Genetic mouse models of extended lifespan.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Experimental Gerontology

• Publication date

  2003-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.EXGER.2003.10.019PMID 14698816
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A personal retrospective on the genetics of aging

  2004cited by this paper
• Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.

  2003cited by this paper
• Multiplex stress resistance in cells from long‐lived dwarf mice

  2003cited by this paper
• The dwarf mutation decreases high dose insulin responses in skeletal muscle, the opposite of effects in liver.

  2003cited by this paper
• Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.

  2003cited by this paper
• Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity.

  2003cited by this paper
• IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

  2003cited by this paper
• Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

  2003cited by this paper
• Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet

  2003cited by this paper
• Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster*

  2003cited by this paper
• Mechanisms of aging: public or private?

  2002cited by this paper
• Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice.

  2002cited by this paper
• Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance.

  2002cited by this paper
• Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease

  2002cited by this paper
• Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway

  2002cited by this paper
• The Snell dwarf mutation Pit1(dw) can increase life span in mice.

  2002cited by this paper
• Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice.

  2002cited by this paper
• Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm.

  2002cited by this paper
• A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

  2002cited by this paper
• Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

  2002cited by this paper
• Extending the lifespan of long-lived mice.

  2001cited by this paper
• Longevity: Extending the lifespan of long-lived mice

  2001cited by this paper
• Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters.

  2001cited by this paper
• Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice

  2001cited by this paper
• Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

  2001cited by this paper
• Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice.

  2001cited by this paper
• Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans.

  2001cited by this paper
• Caloric restriction and aging: an update.

  2000cited by this paper
• Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice.

  2000cited by this paper
• Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase.

  2000cited by this paper
• Printed in U.S.A. Copyright © 2000 by The Endocrine Society Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice*

  2000cited by this paper
• Catalase expression in delayed and premature aging mouse models.

  2000cited by this paper
• Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase1

  2000cited by this paper
• Genetic pathways that regulate ageing in model organisms

  2000cited by this paper
• Protection against Diabetes-Induced Nephropathy in Growth Hormone Receptor/Binding Protein Gene-Disrupted Mice1.

  2000cited by this paper
• Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals.

  1999cited by this paper
• Kleemeier award lecture: are there genes for aging?

  1999cited by this paper
• Antioxidative mechanisms and plasma growth hormone levels

  1999cited by this paper
• Low body temperature in long-lived Ames dwarf mice at rest and during stress.

  1999cited by this paper
• The p66shc adaptor protein controls oxidative stress response and life span in mammals

  1999cited by this paper
• Does growth hormone prevent or accelerate aging?

  1998cited by this paper
• Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor–MAP kinase–fos signalling pathway

  1997cited by this paper
• A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).

  1997cited by this paper
• Dwarf mice and the ageing process

  1996cited by this paper
• Genetic analysis of ageing: role of oxidative damage and environmental stresses

  1996cited by this paper
• Invertebrate gerontology: The age mutations of Caenorhabditis elegans

  1996cited by this paper
• Oxidative Stress, Caloric Restriction, and Aging

  1996cited by this paper
• The Ames dwarf gene is required for Pit-1 gene activation.

  1995cited by this paper
• Diet and the Aging Processes

  1994cited by this paper
• Dietary restriction retards onset but not progression of leukemia in male F344 rats.

  1993cited by this paper
• Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats.

  1993cited by this paper
• Dietary Restriction and Aging

  1993cited by this paper
• GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function

  1993cited by this paper
• Multiple self–healing squamous epitheliomata (ESS1) mapped to chromosome 9q22–q31 in families with common ancestry

  1993cited by this paper
• A C. elegans mutant that lives twice as long as wild type

  1993cited by this paper
• Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).

  1993cited by this paper
• Immunologic disparity in the hypopituitary dwarf mouse.

  1992cited by this paper
• Dietary restriction alters characteristics of glucose fuel use.

  1992cited by this paper
• Retardation of the Aging Processes in Rats by Food Restriction

  1991cited by this paper
• Genetic Effects on Aging

  1990cited by this paper
• Use of genetic models to investigate the hypophyseal regulation of senescence.

  1990cited by this paper
• Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

  1990cited by this paper
• Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein.

  1989cited by this paper
• Evidence for the glycation hypothesis of aging from the food-restricted rodent model.

  1989cited by this paper
• The influence of dietary protein source on longevity and age-related disease processes of Fischer rats.

  1988cited by this paper
• The Retardation of Aging and Disease by Dietary Restriction

  1988cited by this paper
• Food restriction in rodents: an evaluation of its role in the study of aging.

  1988cited by this paper
• Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics.

  1985cited by this paper
• Nutritional influences on aging of Fischer 344 rats: II. Pathology.

  1985cited by this paper
• Effects of food restriction on aging: separation of food intake and adiposity.

  1984cited by this paper
• Etiology of growth hormone deficiency in little, Ames, and Snell dwarf mice.

