Endothelial function and dysfunction: Impact of metformin

ABSTRACT Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti‐diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a timely review on the protective effects and molecular mechanisms of metformin in preventing endothelial dysfunction and cardiovascular and metabolic diseases.

• Publication year

  2018

• Venue

  Pharmacology and Therapeutics

• Publication date

  2018-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.pharmthera.2018.07.007PMID 30056057
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metformin

  2019cited by this paper
• Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation

  2018cited by this paper
• Epigenetic effects of metformin: From molecular mechanisms to clinical implications

  2018cited by this paper
• Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects

  2018cited by this paper
• Atheroprotective Effects and Molecular Targets of Tanshinones Derived From Herbal Medicine Danshen

  2018cited by this paper
• Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction.

  2018cited by this paper
• Suppressive effects of metformin on T-helper 1-related chemokines expression in the human monocytic leukemia cell line THP-1

  2018cited by this paper
• Update on SGLT2 Inhibitors-New Data Released at the American Diabetes Association.

  2017cited by this paper
• Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium

  2017cited by this paper
• Metformin Improves Endothelial Function and Reduces Blood Pressure in Diabetic Spontaneously Hypertensive Rats Independent from Glycemia Control: Comparison to Vildagliptin

  2017cited by this paper
• Role of free fatty acids in endothelial dysfunction

  2017cited by this paper
• REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine

  2017cited by this paper
• Liver Kinase B1/AMP-Activated Protein Kinase Pathway Activation Attenuated the Progression of Endotoxemia in the Diabetic Mice

  2017cited by this paper
• Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death

  2017cited by this paper
• Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial.

  2017cited by this paper
• The emerging role of metformin in gestational diabetes mellitus

  2017cited by this paper
• Synergistic effects of metformin with liraglutide against endothelial dysfunction through GLP-1 receptor and PKA signalling pathway

  2017cited by this paper
• Cardiovascular and cerebrovascular risk with nonsteroidal anti-inflammatory drugs and cyclooxygenase 2 inhibitors: latest evidence and clinical implications

  2017cited by this paper
• Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice

  2016cited by this paper
• Role of mitochondria, ROS, and DNA damage in arsenic induced carcinogenesis.

  2016cited by this paper
• Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY: results from two randomised trials

  2016cited by this paper
• Therapeutic Concentrations of Metformin: A Systematic Review

  2016cited by this paper
• Hyperhomocysteinemia in ApoE-/- Mice Leads to Overexpression of Enhancer of Zeste Homolog 2 via miR-92a Regulation

  2016cited by this paper
• Metformin attenuates expression of endothelial cell adhesion molecules and formation of atherosclerotic plaques via autophagy induction

  2016cited by this paper
• Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 Cells

  2016cited by this paper
• Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association

  2016cited by this paper
• Metformin attenuates fluctuating glucose-induced endothelial dysfunction through enhancing GTPCH1-mediated eNOS recoupling and inhibiting NADPH oxidase.

  2016cited by this paper
• Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis.

  2016cited by this paper
• Metformin regulates oxLDL-facilitated endothelial dysfunction by modulation of SIRT1 through repressing LOX-1-modulated oxidative signaling

  2016cited by this paper
• Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis

  2016cited by this paper
• Vascular endothelium: functioning in norm, changes in atherosclerosis and current dietary approaches to improve endothelial function.

  2015cited by this paper
• New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells.

  2015cited by this paper
• Metformin action: concentrations matter.

  2015cited by this paper
• Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

  2015cited by this paper
• Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells.

  2015cited by this paper
• How leukocytes cross the vascular endothelium

  2015cited by this paper
• Metformin improves endothelial function and carotid intima media thickness in patients with PCOS

  2015cited by this paper
• Forkhead Box O-1 Modulation Improves Endothelial Insulin Resistance in Human Obesity

  2015cited by this paper
• Metformin versus insulin for gestational diabetes mellitus: a meta-analysis.

  2015cited by this paper
• Homocysteine-Induced Endothelial Dysfunction

  2015cited by this paper
• Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention

  2014cited by this paper
• Carbamylated low-density lipoprotein induces endothelial dysfunction.

