Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  1992-06-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0006-291X(92)91701-QPMID 1352681
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular cloning and development analysis of a new glutamate receptor subunit isoform in cerebellum

  1992cited by this paper
• The N-terminal domains of acetylcholine receptor subunits contain recognition signals for the initial steps of receptor assembly.

  1992cited by this paper
• Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit.

  1992cited by this paper
• Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor.

  1991cited by this paper
• Molecular cloning and characterization of the rat NMDA receptor

  1991cited by this paper
• Excitatory amino acid receptors and synaptic plasticity.

  1990cited by this paper
• A family of AMPA-selective glutamate receptors.

  1990cited by this paper
• Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.

  1990cited by this paper
• Ligand-gated ion channels in the brain: The amino acid receptor superfamily

  1990cited by this paper
• Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site.

  1990cited by this paper
• Excitatory amino acid neurotoxicity and neurodegenerative disease.

  1990cited by this paper
• Ligand-gated ion channels in the brain: the amino acid receptor superfamily.

  1990cited by this paper
• The human muscle nicotinic acetylcholine receptor alpha‐subunit exist as two isoforms: a novel exon.

  1990cited by this paper
• The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.

  1989cited by this paper
• Synthesis and processing of asparagine-linked oligosaccharides.

  1981cited by this paper

• Cryo-EM of autoantibody-bound NMDA receptors reveals antigenic hotspots in an active immunization model of anti-NMDAR encephalitis

  2026cites this paper
• New advances in small molecule drugs targeting NMDA receptors

  2025cites this paper
• Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids

  2024cites this paper
• Selective Cell-Surface Expression of Triheteromeric NMDA Receptors.

  2024cites this paper
• Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia

  2023cites this paper
• Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes

  2023cites this paper
• DNA methylation and the opposing NMDAR dysfunction in schizophrenia and major depression disorders: a converging model for the therapeutic effects of psychedelic compounds in the treatment of psychiatric illness

  2023cites this paper
• Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792.

  2021cites this paper
• Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

  2021cites this paper
• Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data

  2021cites this paper
• Regulation of the NMDA receptor by its cytoplasmic domains: (how) is the tail wagging the dog?

  2021cites this paper
• Qualitative review on N‐methyl‐D‐aspartate receptor expression in rat spinal cord during the postnatal development: Implications for central sensitization and pain

  2020cites this paper
• Site of Ketamine Action on the NMDA Receptor

  2020cites this paper
• Ketamine: From Abused Drug to Rapid-Acting Antidepressant

  2020cites this paper
• NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit

  2020cites this paper
• PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits.

  2020cites this paper
• Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight.

  2019cites this paper
• NMDAR plasticity and metaplasticity in early odor preference learning in rats

  2019cites this paper
• Synthesis, radiolabelling and preclinical evaluation of novel NMDA ligands as potential tracers for positron emission tomography

  2019cites this paper
• Remembering Mechanosensitivity of NMDA Receptors

  2019cites this paper
• NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.

  2019cites this paper
• Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta

  2018cites this paper
• Properties of Triheteromeric N-Methyl-d-Aspartate Receptors Containing Two Distinct GluN1 Isoforms

  2018cites this paper
• Structure, function, and allosteric modulation of NMDA receptors

  2018cites this paper
• The Opposing Roles of GluN2C and GluN2D NMDA Receptor Subunits in Modulating Neuronal Oscillations

  2018cites this paper
• Characterising the anti-convulsant effects of CBD and CBDV on layer II of the medial entorhinal cortex of rat and human brain tissue in vitro

  2018cites this paper
• Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.

  2017cites this paper
• Overview of the NMDA Receptor

  2017cites this paper
• NMDA Receptors in the Central Nervous System.

  2017cites this paper
• Synthesis, radiolabeling and evaluation of novel amine guanidine derivatives as potential positron emission tomography tracers for the ion channel of the N-methyl-d-aspartate receptor.

  2016cites this paper
• Target Validation and Pharmacological Characterization of Novel NMDAR Modulators

  2016cites this paper
• Modulation of learning and memory by natural polyamines.

