Sperm PLCζ: From structure to Ca2+ oscillations, egg activation and therapeutic potential

No abstract is available for this paper.

• Publication year

  2013

• Venue

  FEBS Letters

• Publication date

  2013-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2013.10.008PMID 24157362
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mammalian phospholipase C.

  2013cited by this paper
• PLCz Functional Haplotypes Modulating Promoter Transcriptional Activity Are Associated with Semen Quality Traits in Chinese Holstein Bulls

  2013cited by this paper
• Phospholipase Cζ rescues failed oocyte activation in a prototype of male factor infertility

  2013cited by this paper
• Molecular characteristics of horse phospholipase C zeta (PLCζ).

  2013cited by this paper
• Variance in total levels of phospholipase C zeta (PLC-ζ) in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability.

  2013cited by this paper
• PLCζ and the initiation of Ca(2+) oscillations in fertilizing mammalian eggs.

  2013cited by this paper
• Calcium oscillations, oocyte activation, and phospholipase C zeta.

  2012cited by this paper
• Starting a new life: Sperm PLC‐zeta mobilizes the Ca2+ signal that induces egg activation and embryo development

  2012cited by this paper
• Oocyte activation and phospholipase C zeta (PLCζ): diagnostic and therapeutic implications for assisted reproductive technology

  2012cited by this paper
• A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.

  2012cited by this paper
• The Testicular and Epididymal Expression Profile of PLCζ in Mouse and Human Does Not Support Its Role as a Sperm-Borne Oocyte Activating Factor

  2012cited by this paper
• Investigation into association and expression of PLCz and COX-2 as candidate genes for boar sperm quality and fertility.

  2012cited by this paper
• PLCζ causes Ca2+ oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P2

  2012cited by this paper
• Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.

  2012cited by this paper
• Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP2 hydrolysis activity of sperm PLCζ

  2011cited by this paper
• Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP2 hydrolysis activity of sperm PLCζ

  2011cited by this paper
• Pre-treatment of sperm reduces success of ICSI in the pig.

  2011cited by this paper
• Phospholipase Cζ binding to PtdIns(4,5)P2 requires the XY-linker region

  2011cited by this paper
• Novel regulation of PLCζ activity via its XY-linker

  2011cited by this paper
• Divergent effect of mammalian PLCζ in generating Ca2+ oscillations in somatic cells compared with eggs

  2011cited by this paper
• Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.

  2011cited by this paper
• Identification and functional analysis of an ovarian form of the egg activation factor phospholipase C zeta (PLCζ) in pufferfish

  2011cited by this paper
• Molecular Cloning and Characterization of Phospholipase C Zeta in Equine Sperm and Testis Reveals Species-Specific Differences in Expression of Catalytically Active Protein1

  2011cited by this paper
• Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes*♦

  2010cited by this paper
• Inositol 1,4,5‐trisphosphate receptor 1 degradation in mouse eggs and impact on [Ca2+]i oscillations

  2010cited by this paper
• Artificial oocyte activation and intracytoplasmic sperm injection.

  2010cited by this paper
• Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance.

  2010cited by this paper
• Oocyte activation, phospholipase C zeta and human infertility.

  2010cited by this paper
• Oscillatory Ca2+ dynamics and cell cycle resumption at fertilization in mammals: a modelling approach.

  2010cited by this paper
• Complete globozoospermia associated with PLCζ deficiency treated with calcium ionophore and ICSI results in pregnancy.

  2010influential reference
• Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.

  2009influential reference
• Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction.

  2009cited by this paper
• NYD-SP27, a novel intrinsic decapacitation factor in sperm.

  2009cited by this paper
• The pattern of localization of the putative oocyte activation factor, phospholipase Czeta, in uncapacitated, capacitated, and ionophore-treated human spermatozoa.

  2008cited by this paper
• General and versatile autoinhibition of PLC isozymes.

