Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Experimental Cell Research

• Publication date

  1997-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/EXCR.1997.3678PMID 9299158
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Telomere elongation observed in immortalized human fibroblasts by treatment with 60Co gamma rays or 4-nitroquinoline 1-oxide

  2004cited by this paper
• Telomeres and telomerase: a simple picture becomes complex.

  1996cited by this paper
• Telomerase activation by the E6 gene product of human papillomavirus type 16

  1996cited by this paper
• Replicative senescence: an old lives' tale?

  1996cited by this paper
• Inhibitors of cGMP-dependent protein kinase block senescence induced by inactivation of T antigen in SV40-transformed immortal human fibroblasts.

  1995cited by this paper
• Correlation between complementation group for immortality and the cellular distribution of mortalin.

  1995cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• Genetic Complementation of the Immortal Phenotype in Group D Cell Lines by Introduction of Chromosome 7

  1995cited by this paper
• Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas.

  1995cited by this paper
• Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.

  1995cited by this paper
• Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.

  1995cited by this paper
• Telomere elongation in immortal human cells without detectable telomerase activity.

  1995cited by this paper
• Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

  1995cited by this paper
• Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

  1994cited by this paper
• Specific association of human telomerase activity with immortal cells and cancer.

  1994cited by this paper
• Telomerase activity in human ovarian carcinoma.

  1994cited by this paper
• TLC1: template RNA component of Saccharomyces cerevisiae telomerase.

  1994cited by this paper
• Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells

  1994cited by this paper
• Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1.

  1993cited by this paper
• An alternative pathway for yeast telomere maintenance rescues est1- senescence.

  1993cited by this paper
• Differential subcellular distribution of mortalin in mortal and immortal mouse and human fibroblasts.

  1993cited by this paper
• Transposons in place of telomeric repeats at a Drosophila telomere.

  1993cited by this paper
• Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype.

  1993cited by this paper
• Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

  1992cited by this paper
• The human ubiquitin-activating enzyme E1 gene (UBE1) mapped to band Xp11.3----p11.23 by fluorescence in situ hybridization.

  1992cited by this paper
• The telomere hypothesis of cellular aging.

  1992cited by this paper
• A role for both RB and p53 in the regulation of human cellular senescence.

  1991cited by this paper
• Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

  1991cited by this paper
• Telomeres shorten during ageing of human fibroblasts

  1990cited by this paper
• Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length

  1990cited by this paper
• Telomere reduction in human colorectal carcinoma and with ageing

  1990cited by this paper
• Construction of Mouse A9 Clones Containing a Single Human Chromosome Tagged with Neomycin‐resistance Gene via Microcell Fusion

  1989cited by this paper
• A mutant with a defect in telomere elongation leads to senescence in yeast.

  1989cited by this paper
• Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

  1989cited by this paper
• Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen.

  1989cited by this paper
• Genetic analysis of indefinite division in human cells: identification of four complementation groups.

  1988cited by this paper
• Multistep carcinogenesis of normal human fibroblasts. Human fibroblasts immortalized by repeated treatment with Co-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogenes.

  1988cited by this paper
• Immortalization of human fibroblasts transformed by origin-defective simian virus 40

  1987cited by this paper
• Neoplastic transformation of human diploid fibroblasts (KMST‐6) by treatment with 60Co gamma rays

  1985cited by this paper
• Progress of aging in human diploid cells transformed with a tsA mutant of simian virus 40.

  1984cited by this paper
• Reinitiation of host DNA synthesis in senescent human diploid cells by infection with Simian virus 40.

  1983cited by this paper
• THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

  1965cited by this paper

• Upregulated expression of lamin B receptor increases cell proliferation and suppresses genomic instability: implications for cellular immortalization

  2024cites this paper
• Epigenetic Characteristics of Human Subtelomeres Vary in Cells Utilizing the Alternative Lengthening of Telomeres (ALT) Pathway

  2021cites this paper
• The non-canonical functions of telomerase: to turn off or not to turn off

  2018cites this paper
• Functional Significance of Point Mutations in Stress Chaperone Mortalin and Their Relevance to Parkinson Disease*

  2015cites this paper
• Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization

  2013cites this paper
• Mortalin’s Machinery

  2012cites this paper
• Mortalin Staining Pattern as a Reporter for Cell Based Anti-Cancer Drug Screening

  2012cites this paper
• Mortalin Biology: Life, Stress and Death

  2012cites this paper
• Differential Activities of the Two Closely Related Withanolides, Withaferin A and Withanone: Bioinformatics and Experimental Evidences

  2012cites this paper
• Cell and Molecular Aging

  2011cites this paper
• Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

  2010cites this paper
• Tumor suppression by apoptotic and anti‐angiogenic effects of mortalin‐targeting adeno‐oncolytic virus

  2010cites this paper
• Characterization of homologous recombination proteins in telomere processing and t-circle formation

  2009cites this paper
• Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: Combinational approach for enhanced differentiation

  2009cites this paper
• Quantum Dot‐Based Mortalin Staining as a Visual Assay for Detection of Induced Senescence in Cancer Cells

  2007cites this paper
• Internalizing Antibody-Based Targeted Gene Delivery for Human Cancer Cells

  2007cites this paper
• Modeling aging and cancer in the telomerase knockout mouse.

