Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Carcinogenesis

• Publication date

  2010-06-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1093/carcin/bgq073PMID 20382639PMCID PMC2878364
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA Repair in Mammalian Cells

  2009cited by this paper
• Nucleotide excision repair : variations on versatility

  2009cited by this paper
• Early whole-genome transcriptional response induced by benzo[a]pyrene diol epoxide in a normal human cell line.

  2009cited by this paper
• DNA Repair in Mammalian Cells

  2009cited by this paper
• Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53.

  2008influential reference
• Changes in gene expression induced by polycyclic aromatic hydrocarbons in the human cell lines HepG2 and A549.

  2008cited by this paper
• Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells

  2008cited by this paper
• Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway.

  2008cited by this paper
• Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation.

  2008cited by this paper
• Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.

  2008cited by this paper
• Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

  2008cited by this paper
• AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.

  2007cited by this paper
• Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

  2007cited by this paper
• Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway.

  2007cited by this paper
• p53 Regulates Cellular Responses to Environmental Carcinogen Benzo[a]pyrene-7,8-diol-9,10-epoxide in Human Lung Cancer Cells

  2007cited by this paper
• Benzo[a]pyrene diol-epoxide (B[a]PDE) upregulates COX-2 expression through MAPKs/AP-1 and IKKbeta/NF-kappaB in mouse epidermal Cl41 cells.

  2007cited by this paper
• Gene profiling of normal human bronchial epithelial cells in response to asbestos and benzo(a)pyrene diol epoxide (BPDE).

  2007cited by this paper
• Benzo[a]pyrene diol‐epoxide (B[a]PDE) upregulates COX‐2 expression through MAPKs/AP‐1 and IKKβ/NF‐κB in mouse epidermal Cl41 cells

  2007cited by this paper
• Role of chemokines in tumor growth.

  2007cited by this paper
• Rapid and simple comparison of messenger RNA levels using real-time PCR

  2006cited by this paper
• Effects of filtering by Present call on analysis of microarray experiments

  2006cited by this paper
• Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells.

  2006cited by this paper
• Aryl Hydrocarbon Receptor- and Calcium-dependent Induction of the Chemokine CCL1 by the Environmental Contaminant Benzo[a]pyrene*

  2006cited by this paper
• Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

  2006cited by this paper
• Benzo[a]pyrene and its metabolites combined with ultraviolet A synergistically induce 8-hydroxy-2'-deoxyguanosine via reactive oxygen species.

  2005cited by this paper
• Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

  2005cited by this paper
• Differential removal of DNA adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells.

  2005cited by this paper
• An evaluation of the ability of pifithrin-α and -β to inhibit p53 function in two wild-type p53 human tumor cell lines

  2005cited by this paper
• An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines.

  2005cited by this paper
• Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity.

  2005cited by this paper
• Protective effects of aucubin isolated from Eucommia ulmoides against UVB-induced oxidative stress in human skin fibroblasts.

  2005cited by this paper
• Benzo[a]pyrene diol epoxide up-regulates COX-2 expression through NF-kappaB in rat astrocytes.

  2004cited by this paper
• Tobacco smoke and involuntary smoking.

  2004cited by this paper
• Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells.

  2004cited by this paper
• Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.

  2004cited by this paper
• Nuclear factor-kappaB: the enemy within.

  2004cited by this paper
• Nuclear factor-κB: The enemy within

  2004cited by this paper
• MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data

  2003cited by this paper
• Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer

  2003cited by this paper
• A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

  2003cited by this paper
• Environmental polycyclic aromatic hydrocarbons, benzo(a) pyrene (BaP) and BaP-quinones, enhance IgE-mediated histamine release and IL-4 production in human basophils.

  2003cited by this paper
• Exploration, normalization, and summaries of high density oligonucleotide array probe level data.

  2003cited by this paper
• Response of human mammary epithelial cells to DNA damage induced by BPDE: involvement of novel regulatory pathways.

