Neuronal circuits involved in osmotic challenges.

The maintenance of plasma sodium concentration within a narrow limit is crucial to life. When it differs from normal physiological patterns, several mechanisms are activated in order to restore body fluid homeostasis. Such mechanisms may be vegetative and/or behavioral, and several regions of the central nervous system (CNS) are involved in their triggering. Some of these are responsible for sensory pathways that perceive a disturbance of the body fluid homeostasis and transmit information to other regions. These regions, in turn, initiate adequate adjustments in order to restore homeostasis. The main cardiovascular and autonomic responses to a change in plasma sodium concentration are: i) changes in arterial blood pressure and heart rate; ii) changes in sympathetic activity to the renal system in order to ensure adequate renal sodium excretion/absorption, and iii) the secretion of compounds involved in sodium ion homeostasis (ANP, Ang-II, and ADH, for example). Due to their cardiovascular effects, hypertonic saline solutions have been used to promote resuscitation in hemorrhagic patients, thereby increasing survival rates following trauma. In the present review, we expose and discuss the role of several CNS regions involved in body fluid homeostasis and the effects of acute and chronic hyperosmotic challenges.

• Publication year

  2017

• Venue

  Physiological Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.33549/PHYSIOLRES.933373PMID 28248529
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Involvement of sinoaortic afferents in renal sympathoinhibition and vasodilation induced by acute hypernatremia

  2015cited by this paper
• Fetal nutrition and disease in later life

  2015cited by this paper
• Activation of the hypothalamic paraventricular nucleus by forebrain hypertonicity selectively increases tonic vasomotor sympathetic nerve activity.

  2015influential reference
• High sodium intake during postnatal phases induces an increase in arterial blood pressure in adult rats

  2014cited by this paper
• Dietary Salt Intake Exaggerates Sympathetic Reflexes and Increases Blood Pressure Variability in Normotensive Rats

  2014cited by this paper
• The neurogenic phase of angiotensin II–salt hypertension is prevented by chronic intracerebroventricular administration of benzamil

  2014cited by this paper
• Efferent Pathways in Sodium Overload-Induced Renal Vasodilation in Rats

  2014cited by this paper
• Neurogenic and Sympathoexcitatory Actions of NaCl in Hypertension

  2013cited by this paper
• Hemorrhagic Shock Augments Nlrp3 Inflammasome Activation in the Lung through Impaired Pyrin Induction

  2013cited by this paper
• A1 Noradrenergic Neurons Lesions Reduce Natriuresis and Hypertensive Responses to Hypernatremia in Rats

  2013cited by this paper
• What's new in resuscitation strategies for the patient with multiple trauma?

  2012cited by this paper
• High sodium intake adversely affects oxidative-inflammatory response, cardiac remodelling and mortality after myocardial infarction.

  2012cited by this paper
• A2 Noradrenergic Lesions Prevent Renal Sympathoinhibition Induced by Hypernatremia in Rats

  2012cited by this paper
• Cardiovascular adjustments induced by hypertonic saline in hemorrhagic rats: Involvement of carotid body chemoreceptors.

  2011cited by this paper
• Chronic Hyperosmotic Stress Converts GABAergic Inhibition into Excitation in Vasopressin and Oxytocin Neurons in the Rat

  2011cited by this paper
• The Importance of Population-Wide Sodium Reduction as a Means to Prevent Cardiovascular Disease and Stroke: A Call to Action From the American Heart Association

  2011cited by this paper
• Excess dietary salt intake alters the excitability of central sympathetic networks.

  2010cited by this paper
• A comprehensive review on salt and health and current experience of worldwide salt reduction programmes

  2009cited by this paper
• AFFERENT PATHWAYS INVOLVED IN CARDIOVASCULAR ADJUSTMENTS INDUCED BY HYPERTONIC SALINE RESUSCITATION IN RATS SUBMITTED TO HEMORRHAGIC SHOCK

  2009cited by this paper
• Renal vasodilation induced by hypernatraemia: Role of α‐adrenoceptors in the median preoptic nucleus

  2009cited by this paper
• Salt intakes around the world: implications for public health.

  2009cited by this paper
• Central mechanisms of osmosensation and systemic osmoregulation

  2008cited by this paper
• Renal sympathoinhibition induced by hypernatremia: involvement of A1 noradrenergic neurons.

  2008cited by this paper
• Salt and blood pressure in children and adolescents

  2008cited by this paper
• Bench-to-bedside review: Latest results in hemorrhagic shock

  2008cited by this paper
• Intra‐carotid hyperosmotic stimulation increases Fos staining in forebrain organum vasculosum laminae terminalis neurones that project to the hypothalamic paraventricular nucleus

  2008influential reference
• Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)

  2007cited by this paper
• Altered chloride homeostasis in neurological disorders: a new target.