  2005cites this paper
• A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.

  2005cites this paper
• The significance of drug induced DNA damage of telomeres in human tumour cells

  2005cites this paper
• Suppression of Alternative Lengthening of Telomeres by Sp100-Mediated Sequestration of the MRE11/RAD50/NBS1 Complex

  2005cites this paper
• Identification and characterization of molecular interactions between mortalin / mtHsp 70 and HSP 60

  2005cites this paper
• Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.

  2005cites this paper
• Senescence and immortalization of human cells

  2004cites this paper
• Telomeres and Cellular Aging

  2003cites this paper
• Alternative lengthening of telomeres, telomerase, and cancer.

  2003cites this paper
• Candidate chromosomal regions for genes involved in activation of alternative lengthening of telomeres in human immortal cell lines.

  2003cites this paper
• Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression.

  2003cites this paper
• Alternative lengthening of telomeres in mammalian cells

  2002cites this paper
• Genetics of cellular senescence.

  2002cites this paper
• Demethylation of classical satellite 2 and 3 DNA with chromosomal instability in senescent human fibroblasts.

  2002cites this paper
• Induction of cellular senescence in a telomerase negative human immortal fibroblast cell line, LCS-AF.1-3, by human chromosome 6.

  2002cites this paper
• Xenoantigen, an αGal epitope-expression construct driven by the hTERT-promoter, specifically kills human pancreatic cancer cell line

  2002cites this paper
• Loss of heterozygosity on chromosome 7q in in vitro-immortalized human oral keratinocyte cell lines.

  2002cites this paper
• 5-Bromodeoxyuridine suppresses position effect variegation of transgenes in HeLa cells.

  2001cites this paper
• Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway.

  2001cites this paper
• Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells

  2001cites this paper
• The Latency-associated Nuclear Antigen of Kaposi's Sarcoma-associated Herpesvirus Transactivates the Telomerase Reverse Transcriptase Promoter*

  2001cites this paper
• Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.

  2000cites this paper
• Advances in Brief Selective Toxicity of MKT-077 to Cancer Cells Is Mediated by Its Binding to the hsp 70 Family Protein mot-2 and Reactivation of p 53 Function

  2000cites this paper
• A theory on cellular aging and cell immortalization.

  2000cites this paper
• The role of senescence and immortalization in carcinogenesis.

  2000cites this paper
• Cellular mortality and immortalization: a complex interplay of multiple gene functions.

  2000cites this paper
• Metastasis-suppressor genes: a review and perspective on an emerging field.

  2000cites this paper
• Genetic approaches to the study of replicative senescence.

  2000cites this paper
• Differential gene expression in p53-mediated G(1) arrest of human fibroblasts after gamma-irradiation or N-phosphoacetyl-L-aspartate treatment.

  2000cites this paper
• Extramitochondrial localization of mortalin/mthsp70/PBP74/GRP75.

  2000cites this paper
• In vitro aging research in Japan.

  2000cites this paper
• Introduction of chromosome 7 suppresses telomerase with shortening of telomeres in a human mesothelial cell line.

  1999cites this paper
• Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids

  1999cites this paper
• Telomere maintenance mechanisms and cellular immortalization.

  1999cites this paper
• The introduction of dominant-negative p53 mutants suppresses temperature shift-induced senescence in immortal human fibroblasts expressing a thermolabile SV40 large T antigen.

  1999cites this paper
• 5-Bromodeoxyuridine induces senescence-like phenomena in mammalian cells regardless of cell type or species.

  1999cites this paper
• Telomerase activation in human fibroblasts during escape from crisis

  1999cites this paper
• Characterization of a multi-tissue tumour suppressor and senescence gene.

  1999cites this paper
• Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

  1999cites this paper
• Clustering of human chromosome fragments on the mouse genome by chromosome-mediated gene transfer.

  1998cites this paper
• A reassessment of the telomere hypothesis of senescence

  1998cites this paper
• Suppression of senescence in normal human fibroblasts by introduction of dominant-negative p53 mutants or human papilloma virus type 16 E6 protein.

  1998cites this paper
• Release of telomeric DNA from chromosomes in immortal human cells lacking telomerase activity.

  1998cites this paper
• DNA topoisomerase inhibitors induce reversible senescence in normal human fibroblasts.

  1998cites this paper
• Anti-Aging Medicine LiteratureWatch

  1998cites this paper
• Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci.

  1998cites this paper