  2008cited by this paper
• Multiple roles of phosphoinositide-specific phospholipase C isozymes.

  2008cited by this paper
• Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development.

  2008cited by this paper
• Infertility and the provision of infertility medical services in developing countries

  2008cited by this paper
• Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish.

  2008cited by this paper
• Relationship between nuclear sequestration of PLCζ and termination of PLCζ-induced Ca2+ oscillations in mouse eggs

  2008cited by this paper
• Efficiency of assisted oocyte activation as a solution for failed intracytoplasmic sperm injection.

  2008cited by this paper
• Microinjection of mouse phospholipase C zeta complementary RNA into mare oocytes induces long-lasting intracellular calcium oscillations and embryonic development.

  2008cited by this paper
• Relationship between nuclear sequestration of PLCzeta and termination of PLCzeta-induced Ca2+ oscillations in mouse eggs.

  2008cited by this paper
• The role of X/Y linker region and N-terminal EF-hand domain in nuclear translocation and Ca[2+] oscillation-inducing activities of phospholipase Cζ, a mammalian egg-activating factor

  2007cited by this paper
• Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues.

  2007cited by this paper
• PAWP, a Sperm-specific WW Domain-binding Protein, Promotes Meiotic Resumption and Pronuclear Development during Fertilization*♦

  2007cited by this paper
• Binding of Phosphoinositide-specific Phospholipase C-ζ (PLC-ζ) to Phospholipid Membranes

  2007cited by this paper
• Proteolytic processing of phospholipase Czeta and [Ca2+]i oscillations during mammalian fertilization.

  2007cited by this paper
• PLCzeta, a sperm-specific PLC and its potential role in fertilization.

  2007cited by this paper
• International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care.

  2007cited by this paper
• Release of phospholipase C z and [Ca 2 C ] i oscillation-inducing activity during mammalian fertilization

  2007cited by this paper
• Ca2+ oscillatory pattern in fertilized mouse eggs affects gene expression and development to term.

  2006cited by this paper
• The Role of X/Y Linker Region and N-terminal EF-hand Domain in Nuclear Translocation and Ca2+ Oscillation-inducing Activities of Phospholipase Cζ, a Mammalian Egg-activating Factor*

  2006influential reference
• Ca[2+] oscillation-inducing phospholipase C zeta expressed in mouse eggs is accumulated to the pronucleus during egg activation

  2006cited by this paper
• PLCzeta(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals.

  2006cited by this paper
• Molecular cloning, testicular postnatal expression, and oocyte-activating potential of porcine phospholipase Czeta.

  2006cited by this paper
• The Role of EF-hand Domains and C2 Domain in Regulation of Enzymatic Activity of Phospholipase Cζ*

  2005cited by this paper
• Phospholipase C z , the trigger of egg activation in mammals, is present in a non-mammalian species

  2005cited by this paper
• Functional, biochemical, and chromatographic characterization of the complete [Ca2+]i oscillation-inducing activity of porcine sperm.

  2005cited by this paper
• Transgenic RNA Interference Reveals Role for Mouse Sperm Phospholipase Cζ in Triggering Ca2+ Oscillations During Fertilization1

  2005cited by this paper
• Role of Phospholipase C- (cid:1) Domains in Ca 2 (cid:2) -dependent Phosphatidylinositol 4,5-Bisphosphate Hydrolysis and Cytoplasmic Ca 2 (cid:2) Oscillations*

  2005cited by this paper
• Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes.

  2004cited by this paper
• Mammalian phospholipase Czeta induces oocyte activation from the sperm perinuclear matrix.

  2004cited by this paper
• Recombinant Phospholipase Cζ Has High Ca2+ Sensitivity and Induces Ca2+ Oscillations in Mouse Eggs*

  2004cited by this paper
• Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCζ

  2004cited by this paper
• Ca2+ oscillation-inducing phospholipase C zeta expressed in mouse eggs is accumulated to the pronucleus during egg activation.