  1983cited by this paper
• Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: longevity, growth, lean body mass and disease.

  1982cited by this paper
• Changes in adipose mass and cellularity through the adult life of rats fed ad libitum or a life-prolonging restricted diet.

  1980cited by this paper
• New mouse dw allele: genetic location and effects on lifespan and growth hormone levels.

  1980cited by this paper
• T and B lymphocytes in pituitary dwarf Snell-Bagg mice.

  1979cited by this paper
• Animal models for research on contraception and fertility

  1979cited by this paper
• Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F 1 hybrids.

  1973cited by this paper
• Tumorigenesis in strain DW-J mice and induction by prolactin of the group-specific antigen of endogenous C-type RNA tumor virus.

  1972cited by this paper
• Longevity and gross pathology at death in 22 inbred mouse strains.

  1966cited by this paper
• The genetics of the mouse

  1952cited by this paper
• The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.

  1935cited by this paper
• DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE.

  1929cited by this paper

• Non-invasive ovulation tracking enables genetic engineering in wild rodents.

  2026cites this paper
• Reactive oxygen species (ROS) potentially affected survival rate after ionizing radiation in scallops.

  2025cites this paper
• The impact of co-housing on murine aging studies

  2025influential citation
• Common and uncommon mouse models of growth hormone deficiency.

  2024cites this paper
• Roles of Growth Hormone–Dependent JAK-STAT5 and Lyn Kinase Signaling in Determining Lifespan and Cancer Incidence

  2024cites this paper
• Accelerated sarcopenia precedes learning and memory impairments in the P301S mouse model of tauopathies and Alzheimer's disease

  2024cites this paper
• Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice

  2024cites this paper
• Quantifying the Impact of Co-Housing on Murine Aging Studies

  2024cites this paper
• Negative effects of lifespan extending intervention on resilience in mice

  2024cites this paper
• Neuroendocrine control of brown adipocyte function by prolactin and growth hormone

  2023cites this paper
• Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

  2023cites this paper
• Upstream migrant sea lamprey (Petromyzon marinus) show signs of increasing oxidative stress but maintain aerobic capacity with age.

  2023cites this paper
• Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation

  2023cites this paper
• Cell non-autonomous regulation of cerebrovascular aging processes by the somatotropic axis

  2023cites this paper
• Regulation of metabolic health by dietary histidine in mice

  2022cites this paper
• Antiageing strategies

  2022cites this paper
• Mammalian Resilience Revealed by a Comparison of Human Diseases and Mouse Models Associated With DNA Helicase Deficiencies

  2022cites this paper
• Fasting drives the metabolic, molecular, and geroprotective effects of a calorie restricted diet in mice

  2021cites this paper
• A Reevaluation of the Effect of Dietary Restriction on Different Recombinant Inbred (RI) Lines of Male and Female Mice

  2021cites this paper
• Cardiac aging

  2021cites this paper
• Neuroendocrine Control of Brown Adipocytes: Functions, Beiging, Whitening and Autophagy

  2021cites this paper
• Insights into the mechanism of shortened developmental duration and accelerated weight gain associated with Wolbachia infection in Hylyphantes graminicola.

  2021cites this paper
• Mice with gene alterations in the GH and IGF family

  2021cites this paper
• Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice

  2021cites this paper
• Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the Physiopathological Status of the Aged Male Gonad

  2021cites this paper
• Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease

  2020cites this paper
• Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice

  2020cites this paper
• Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6

  2020cites this paper
• THE (A)SYMMETRY OF THE MALE GRAYING BEARD HAIRS AS AN INDICATION OF THE PROGRAMMED AGING PROCESS

  2020cites this paper
• Translational control in aging and neurodegeneration

  2020cites this paper
• Mouse models of growth hormone deficiency

  2020cites this paper
• Hallmarks of Aging: An Autophagic Perspective

  2019cites this paper
• Anti-aging: Myth or Reality

  2019cites this paper
• Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research

  2019cites this paper
• Ageing, Age-related Diseases and Oxidative Stress: What to Do Next?

  2019cites this paper
• Insulin/IGF-like signalling and brain ageing in Drosophila melanogaster

  2019cites this paper
• MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?

  2018cites this paper
• DNA damage responses and p53 in the aging process.

  2018cites this paper
• Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long‐Lived Growth Hormone Receptor Null Mice

  2018cites this paper
• The Comparative Biology of Mitochondrial Function and the Rate of Aging.

  2018cites this paper
• Lifelong reduction in complex IV induces tissue‐specific metabolic effects but does not reduce lifespan or healthspan in mice

  2018cites this paper
• Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.

  2018cites this paper
• Ras signaling in aging and metabolic regulation

  2017cites this paper
• The Effects of Growth Hormone and Thyroxine Treatment on the Insulin Signaling of Female Ames Dwarf Mouse Skeletal Muscle Tissue 2013

  2017cites this paper
• Chapter 17 – Cardiac Aging

  2016cites this paper
• Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions

  2016cites this paper
• The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.

