Selective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophages.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  1994-04-30

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1006/BBRC.1994.1511PMID 7513994
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nitric oxide synthases in mammals.

  1994cited by this paper
• Characterization of endothelial cell amino acid transport systems involved in the actions of nitric oxide synthase inhibitors.

  1993cited by this paper
• Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver.

  1993cited by this paper
• Selective inhibition by dexamethasone of induction of NO synthase, but not of induction of l‐arginine transport, in activated murine macrophage J774 cells

  1993cited by this paper
• L-arginine transport is increased in macrophages generating nitric oxide.

  1992cited by this paper
• Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l‐arginine transporter

  1992cited by this paper
• Identification of N‐iminoethyl‐l‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells

  1991cited by this paper
• The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine.

  1990cited by this paper
• Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine.

  1990cited by this paper
• L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

  1987cited by this paper
• Neutral amino acid transport in mouse peritoneal macrophages.

  1987cited by this paper
• The transport of cationic amino acids across the plasma membrane of mammalian cells.

  1985cited by this paper
• Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

  1982cited by this paper

• Poultry macrophages as immune gatekeepers: role in diseases and effect of nutrients on their biology

  2026cites this paper
• Effects of simvastatin on CAT-1-mediated arginine transport and NO level under high glucose conditions in conditionally immortalized rat inner blood-retinal barrier cell lines (TR-iBRB).

  2017cites this paper
• Bacterial toxins activation of abbreviated urea cycle in porcine cerebral vascular smooth muscle cells.

  2016cites this paper
• Glucose uptake during contraction in isolated skeletal muscles from neuronal nitric oxide synthase μ knockout mice.

  2015cites this paper
• The use of nitric oxide free radical sensitive flourephores to detect macrophage phagolysosome activity.

  2014cites this paper
• The role of the JNK/AP-1 pathway in the induction of iNOS and CATs in vascular cells

  2013cites this paper
• Characterization of C‐Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH‐1

  2011cites this paper
• Regulation of the Inducible L-Arginine-Nitric Oxide Pathway by Oxidative Stress and Statins

  2010cites this paper
• Transfer of Nitric Oxide by Blood From Upstream to Downstream Resistance Vessels Causes Microvascular Dilation

  2009cites this paper
• A molecular chromatographic approach to analyze the cell diffusion of arginase inhibitors.

  2009cites this paper
• Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.

  2009cites this paper
• Binding specificity of the l-arginine transport systems in mouse macrophages and human cells overexpressing the cationic amino acid transporter hCAT-1

  2009influential citation
• PROINFLAMMATORY CYTOKINES AND LIPOPOLYSACCHARIDE SYNERGIZE TO INDUCE L-ARGININE TRANSPORT AND NITRIC OXIDE SYNTHASE IN VASCULAR SMOOTH MUSCLE CELLS

  2008cites this paper
• Nitric oxide: Ocular blood flow, glaucoma, and diabetic retinopathy

  2007cites this paper
• L-arginine transporters in cardiovascular disease: a novel therapeutic target.

  2007cites this paper
• l-Arginine and Cationic Amino Acid Transporter 2B Regulate Growth and Survival of Leishmania amazonensis Amastigotes in Macrophages

  2007cites this paper
• y+ LAT-1 mediates transport of the potent and selective iNOS inhibitor, GW274150, in control J774 macrophages

  2006cites this paper
• Phylogenesis of constitutively formed nitric oxide in non-mammals.

  2006cites this paper
• Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases?

  2006cites this paper
• The transport of cationic amino acids in human airway cells: expression of system y+L activity and transepithelial delivery of NOS inhibitors

  2005cites this paper
• The Inhibitory Effects of Nω-Nitro-L-Arginine Methyl Ester on Nitric Oxide Synthase Activity Vary Among Brain Regions in Vivo but Not in Vitro

  2004cites this paper
• The role of iNOS in chronic inflammatory processes in vivo: is it damage-promoting, protective, or active at all?

  2004cites this paper
• Teratological consequences of nitric oxide synthesis inhibition.

  2004cites this paper
• Modulation of the L-arginine/nitric oxide signalling pathway in vascular endothelial cells.

  2004cites this paper
• The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

  2003cites this paper
• Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells.

  2003influential citation
• Localization and role of nitric oxide synthase and endogenous nitric oxide synthase inhibitors in the rabbit lower urinary tract.

  2002cites this paper
• Membrane Transporters as Drug Targets

  2002cites this paper
• Cationic Amino Acid Transporters (CATs)

  2002cites this paper
• Radiosynthesis, in vitro validation, and in vivo evaluation of 18F-labeled COX-1 and COX-2 inhibitors.

  2002cites this paper
• Arginase in glomerulonephritis.

