An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  1997-07-18

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1006/BBRC.1997.6943PMID 9240432
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif

  1997cited by this paper
• Antioxidant-inducible genes.

  1997cited by this paper
• Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene.

  1996cited by this paper
• Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site

  1996cited by this paper
• Oxidative stress induces the levels of a MafG homolog in hamster HA-1 cells.

  1996cited by this paper
• NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development.

  1996cited by this paper
• Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

  1995cited by this paper
• cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor.

  1995cited by this paper
• Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor

  1995cited by this paper
• Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz.

  1995cited by this paper
• ARE- and TRE-mediated Regulation of Gene Expression

  1995cited by this paper
• Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22.

  1994cited by this paper
• Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins

  1994cited by this paper
• Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression.

  1994cited by this paper
• Two murine GSTpi genes are arranged in tandem and are differentially expressed.

  1994cited by this paper
• Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun

  1994cited by this paper
• Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

  1994cited by this paper
• 酵母での遺伝的選択によるNF-E2関連転写因子、Nrf1のクローニング

  1993cited by this paper
• The structure of two murine class-mu glutathione transferase genes coordinately induced by butylated hydroxyanisole.

  1993cited by this paper
• Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.

  1993cited by this paper
• The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.

  1993cited by this paper
• Chemical and molecular regulation of enzymes that detoxify carcinogens.

  1993cited by this paper
• Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

  1993cited by this paper
• Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177.

  1992cited by this paper
• Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene.

  1992cited by this paper
• Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Isolation of mouse glutathione S-transferase heterodimers by gradient elution of the glutathione-Sepharose affinity matrix.

  1991cited by this paper
• The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.

  1991cited by this paper
• Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis.

  1991cited by this paper
• Expression of recombinant glutathione S-transferase pi, Ya, or Yb1 confers resistance to alkylating agents.

  1990cited by this paper
• Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.

  1990cited by this paper
• Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.

  1990cited by this paper
• Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

  1990cited by this paper
• The peroxidase-dependent activation of butylated hydroxyanisole and butylated hydroxytoluene (BHT) to reactive intermediates. Formation of BHT-quinone methide via a chemical-chemical interaction.

  1989cited by this paper
• Differential induction of class alpha glutathione S-transferases in mouse liver by the anticarcinogenic antioxidant butylated hydroxyanisole. Purification and characterization of glutathione S-transferase Ya1Ya1.

  1989cited by this paper
• Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2).

  1989cited by this paper
• Structural and functional analysis of an enhancer GPEI having a phorbol 12-O-tetradecanoate 13-acetate responsive element-like sequence found in the rat glutathione transferase P gene.

  1989cited by this paper
• Free radical intermediates during peroxidase oxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds.

  1989cited by this paper
• Glutathione transferases--structure and catalytic activity.

  1988cited by this paper
• Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole.

  1988cited by this paper
• The structure of the rat glutathione S-transferase P gene and related pseudogenes.

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

  1987cited by this paper
• Developmental and hormonal regulation of the major form of hepatic glutathione S-transferase in male mice.

  1986cited by this paper
• Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis.

  1985cited by this paper
• The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.

  1979cited by this paper
• Inhibitors of chemical carcinogenesis.

  1978cited by this paper
• Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene

  1975cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Design and optimisation of meta-substituted bis(arylsulfonamido)benzene inhibitors through a molecular hybridisation strategy targeting the Keap1-Nrf2 protein-protein interaction

  2026cites this paper
• The Nrf2-SLPI axis in aging and its role in the pathophysiology of pulmonary Mycobacterium avium complex disease

  2026cites this paper
• Mechanistic insights into PM2.5-induced myopia in mice: Role of NRF2/HIF-1α signaling and therapeutic potential of sulforaphane.

  2026cites this paper
• Mechanistic pathways predictive modeling and translational interventions for radiation enteritis in cervical cancer radiotherapy

  2026cites this paper
• Nuclear factor erythroid 2-related factor: potential use as a therapeutic strategy for viral infections

  2026cites this paper
• The Keto–Inflammatory Network: From Systems Biology to Biological Code

  2026cites this paper
• NRF2-Targeted Therapy in Cardiovascular Disease Transitions from Systemic Activation to Precision Redox Medicine.

