Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Cell Science

• Publication date

  2002-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.00166PMID 12432066
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2002influential reference
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  2000influential reference
• Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction.

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  1999cited by this paper
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• The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995influential reference
• The molecular architecture of focal adhesions.

  1995cited by this paper
• Integrins and signal transduction pathways: the road taken.

  1995cited by this paper
• Integrins: emerging paradigms of signal transduction.

  1995cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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