Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  British Journal of Clinical Pharmacology

• Publication date

  2012-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/j.1365-2125.2012.04198.xPMID 22295895PMCID PMC3630750
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The use of ketamine in complex regional pain syndrome: possible mechanisms

  2011cited by this paper
• Low-dose ketamine for analgesia in the ED: a retrospective case series.

  2011cited by this paper
• Advances in Translational Neuropathic Research: Example of Enantioselective Pharmacokinetic–Pharmacodynamic Modeling of Ketamine-induced Pain Relief in Complex Regional Pain Syndrome

  2011cited by this paper
• Enantioselective pharmacokinetics of (R)- and (S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome.

  2011cited by this paper
• Population pharmacokinetic—pharmacodynamic modeling of ketamine‐induced pain relief of chronic pain

  2011cited by this paper
• Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder.

  2010cited by this paper
• A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.

  2010cited by this paper
• A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome.

  2010cited by this paper
• Intraoperative Ketamine Reduces Perioperative Opiate Consumption in Opiate-dependent Patients with Chronic Back Pain Undergoing Back Surgery

  2010cited by this paper
• Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro.

  2010cited by this paper
• Low-dose ketamine for analgesia in the ED: a retrospective case series.

  2010cited by this paper
• Taming the Ketamine Tiger

  2010cited by this paper
• Ketamine produces effective and long‐term pain relief in patients with Complex Regional Pain Syndrome Type 1

  2009cited by this paper
• Stereoselective pharmacokinetics of ketamine and norketamine after constant rate infusion of a subanesthetic dose of racemic ketamine or S-ketamine in Shetland ponies.

  2009cited by this paper
• Use of Human Microsomes and Deuterated Substrates: An Alternative Approach for the Identification of Novel Metabolites of Ketamine by Mass Spectrometry

  2009cited by this paper
• S(+)-ketamine Effect on Experimental Pain and Cardiac Output: A Population Pharmacokinetic-Pharmacodynamic Modeling Study in Healthy Volunteers

  2009cited by this paper
• Effects of norketamine enantiomers in rodent models of persistent pain.

  2008cited by this paper
• Enantioselective analysis of ketamine and its metabolites in equine plasma and urine by CE with multiple isomer sulfated β‐CD

  2007cited by this paper
• Modeling the norketamine metabolite in children and the implications for analgesia

  2007cited by this paper
• A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

  2006cited by this paper
• Pharmacokinetics of S(+) ketamine derived from target controlled infusion.

  2006cited by this paper
• Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats.

  2004cited by this paper
• Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers

  2003cited by this paper
• Stereoselective pharmacokinetics of ketamine: R(−)‐Ketamine inhibits the elimination of S(+)‐ketamine

  2001cited by this paper
• Ketamine: Teaching an Old Drug New Tricks

  1998cited by this paper
• HPLC determination of ketamine, norketamine, and dehydronorketamine in plasma with a high-purity reversed-phase sorbent.

  1998cited by this paper
• Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method.

  1993cited by this paper
• Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine.

  1986cited by this paper
• Pharmacokinetics of ketamine in man.

  1975cited by this paper

• Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

  2025cites this paper
• General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics

  2025cites this paper
• Uso de cetamina e escetamina na depressão resistente: evidências clínicas e avanços terapêuticos em transtornos unipolares e bipolares

  2025cites this paper
• Monoamine depletion and oxidative imbalance underlie ketamine-induced motor deficits in adolescent rats.

  2025cites this paper
• Auto-Induction in Oral Esketamine Treatment for Treatment-Resistant Depression: An Exploratory Study

  2025cites this paper
• Enantioselective capillary electrophoresis with sulfated cyclodextrins for monitoring ketamine and its metabolites in biosamples and its application to assess metabolic steps and kinetic parameters

  2025cites this paper
• The effectiveness of ketamine in medication of treatment-resistant depression - review

  2024cites this paper
• A meta-analysis of the effects of ketamine on suicidal ideation in depression patients

  2024cites this paper
• Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions

  2024cites this paper
• Increasing the bioavailability of oral esketamine by a single dose of cobicistat: A case study

  2024cites this paper
• Cortisol-dependent impairment of dendrite plasticity in human dopaminergic neurons derived from hiPSCs is restored by ketamine: Relevance for major depressive disorders.