  2026cites this paper
• Nrf2 regulates monocyte/macrophage recruitment during initial stages of neointimal formation after vascular injury.

  2026cites this paper
• Integrating metabolomics and machine learning to forecast anti-inflammatory and antioxidant activities in D. officinale leaves

  2026cites this paper
• NRF2: Master regulator of cellular homeostasis and therapeutic vulnerability in cancer

  2026cites this paper
• Poly-D,L-Lactic Acid Filler Restores Hair Thickness and Shine by Ameliorating Age-Associated Follicular Decline

  2026cites this paper
• A semi-analytical approach for solving a fractional-order mathematical model of skin cell damage and repair driven by environmental pollutants

  2026cites this paper
• The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2

  2026cites this paper
• Protective effects of a highly water-soluble rutin on cognitive dysfunction in mice.

  2026cites this paper
• Qinggan Mingshi Granules Inhibited Ferroptosis to Treat Diabetic Retinopathy in Mice Through NRF2/GPX4 Axis

  2026cites this paper
• Allosecurinine Derivative with Two Michael Acceptors Activates Keap1-Nrf2 Pathway.

  2026cites this paper
• Nutritional Strategies and Aging: Current Evidence and Future Directions

  2026cites this paper
• Activation of Nrf2 with natural flavonoids and mesenchymal stromal/stem cells: mechanisms and therapeutic potential for inflammatory diseases.

  2026cites this paper
• Atraric acid alleviates high-fat diet-induced renal injury, lipid accumulation, and fibrosis in mice by regulating oxidative stress and inflammation through AMPK-dependent Nrf2 and NF-κB signaling pathways.

  2026cites this paper
• NRF2 AT THE CROSSROADS OF PARKINSON'S DISEASE AND AGING: MECHANISTIC INSIGHTS AND TRANSLATIONAL PERSPECTIVES.

  2026cites this paper
• GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model

  2026cites this paper
• The role of histone demethylase PHF2 as a tumour suppressor in hepatocellular carcinoma by regulating SRXN1

  2026cites this paper
• Glutathione is critical for NK cell-mediated immunity.

  2026cites this paper
• A Study on Toxicity and Antimalarial Efficacy of Ocimum Gratissimum, Influence on Lung Antioxidant Defense and Nrf2 Expression in Plasmodium Berghei (Nk65) Infected Mice

  2025cites this paper
• Systemic activation of NRF2 contributes to the therapeutic efficacy of clinically-approved KRAS-G12C anti-cancer drugs

  2025cites this paper
• OROPHARYNGEAL ADMINISTRATION OF POLYSTYRENE MICROPLASTICS INDUCES PROFIBROTIC AND OXIDATIVE CHANGES IN MURINE LUNG TISSUE

  2025cites this paper
• Bidirectional regulation of KEAP1 BTB domain-based sensor activity

  2025cites this paper
• Targeting the Keap1/Nrf2 axis in cancer: molecular mechanisms and pharmacological interventions

  2025cites this paper
• Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling.

  2025cites this paper
• Advances in targeting glycogen synthase kinase 3β for diabetes therapy.

  2025cites this paper
• Enhanced Expression of the Female-Biased Gene Gsta2 in Male Proximal Tubule Cells Improves Renal Resilience to Ischemia-Reperfusion Injury.

  2025cites this paper
• Deregulated Nrf2-Keap1-BACH1 axis in autism spectrum disorder

  2025cites this paper
• A regulator of amino acid sensing links lipid peroxidation and lipid droplet-dependent antioxidant response.

  2025cites this paper
• A mechano-resistance mechanism in skin adapts to terrestrial locomotion.

  2025cites this paper
• Bionanotechnological innovations to improve the bioavailability of flavonoid polyphenols: a review

  2025cites this paper
• Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells.