  2014cited by this paper
• Paradoxic effects of metformin on endothelial cells and angiogenesis

  2014cited by this paper
• Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis.

  2014cited by this paper
• OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators.

  2014cited by this paper
• Metformin Protects Endothelial Function in Diet-Induced Obese Mice by Inhibition of Endoplasmic Reticulum Stress Through 5′ Adenosine Monophosphate–Activated Protein Kinase–Peroxisome Proliferator–Activated Receptor &dgr; Pathway

  2014influential reference
• An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

  2014cited by this paper
• TNF-α-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes.

  2014cited by this paper
• Long‐term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial

  2014cited by this paper
• Safe prescribing of metformin in diabetes

  2014cited by this paper
• Transforming growth factor β‐mediated site‐specific Smad linker region phosphorylation in vascular endothelial cells

  2014cited by this paper
• Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis.

  2014cited by this paper
• Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.

  2014cited by this paper
• Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase.

  2014cited by this paper
• The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice.

  2014cited by this paper
• Endothelial dysfunction - a major mediator of diabetic vascular disease.

  2013cited by this paper
• Prevention and endothelial therapy of coronary artery disease.

  2013cited by this paper
• Crucial roles of Nox2‐derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle‐aged mice

  2013cited by this paper
• Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy.

  2013cited by this paper
• Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells.

  2013cited by this paper
• Exposure to high or low glucose levels accelerates the appearance of markers of endothelial cell senescence and induces dysregulation of nitric oxide synthase.

  2013cited by this paper
• Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

  2013cited by this paper
• Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

  2013cited by this paper
• Metformin improves endothelial function in type 1 diabetic subjects: a pilot, placebo‐controlled randomized study

  2013cited by this paper
• Deficient eNOS Phosphorylation Is a Mechanism for Diabetic Vascular Dysfunction Contributing to Increased Stroke Size

  2013cited by this paper
• AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6

  2013cited by this paper
• Role of insulin resistance in endothelial dysfunction

  2013cited by this paper
• Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice

  2013cited by this paper
• Aging and Atherosclerosis: Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular Senescence

  2012cited by this paper
• Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

  2012cited by this paper
• Association of lower habitual physical activity level with mitochondrial and endothelial dysfunction in patients with stable coronary artery disease.

  2012cited by this paper
• Protein Kinase C-&bgr; Contributes to Impaired Endothelial Insulin Signaling in Humans With Diabetes Mellitus

  2012cited by this paper
• An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats

  2012cited by this paper
• Metformin pathways: pharmacokinetics and pharmacodynamics

  2012cited by this paper
• The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts

  2012cited by this paper
• Methylglyoxal promotes oxidative stress and endothelial dysfunction.

  2012cited by this paper
• Reactive oxygen species and endothelial function--role of nitric oxide synthase uncoupling and Nox family nicotinamide adenine dinucleotide phosphate oxidases.

  2012cited by this paper
• LOX-1 in atherosclerosis: biological functions and pharmacological modifiers

  2012cited by this paper
• Metformin restores endothelial function in aorta of diabetic rats

  2011cited by this paper
• EDHF: spreading the influence of the endothelium

  2011cited by this paper
• Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation.

  2011cited by this paper
• Four faces of cellular senescence

  2011cited by this paper
• Progress and challenges in translating the biology of atherosclerosis

  2011cited by this paper
• Dose-Dependent Modulatory Effects of Insulin on Glucose-Induced Endothelial Senescence In Vitro and In Vivo: A Relationship between Telomeres and Nitric Oxide

  2011cited by this paper
• The role of incretin therapy at different stages of diabetes.

  2011cited by this paper
• Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

  2011cited by this paper
• Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats.

  2011cited by this paper
• Effect of the insulin sensitizers metformin and pioglitazone on endothelial function in young women with polycystic ovary syndrome: a prospective randomized study.

  2011cited by this paper
• Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis.

  2011cited by this paper
• Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives.