  2016cites this paper
• Anti-Epileptic Activity

  2016cites this paper
• NMDA Receptor GluN 2 B ( GluR 2 / NR 2 B ) Subunit Is Crucial for Channel Function , Postsynaptic Macromolecular Organization , and Actin Cytoskeleton at Hippocampal CA 3 Synapses

  2016cites this paper
• Handbook of ion channels

  2015cites this paper
• The Structural Mechanism of Allosteric Modulation of the NMDA Receptor: A Balance of Tensions

  2015cites this paper
• Specific Roles of NMDA Receptor Subunits in Mental Disorders

  2015cites this paper
• Ketamine is toxic to chondrocyte cell cultures.

  2014cites this paper
• Cloning and sequencing of c-DNA encoding N-methyl-D-aspartate receptor subunit-1 in the hypothalamus of male sheep

  2014cites this paper
• Intracellular calcium elevation during plateau potentials mediated by extrasynaptic NMDA receptor activation in rat hippocampal CA1 pyramidal neurons.

  2014cites this paper
• Cloning and characterization of the N-methyl-D-aspartate receptor subunit NR1 gene from chum salmon, Oncorhynchus keta (Walbaum, 1792)

  2014cites this paper
• NMDA receptor structures reveal subunit arrangement and pore architecture

  2014cites this paper
• Effects of Dizocilpine (MK-801) via Up-modulation of N-methyl-D-aspartate (NMDA) Receptors on Hypoxic-Ischemic Brain Injury in Neonatal Rats

  2014cites this paper
• Ligand-gated ion channel interacting proteins and their role in neuroprotection

  2014cites this paper
• Neuroprotectants Targeting NMDA Receptor Signaling

  2014cites this paper
• Role of ionotropic glutamate receptors in neurodegenerative and other disorders

  2014cites this paper
• Molecular Architecture of Glutamate Signaling Pathway in Glaucomatous Optic Neuropathy

  2014cites this paper
• Intracellular calcium elevation during plateau potentials mediated by extrasynaptic NMDA receptor activation in rat hippocampal CA1 pyramidal neurons is primarily due to calcium entry through voltage‐gated calcium channels

  2014cites this paper
• Structure, function, and pharmacology of NMDA receptor channels.

  2014cites this paper
• Influence of GluN2 subunit identity on NMDA receptor function

  2013cites this paper
• Receptor heteromers in Parkinson's disease and L-DOPA-induced dyskinesia.

  2013cites this paper
• Conserved Expression of the Glutamate NMDA Receptor 1 Subunit Splice Variants during the Development of the Siberian Hamster Suprachiasmatic Nucleus

  2012cites this paper
• Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

  2012cites this paper
• Calcium signaling in dendritic spines.

  2012cites this paper
• "Smart fats", healthy brain and function of lipid-sensing NMDA receptors

  2012cites this paper
• Aging of the NMDA receptor: from a mouse's point of view.

  2012cites this paper
• TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner

  2012cites this paper
• Characterization of NP22 and its Potential Role in NMDA Receptor-mediated Transmission

  2011cites this paper
• Acamprosate in Relapse Prevention of Alcoholism

  2011cites this paper
• Endogenous ion channel complexes: the NMDA receptor.

  2011cites this paper
• Envolvimento de Rac1 na excitotoxicidade induzida por NMDA na retina de ratos.

  2011cites this paper
• Exploring open channel block of the NMDA receptor

  2011cites this paper
• Separation of Domain Contacts Is Required for Heterotetrameric Assembly of Functional NMDA Receptors

  2011cites this paper
• Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging.

  2011cites this paper
• Analysis of the adaptor proteins, gephyrin and GRIP1, in KIF5-driven neuronal transport in Mus musculus, (Linnaeus, 1758)

  2011cites this paper
• Der Einfluss einer genetischen Variation im GRIN1-Gen

  2011cites this paper
• Identification of four functional NR3B isoforms in developing white matter reveals unexpected diversity among glutamate receptors

  2011cites this paper
• Deciphering the molecular signaling cascade in neuronal death

  2011cites this paper
• NMDA receptor subunit expression in the supraoptic nucleus of adult rats: dominance of NR2B and NR2D.