  2025cites this paper
• NRF2 deficiency is associated with synaptic alterations and ether-linked phospholipid imbalance in the hippocampus

  2025cites this paper
• Nrf2 signaling in bone health: unlocking new avenues for osteoporosis management

  2025influential citation
• Effects of Different Forms of Organic Selenium on Growth Performance, Antioxidant Capacity, and Intestinal Health in Rice Field Eel (Monopterus albus)

  2025cites this paper
• NRF2 supports non-small cell lung cancer growth independently of CBP/p300-enhanced glutathione synthesis

  2025cites this paper
• Sheng Mai San Modulates the Heart-Gut-Microbiota Axis to Mitigate Heat Stress-Induced Damage in Rats

  2025cites this paper
• Elucidating the mechanistic interplay of AMPK and Nrf2 in MASLD: A focus on dietary phytochemical modulation of lipid and redox homeostasis.

  2025cites this paper
• Antioral cancer effects of ginger derivative 3-HDM exert oxidative stress-associated apoptosis and DNA damage

  2025cites this paper
• Alleviation of LPS-induced oxidative stress and inflammation by lesbicoumestan (7) via the increase of Nrf2 expression in mouse Kupffer cells.

  2025cites this paper
• The impact of oxidative stress and the NRF2-KEAP1-ARE signaling pathway on anticancer drug resistance

  2025cites this paper
• The Role of Nrf2 in the Regulation of Periodontitis, Peri-implantitis, Dentin Infection, and Apical Periodontitis

  2025cites this paper
• Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1,8-Dinitropyrene and Its Metabolite 1-Amino-8-nitropyrene via Nitroreduction in Human Lung Cells.

  2025cites this paper
• The gap between amyloid pathology and cognition

  2025cites this paper
• Nrf2 controls homeostatic transcriptional signatures and inflammatory responses in a cell-type specific manner in the adult mouse brain

  2025cites this paper
• Dual targeting of Keap1 and Gsk-3 by hexaraphane in the regulation of transcription factor Nrf2.

  2025cites this paper
• ROS-dependent localization of glycolytic enzymes to mitochondria

  2025cites this paper
• NRF2 activation in cancer and overview of NRF2 small molecule inhibitors

  2025influential citation
• The protection of sulforaphane on subarachnoid hemorrhage-induced intestinal mucosa injury in rats

  2025cites this paper
• Delivery strategies to improve the pharmacological efficacy of NRF2 modulators: a review

  2025cites this paper
• Pyrimethamine and a potent analog inhibit NRF2 by suppressing one-carbon metabolism

  2025cites this paper
• The Involvement of RIPK‐3/Caspase‐8 Inhibition and Nrf2/HO‐1 Upregulation in the Protective Effect of Umbelliferone Against Chlorpyrifos‐Induced Pulmonary Toxicity

  2025cites this paper
• Expression profiles of Nrf1 and Nrf2 in adult rat small intestine

  2025cites this paper
• Cisplatin-induced genetic alterations in KEAP1 promote therapeutic resistance in head and neck squamous cell carcinoma

  2025cites this paper
• Multicomponent-based analyses of ACS-patient-derived extracellular vesicles as likely tools for tailored interventional approaches

  2025cites this paper
• Metabolic Syndrome Develops Cardia Cancer via Nuclear Factor-E2-related Factor 2-Programmed Death-Ligand 1 Signaling

  2025cites this paper
• Beyond Antioxidants: How Redox Pathways Shape Cellular Signaling and Disease Outcomes

  2025cites this paper
• NRF2 activation in cancer cells suppresses immune infiltration into the tumor microenvironment

  2025cites this paper
• Synergistic action of cilnidipine and bexarotene in mitigating cholestatic liver damage: role of FXR signaling cascade

  2025cites this paper
• Pilot Study on CpG Methylation of the NRF2 Promoter Across Different Ages and Sex in Healthy and Lung Cancer Prediagnostic Individuals.

  2025cites this paper
• The clinical-grade CBP/ p300 inhibitor CCS1477 represses the global NRF2-dependent cytoprotective transcription program and re-sensitizes cancer cells to chemotherapeutic drugs.

  2025cites this paper
• A Review of the Effects of Flavonoids on NAD(P)H Quinone Oxidoreductase 1 Expression and Activity

  2025cites this paper
• Endothelial miR-34a deletion guards against aneurysm development despite endothelial dysfunction.