  2003cited by this paper
• Controls Global Nucleotide Excision Repair of Low Levels of Structurally Diverse Benzo ( g ) chrysene-DNA Adducts in Human Fibroblasts 1

  2002cited by this paper
• Inflammation and cancer

  2002cited by this paper
• Polycyclic Aromatic Hydrocarbons

  2002cited by this paper
• p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts.

  2002cited by this paper
• Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues.

  2002cited by this paper
• Induction of cellular oxidative stress by aryl hydrocarbon receptor activation.

  2002cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Identification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays

  2000cited by this paper
• The effect of dibenzo[a,1]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: the induction of DNA adducts, expression of p53 and p21(WAF1) proteins and cell cycle distribution.

  2000cited by this paper
• The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7.

  1999cited by this paper
• A role for ATR in the DNA damage-induced phosphorylation of p53.

  1999cited by this paper
• Stimulus‐specific regulation of chemokine expression involves differential activation of the redox‐responsive transcription factors AP‐1 and NF‐κB

  1999cited by this paper
• Tobacco smoke carcinogens and lung cancer.

  1999cited by this paper
• A Chemical Inhibitor of p 53 That Protects Mice from the Side Effects of Cancer Therapy

  1999cited by this paper
• A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.

  1999cited by this paper
• Enhanced phosphorylation of p53 by ATM in response to DNA damage.

  1998cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.

  1991cited by this paper
• The Ah regulatory gene product. Survey of nineteen polycyclic aromatic compounds' and fifteen benzo[a]pyrene metabolites' capacity to bind to the cytosolic receptor.

  1982cited by this paper
• The natural history of chronic airflow obstruction.

  1977cited by this paper
• [Inflammation and cancer].

  1974cited by this paper
• Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

  1974cited by this paper

• Exposure risks of polycyclic aromatic hydrocarbons and potential targets and mechanisms for lung and skin cancer induction: An integrated study based on GBD 2021 and computational toxicology

  2026cites this paper
• Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

  2024cites this paper
• The activation of SIRT1 ameliorates BPDE‐induced inflammatory damage in BEAS‐2B cells via HMGB1/TLR4/NF‐κB pathway

  2023cites this paper
• Inhibition of RNF182 mediated by Bap promotes non-small cell lung cancer progression

  2023cites this paper
• Benzo[a]pyrene induces NLRP1 expression and promotes prolonged inflammasome signaling

  2023cites this paper
• Crystalline silica-exposed human lung epithelial cells presented enhanced anchorage-independent growth with upregulated expression of BRD4 and EZH2 in autocrine and paracrine manners

  2023cites this paper
• Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: A review.

  2023cites this paper
• Endoplasmic reticulum stress regulates pyroptosis in BPDE‐induced BEAS‐2B cells

  2022cites this paper
• Benzo[a]pyrene exposure promotes RIP1-mediated necroptotic death of osteocytes and the JNK/IL-18 pathway activation via generation of reactive oxygen species.

  2022cites this paper
• Multiple endpoint in vitro toxicity assessment of a prototype heated tobacco product indicates substantially reduced effects compared to those of combustible cigarette.

  2022cites this paper
• Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures

  2022cites this paper
• KIF11, a plus end-directed kinesin, as a key gene in benzo(a)pyrene-induced non-small cell lung cancer.

  2021cites this paper
• Benzo[a]pyrene and Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced locomotor and reproductive senescence and altered biochemical parameters of oxidative damage in Canton-S Drosophila melanogaster

  2021cites this paper
• Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA).

  2021cites this paper
• Persistent expression of microRNA-125a is required to induce murine hematopoietic stem cell repopulating activity.

  2020cites this paper
• Transcriptional mutagenesis dramatically alters genome-wide p53 transactivation landscape

  2020cites this paper
• Environmental exposures and RNA N6-Methyladenosine modified long Non-Coding RNAs

  2020cites this paper
• Genotoxicity and DNA damage signaling in response to complex mixtures of PAHs in biomass burning particulate matter from cashew nut roasting.