  2011cited by this paper
• Inhibition of Insulin Signaling in Endothelial Cells by Protein Kinase C-induced Phosphorylation of p85 Subunit of Phosphatidylinositol 3-Kinase (PI3K)*

  2011cited by this paper
• The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c

  2011cited by this paper
• Adipokines in inflammation and metabolic disease

  2011cited by this paper
• Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy.

  2011cited by this paper
• Characterization of the Differential Response of Endothelial Cells Exposed to Normal and Elevated Laminar Shear Stress

  2011cited by this paper
• The Endothelium, Part II: EDHF-Mediated Responses "The Classical Pathway"

  2011influential reference
• Transforming growth factor‐β regulation of proteoglycan synthesis in vascular smooth muscle: Contribution to lipid binding and accelerated atherosclerosis in diabetes

  2010cited by this paper
• Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus

  2010cited by this paper
• Cellular signaling and NO production

  2010cited by this paper
• Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations.

  2010cited by this paper

• Causal Role of Endothelial Dysfunction in Ischemic Stroke and Its Subtypes: A Two-Stage Analysis.

  2025cites this paper
• Evaluating oxidative stress targeting treatments in in vitro models of placental stress relevant to preeclampsia

  2025cites this paper
• Enhancing immunity during ageing by targeting interactions within the tissue environment

  2025cites this paper
• The cardiometabolic benefits of curcumin: a focus on endothelial dysfunction and arterial stiffness in metabolic syndrome

  2025cites this paper
• Spontaneous resolution of traumatic pseudoaneurysm: A case report

  2025cites this paper
• Metformin for endothelial dysfunction in non-diabetic disorders: a scoping review

  2025cites this paper
• A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID.

  2025cites this paper
• Endothelial dysfunction in the kidney transplant population: Current evidence and management strategies

  2025cites this paper
• Endothelial Protein Changes Indicative of Endometriosis in Unexplained Infertility, an Exploratory Study

  2025cites this paper
• Utility of Pharmacological Agents for Diabetes Mellitus in the Prevention of Alzheimer’s Disease: Comparison of Metformin, Glucagon-Like Peptide-1 (GLP-1) Agonists, Insulin, and Sulfonylureas

  2025cites this paper
• Study of the neuroprotective properties of metformin in rats with type 2 diabetes mellitus and brain injury induced by intracerebral hemorrhage

  2024cites this paper
• Exploring the clinical connections between epilepsy and diabetes mellitus: Promising therapeutic strategies utilizing agmatine and metformin

  2024cites this paper
• SWATH-proteomics reveals Mathurameha, a traditional anti-diabetic herbal formula, attenuates high glucose-induced endothelial dysfunction through the EGF/NO/IL-1β regulatory axis.

  2024cites this paper
• The potential therapeutic value of the natural plant compounds matrine and oxymatrine in cardiovascular diseases

  2024cites this paper
• Pathogenetic basis of treating endothelial dysfunction with metformin in patients with diabetes (literature review and own data)

  2024cites this paper
• Analysis of the Involvement of Susceptibility Genes to Coronary Heart Disease in Implementation Signaling and Metabolic Pathways

  2024cites this paper
• Investigation of the Dysfunction Caused by High Glucose, Advanced Glycation End Products, and Interleukin‐1 Beta and the Effects of Therapeutic Agents on the Microphysiological Artery Model

  2024cites this paper
• Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery

  2024cites this paper
• Panduratin A Inhibits TNF Alpha-Stimulated Endothelial Cell Activation Through Suppressing the NF-κB Pathway

  2024cites this paper
• Targeting oxidative stress in preeclampsia

  2024cites this paper
• Metformin in Antiviral Therapy: Evidence and Perspectives

  2024cites this paper
• Angiotensin II Exposure In Vitro Reduces High Salt-Induced Reactive Oxygen Species Production and Modulates Cell Adhesion Molecules’ Expression in Human Aortic Endothelial Cell Line

  2024cites this paper
• Mechanistic insights into the regression of atherosclerotic plaques

  2024cites this paper
• Mechanisms of long COVID and the path toward therapeutics.