  2024influential citation
• Beyond NMDA Receptors: A Narrative Review of Ketamine’s Rapid and Multifaceted Mechanisms in Depression Treatment

  2024cites this paper
• Ketamine Prevents Inflammation-Induced Reduction of Human Hippocampal Neurogenesis via Inhibiting the Production of Neurotoxic Metabolites of the Kynurenine Pathway

  2024cites this paper
• Serotonergic transmission plays differentiated roles in the rapid and sustained antidepressant‐like effects of ketamine

  2024cites this paper
• A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)‐Hydroxynorketamine in Healthy Volunteers

  2024influential citation
• Pharmacotherapy: Ketamine and Esketamine.

  2023cites this paper
• Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine

  2023cites this paper
• Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment.

  2023cites this paper
• Acetylcholine and metacognition during sleep.

  2023cites this paper
• Cerebrospinal fluid exploratory proteomics and ketamine metabolite pharmacokinetics in human volunteers after ketamine infusion

  2023cites this paper
• Ketamine – A New Antidepressant Drug with Anti-Inflammatory Properties

  2023cites this paper
• Ketamine for Major Depressive Disorder.

  2023cites this paper
• Antidepressants enter cells, organelles, and membranes

  2023influential citation
• Ketamine: Mechanisms and Relevance to Treatment of Depression.

  2023cites this paper
• Ketamine-induced changes in resting state connectivity, 2 h after the drug administration in patients with remitted depression

  2023cites this paper
• Bridging rapid and sustained antidepressant effects of ketamine.

  2023cites this paper
• SYSTEMATIC REVIEW AND META-ANALYSIS Efficacy and safety of racemic ketamine and esketamine for depression: a systematic review and meta-analysis

  2022cites this paper
• Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines.

  2022cites this paper
• Enantioselective CE–MS analysis of ketamine metabolites in urine

  2022cites this paper
• Ketamine and its metabolites: Potential as novel treatments for depression.

  2022cites this paper
• Ketamine as Potential Treatment for Postpartum Depression: A Narrative Review

  2022cites this paper
• Revealing Metabolic Path of Ketamine catalyzed by CYP450 via Quantum Mechanical Approach

  2022cites this paper
• The molecular pathophysiology of depression and the new therapeutics

  2022cites this paper
• Pharmacogenetic and drug interaction aspects on ketamine safety in its use as antidepressant ‐ implications for precision dosing in a global perspective

  2022influential citation
• Population Pharmacokinetics and Pharmacodynamics of the Therapeutic and Adverse Effects of Ketamine in Patients With Treatment‐Refractory Depression

  2022cites this paper
• High Yielding Continuous-Flow Synthesis of Norketamine

  2022cites this paper
• Ketamine and Other Glutamate Receptor Antagonists As Fast-Actin

  2022cites this paper
• Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans

  2021cites this paper
• Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers

  2021cites this paper
• The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression

  2021cites this paper
• Mechanisms of Ketamine and its Metabolites as Antidepressants.

  2021cites this paper
• CYP 450 enzymes influence (R,S)-ketamine brain delivery and its antidepressant activity.

  2021cites this paper
• Ketamine in Psychiatric Disorders

  2021cites this paper
• Pharmacokinetic Modeling of Ketamine Enantiomers and Their Metabolites After Administration of Prolonged‐Release Ketamine With Emphasis on 2,6‐Hydroxynorketamines

  2021cites this paper
• Antidepressant efficacy of oral ketamine treatment

  2021cites this paper
• Chiral Pharmacokinetics and Metabolite Profile of Prolonged-release Ketamine Tablets in Healthy Human Subjects

  2021cites this paper
• (2R,6R)-Hydroxynorketamine as a novel antidepressant and its role in the antidepressant actions of (R,S)-ketamine

  2021cites this paper
• Review of Ketamine as a Rapid Antidepressant for Treatment-Resistant Depression

  2021influential citation
• Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation.

  2021cites this paper
• Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications

  2021influential citation
• Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms

  2021cites this paper
• Targeted mass spectrometry of ketamine and its metabolites cis-6-hydroxynorketamine and norketamine in human blood serum.

  2020cites this paper
• The role of eEF2 kinase in the rapid antidepressant actions of ketamine.

  2020cites this paper
• The neurophysiology of ketamine: an integrative review

  2020cites this paper
• Ketamine Pharmacokinetics

  2020influential citation
• Effect of Ketamine on Limbic GABA and Glutamate: A Human In Vivo Multivoxel Magnetic Resonance Spectroscopy Study

  2020cites this paper
• Antidepressant mechanisms of ketamine: Focus on GABAergic inhibition.

  2020cites this paper
• Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis.

  2020cites this paper
• Ketamine-induced changes in plasma brain-derived neurotrophic factor (BDNF) levels are associated with the resting-state functional connectivity of the prefrontal cortex

  2020cites this paper
• Pharmacokinetics of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy.