  2019cites this paper
• Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells

  2019cites this paper
• Levels of bioactive compounds in food crops in the prevention and treatment of chronic diseases

  2018cites this paper
• TGF beta promotes repair of bulky DNA damage through increased ERCC1/XPF and ERCC1/XPA interaction.

  2018cites this paper
• Chemical carcinogens and chronic inflammation

  2017influential citation
• Nanomolar levels of PAHs in extracts from urban air induce

  2017cites this paper
• Altered gene expression profiles in the lungs of benzo[a]pyrene-exposed mice in the presence of lipopolysaccharide-induced pulmonary inflammation

  2017cites this paper
• Effect of interleukin (IL)-8 on benzo[a]pyrene metabolism and DNA damage in human lung epithelial cells.

  2017cites this paper
• c-Jun enhances intestinal epithelial restitution after wounding by increasing phospholipase C-γ1 transcription.

  2017cites this paper
• Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in Apc(Min) mouse model.

  2016cites this paper
• The role of nutraceuticals, functional foods and value added food products in the prevention and treatment of chronic diseases

  2016cites this paper
• Testing differentially expressed genes in dose-response studies and with ordinal phenotypes

  2016cites this paper
• Comparative assessment of HIF‐1α and Akt responses in human lung and skin cells exposed to benzo[α]pyrene: Effect of conditioned medium from pre‐exposed primary fibroblasts

  2016cites this paper
• Novel long chain fatty acid derivatives of quercetin-3-O-glucoside reduce cytotoxicity induced by cigarette smoke toxicants in human fetal lung fibroblasts.

  2016cites this paper
• The role of nutraceuticals , functional foods and value added food products in the prevention and treatment of chronic diseases

  2016cites this paper
• SIRT1 in B[a]P-induced lung tumorigenesis

  2015cites this paper
• The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution

  2015cites this paper
• Metabolism of benzo(a)pyrene by aortic subcellular fractions in the setting of abdominal aortic aneurysms

  2015cites this paper
• Tobacco smoke induces production of chemokine CCL20 to promote lung cancer.

  2015cites this paper
• Carcinogenic Polycyclic Aromatic Hydrocarbons

  2014cites this paper
• Cell cycle changes mediated by the p53/miR-34c axis are involved in the malignant transformation of human bronchial epithelial cells by benzo[a]pyrene.

  2014cites this paper
• Systematic Omics Analysis Review (SOAR) Tool to Support Risk Assessment

  2014cites this paper
• Nanomolar levels of PAHs in extracts from urban air induce MAPK signaling in HepG2 cells.

  2014cites this paper
• Relative Apoptosis-inducing Potential of Homeopa-thic Condurango 6C and 30C in H460 Lung Cancer Cells In vitro

  2014cites this paper
• Toward Understanding the Role of Aryl Hydrocarbon Receptor in the Immune System: Current Progress and Future Trends

  2014cites this paper
• Using Immunotoxicity Information to Improve Cancer Risk Assessment for Polycyclic Aromatic Hydrocarbon Mixtures

  2013cites this paper
• Benzo[a]pyrene decreases global and gene specific DNA methylation during zebrafish development.

  2013cites this paper
• The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts.

  2013cites this paper
• Collective properties of cellular identity: a computational approach

  2013cites this paper
• Anti-benzopyrene-7,8-diol-9,10-epoxide induces apoptosis via mitochondrial pathway in human bronchiolar epithelium cells independent of the mitochondria permeability transition pore.

  2012cites this paper
• GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics

  2012influential citation
• Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen.

  2012cites this paper
• Benzo[a]pyrene and tumor necrosis factor-α coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells.

  2011cites this paper
• Epigenetic effects of benzo(a)pyrene in Fundulus heteroclitus and Danio rerio

  2011cites this paper
• Interactions of the aryl hydrocarbon receptor with inflammatory mediators: beyond CYP1A regulation.

  2011cites this paper