Cisapride‐induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres

No abstract is available for this paper.

• Publication year

  1996

• Venue

  British Journal of Pharmacology

• Publication date

  1996-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1476-5381.1996.tb15295.xPMID 8730728PMCID PMC1909459
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cisapride

  2012cited by this paper
• Electrophysiological and Arrhythmogenic Effects of the Histamine Type 1‐Receptor Antagonist Astemizole on Rabbit Purkinje Fibers: Clinical Relevance

  1995cited by this paper
• Long QT syndrome during high-dose cisapride.

  1995cited by this paper
• Cisapride and torsades de pointes

  1995cited by this paper
• Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes.

  1994cited by this paper
• Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.

  1990cited by this paper
• Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early afterdepolarizations?

  1989cited by this paper

• A comprehensive review of 20 years of progress in nonclinical QT evaluation and proarrhythmic assessment

  2025cites this paper
• Salidroside modulates repolarization through stimulating Kv2.1 in rats.

  2024cites this paper
• Fast-slow analysis and bifurcations in the generation of the early afterdepolarization phenomenon in a realistic mathematical human ventricular myocyte model.

  2024cites this paper
• Bifurcations to transient and oscillatory excitations in inhomogeneous excitable media: Insights into arrhythmogenesis in long QT syndrome.

  2023cites this paper
• Induced Pluripotent Stem Cell-Derived Cardiomyocytes with SCN5A R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes

  2021cites this paper
• Assessment of Proarrhythmic Potential of Drugs in Optogenetically Paced Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

  2019cites this paper
• Cardiovascular safety of prokinetic agents: A focus on drug‐induced arrhythmias

  2018cites this paper
• Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel–Drug Binding Kinetics and Multichannel Pharmacology

  2017cites this paper
• Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential

  2016cites this paper
• Acute and Chronic Effects of Disturbance Control Factors, Complications and Treatment Method

  2015cites this paper
• Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes.

  2015influential citation
• Complex Early and Delayed Afterdepolarization Dynamics caused by Voltage-Calcium Coupling in Cardiac Myocytes

  2015cites this paper
• Cisapride protects against cardiac hypertrophy via inhibiting the up-regulation of calcineurin and NFATc-3.

  2014influential citation
• A straightforward guide to the basic science behind arrhythmogenesis

  2014cites this paper
• Acute and subchronic toxicities of QX100626, a 5-HT4 receptor agonist, in rodents and Beagle dogs.

  2014cites this paper
• Republished: A straightforward guide to the basic science behind arrhythmogenesis

  2014cites this paper
• An Overview of QT Interval Assessment in Safety Pharmacology

  2013cites this paper
• Irritable Bowel Syndrome

  2012cites this paper
• Cisapride Improves Enteral Tolerance in Pediatric Short-bowel Syndrome With Dysmotility

  2011cites this paper
• 25 – Management of nausea and vomiting in patients with advanced cancer*

  2011cites this paper
• Treating nausea and vomiting in palliative care: a review

  2011cites this paper
• Quantitative prediction of the arrhythmogenic effects of de novo hERG mutations in computational models of human ventricular tissues

  2011cites this paper
• Prokinetic agents and QT prolongation: a familiar scene with new actors.

  2010cites this paper
• Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.

  2008cites this paper
• Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro.

  2007cites this paper
• Death by QT: a new safety challenge

  2007cites this paper
• The Cardiovascular Safety Profile of Renzapride, a Novel Treatment for Irritable Bowel Syndrome

  2007cites this paper
• Application of the Bradford Hill Criteria to Assess the Causality of Cisapride-Induced Arrhythmia

  2007cites this paper
• The Prokinetic Cinitapride Has No Clinically Relevant Pharmacokinetic Interaction and Effect on QT during Coadministration with Ketoconazole

  2007cites this paper
• Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart.

  2006cites this paper
• Cellular, Molecular, and Pharmacologic Mechanisms Underlying Drug-Induced Cardiac Arrhythmogenesis

  2005cites this paper
• Effect on QT Interval with Cisapride Use in Neonates

  2005cites this paper
• Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc.

  2004cites this paper
• Inhibition of L-Type Ca2+ Current in Guinea Pig Ventricular Myocytes by Cisapride

  2004cites this paper
• Lack of action potential-prolonging effect of terfenadine on rabbit myocardial tissue preparations.

  2004cites this paper
• 24-Hour Electrocardiogram before and during Cisapride Treatment in Neonates and Infants

  2004cites this paper
• Proarrhythmia with Non-Antiarrhythmics

  2004cites this paper
• Electrophysiologic Properties and Antiarrhythmic Actions of a Novel Antianginal Agent

  2004cites this paper
• Inhibition of L-type Ca(2+) current in Guinea pig ventricular myocytes by cisapride.

  2004cites this paper
• Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.

  2003cites this paper
• Age-Related Differences in the Direct Cardiac Effects of Cisapride: Narrower Safety Range in the Hearts of Young Rabbits

  2003influential citation
• Prolongation of the QT interval and cardiac arrhythmias associated with cisapride: limitations of the pharmacoepidemiological studies conducted and proposals for the future

  2003cites this paper
• TEGASEROD: A NOVEL, SELECTIVE 5‐HT4 RECEPTOR PARTIAL AGONIST FOR IRRITABLE BOWEL SYNDROME

  2002cites this paper
• Effects of sildenafil on cardiac repolarization.

  2002cites this paper
• Risperidone prolongs cardiac action potential through reduction of K+ currents in rabbit myocytes.

  2002cites this paper
• Electrocardiographic and hemodynamic effects of cisapride alone and combined with erythromycin in anesthetized dogs

  2002cites this paper
• Pharmacology for the gastrointestinal tract.

