Dose-Dependent Modulatory Effects of Insulin on Glucose-Induced Endothelial Senescence In Vitro and In Vivo: A Relationship between Telomeres and Nitric Oxide

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2011-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/jpet.110.177584PMID 21357660
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
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  2007cited by this paper
• Cardiovascular actions of insulin.

  2007cited by this paper
• Vascular Cell Senescence Contribution to Atherosclerosis

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• Apoptosis Signal-Regulating Kinase 1 Mediates Cellular Senescence Induced by High Glucose in Endothelial Cells

  2006cited by this paper
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• Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes

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  2005cited by this paper
• Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity.

  2005cited by this paper
• Trends in cardiovascular complications of diabetes.

  2005cited by this paper
• Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway

  2004influential reference
• From the Cover : Accelerated telomere shortening in response to life stress

  2004cited by this paper
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  2004cited by this paper
• Impact of diabetes on mortality in patients with myocardial infarction and left ventricular dysfunction.

  2004cited by this paper
• Trends in cardiovascular complications of diabetes.

  2004influential reference
• Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis

  2004cited by this paper
• c-Jun-Deficient Cells Undergo Premature Senescence as a Result of Spontaneous DNA Damage Accumulation

  2004cited by this paper
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  2004cited by this paper
• Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

  2003influential reference
• White Cell Telomere Length and Risk of Premature Myocardial Infarction

  2003influential reference
• Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells.

  2003cited by this paper
• Expression of Human Telomerase (hTERT) Does Not Prevent Stress-induced Senescence in Normal Human Fibroblasts but Protects the Cells from Stress-induced Apoptosis and Necrosis*

  2002cited by this paper
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  2002cited by this paper
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  2001influential reference
• Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

  2000cited by this paper
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  2000cited by this paper
• Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit*

  1999cited by this paper
• Extension of life-span by introduction of telomerase into normal human cells.

  1998cited by this paper
• Impaired Glucose Tolerance, Diabetes, and Cardiovascular Disease Risk Factor Profiles in the Elderly: The Honolulu Heart Program

  1996cited by this paper
• Acute stimulation of glucose transport by histamine in cardiac microvascular endothelial cells.

  1995cited by this paper
• Low level hyperlipidemia impairs endothelium-dependent relaxation of porcine coronary arteries by two mechanisms. Functional change in endothelium and impairment of endothelium-dependent relaxation by two mediators.

  1991cited by this paper
• The Honolulu Heart Program

  1991cited by this paper
• Insulin and atheroma. 20-yr perspective.

  1990cited by this paper
• Insulin and atheroma.

  1969cited by this paper

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  2021cites this paper
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