CBF‐1 promotes transcriptional silencing during the establishment of HIV‐1 latency

No abstract is available for this paper.

• Publication year

  2007

• Venue

  EMBO Journal

• Publication date

  2007-12-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.emboj.7601928PMID 18007589PMCID PMC2140115
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
• Suv39H1 and HP1γ are responsible for chromatin‐mediated HIV‐1 transcriptional silencing and post‐integration latency

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• Recruitment of chromatin‐modifying enzymes by CTIP2 promotes HIV‐1 transcriptional silencing

  2007influential reference
• Requirement for SWI/SNF chromatin‐remodeling complex in Tat‐mediated activation of the HIV‐1 promoter

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• Recruitment of TFIIH to the HIV LTR is a rate‐limiting step in the emergence of HIV from latency

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• Depletion of Latent HIV-1 Infection In Vivo: A Proof-of-Concept Study

  2006cited by this paper
• An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer

  2006cited by this paper
• The SWI/SNF Chromatin-remodeling Complex Is a Cofactor for Tat Transactivation of the HIV Promoter*

  2006influential reference
• Rapid Expression of Human Immunodeficiency Virus following Activation of Latently Infected Cells

  2006cited by this paper
• Hexamethylbisacetamide Remodels the Human Immunodeficiency Virus Type 1 (HIV-1) Promoter and Induces Tat-Independent HIV-1 Expression but Blunts Cell Activation

  2006cited by this paper
• NF‐κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation

  2006influential reference
• Depletion of latent HIV-1 infection in vivo: a proof-of-concept study.

  2005cited by this paper
• Genome-Wide Analysis of Chromosomal Features Repressing Human Immunodeficiency Virus Transcription

  2005cited by this paper
• Single-molecule FRET studies of important intermediates in the nucleocapsid-protein-chaperoned minus-strand transfer step in HIV-1 reverse transcription.

  2005cited by this paper
• Mining microarray data to identify transcription factors expressed in naïve resting but not activated T lymphocytes

  2004cited by this paper
• Resting CD4+ T Cells from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals Carry Integrated HIV-1 Genomes within Actively Transcribed Host Genes

  2004cited by this paper
• Recruitment of SWI/SNF to the Human Immunodeficiency Virus Type 1 Promoter

  2004cited by this paper
• Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression

  2004cited by this paper
• Transcriptional Profiles of Latent Human Immunodeficiency Virus in Infected Individuals: Effects of Tat on the Host and Reservoir

  2003influential reference
• Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1*

  2003cited by this paper
• A Naturally Occurring Substitution in Human Immunodeficiency Virus Tat Increases Expression of the Viral Genome

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• Regulation of HIV‐1 gene expression by histone acetylation and factor recruitment at the LTR promoter

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• Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1.

  2003cited by this paper
• HIV reproducibly establishes a latent infection after acute infection of T cells in vitro

  2003influential reference
• Identification of T cell-signaling pathways that stimulate latent HIV in primary cells

  2003influential reference
• CD154-CD40-induced reactivation of latent HIV-1 infection.

  2003influential reference
• Interleukin-7 Induces Expression of Latent Human Immunodeficiency Virus Type 1 with Minimal Effects on T-Cell Phenotype

  2002cited by this paper
• Direct and Quantitative Single-Cell Analysis of Human Immunodeficiency Virus Type 1 Reactivation from Latency

  2002influential reference
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  2000cited by this paper
• CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.

  1999cited by this paper
• A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.

  1998cited by this paper
• NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ

  1998cited by this paper
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  1998cited by this paper
• The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription.

  1998cited by this paper
• A Third-Generation Lentivirus Vector with a Conditional Packaging System

  1998cited by this paper
• The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells.

  1997cited by this paper
• CREB-binding protein/p300 are transcriptional coactivators of p65.

  1997influential reference
• Gradual shutdown of virus production resulting in latency is the norm during the chronic phase of human immunodeficiency virus replication and differential rates and mechanisms of shutdown are determined by viral sequences.

  1996cited by this paper
• In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

  1996cited by this paper
• Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2

  1996cited by this paper
• A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency.

  1996cited by this paper
• Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.

  1995cited by this paper
• Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

  1995cited by this paper
• Viral dynamics in human immunodeficiency virus type 1 infection

  1995cited by this paper
• Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation.

  1993influential reference
• An inducible transcription factor activates expression of human immunodeficiency virus in T cells

  1990cited by this paper
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  1987cited by this paper

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• The HIV-1 Transcriptional Program: From Initiation to Elongation Control.

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• Cocaine-Induced DNA-Dependent Protein Kinase Relieves RNAP II Pausing by Promoting TRIM28 Phosphorylation and RNAP II Hyperphosphorylation to Enhance HIV Transcription

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• Cocaine-induced DNA-PK relieves RNAP II pausing by promoting TRIM28 phosphorylation

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