Genetic Complementation of the Immortal Phenotype in Group D Cell Lines by Introduction of Chromosome 7

Human immortal cell lines have been classified into at least four (A–D) genetic complementation groups by cell‐cell hybrid analysis, i.e., a hybrid derived from different groups becomes mortal. Recently we have demonstrated that introduction of human chromosome 7 suppresses indefinite division potential in the non‐tumorigenic human immortalized fibroblast lines KMST‐6 and SUSM‐1, both assigned to complementation group D. By extending our microcell‐mediated chromosome transfer, we found that chromosome 7 also suppresses division potential in the human hepatoma line HepG2 (again, assigned to group D). Chromosome 7 was thus shown to suppress indefinite growth in the above group D cell lines irrespective of their cell types, or whether they are tumorigenic or not. Since chromosome 7 had no such effect on representative cell lines derived from complementation group A, B or C, these results indicate that the senescence gene(s) commonly mutated in the group D cell lines is located on chromosome 7.

• Publication year

  1995

• Venue

  Japanese journal of cancer research : Gann

• Publication date

  1995-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/J.1349-7006.1995.TB02985.XPMID 7737907PMCID 5920584
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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