  2016cites this paper
• Discrepancies in insulin-like growth factor signaling? No, not really.

  2016cites this paper
• Systemic DNA damage responses in aging and diseases.

  2016cites this paper
• Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates

  2016cites this paper
• EXPLORING POLYMORPHISM AND EFFECTS OF THE IGFIR GENE ON PRODUCTIVE LIFE IN BARKI EWES

  2016cites this paper
• Effect of a long-term high-protein diet on survival, obesity development, and gut microbiota in mice.

  2016cites this paper
• The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?

  2016cites this paper
• Recent progress of thioredoxin-1 and aging

  2016cites this paper
• Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice.

  2015cites this paper
• The problem of genotype and sex differences in life expectancy in transgenic AD mice.

  2015cites this paper
• Oxidative Mechanisms in Liver Senescence and Regeneration

  2015cites this paper
• Effects of growth hormone-releasing hormone on sleep and brain interstitial fluid amyloid-β in an APP transgenic mouse model.

  2015cites this paper
• The paradoxical role of thioredoxin on oxidative stress and aging.

  2015cites this paper
• Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice

  2015cites this paper
• An Intensive Mind and Body Therapeutic Program Leads to Alteration in Gene Expression Critical to Aging Process in Peripheral Blood Stem Cells

  2015cites this paper
• Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection

  2015cites this paper
• Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver.

  2015cites this paper
• The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling.

  2014cites this paper
• PNS1300383 260..270

  2014cites this paper
• Mediators and markers of mammalian lifespan extension: Proteomic, proliferative and hormonal adaptations in mouse models of extended lifespan

  2014cites this paper
• Conference on 'Nutrition and healthy ageing' Symposium 3: Nutritional modulation of the ageing trajectory

  2014cites this paper
• Young little mice express a premature cardiovascular aging phenotype.

  2014cites this paper
• Adipose tissue FABP deficiency promotes metabolic reprogramming and positively impacts healthspan

  2014cites this paper
• Mouse models and aging: longevity and progeria.

  2014cites this paper
• Aging and the Cardiovascular System

  2014cites this paper
• Identification and characterization of differentially expressed microRNAs in adult tissues of the long-lived Drosophila dilp2-3,5 mutant

  2014cites this paper
• The influence of Shc proteins on life span in mice.

  2014cites this paper
• Age-dependent myocardial transcriptomic changes in the rat. Novel insights into atrial and ventricular arrhythmias pathogenesis

  2014cites this paper
• regulation through mitochondrial signaling

  2014cites this paper
• Fibroblast Growth Factor 21 Is Not Required for the Reductions in Circulating Insulin-Like Growth Factor-1 or Global Cell Proliferation Rates in Response to Moderate Calorie Restriction in Adult Mice

  2014cites this paper
• Defining the toxicology of aging.

  2014cites this paper
• Lifespan Modulation in Mice and the Confounding Effects of Genetic Background

  2014cites this paper
• The effects of chronic and acute toxicological exposures on the expression of the tumor suppressor p16INK4a

  2013cites this paper
• Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1

  2013cites this paper
• Movement analysis across the life span

  2013cites this paper
• The GH/IGF-1 axis in ageing and longevity

  2013cites this paper
• Growth Signaling in Aging and Disease

  2013cites this paper
• Prevention of Neuromusculoskeletal Frailty in Slow-Aging Ames Dwarf Mice: Longitudinal Investigation of Interaction of Longevity Genes and Caloric Restriction

  2013cites this paper
• Metabolic and cellular effects of calorie restriction and whey proteins in experimental obesity

  2013cites this paper
• Longevity effect of IGF-1R+/− mutation depends on genetic background-specific receptor activation

  2013cites this paper
• Queen Honeybee and Me: Forever Young? Conserved Pathways for Longevity

  2013cites this paper
• Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice.

  2013cites this paper
• Genetic variation in responses to dietary restriction--an unbiased tool for hypothesis testing.

  2013influential citation
• Chronic kidney disease: a clinical model of premature aging.

  2013cites this paper
• Dietary Restriction as a Potential Intervention to Retard Age-associated Impairment of Brain Functions

  2012cites this paper
• Aging and Kidney Disease

  2012cites this paper
• Xenobiotic-metabolizing enzymes elevated in multiple mouse models of slow aging

  2012cites this paper
• The mystery of C. elegans aging: An emerging role for fat

  2012cites this paper
• Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.

  2012cites this paper
• Chemical analysis of ageing tissue indrosophila melanogaster

  2012cites this paper
• Thioredoxin, oxidative stress, cancer and aging

  2012cites this paper
• The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

  2012cites this paper
• Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan.

  2012cites this paper
• Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease

  2012cites this paper