  2004cited by this paper
• Mammalian phospholipase C

  2003influential reference
• Successful pregnancy and delivery after calcium ionophore oocyte activation in a normozoospermic patient with previous repeated failed fertilization after intracytoplasmic sperm injection.

  2003cited by this paper
• Maturation-associated increase in IP3 receptor type 1: role in conferring increased IP3 sensitivity and Ca2+ oscillatory behavior in mouse eggs.

  2003cited by this paper
• Egg activation at fertilization: where it all begins.

  2002cited by this paper
• Interactions between calcium release pathways: multiple messengers and multiple stores.

  2002influential reference
• Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes.

  2002cited by this paper
• PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development.

  2002cited by this paper
• Failed fertilization: is it predictable?

  2002cited by this paper
• Phospholipase C isoforms in mammalian spermatozoa: potential components of the sperm factor that causes Ca2+ release in eggs.

  2002cited by this paper
• Sperm Factor Induces Intracellular Free Calcium Oscillations by Stimulating the Phosphoinositide Pathway1

  2001influential reference
• Phospholipase C(epsilon): a novel Ras effector.

  2001cited by this paper
• Regulation of a Novel Human Phospholipase C, PLCε, through Membrane Targeting by Ras*

  2001cited by this paper
• Phospholipase Cϵ: a novel Ras effector

  2001cited by this paper
• NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes

  2001cited by this paper
• Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.

  2001cited by this paper
• Sperm-induced Ca(2+) oscillations in mouse oocytes and eggs can be mimicked by photolysis of caged inositol 1,4,5-trisphosphate: evidence to support a continuous low level production of inositol 1, 4,5-trisphosphate during mammalian fertilization.

  2000cited by this paper
• Distinct Ca2+ Binding Properties of Novel C2 Domains of Plant Phospholipase Dα and β*

  2000cited by this paper
• Inositol 1,4,5-trisphosphate receptors are downregulated in mouse oocytes in response to sperm or adenophostin A but not to increases in intracellular Ca(2+) or egg activation.

  2000cited by this paper
• Signaling and subcellular targeting by membrane-binding domains.

  2000cited by this paper
• Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic activation.

  2000cited by this paper
• Mammalian sperm contain a Ca(2+)-sensitive phospholipase C activity that can generate InsP(3) from PIP(2) associated with intracellular organelles.

  2000cited by this paper
• NO is necessary and sufficient for egg activation at fertilization

  2000cited by this paper
• Different Ca2+-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs.

  2000cited by this paper
• Distinct Ca2+ binding properties of novel C2 domains of plant phospholipase dalpha and beta.

  2000cited by this paper
• Inositol 1,4,5-trisphosphate receptors are downregulated in mouse oocytes in response to sperm or adenophostin a but not to increases in intracellular Ca2+ or egg activation.

  2000cited by this paper
• Comparative biology of calcium signaling during fertilization and egg activation in animals.

  1999cited by this paper
• A mammalian sperm cytosolic phospholipase C activity generates inositol trisphosphate and causes Ca2+ release in sea urchin egg homogenates

  1998cited by this paper
• Partial characterization of the calcium-releasing activity of porcine sperm cytosolic extracts.

  1998cited by this paper
• C2-domains, Structure and Function of a Universal Ca2+-binding Domain*

  1998cited by this paper
• C 2-domains , Structure and Function of a Universal Ca 2 1-binding Domain *

  1998cited by this paper
• Parthenogenetic activation of mouse eggs by microinjection of a truncated c-kit tyrosine kinase present in spermatozoa.

  1997cited by this paper
• Intracellular injections of a soluble sperm factor trigger calcium oscillations and meiotic maturation in unfertilized oocytes of a marine worm.

  1997cited by this paper
• Spatiotemporal dynamics of intracellular calcium in the mouse egg injected with a spermatozoon.

  1997cited by this paper
• Soluble sperm factors and Ca2+ release in eggs at fertilization.