  2024cites this paper
• Metformin modulates microbiota and improves blood pressure and cardiac remodeling in a rat model of hypertension

  2024cites this paper
• Association of the vitamin D metabolism gene polymorphism with the severity of coronary lesions assessed by SYNTAX score

  2024cites this paper
• Metformin in COVID-19: a magical role beyond the hyperglycemia

  2024cites this paper
• Metformin effect on internal carotid artery blood flow assessed by area under the curve of carotid artery Doppler in women with polycystic ovarian syndrome

  2023cites this paper
• LONG-TERM COVID-19 EFFECT TO ENDOTHELIAL DAMAGE TROUGH EXTRINSIC APOPTOSIS LED TO CARDIOVASCULAR DISEASE PROGRESSION: AN UPDATE REVIEW

  2023cites this paper
• The Role of Polymorphism in the Endothelial Homeostasis and Vitamin D Metabolism Genes in the Severity of Coronary Artery Disease

  2023cites this paper
• Metformin-mediated epigenetic modifications in diabetes and associated conditions: biological and clinical relevance.

  2023cites this paper
• Real‐world risk of cardiovascular diseases in patients with type 2 diabetes associated with sodium–glucose cotransporter 2 inhibitors in comparison with metformin: A propensity score‐matched model analysis in Japan

  2023cites this paper
• Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation

  2023cites this paper
• Inflammatory Mediators of Endothelial Dysfunction

  2023cites this paper
• Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications

  2023cites this paper
• Gastrodin protects endothelial cells against high glucose-induced injury through up-regulation of PPARβ and alleviation of nitrative stress.

  2023cites this paper
• Endothelial Autophagy Dysregulation in Diabetes

  2023cites this paper
• Cardiovascular-related proteomic changes in ECFCs exposed to the serum of COVID-19 patients

  2023cites this paper
• Influence of metformin on hyperandrogenism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials

  2023cites this paper
• Pharmacological effects of statins in adult patients with type 2 diabetes mellitus: A protocol for systematic review and meta-analysis

  2022cites this paper
• Association of Metformin with Risk of Venous Thromboembolism in Adults with Type 2 Diabetes: A General Population-Based Cohort Study.

  2022cites this paper
• Mitochondria as an important target of metformin: the mechanism of action, toxic and side effects, and new therapeutic applications.

  2022cites this paper
• Acute metabolic effects of metformin during critical illness

  2022cites this paper
• Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms

  2022cites this paper
• A Clinical Perspective of the Multifaceted Mechanism of Metformin in Diabetes, Infections, Cognitive Dysfunction, and Cancer

  2022cites this paper
• Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article

  2022cites this paper
• Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease

  2022cites this paper
• Metformin Protects against Diabetic Cardiomyopathy: An Association between Desmin–Sarcomere Injury and the iNOS/mTOR/TIMP-1 Fibrosis Axis

  2022influential citation
• Mechanisms and Clinical Implications of Endothelial Dysfunction in Arterial Hypertension

  2022cites this paper
• Targeting Peptide, Fluorescent Reagent Modified Magnetic Liposomes Coated with Rapamycin Target Early Atherosclerotic Plaque and Therapy

  2022cites this paper
• Metformin: Is it a drug for all reasons and diseases?

  2022cites this paper
• Ginsenoside Rh1 protects human endothelial cells against lipopolysaccharide-induced inflammatory injury through inhibiting TLR2/4-mediated STAT3, NF-κB, and ER stress signaling pathways.

  2022cites this paper
• Metformin Alleviates LPS-Induced Acute Lung Injury by Regulating the SIRT1/NF-κB/NLRP3 Pathway and Inhibiting Endothelial Cell Pyroptosis

  2022cites this paper
• Repurposing Metformin for Vascular Disease

  2022cites this paper
• Obesity induces extracellular vesicle release from the endothelium as a contributor to brain damage after cerebral ischemia in rats

  2022cites this paper
• Cellular senescence and cardiovascular diseases: moving to the "heart" of the problem.