  2020cites this paper
• Pharmacokinetic and pharmacodynamic considerations for NMDA-receptor antagonist ketamine in the treatment of chronic neuropathic pain: an update of the most recent literature

  2019influential citation
• NMDA Antagonists for Treatment-Resistant Depression.

  2019cites this paper
• Structural Plasticity Induced by Ketamine in Human Dopaminergic Neurons as Mechanism Relevant for Treatment-Resistant Depression

  2019cites this paper
• Perioperative ketamine for acute analgesia and beyond

  2019cites this paper
• Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks

  2019cites this paper
• Dextromethorphan and memantine after ketamine analgesia: a randomized control trial

  2019cites this paper
• Rapid-acting antidepressants: shared neuropharmacological mechanisms

  2019influential citation
• Ketamine and Active Ketamine Metabolites Regulate STAT3 and the Type I Interferon Pathway in Human Microglia: Molecular Mechanisms Linked to the Antidepressant Effects of Ketamine

  2019cites this paper
• Antidepressant effects of ketamine on depression-related phenotypes and dopamine dysfunction in rodent models of stress.

  2019cites this paper
• DDDT_A_207350 2677..2688

  2019cites this paper
• Characterization of the Wistar-Kyoto rat model of depression in the context of hippocampal synaptic plasticity and ketamine’s antidepressant properties

  2019influential citation
• Chronic sub-anesthetic ketamine induces permanent hypolocomotion and impairment of hippocampus in adolescent cynomolgus monkeys.

  2019cites this paper
• Default mode network connectivity change corresponds to ketamine’s delayed glutamatergic effects

  2018cites this paper
• (2R,6R)-Hydroxynorketamine promotes dendrite outgrowth in human inducible pluripotent stem cell-derived neurons through AMPA receptor with timing and exposure compatible with ketamine infusion pharmacokinetics in humans

  2018cites this paper
• Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

  2018influential citation
• Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

  2018cites this paper
• Differential Effects of Active Coping and Ketamine on Stress Resilience in Females

  2018influential citation
• Stereochemical and structural effects of (2R,6R)-hydroxynorketamine on the mitochondrial metabolome in PC-12 cells.

  2018cites this paper
• Ketamine nano-delivery based on poly-lactic-co-glycolic acid (PLGA) nanoparticles

  2018cites this paper
• The role of glutamatergic modulation in the mechanism of action of ketamine, a prototype rapid-acting antidepressant drug

  2018cites this paper
• Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(–) Ketamine Concentrations

  2018cites this paper
• Ketamine as a Rapid Antidepressant

  2018cites this paper
• A brief history of antidepressant drug development: from tricyclics to beyond ketamine

  2018cites this paper
• Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling

  2018cites this paper
• Dose‐response characteristics of intravenous ketamine on dissociative stereotypy, locomotion, sensorimotor gating, and nociception in male Sprague‐Dawley rats

  2017cites this paper
• Quantitative chiral and achiral determination of ketamine and its metabolites by LC‐MS/MS in human serum, urine and fecal samples

  2017cites this paper
• Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine’s Antidepressant Action

  2017influential citation
• Separation of hydroxynorketamine stereoisomers using capillary electrophoresis with sulfated β‐cyclodextrin and highly sulfated γ‐cyclodextrin

  2017cites this paper
• Effect of the α2‐receptor agonists medetomidine, detomidine, xylazine, and romifidine on the ketamine metabolism in equines assessed with enantioselective capillary electrophoresis

  2017cites this paper
• Prediction of human efficacious antidepressant doses using the mouse forced swim test

  2017cites this paper
• Experimental medication treatment approaches for depression

  2017influential citation
• Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression

  2017cites this paper
• Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine

  2017cites this paper
• Assessment of Ketamine Binding of the Serotonin Transporter in Humans with Positron Emission Tomography

  2017cites this paper
• Effect of α₂-receptor agonists on the ketamine metabolism in different species assessed by enantioselective capillary electrophoresis

  2016cites this paper
• Subchronic administration of (R,S)-ketamine induces ketamine ring hydroxylation in Wistar rats.

  2016influential citation
• Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance

  2016cites this paper
• The modulation of BDNF expression and signalling dissects the antidepressant from the reinforcing properties of ketamine: Effects of single infusion vs. chronic self-administration in rats.

  2016cites this paper
• Molecular Mechanism and Clinical Relevance of Ketamine as Rapid‐Acting Antidepressant

  2016cites this paper
• Ketamine: NMDA Receptors and Beyond

  2016cites this paper