  1996cited by this paper

• Comparison of the effects of piezoelectric and calcium ionophore activation on fertilization and blastulation rates of sibling oocytes

  2025cites this paper
• Phospholipase Cζ, the Molecular Spark of Fertilization and Male Infertility: Insights from Bench to Bedside

  2025cites this paper
• The role of sperm protein in mammal fertilization: insights into gamete adhesion, membrane fusion and oocyte activation.

  2025cites this paper
• The Xenopus Oocyte System: Molecular Dynamics of Maturation, Fertilization, and Post-Ovulatory Fate

  2025cites this paper
• Bovine oocyte activation with bull or human sperm by conventional ICSI and Piezo-ICSI: Its relationship with PLCɀ activity

  2024cites this paper
• Genome and Epigenome Disorders and Male Infertility: Feedback from 15 Years of Clinical and Research Experience

  2024cites this paper
• MicroRNAs and Their Associated Genes Regulating the Acrosome Reaction in Sperm of High- versus Low-Fertility Holstein Bulls

  2024cites this paper
• Oocyte competence develops: nuclear maturation synchronously with cytoplasm maturation.

  2024cites this paper
• Kappa opioids inhibit spinal output neurons to suppress itch

  2024cites this paper
• Novel PLCZ1 compound heterozygous mutations indicate gene dosage effect involved in total fertilisation failure after ICSI

  2024cites this paper
• Applications of advances in mRNA-based platforms as therapeutics and diagnostics in reproductive technologies

  2023cites this paper
• Phospholipase C Zeta 1 (PLCZ1): The Function and Potential for Fertility Assessment and In Vitro Embryo Production in Cattle and Horses

  2023cites this paper
• Rapid thawing of frozen bull spermatozoa by transient exposure to 70 °C improves the viability, motility and mitochondrial health

  2023cites this paper
• Identification of a convergent spinal neuron population that encodes itch

  2023cites this paper
• Cryopreservation of equine spermatozoa reduces plasma membrane integrity and phospholipase C zeta 1 content as associated with oocyte activation

  2023cites this paper
• Novel mutations in PLCZ1 lead to early embryonic arrest as a male factor

  2023cites this paper
• Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation.

  2023cites this paper
• The Therapeutic and Diagnostic Potential of Phospholipase C Zeta, Oocyte Activation, and Calcium in Treating Human Infertility

  2023cites this paper
• The structure and function relationship of sperm PLC-zeta.

  2022cites this paper
• SPERM FACTORS AND EGG ACTIVATION: Phospholipase C zeta (PLCZ1) and the clinical diagnosis of oocyte activation deficiency

  2022cites this paper
• Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application

  2022cites this paper
• Assisted Oocyte Activation With Calcium Ionophore Improves Pregnancy Outcomes and Offspring Safety in Infertile Patients: A Systematic Review and Meta-Analysis

  2022cites this paper
• A loss-of-function variant in SSFA2 causes male infertility with globozoospermia and failed oocyte activation

  2022cites this paper
• Ouabain-induced activation of phospholipase C zeta and its contributions to bovine sperm capacitation

  2021cites this paper
• Sperm-oocyte interplay: an overview of spermatozoon’s role in oocyte activation and current perspectives in diagnosis and fertility treatment

  2021cites this paper
• Intracytoplasmic Sperm Injection in Cattle

  2021cites this paper
• Lipids | Phospholipase C

  2021cites this paper
• Neurons | Calcium Signaling in Neurons and Oocytes

  2021cites this paper
• Clinical exome sequencing identifies novel compound heterozygous mutations of the WEE2 gene in primary infertile women with fertilization failure

  2021cites this paper
• Lack of trusted diagnostic tools for undetermined male infertility

  2021cites this paper
• Increasing associations between defects in phospholipase C zeta and conditions of male infertility: not just ICSI failure?

