OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Free Radical Biology & Medicine

• Publication date

  2014-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.freeradbiomed.2014.02.014PMID 24561578PMCID PMC4006317
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide‐dependent TRAF3IP2/JNK signaling

  2013cited by this paper
• Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin.

  2013cited by this paper
• CIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction.

  2013cited by this paper
• Polyoxygenated Cholesterol Ester Hydroperoxide Activates TLR4 and SYK Dependent Signaling in Macrophages

  2013cited by this paper
• Molecular mechanisms of vascular effects of High-density lipoprotein: alterations in cardiovascular disease

  2012influential reference
• CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy.

  2012cited by this paper
• Upregulation of lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human endothelial cells by modified high density lipoproteins.

  2012cited by this paper
• Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.

  2012cited by this paper
• The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4*

  2011cited by this paper
• Oxidized low-density lipoprotein.

  2010cited by this paper
• The Adaptor Protein CIKS/Act1 Is Essential for IL-25-Mediated Allergic Airway Inflammation1

  2009cited by this paper
• Mechanism and Role of High Density Lipoprotein-induced Activation of AMP-activated Protein Kinase in Endothelial Cells*

  2009cited by this paper
• Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via a RAGE-Mediated Signaling Pathway

  2008cited by this paper
• Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression*

  2008cited by this paper
• Cholesteryl Ester Hydroperoxides Are Biologically Active Components of Minimally Oxidized Low Density Lipoprotein*

  2008cited by this paper
• Enhanced Levels of Oxidized Low-Density Lipoprotein Prime Monocytes to Cytokine Overproduction via Upregulation of CD14 and Toll-Like Receptor 4 in Unstable Angina

  2007cited by this paper
• Molecular Dissection of Angiotensin II–Activated Human LOX-1 Promoter

  2006cited by this paper
• C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients.

  2006cited by this paper
• Impairment of endothelium-dependent aorta relaxation by phospholipid components of oxidized low-density lipoprotein.

  2006cited by this paper
• Modified HDL: biological and physiopathological consequences.

  2006cited by this paper
• Activation of the AMP-activated Protein Kinase by the Anti-diabetic Drug Metformin in Vivo

  2004cited by this paper
• Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin

  2004cited by this paper
• IFN Regulatory Factor-1 Is Required for the Up-Regulation of the CD40-NF-κB Activator 1 Axis During Airway Inflammation1

  2003cited by this paper
• CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.

  2000influential reference
• The oxidative modification hypothesis of atherogenesis: an overview.

  2000cited by this paper
• Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells.

  2000cited by this paper
• Act1, an NF-κB-activating protein

  2000cited by this paper
• Act1, an NF-kappa B-activating protein.

  2000influential reference
• Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene.

  1999cited by this paper
• Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.

  1999cited by this paper
• Oxidants and antioxidants in atherogenesis. An appraisal.

  1999cited by this paper
• Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells.

  1999cited by this paper
• Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas.

  1998cited by this paper
• Oxidized LDL activates fas-mediated endothelial cell apoptosis.

  1998cited by this paper
• Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas.

  1998cited by this paper
• Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells.

  1998influential reference
• An endothelial receptor for oxidized low-density lipoprotein

  1997influential reference
• HDL3 exerts more powerful anti-oxidative, protective effects against copper-catalyzed LDL oxidation than HDL2.

  1997cited by this paper
• Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques.

  1995cited by this paper
• Lysophosphatidylcholine: essential role in the inhibition of endothelium-dependent vasorelaxation by oxidized low density lipoprotein.

  1990cited by this paper
• Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

  1990cited by this paper
• Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

  1990cited by this paper
• High-density lipoproteins: biochemical and metabolic factors.

  1983cited by this paper

• Upregulation of IL-32γ in endothelial cells promotes macrophage recruitment and inflammatory progression in atherosclerosis.