  2025cites this paper
• Nrf2-dependent effects of CDDO-Me on bactericidal activity in macrophage infection models

  2025cites this paper
• Broccoli for the brain: a review of the neuroprotective mechanisms of sulforaphane

  2025cites this paper
• Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review

  2025cites this paper
• Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin

  2025cites this paper
• Thirty years of NRF2: advances and therapeutic challenges

  2025cites this paper
• Capacity of fullerenols to modulate neurodegeneration induced by ferroptosis: Focus on multiple sclerosis.

  2025cites this paper
• Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism

  2025cites this paper
• Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.

  2025cites this paper
• Health position paper and redox perspectives – Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases

  2025cites this paper
• CD36 promotes iron accumulation and dysfunction in CD8+ T cells via the p38-CEBPB-TfR1 axis in early-stage hepatocellular carcinoma

  2025cites this paper
• Activation of the Nrf2 Pathway by Sulforaphane Improves Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes

  2025cites this paper
• Identification and inhibition of PIN1-NRF2 protein–protein interactions through computational and biophysical approaches

  2025cites this paper
• Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer.

  2025cites this paper
• Oxidative stress and mitochondrial dysfunctions induced by cyanobacterial microcystin-LR in primary grass carp hepatocytes.

  2025cites this paper
• The Keap1/Nrf2/ARE/HO-1 axis in epilepsy: Crosstalk between oxidative stress and neuroinflammation.

  2025cites this paper
• Engineered Macrophage Membrane-Camouflaged Nanodecoys Reshape the Infectious Microenvironment for Efficient Periodontitis Treatment.

  2025cites this paper
• Major Oxidative and Antioxidant Mechanisms During Heat Stress-Induced Oxidative Stress in Chickens

  2025cites this paper
• Emerging Therapeutic Targets in Rheumatoid Arthritis: Focusing on HIF-1α, Nrf2, STATs, and RORγt.

  2025cites this paper
• Co-stimulation with high-fat diet and acidic bile salts may promote Warburg effect in gastric carcinogenesis around the squamo-columnar junction in Gan mice.

  2025cites this paper
• McFerritin cooperates with McNrf2 to attenuate benzo[a]pyrene-induced oxidative stress in the thick-shell mussel Mytilus coruscus.

  2025cites this paper
• The NFE2L2 (NRF2) transcription factor controls genes involved in the oxidative stress response and inflammation in myometrial cells.

  2025cites this paper
• Bixin alleviates radiation-induced intestinal damage via inflammation regulation and barrier recovery

  2025cites this paper
• Sequential activation of transcription factors promotes liver regeneration through specific and developmental enhancers

  2025cites this paper
• Attenuating Potential of Ginger (Zingiber officinale) Against Fluoride and Dimethoate‐Induced Oxidative Stress–Associated Hepatotoxicity in Wistar Rats

  2025cites this paper
• Acquisition mechanism of heme oxygenase-1 induction by heat shock in human monocytic cell line THP-1 after differentiation to macrophage-like cells.

  2025cites this paper
• Cannabinol’s Modulation of Genes Involved in Oxidative Stress Response and Neuronal Plasticity: A Transcriptomic Analysis

  2025cites this paper
• The inhibition of TXNRD1 by methylglyoxal impairs the intracellular control of Mycobacterium tuberculosis

  2025cites this paper
• A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapy

  2025cites this paper
• UPLC-QTOF-MS/MS-Guided phytochemical characterization and molecular docking of Rosa rusoga extract for Keap1-Nrf2 modulation.

  2025cites this paper
• Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories

  2025cites this paper
• DNA damage response pathway regulates Nrf2 in response to oxidative stress

  2025cites this paper
• Nrf2-driven redox coupling of tumour and associated adipose tissue during early tumour growth in an orthotopic breast cancer model.

  2025cites this paper
• Rapid thawing enhances tissue destruction in a mouse model of cutaneous cryoablation: Insights into oxidative stress and neutrophil activation.

  2025cites this paper