  2022cites this paper
• Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor

  2022cites this paper
• Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women

  2022cites this paper
• Vascular diseases

  2022cites this paper
• Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female Mice

  2021cites this paper
• Changes in biomarkers of endothelial function in the blood after intracerebral hemorrhage in rats with type 2 diabetes mellitus

  2021cites this paper
• Association of Preadmission Metformin Use and Prognosis in Patients With Sepsis and Diabetes Mellitus: A Systematic Review and Meta-Analysis

  2021cites this paper
• Editorial: Metabolic Regulation in the Development of Cardiovascular Diseases

  2021cites this paper
• The association between chronic stress, hair cortisol, and angiographically documented coronary atherosclerosis, a case-control study

  2021cites this paper
• Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77)

  2021cites this paper
• Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia

  2021cites this paper
• CARDIOVASCULAR EFFECTS OF NON-INSULIN GLUCOSE-LOWERING AGENTS: A COMPREHENSIVE REVIEW OF TRIAL EVIDENCE AND POTENTIAL CARDIOPROTECTIVE MECHANISMS.

  2021cites this paper
• A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

  2021cites this paper
• Renal Delivery of Pharmacologic Agents During Machine Perfusion to Prevent Ischaemia-Reperfusion Injury: From Murine Model to Clinical Trials

  2021cites this paper
• Metformin alleviates monoamine oxidase-related vascular oxidative stress and endothelial dysfunction in rats with diet-induced obesity

  2021cites this paper
• The Hormetic Effect of Metformin: “Less Is More”?

  2021cites this paper
• Metformin, Macrophage Dysfunction and Atherosclerosis

  2021cites this paper
• Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

  2021cites this paper
• Metformin Reverses Hashimoto’s Thyroiditis by Regulating Key Immune Events

  2021cites this paper
• A novel human arterial wall-on-a-chip to study endothelial inflammation and vascular smooth muscle cell migration in early atherosclerosis.

  2021cites this paper
• INTERDISCIPLINARY CLINICAL PRACTICE GUIDELINES "MANAGEMENT OF OBESITY AND ITS COMORBIDITIES"

  2021cites this paper
• Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches

  2021influential citation
• Mitochondrial Contributions to Vascular Endothelial Dysfunction, Arterial Stiffness and Cardiovascular Diseases.

  2021cites this paper
• The Current and Potential Therapeutic Use of Metformin—The Good Old Drug

  2021cites this paper
• Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

  2021cites this paper
• Дисфункция эндотелия. Правильно ли мы понимаем этот термин

  2020cites this paper
• Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model

  2020cites this paper
• Endothelial Dysfunction in Diabetes

  2020cites this paper
• Targeting mitochondrial fitness as a strategy for healthy vascular aging.

  2020cites this paper
• Poor glycemic control impairs the cardioprotective effects of red blood cells on myocardial ischemia/reperfusion injury.

  2020cites this paper
• The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome

  2020cites this paper
• Endothelial dysfunction. Do we understand this term properly?

  2020cites this paper
• Endothelial function in obesity and effects of bariatric and metabolic surgery

  2020cites this paper
• Novel Targets of Metformin in Cardioprotection: Beyond the Effects Mediated by AMPK.

  2020cites this paper
• Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function

  2020cites this paper
• Sirtuins family as a target in endothelial cell dysfunction: implications for vascular ageing

  2020cites this paper
• Effects of drugs, phytoestrogens, nutrients and probiotics on endothelial dysfunction in the estrogen-deficient state.

  2020cites this paper
• Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease.'

  2020cites this paper
• An investigation into the pleiotropic activity of metformin. A glimpse of haemostasis.

  2020cites this paper
• Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?

  2020cites this paper
• Combination of hyperglycaemia and hyperlipidaemia induces endothelial dysfunction: Role of the endothelin and nitric oxide systems

  2020cites this paper
• Metabolic adaptations of cells at the vascular-immune interface during atherosclerosis

  2020cites this paper
• Is metformin associated with acute kidney injury? A case-control study of patients with type 2 diabetes admitted with acute infection

  2020cites this paper
• Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice

  2020cites this paper
• Metformin as a Potential Agent in the Treatment of Multiple Sclerosis

  2020cites this paper