The yeast p24 complex regulates GPI-anchored protein transport and quality control by monitoring anchor remodeling

Guillaume A. Castillon,A. Aguilera-Romero,Javier Manzano-López,Sharon Epstein,Kentaro Kajiwara,K. Funato,R. Watanabe,H. Riezman,M. Muñiz

Published 2011 in Molecular Biology of the Cell

ABSTRACT

Two functions of the p24 complex are described: one connects GPI-anchored proteins to COPII proteins at ER exit sites to facilitate their incorporation into ER-derived vesicles, and the other serves in quality control of GPI-anchored proteins to retrieve unremodeled GPI-anchored proteins from the Golgi back to the ER.

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