  2026cites this paper
• Rhynchophylline alleviates early atherosclerosis by attenuating oxidized low-density lipoprotein-induced foam cell formation and endothelial dysfunction

  2025cites this paper
• TRAF3IP2 as a novel inflammatory biomarker for coronary artery disease: development and validation of a multimodal prediction model

  2025cites this paper
• Endothelial NADPH oxidase 5 overexpression promotes thrombosis and alters thrombus composition by sex-dependent mechanisms in mice.

  2025cites this paper
• Oxidative low-density lipoprotein and shear induced calcification within a calcific aortic valve disease-on-a-chip platform

  2025cites this paper
• The Role of Olive Oil in Cardiometabolic Risk

  2025cites this paper
• High-Density Lipoprotein in Patients with Diabetic Kidney Disease: Friend or Foe?

  2025cites this paper
• Dual Exosome Coating for Modulating Endothelial Function and Inflammation.

  2025cites this paper
• Pathogenetic basis of treating endothelial dysfunction with metformin in patients with diabetes (literature review and own data)

  2024cites this paper
• Silymarin prevents endothelial dysfunction by upregulating Erk-5 in oxidized LDL exposed endothelial cells.

  2024cites this paper
• Chronic Intermittent Hypoxia Facilitates the Development of Angiotensin II-Induced Abdominal Aortic Aneurysm in Male Mice.

  2024cites this paper
• Oxidized low-density lipoproteins and their contribution to atherosclerosis

  2024cites this paper
• Chronic inflammation and vascular cell plasticity in atherosclerosis

  2024cites this paper
• Ox-LDL induces a non-inflammatory response enriched for coronary artery disease risk in human endothelial cells

  2024cites this paper
• OxLDL/LOX-1 mediated sex, age, stiffness, and endothelial dependent alterations in mouse thoracic aortic vascular reactivity

  2024cites this paper
• Multifaceted bioactivity of marine fungal derived secondary metabolite, xyloketal B -a review.

  2024cites this paper
• Dysfunctional HDL Diagnostic Metrics for Cardiovascular Disease Risk Stratification: Are we Ready to Implement in Clinics?

  2024cites this paper
• Vascular NADPH Oxidases and Atherothrombotic Stroke

  2024cites this paper
• Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders.

  2023cites this paper
• CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4 Pathway: Implications for Atherosclerosis Protection

  2023cites this paper
• Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration

  2023cites this paper
• Metformin Impedes Oxidation of LDL In Vitro

  2023cites this paper
• Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases

  2023cites this paper
• The lncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging

  2023influential citation
• OLR1 Geni 3’UTR 188 C>T Polimorfizmi: Koroner Arter Hastalarında Serum Okside LDL Düzeylerine ve Metabolik Parametrelere Etkileri

  2023cites this paper
• Schisanhenol ameliorates oxLDL‐caused endothelial dysfunction by inhibiting LOX‐1 signaling

  2023cites this paper
• The Role of Potential Oxidative Biomarkers in the Prognosis of Acute Ischemic Stroke and the Exploration of Antioxidants as Possible Preventive and Treatment Options

  2023cites this paper
• Constructing Mal‐Efferocytic Macrophage Model and Its Atherosclerotic Spheroids and Rat Model for Therapeutic Evaluation

  2023cites this paper
• Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions

  2023cites this paper
• Silencing of UCA1 attenuates the ox‐LDL‐induced injury of human umbilical vein endothelial cells via miR‐873‐5p/MAPK8 axis

  2022cites this paper
• MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation.

  2022cites this paper
• Exosome-Loaded Pro-efferocytic Vascular Stent with Lp-PLA2-Triggered Release for Preventing In-Stent Restenosis.

  2022cites this paper
• Role of Cigarette Smoking on Serum Angiotensin-Converting Enzyme and Its Association With Inflammation and Lipid Peroxidation

  2022cites this paper
• The Relationship between Cancer and Paraoxonase 1

  2022cites this paper
• Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation

  2022cites this paper
• Novel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking During Eimeria bovis Macromeront Formation

  2022cites this paper
• Relevance of circulating markers of endothelial activation for cardiovascular risk assessment in rheumatoid arthritis: A narrative review.

