper
• Operating characteristics of a rank correlation test for publication bias.

  1994cited by this paper
• Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment.

  1994cited by this paper
• Pain perception in psychiatric disorders: a review of the literature.

  1994cited by this paper
• Pain perception in depression: relationships to symptomatology and naloxone‐sensitive mechanisms.

  1994cited by this paper
• Pain perception threshold in major depression.

  1993influential reference
• Somatization and the recognition of depression and anxiety in primary care.

  1993cited by this paper
• Depressive and distress symptoms as predictors of low back pain, neck‐shoulder pain, and other musculoskeletal morbidity: a 10‐year follow‐up of metal industry employees

  1993cited by this paper
• Study of experimental pain measures and nociceptive reflex in chronic pain patients and normal subjects

  1991cited by this paper
• Depression and chronic medical illness.

  1990cited by this paper
• Chest pain, cardiac disease, and panic disorder.

  1990cited by this paper
• Textbook of pain

  1989cited by this paper
• Depression, Pain, and Hemispheric Activation

  1989cited by this paper
• Somatic presentation of DSM III psychiatric disorders in primary care.

  1985cited by this paper
• Hypoalgesia in Depressive Illness

  1981cited by this paper
• Analgesia to painful stimuli in affective illness.

  1979cited by this paper
• The measurement of observer agreement for categorical data.

  1977cited by this paper
• EXPERIMENTALLY INDUCED PAIN IN PATIENTS WITH DEPRESSIVE DISORDERS

  1974cited by this paper
• An inventory for measuring depression.

  1961cited by this paper
• A RATING SCALE FOR DEPRESSION

  1960cited by this paper

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  2025cites this paper
• Childhood sexual abuse and post-cesarean pain

  2025cites this paper
• Altered states and transitions in major depressive disorder and their clinical and molecular associations.

  2025cites this paper
• Psychological Factors Influencing Pain Perception and Experience in Women Undergoing Mammography: Protocol for a Systematic Review

  2025cites this paper
• Migration of a Separated Endodontic File into the Mandibular Canal: An 8-Year Follow-up Case Report.

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• Examining brain structural-functional coupling in major depressive disorder across episode status.

  2025cites this paper
• Impact of treatment of molar-incisor hypomineralisation on children's oral health-related quality of life: a systematic review.

  2025cites this paper
• Psilocybin-Assisted Psychotherapy for Chronic Somatoform Pain Disorder: A Case Report

  2025cites this paper
• Pragmatic approaches to screening for anxiety and depression in physiotherapy: simple tools for busy clinicians

  2025cites this paper
• Increased functional connectivity between motor and arousal brainstem nuclei and sensorimotor cortex in therapy resistant depression.

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• Beyond Analgesia: Psychobiotics as an Adjunctive Approach to Pain Management in Gastrointestinal Oncology—A Post Hoc Analysis from the ProDeCa Study

  2025cites this paper
• Sleep as a Key to Understanding Racial and Ethnic Health Disparities.

  2025cites this paper
• Patterns of pain perception in individuals with anxiety or depressive disorders: a systematic review and meta-analysis of experimental pain research.

  2025cites this paper
• Chronic pain in mental disorders: An umbrella review of the prevalence, risk factors, and treatments across 957,168 people with mental disorders and 16,606,910 controls

  2025cites this paper
• The effect of lithium on behavioral functions in adolescent rats exposed to chronic unpredictable mild stress with respect to brain-derived neurotrophic factor and glycogen synthase kinase-3 beta levels in the prefrontal cortex.

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  2025influential citation
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• Pain threshold and pain tolerance in young people with self-injurious behavior: A systematic review and meta-analysis.

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• The role of biological sex in neurophysiological associations of patients with chronic osteoarthritis pain: a prospective cross-sectional study

  2025cites this paper
• The Intersection of Interoception and Anticipation Related to Pain.

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• Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

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• Brain activity differences between difficulty in falling asleep and early awakening symptoms in major depressive disorder: A resting-state fMRI study.

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• Sex differences in treatment response in patients with rheumatoid arthritis treated with tumour necrosis factor inhibitor: a cohort study from the DANBIO registry

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• Unraveling the genetic links between depression and type 2 diabetes.

  2025cites this paper
• Altered Pain Perception and Nociceptive Thresholds in Major Depression and Anxiety Disorders: A Meta-Analysis.

  2025cites this paper
• Cognitive impairments in chronic pain: a brain aging framework.

  2025cites this paper
• Association between gynecological disorders and insomnia and depression trajectories: a longitudinal study of middle-aged women

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• Different Perspectives of Patients Suffering from Pain After Undergoing Bariatric Surgery

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• Reduced Trust in Bodily Sensations Predicts Suicidal Ideation in Hospitalized Patients With Major Depression: An Observational Study

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• Impact of equine interactions on human acute pain perception: Two cross sectional studies

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• How control modulates pain.

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