  2002cites this paper
• Reduced arginine availability and nitric oxide production.

  2002cites this paper
• Induction of L-arginine transport is inhibited by atrial natriuretic peptide: a peptide hormone as a novel regulator of inducible nitric-oxide synthase substrate availability.

  2001cites this paper
• Na+ - and Cl- -coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+).

  2001cites this paper
• Arginine metabolism and the synthesis of nitric oxide in the nervous system.

  2001cites this paper
• Arginase in Glomerulonephritis

  2000cites this paper
• Membrane Transport of l-Arginine and Cationic Amino Acid Analogs

  2000cites this paper
• Genetic variation in in-vitro cytokine-induced production of nitric oxide by murine peritoneal macrophages.

  2000cites this paper
• Nitric oxide regulates nucleoside transport in activated B lymphocytes

  2000cites this paper
• Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy.

  2000cites this paper
• L-arginine transport in retinas from streptozotocin diabetic rats: correlation with the level of IL-1 beta and NO synthase activity.

  1999cites this paper
• CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages.

  1999cites this paper
• Electron microscopic studies on NO-synthase activity in brain phagocytes of rat cerebral cortex after ischemic and traumatic brain injury.

  1999cites this paper
• Chronic liver injury alters basal and stimulated nitric oxide production and 3H-thymidine incorporation in cultured sinusoidal endothelial cells from rats.

  1999cites this paper
• The recycling of L-citrulline to L-arginine in a chicken macrophage cell line.

  1999influential citation
• Transport of NG-Nitro-L-Arginine Across Intestinal Brush Border Membranes by Na+-Dependent and Na+ Independent Amino Acid Transporters

  1999cites this paper
• Role of nitric oxide in acetaminophen‐induced hepatotoxicity in the rat

  1998cites this paper
• Cardiovascular responses attenuate with repeated NO synthesis inhibition in conscious fetal sheep.

  1998cites this paper
• Maternal dietary protein deficiency decreases nitric oxide synthase and ornithine decarboxylase activities in placenta and endometrium of pigs during early gestation.

  1998cites this paper
• Cardiovascular responses attenuate with repeated NO synthesis inhibition in conscious fetal sheep.

  1998cites this paper
• Arginine metabolism: nitric oxide and beyond.

  1998cites this paper
• Transporters for cationic amino acids in animal cells: discovery, structure, and function.

  1998cites this paper
• Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects.

  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1998cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
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  1997cites this paper
• Design of nitric oxide synthase inhibitors and their use to reverse hypotension associated with cancer immunotherapy.

  1997cites this paper
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  1997cites this paper
• A potential role for nitric oxide in dyserythropoiesis

  1996cites this paper
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  1996cites this paper
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  1996cites this paper
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  1996cites this paper
• Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers.

  1996cites this paper
• Platelet‐activating factor augments lipopolysaccharide‐induced nitric oxide formation by rat Kupffer cells

  1996cites this paper
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  1996cites this paper
• Effects of the nitric oxide synthase inhibitor N omega nitro-L-arginine methyl ester on electrical activity and ion channels of mouse pancreatic B cells.

  1996cites this paper
• Induced Nitric Oxide Synthesis Is Dependent on Induced Alternatively Spliced CAT-2 Encoding L-Arginine Transport in Brain Astrocytes*

  1996cites this paper
• Role of nitric oxide synthase isozymes in endotoxin-induced uveitis.

  1996cites this paper
• Induction of L‐arginine transport and nitric oxide synthase in vascular smooth muscle cells: synergistic actions of pro‐inflammatory cytokines and bacterial lipopolysaccharide

  1995cites this paper
• Nitric oxide: a new paradigm for second messengers.

  1995cites this paper
• Recycling of L-citrulline to sustain nitric oxide-dependent enteric neurotransmission.

  1995cites this paper
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  1995cites this paper
• NO synthase activity does not influence electrical activity of mouse pancreatic B-cells.

  1995cites this paper
• Transport of nitric oxide synthase inhibitors through cationic amino acid carriers in human erythrocytes.

  1995cites this paper
• Molecular mechanisms and therapeutic strategies related to nitric oxide

  1995cites this paper
• Modulation of nitric oxide synthase activity in macrophages

  1995cites this paper
• Characterization of Neuronal Amino Acid Transporters: Uptake of Nitric Oxide Synthase Inhibitors and Implication for Their Biological Effects

  1995cites this paper
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  1995cites this paper
• Novel potent and selective inhibitors of inducible nitric oxide synthase.

  1995cites this paper
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  1995cites this paper
• Amino acids differentially inhibit the L-[3H]arginine transport and nitric oxide synthase in rat brain synaptosomes.

  1994cites this paper