  2022cites this paper
• Effects of Empagliflozin on Intermittent Hypoxia-Induced TRAF3IP2-Dependent Human Aortic Smooth Muscle Cell Proliferation

  2022cites this paper
• New insights into mechanisms of endothelial insulin resistance in type 2 diabetes.

  2022cites this paper
• Knockdown of lncRNA ENST00000609755.1 Confers Protection Against Early oxLDL-Induced Coronary Heart Disease

  2021cites this paper
• Relationship Between Autophagy and Metabolic Syndrome Characteristics in the Pathogenesis of Atherosclerosis

  2021cites this paper
• D-4F Ameliorates Contrast Media–Induced Oxidative Injuries in Endothelial Cells via the AMPK/PKC Pathway

  2021cites this paper
• Effect of Metformin on Cardiac Metabolism and Longevity in Aged Female Mice

  2021cites this paper
• Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis.

  2021cites this paper
• Oxidative distress in aging and age-related diseases: Spatiotemporal dysregulation of protein oxidation and degradation.

  2021cites this paper
• High-Fat Diets-Induced Metabolic Disorders to Study Molecular Mechanism of Hyperlipidemia in Rats

  2021cites this paper
• Novel function of fluvastatin in attenuating oxidized low-density lipoprotein-induced endothelial cell ferroptosis in a glutathione peroxidase4- and cystine-glutamate antiporter-dependent manner

  2021influential citation
• Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function

  2021cites this paper
• Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis

  2021cites this paper
• Association of Pericardiac Adipose Tissue With Coronary Artery Disease

  2021cites this paper
• LncRNA SNHG12 regulates ox-LDL-induced endothelial cell injury by the miR-218-5p/IGF2 axis in atherosclerosis

  2021cites this paper
• Inflammatory Mechanisms Contributing to Endothelial Dysfunction

  2021cites this paper
• Targeting TRAF3IP2 alleviates high glucose‐induced cardiomyocyte inflammation and apoptosis

  2021cites this paper
• Nanomaterials to Resolve Atherosclerosis.

  2020cites this paper
• Endothelial cell and T‐cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation

  2020cites this paper
• Mediterranean Diet Increases Endothelial Function in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  2020cites this paper
• Determining the Significance of Coronary Plaque Lesions: Physiological Stenosis Severity and Plaque Characteristics

  2020cites this paper
• HRD1 prevents atherosclerosis-mediated endothelial cell apoptosis by promoting LOX-1 degradation

  2020cites this paper
• LOX-1 (Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) Deletion Has Protective Effects on Stroke in the Genetic Background of Stroke-Prone Spontaneously Hypertensive Rat

  2020cites this paper
• High fat diet altered cardiac metabolic gene profile in Psammomys obesus gerbils

  2020cites this paper
• BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL‐induced DNA damage and endothelial apoptosis

  2020cites this paper
• Circulating microparticles released during dyslipidemia may exert deleterious effects on blood vessels and endothelial function.

  2020cites this paper
• TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice

  2020cites this paper
• The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion.

  2020cites this paper
• Cardiovascular disease and stroke risk assessment in patients with chronic kidney disease using integration of estimated glomerular filtration rate, ultrasonic image phenotypes, and artificial intelligence: a narrative review.

  2020cites this paper
• Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?

  2020cites this paper
• Minocycline inhibits PDGF-BB-induced human aortic smooth muscle cell proliferation and migration by reversing miR-221- and -222-mediated RECK suppression.

  2019cites this paper
• The combination of a neprilysin inhibitor (sacubitril) and angiotensin-II receptor blocker (valsartan) attenuates glomerular and tubular injury in the Zucker Obese rat

  2019cites this paper
• Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition.

  2019cites this paper
• Evaluating the link between Paraoxonase-1 levels and Alzheimer's disease development.