  2020cites this paper
• The identification of novel mutations in PLCZ1 responsible for human fertilization failure and a therapeutic intervention by artificial oocyte activation.

  2020cites this paper
• Diagnosis and Treatment of Male Infertility-Related Fertilization Failure

  2020cites this paper
• Comparative study of pre-implantation development following distinct assisted oocyte activation protocols in a PLC-Zeta knockout mouse model.

  2020cites this paper
• Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update

  2020influential citation
• Reduction of truncated Kit Expression in Men with Abnormal Semen Parameters, Globozoospermia and History of Low or Fertilization Failure

  2019cites this paper
• Expression of phospholipase PLC Zeta in human spermatozoa: impact of cryopreservation

  2019cites this paper
• The Embryonic Environment and Developmental Origins of Health

  2018cites this paper
• New Paradigms in De Novo Creation of Functional Human Spermatozoa: A Review of Biological Progress Towards Clinical Application

  2018cites this paper
• The Role of Phospholipase in Sperm Physiology and its Therapeutic Potential in Male Infertility

  2018cites this paper
• The eggstraordinary story of how life begins

  2018cites this paper
• New Insights into the Molecular Events of Mammalian Fertilization.

  2018cites this paper
• Artificial oocyte activation with SrCl2 or calcimycin after ICSI improves clinical and embryological outcomes compared with ICSI alone: results of a randomized clinical trial

  2018cites this paper
• Dissipative structures in biological systems: bistability, oscillations, spatial patterns and waves

  2018cites this paper
• Phospholipase C zeta parameters in sperm from polymorphic teratozoospermic men.

  2018cites this paper
• Comparative analysis of testis transcriptomes associated with male infertility in cattleyak.

  2017cites this paper
• Phospholipase C zeta and calcium oscillations at fertilisation: The evidence, applications, and further questions.

  2017cites this paper
• PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence

  2017cites this paper
• The establishment of appropriate methods for egg-activation by human PLCZ1 RNA injection into human oocyte.

  2017cites this paper
• Genetic abnormalities leading to qualitative defects of sperm morphology or function

  2017cites this paper
• hospholipase C zeta parameters in sperm from polymorphic eratozoospermic men

  2017cites this paper
• Dissipative structures and biological rhythms.

  2017cites this paper
• The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation.

  2017cites this paper
• Viable offspring after imaging of Ca2+ oscillations and visualization of the cortical reaction in mouse eggs†

  2017cites this paper
• Egg Activation at Fertilization.

  2017cites this paper
• Regulation and physiological functions of mammalian phospholipase C.

  2017cites this paper
• Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

  2017cites this paper
• Phosphoinositide signaling in sperm development.

  2016cites this paper
• Oocyte activation deficiency: a role for an oocyte contribution?

  2016influential citation
• Calcium signals and the activation of embryo development in mice and humans

  2016cites this paper
• Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP.

  2016cites this paper
• Molecular triggers of egg activation at fertilization in mammals.

  2016cites this paper
• Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation

  2016cites this paper
• Fourteen babies born after round spermatid injection into human oocytes

  2015cites this paper
• PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis.

  2015influential citation
• Novel signalling mechanism and clinical applications of sperm-specific PLCζ.

  2015cites this paper
• Fertilization in Mammals

  2015cites this paper
• The role of Phospholipase C enzymes in health and disease

  2015cites this paper
• Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ

  2015cites this paper
• Signal transduction in mammalian oocytes during fertilization

  2015cites this paper
• The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils

  2015cites this paper
• Phosphoinositide-specific phospholipase C in health and disease

  2015cites this paper
• Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2)*

  2015cites this paper
• Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation.

  2015influential citation
• Fertilization and the Signaling of Egg Activation

  2014cites this paper
• Sperm functional tests.

  2014cites this paper
• Where Life Begins: Sperm PLCζ in Mammalian Egg Activation and Implications in Male Infertility

  2014cites this paper
• Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes.

  2014cites this paper