  2002cites this paper
• Safety pharmacology – a progressive approach

  2002cites this paper
• ICH Topic: The draft ICH S7B step 2: Note for guidance on safety pharmacology studies for human pharmaceuticals

  2002cites this paper
• Sertindole: cardiac electrophysiological profile

  2002cites this paper
• A method for QT correction based on beat-to-beat analysis of the QT/RR interval relationship in conscious telemetred beagle dogs.

  2002cites this paper
• Tegaserod, a 5-hydroxytryptamine type 4 receptor partial agonist, is devoid of electrocardiographic effects

  2002cites this paper
• An Overview of QT Interval Assessment in Safety Pharmacology

  2001cites this paper
• Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus

  2001cites this paper
• QT interval effects of cisapride in the clinical setting.

  2001cites this paper
• Effects of grapefruit juice on the pharmacokinetics of selected CYP3A4 substrate drugs

  2001cites this paper
• Tegaserod, a 5‐HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation

  2001cites this paper
• "Use-dependent" effects of cisapride on postrest action potentials in rabbit ventricular myocardium.

  2001cites this paper
• Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole.

  2001cites this paper
• An Overview of QT Interval Assessment in Safety Pharmacology

  2001cites this paper
• Torsades de Pointes Ventricular Tachycardia Induced by Mosapride and Flecainide in the Presence of Hypokalemia

  2001cites this paper
• Effects of 5-HT4 Receptor Agonist Prokinetic Agents on the Action Potential Parameters of Isolated Rabbit Myocardium

  2001cites this paper
• Effects of Cisapride on Ventricular Depolarization-Repolarization and Arrhythmia Markers in Infants

  2001cites this paper
• Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice.

  2001cites this paper
• Irritable bowel syndrome: new agents targeting serotonin receptor subtypes.

  2001cites this paper
• Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel.

  2001cites this paper
• Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A.

  2001cites this paper
• Cisapride poisoning associated with negative T waves.

  2000cites this paper
• Drug Interactions with Cisapride

  2000cites this paper
• Evidence for a Cardiac Ion Channel Mutation Underlying Drug‐Induced QT Prolongation and Life‐Threatening Arrhythmias

  2000cites this paper
• Effects of Cisapride on QTc Interval and QT Dispersion in Preterm Infants

  2000cites this paper
• Gastrointestinal Complications of Diabetes Mellitus

  1999cites this paper
• Can Drowning in Swimming Pools Be Prevented?

  1999cites this paper
• Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo.

  1999cites this paper
• Review article: cardiac adverse effects of gastrointestinal prokinetics

  1999cites this paper
• Observers of Childhood Sexual Behavior

  1999cites this paper
• Repeated consumption of grapefruit juice considerably increases plasma concentrations of cisapride

  1999cites this paper
• Nitrogen‐containing heteroalicycles with serotonin receptor binding affinity: Development of gastroprokinetic and antiemetic agents

  1999cites this paper
• Inhibition of the human ether‐a‐go‐go‐related gene (HERG) potassium channel by cisapride: affinity for open and inactivated states

  1999cites this paper
• Comparison of tegaserod (HTF 919) and its main human metabolite with cisapride and erythromycin on cardiac repolarization in the isolated rabbit heart.

  1999cites this paper
• The role of cisapride in the treatment of pediatric gastroesophageal reflux. The European Society of Paediatric Gastroenterology, Hepatology and Nutrition.

  1999cites this paper
• Preclinical In Vitro Cardiac Electrophysiology

  1999cites this paper
• Effects of 17β‐Estradiol on Tachycardia‐Induced Changes of Atrial Refractoriness and Cisapride‐Induced Ventricular Arrhythmia

  1999cites this paper
• Crazy Glue and Foreign Bodies

  1999cites this paper
• Cisapride and Proarrhythmia in Childhood

  1999cites this paper
• Early Menarche in Japanese Down Syndrome

  1999cites this paper
• [Long QTc interval complicating halofantrine therapy in 2 children with Plasmodium falciparum malaria].

  1999cites this paper
• Allongement de l'espace QTc compliquant la prescription d'halofantrine chez deux enfants présentant un accès palustre à Plasmodium falciparum

  1999cites this paper
• A Case of Torsades de Pointes Induced by Cisapride

  1999cites this paper
• Repercussions of pharmacologic reduction in ionic currents on action potential configuration in rabbit Purkinje fibers: Are they indicative of proarrhythmic potential?

  1999cites this paper
• Cisapride에 의해 유발된 Torsades de Pointes

  1999cites this paper
• Sparfloxacin but not levofloxacin or ofloxacin prolongs cardiac repolarization in rabbit Purkinje fibers

  1998cites this paper
• Prepulsid® et allongement de l'espace QT

  1998cites this paper
• Effects of gastrointestinal prokinetic agents, TKS159 and cisapride, on the in situ canine heart assessed by cardiohemodynamic and electrophysiological monitoring.

  1998cites this paper
• Effect of Cisapride on ATP-sensitive K Channel of Ventricular Cell

  1998cites this paper
• Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval.

  1998cites this paper
• Cisapride‐Induced Torsades de Pointes

  1998cites this paper
• [Electrophysiologic effects and arrhythmogenic potential of diphemanil methylsulfate on rabbit purkinje fibers. Correlations with clinical observations of QT prolongation in pediatrics].

  1998cites this paper
• Functional gut disorders: from motility to sensitivity disorders. A review of current and investigational drugs for their management.

  1998cites this paper
• The pre-clinical assessment of QT interval prolongation: a comparison of in vitro and in vivo methods

  1998cites this paper