  2011cites this paper
• Age and Visual Experience-dependent Expression of NMDAR1 Splice Variants in Rat Retina

  2011cites this paper
• Signaling pathways involved in enhanced NMDA receptor-dependent excitotoxicity in a mouse model of Huntington disease

  2011cites this paper
• Role of the NMDA receptor subunit, NR3A, in glutamatergic synapse development

  2010cites this paper
• Studies of emotionality in genetic mouse models of altered glutamate or 5-HT function

  2010cites this paper
• Development of a SYBR Green Real-time Polymerase Chain Reaction Assay for Quantitative Detection of Human N-methyl-D-aspartate Receptors Subtype 1 Splice Variants

  2010cites this paper
• Triheteromeric NR 1 / NR 2 A / NR 2 B receptors constitute the major NMDA receptor population in adult hippocampal synapses INAUGURAL

  2010cites this paper
• Influence of the NR3A subunit on NMDA receptor functions.

  2010cites this paper
• N-METHYL-D-ASPARTATE (NMDA) RECEPTORS IN THE ENTERIC NERVOUS SYSTEM (ENS)

  2009cites this paper
• The N-Methyl-D-Aspartate Receptor in Cerebral Ischemia

  2009cites this paper
• Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors

  2009cites this paper
• NMDA Receptor-Mediated Calcium Transients in Dendritic Spines

  2009cites this paper
• Activity-Dependent Anchoring of Importin α at the Synapse Involves Regulated Binding to the Cytoplasmic Tail of the NR1-1a Subunit of the NMDA Receptor

  2009cites this paper
• Differentiated P19 cells express N‐methyl‐d‐aspartate receptor 1 mRNA binding trans‐acting proteins and four N‐methyl‐D‐aspartate receptor 1 splice variants comparable to those in cultured fetal cortical neurons

  2009cites this paper
• N-Methyl-D-aspartate ( NMDA ) Receptor NR 2 Subunit Selectivity of a Series of Novel Piperazine-2 , 3-dicarboxylate Derivatives : Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat Hippocampal CA 3-CA 1 Synapse

  2009cites this paper
• Blockade of hindbrain NMDA receptors containing NR2 subunits increases sucrose intake.

  2009cites this paper
• Molecular pharmacology of AMPA receptor trafficking proteins - TARPs : evidence for an association with 5HT(_2c) receptors

  2009cites this paper
• Molecular and functional characterization of Xenopus laevis N-methyl-d-aspartate receptors

  2009cites this paper
• Extracellular Modulation of NMDA Receptors

  2009cites this paper
• N-Methyl-d-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat Hippocampal CA3-CA1 Synapse

  2009influential citation
• The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.

  2009cites this paper
• Spinal NMDA NR1 subunit expression following transient TNBS colitis.

  2009cites this paper
• TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5.

  2009cites this paper
• Pharmacology of NMDA Receptors

  2009cites this paper
• NMDA Receptor GluN2B (GluRε2/NR2B) Subunit Is Crucial for Channel Function, Postsynaptic Macromolecular Organization, and Actin Cytoskeleton at Hippocampal CA3 Synapses

  2009cites this paper
• Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit.

  2008cites this paper
• THE ROLE OF NR2-TYPE NMDA RECEPTORS IN THE CONTROL OF MEAL SIZE

  2008cites this paper
• Cloning and Phylogenetic Analysis of NMDA Receptor Subunits NR1, NR2A and NR2B in Xenopus laevis Tadpoles

  2008cites this paper
• Subunit- and Pathway-Specific Localization of NMDA Receptors and Scaffolding Proteins at Ganglion Cell Synapses in Rat Retina

  2008cites this paper
• Relationship between mRNA expression of splice forms of the zeta1 subunit of the N-methyl-D-aspartate receptor and spatial memory in aged mice.

  2008cites this paper
• Studies on the structure of the channel pore of NMDA receptor and development of its channel blocker

  2008cites this paper
• Immunolocalization of NMDA receptor subunit NR3B in selected structures in the rat forebrain, cerebellum, and lumbar spinal cord

  2008cites this paper