  2007cited by this paper
• Increased Dietary Salt Enhances Sympathoexcitatory and Sympathoinhibitory Responses From the Rostral Ventrolateral Medulla

  2007cited by this paper
• Altered chloride homeostasis in neurological disorders: a new target.

  2007cited by this paper
• Organum vasculosum laminae terminalis contributes to increased sympathetic nerve activity induced by central hyperosmolality.

  2007cited by this paper
• High- or low-salt diet from weaning to adulthood: effect on body weight, food intake and energy balance in rats.

  2006cited by this paper
• Role of catecholaminergic neurones of the caudal ventrolateral medulla in cardiovascular responses induced by acute changes in circulating volume in rats

  2006cited by this paper
• Molecular Transient Receptor Potential Vanilloid 1 Is Required for Intrinsic Osmoreception in Organum Vasculosum Lamina Terminalis Neurons and for Normal Thirst Responses to Systemic Hyperosmolality

  2006influential reference
• Neurochemical brain groups activated after an isotonic blood volume expansion in rats.

  2005cited by this paper
• Anteroventral third ventricle lesions impair cardiovascular responses to intravenous hypertonic saline infusion.

  2005cited by this paper
• Perinatal Salt Restriction: A New Pathway to Programming Insulin Resistance and Dyslipidemia in Adult Wistar Rats

  2004cited by this paper
• Neuroendocrine control of body fluid metabolism.

  2004cited by this paper
• The physiological regulation of thirst and fluid intake.

  2004cited by this paper
• Acute and chronic increases in osmolality increase excitatory amino acid drive of the rostral ventrolateral medulla in rats.

  2004cited by this paper
• Glutamatergic input in the PVN is important in renal nerve response to elevations in osmolality.

  2003cited by this paper
• Central osmotic regulation of sympathetic nerve activity.

  2003cited by this paper
• EFFECTS OF CHRONIC EXCESS SALT INGESTION ROLE OF GENETIC FACTORS

  2003cited by this paper
• Identification and characterization of two functionally distinct groups of spinal cord-projecting paraventricular nucleus neurons with sympathetic-related activity

  2003cited by this paper
• The action of the A1 noradrenergic region on the activity of subfornical organ neurons in the rat.

  2002cited by this paper
• Anteroventral third ventricle (AV3V) lesions impair cardiovascular responses to intravenous hypertonic saline (HT) infusion

  2002cited by this paper
• Advances in fluid resuscitation of hemorrhagic shock.

  2001cited by this paper
• Effect of hyperosmotic solutions on salt excretion and thirst in rats.

  2000cited by this paper
• Oxytocin-induced renin secretion in conscious rats.

  2000cited by this paper
• Angiotensin, thirst, and sodium appetite.

  1998cited by this paper
• The area postrema modulates hypothalamic fos responses to intragastric hypertonic saline in conscious rats.

  1998cited by this paper
• A1 noradrenergic modulation of AV3V inputs to PVN neurosecretory cells

  1997cited by this paper
• Maternal nutrition, fetal nutrition, and disease in later life.

  1997cited by this paper
• Intragastric hypertonic saline increases vasopressin and central Fos immunoreactivity in conscious rats.

  1997cited by this paper
• INTEGRATIVE ROLE OF THE LAMINA TERMINALIS IN THE REGULATION OF CARDIOVASCULAR AND BODY FLUID HOMEOSTASIS

  1996cited by this paper
• Nonuniform sympathetic nerve responses to intravenous hypertonic saline infusion.

  1996influential reference
• Oxytocin mediates atrial natriuretic peptide release and natriuresis after volume expansion in the rat.

  1995cited by this paper
• Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study.

  1995cited by this paper
• Chemical topography of efferent projections from the median preoptic nucleus to pontine monoaminergic cell groups in the rat.

  1995cited by this paper
• Natriuretic role of endogenous oxytocin in male rats infused with hypertonic NaCl.

  1995cited by this paper
• Osmoreceptors, osmoreception, and osmoregulation.

  1994cited by this paper
• Nucleus tractus solitarius--gateway to neural circulatory control.

  1994cited by this paper
• Mechanosensitive channels transduce osmosensitivity in supraoptic neurons

  1993cited by this paper
• Electrophysiology and neuropharmacology of noradrenergic projections to rat PVN magnocellular neurons.

  1993cited by this paper
• Carotid-aortic and renal baroreceptors mediate the atrial natriuretic peptide release induced by blood volume expansion.

  1992cited by this paper
• Lesion of the anteroventral third ventricle region impairs the recovery of arterial pressure induced by hypertonic saline in rats submitted to hemorrhagic shock.