  2019cites this paper
• The protein S-nitrosylation of splicing and translational machinery in vascular endothelial cells is susceptible to oxidative stress induced by oxidized low-density lipoprotein.

  2019cites this paper
• Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers

  2019cites this paper
• Nitric Oxide (Prong-2)

  2019cites this paper
• Clinical Autonomic and Mitochondrial Disorders: Diagnosis, Prevention, and Treatment for Mind-Body Wellness

  2019cites this paper
• Vulnerable Plaque, Characteristics, Detection, and Potential Therapies

  2019cites this paper
• Comparison of Mechanisms of Endothelial Cell Protections Between High-Density Lipoprotein and Apolipoprotein A-I Mimetic Peptide

  2019cites this paper
• The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology

  2019cites this paper
• Induction of endothelial dysfunction by oxidized low-density lipoproteins via downregulation of Erk-5/Mef2c/KLF2 signaling: Amelioration by fisetin.

  2019cites this paper
• The effects of quercetin supplementation on blood pressures and endothelial function among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.

  2019cites this paper
• Effectiveness of a Novel Nutraceutical Compound Containing Red Yeast Rice, Polymethoxyflavones and Antioxidants in the Modulation of Cholesterol Levels in Subjects With Hypercholesterolemia and Low-Moderate Cardiovascular Risk: The NIRVANA Study

  2019cites this paper
• Elevation of serum oxLDL/β2‐GPI complexes was correlated with diabetic microvascular complications in Type 2 diabetes mellitus patients

  2018cites this paper
• Endothelial function and dysfunction: Impact of metformin

  2018cites this paper
• Anti-inflammatory actions of nutraceuticals: Novel emerging therapies for atherosclerosis?

  2018cites this paper
• Distribution of Paraoxonase-1 (PON-1) and Lipoprotein Phospholipase A2 (Lp-PLA2) across Lipoprotein Subclasses in Subjects with Type 2 Diabetes

  2018cites this paper
• Dysfunctional endothelial‐derived microparticles promote inflammatory macrophage formation via NF‐кB and IL‐1β signal pathways

  2018cites this paper
• OxInflammation: From Subclinical Condition to Pathological Biomarker

  2018cites this paper
• Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes

  2018cites this paper
• Knockdown of long noncoding RNA XIST alleviates oxidative low-density lipoprotein-mediated endothelial cells injury through modulation of miR-320/NOD2 axis.

  2018cites this paper
• TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells.

  2018influential citation
• Oxidized low‐density lipoprotein stimulates epithelial sodium channels in endothelial cells of mouse thoracic aorta

  2018cites this paper
• Elevated Levels of Serum β2-Glycoprotein I/Oxidized Low-Density Lipoprotein Complexes Are Associated with Cerebral Infarction in Patients with Type 2 Diabetes Mellitus

  2018cites this paper
• Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart

  2018cites this paper
• The apolipoprotein A-I mimetic peptide, D-4F, alleviates ox-LDL-induced oxidative stress and promotes endothelial repair through the eNOS/HO-1 pathway.

  2017cites this paper
• Novel Insights in the Metabolic Syndrome-induced Oxidative Stress and Inflammation-mediated Atherosclerosis

  2017cites this paper
• The effects of oleanolic acid on atherosclerosis in different animal models

  2017cites this paper
• Computational Analysis on Down-Regulated Images of Macrophage Scavenger Receptor

  2017cites this paper
• Endothelial long non-coding RNAs regulated by oxidized LDL

  2017cites this paper
• Coronary Atherosclerotic Vulnerable Plaque: Current Perspectives

  2017cites this paper
• Lipoproteins and Cardiovascular Redox Signaling: Role in Atherosclerosis and Coronary Disease

  2017cites this paper
• Anti-inflammatory Effects of Atorvastatin by Suppressing TRAF3IP2 and IL-17RA in Human Glioblastoma Spheroids Cultured in a Three-dimensional Model: Possible Relevance to Glioblastoma Treatment

  2017cites this paper