  1992cited by this paper
• Noradrenergic excitatory inputs to median preoptic neurones in rats.

  1992cited by this paper
• Efferent neural pathways of the lamina terminalis subserving osmoregulation.

  1992influential reference
• Lesions of the hypothalamus and pituitary inhibit volume-expansion-induced release of atrial natriuretic peptide.

  1991cited by this paper
• Effects of atrial natriuretic factor on blood flow distribution and vascular resistance in conscious dogs.

  1991cited by this paper
• Regulation of plasma atrial natriuretic peptide by the central nervous system.

  1990cited by this paper
• Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus

  1988cited by this paper
• Baroreceptor influences on plasma atrial natriuretic peptide (ANP): sinoaortic denervation reduces basal levels and the response to an osmotic challenge.

  1988cited by this paper
• Organization of central adrenergic pathways: I. Relationships of ventrolateral medullary projections to the hypothalamus and spinal cord

  1987cited by this paper
• Longitudinal Studies of Blood Pressure in Children

  1987cited by this paper
• Hypertonic resuscitation from severe hemorrhagic shock: patterns of regional circulation.

  1986cited by this paper
• Atriopeptins: correlation between renal vasodilation and natriuresis.

  1985cited by this paper
• The role of lung innervation in the hemodynamic response to hypertonic sodium chloride solutions in hemorrhagic shock.

  1985cited by this paper
• Effects of volume expansion on renal nerve activity, renal blood flow, and sodium and water excretion in conscious dogs.

  1985cited by this paper
• Effects of synthetic atrial natriuretic factor on renal function and renin release.

  1984cited by this paper
• Sodium excretion following lesions of preoptic recess periventricular tissue in the rat.

  1983cited by this paper
• Preoptic-hypothalamic periventricular lesions reduce natriuresis to volume expansion.

  1983cited by this paper
• Afferent connections of the median preoptic nucleus in the rat: anatomical evidence for a cardiovascular integrative mechanism in the anteroventral third ventricular (AV3V) region.

  1983cited by this paper
• Medullary catecholamine inputs to the anteroventral third ventricular cardiovascular regulatory region in the rat.

  1983cited by this paper
• Hypothalamic integration: organization of the paraventricular and supraoptic nuclei.

  1983cited by this paper
• Hyperosmotic NaCl and severe hemorrhagic shock: role of the innervated lung.

  1981cited by this paper
• Treatment of refractory hypovolaemic shock by 7.5% sodium chloride injections.

  1980cited by this paper
• Osmoreceptors, vasopressin, and control of renal water excretion.

  1980cited by this paper
• Supraoptic neurones of rat hypothalamus are osmosensitive

  1980cited by this paper
• TREATMENT OF REFRACTORY HYPOVOLÆMIC SHOCK BY 7·5% SODIUM CHLORIDE INJECTIONS

  1980cited by this paper
• Hyperosmotic NaCl and severe hemorrhagic shock.

  1980influential reference
• EFFECTS OF CHRONIC EXCESS SALT INGESTION

  1963cited by this paper

• Haemodynamic Frailty-A Risk Factor for Acute Kidney Injury in the Elderly.

  2021cites this paper
• Presynaptic inputs to vasopressin neurons in the hypothalamic supraoptic nucleus and paraventricular nucleus in mice.

  2021cites this paper
• Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia

  2020cites this paper
• Oxytocin‐monomeric red fluorescent protein 1 synthesis in the hypothalamus under osmotic challenge and acute hypovolemia in a transgenic rat line

  2020cites this paper
• The circle of Willis revisited: Forebrain dehydration sensing facilitated by the anterior communicating artery

  2020cites this paper
• Effects of acute kidney dysfunction on hypothalamic arginine vasopressin synthesis in transgenic rats

  2019cites this paper
• Up‐regulation of hypothalamic arginine vasopressin by peripherally administered furosemide in transgenic rats expressing arginine vasopressin‐enhanced green fluorescent protein

  2018cites this paper
• Involvement of median preoptic nucleus and medullary noradrenergic neurons in cardiovascular and sympathetic responses of hemorrhagic rats

  2018cites this paper
• The effect of chronic tBHQ treatment on high salt-induced hypertension is reported • Chronic tBHQ supplementation attenuates hypertension and sympathoexcitation • Chronic tBHQ supplementation attenuates PVN oxidative stress and inflammation

  2017cites this paper
• A Cross-Talk between the Renin-Angiotensin and Adrenergic Systems in Cardiovascular Health and Disease

  2017cites this paper
• Tert-butylhydroquinone attenuates oxidative stress and inflammation in hypothalamic paraventricular nucleus in high salt-induced hypertension.

  2017cites this paper