NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1998-07-21

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/PNAS.95.15.8963PMID 9671787PMCID PMC21185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inflammation in Chronic Venous Insufficiency: Is the Problem Insurmountable?

  1999cited by this paper
• Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo.

  1998cited by this paper
• SNS Na+ channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model

  1998cited by this paper
• Functional Analysis of the Rat I Sodium Channel inXenopus Oocytes

  1998cited by this paper
• NaG: A sodium channel‐like mRNA shared by Schwann cells and other neural crest derivatives

  1997cited by this paper
• Structure and distribution of a broadly expressed atypical sodium channel

  1997cited by this paper
• A single serine residue confers tetrodotoxin insensitivity on the rat sensory‐neuron‐specific sodium channel SNS

  1997cited by this paper
• From mutation to myotonia in sodium channel disorders.

  1997cited by this paper
• Differential expression of sodium channel genes in retinal ganglion cells.

  1997cited by this paper
• Insertion of a SNS‐specific tetrapeptide in S3–S4 linker of D4 accelerates recovery from inactivation of skeletal muscle voltage‐gated Na channel μ1 in HEK293 cells

  1997cited by this paper
• Experimental and modeling study of Na+ current heterogeneity in rat nodose neurons and its impact on neuronal discharge.

  1997cited by this paper
• Channelopathies: ion channel disorders of muscle as a paradigm for paroxysmal disorders of the nervous system.

  1997cited by this paper
• Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons.

  1997cited by this paper
• TTX resistivity of Na+ channel in newt retinal neuron.

  1997cited by this paper
• Phosphorylation at a Single Site in the Rat Brain Sodium Channel Is Necessary and Sufficient for Current Reduction by Protein Kinase A

  1997cited by this paper
• Downregulation of Tetrodotoxin-Resistant Sodium Currents and Upregulation of a Rapidly Repriming Tetrodotoxin-Sensitive Sodium Current in Small Spinal Sensory Neurons after Nerve Injury

  1997cited by this paper
• Phenytoin and carbamazepine: differential inhibition of sodium currents in small cells from adult rat dorsal root ganglia.

  1997cited by this paper
• Down-Regulation of Transcripts for Na Channel α -SNS in Spinal Sensory Neurons Following Axotomy

  1996cited by this paper
• Mechanisms of Paresthesiae, Dysesthesiae, and Hyperesthesiae: Role of Na+ Channel Heterogeneity

  1996cited by this paper
• A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

  1996cited by this paper
• Sodium channel mRNA in the B104 neuroblastoma cell line

  1996cited by this paper
• Molecular basis of charge movement in voltage-gated sodium channels.

  1996cited by this paper
• Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy.

  1996cited by this paper
• Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.

  1996cited by this paper
• Multiple mechanisms of Na+ channel--linked long-QT syndrome.

  1996cited by this paper
• PGE2 modulates the tetrodotoxin‐resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP‐protein kinase A cascade.

  1996cited by this paper
• Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs.

  1996cited by this paper
• Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons (*)

  1996cited by this paper
• Spinal sensory neurons express multiple sodium channel α-subunit mRNAs

  1996cited by this paper
• Molecular pathology of the skeletal muscle sodium channel.

  1995cited by this paper
• A novel, abundant sodium channel expressed in neurons and glia

  1995cited by this paper
• Selective loss of slow and enhancement of fast Na+ currents in cutaneous afferent dorsal root ganglion neurones following axotomy.

  1995cited by this paper
• Delayed depolarization and slow sodium currents in cutaneous afferents.

  1994cited by this paper
• Slow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity.

  1994cited by this paper
• A- and C-type rat nodose sensory neurons: model interpretations of dynamic discharge characteristics.

  1994cited by this paper
• Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy.

  1994cited by this paper
• Primary structure and differential expression during development and pregnancy of a novel voltage-gated sodium channel in the mouse.

  1994cited by this paper
• The role of tetrodotoxin-resistant sodium channels of small primary afferent fibers.

  1994cited by this paper
• Characterization of TTX‐sensitive and TTX‐resistant sodium currents in small cells from adult rat dorsal root ganglia.

  1993cited by this paper
• Structure and function of voltage-gated ion channels.

  1993cited by this paper
• Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase.

  1993cited by this paper
• A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

  1992cited by this paper
• A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties

  1992cited by this paper
• The glial voltage-gated sodium channel: cell- and tissue-specific mRNA expression.

  1992cited by this paper
• Differential properties of tetrodotoxin-sensitive and tetrodotoxin- resistant sodium channels in rat dorsal root ganglion neurons

  1992cited by this paper
• Three types of sodium channels in adult rat dorsal root ganglion neurons.

  1992cited by this paper
• Quantification of gene expression over a wide range by the polymerase chain reaction.

  1992cited by this paper
• Structural features in eukaryotic mRNAs that modulate the initiation of translation.

  1991cited by this paper
• Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development.

  1989cited by this paper
• A rat brain Na+ channel alpha subunit with novel gating properties.

  1988cited by this paper
• Functional expression of cloned cDNA encoding sodium channel III

  1988cited by this paper
• Primary structure of rat brain sodium channel III deduced from the cDNA sequence

  1988cited by this paper
• A rat brain na + channel α subunit with novel gating properties

  1988cited by this paper
• Effects of central or peripheral axotomy on membrane properties of sensory neurones in the petrosal ganglion of the cat.

  1987cited by this paper
• Existence of distinct sodium channel messenger RNAs in rat brain

  1986cited by this paper
• Altered excitability of goldfish Mauthner cell following axotomy. II. Localization and ionic basis.

  1986cited by this paper
• Sodium-dependent regenerative responses in dendrites of axotomized motoneurons in the cat.

  1986cited by this paper
• Expression of functional sodium channels from cloned cDNA

  1986cited by this paper
• Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones.

  1985cited by this paper
• Enhancement of synaptic transmission by dendritic potentials in chromatolysed motoneurones of the cat

  1970cited by this paper

• Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine).

  2025cites this paper
• Neuropharmacology and physiology of human dorsal root ganglion neurons responsible for nociception: state-of-the-art and future directions.

  2025cites this paper
• TTX‐R and TTX‐S Sodium Channels in CGRP‐Positive Dorsal Root Ganglia Neurons Mediate Referred Somatic Hyperalgesia in Ulcerative Colitis Mice

  2025influential citation
• Voltage-gated sodium channels in excitable cells as drug targets

  2025cites this paper
• Epigenetics of pain highways (Review)

  2025influential citation
• Voltage-gated sodium channels (NaV) in GtoPdb v.2025.3

  2025cites this paper
• Species-specific differences and the role of Nav1.9 in pain pathophysiology.

  2024cites this paper
• Persistent (Nav1.9) sodium currents in human dorsal root ganglion neurons.

  2024cites this paper
• Drug discovery targeting Nav1.8: Structural insights and therapeutic potential.

  2024cites this paper
• The synthetic peptide, PnPP-15, derived from the PnTx2-6 toxin of the spider Phoneutria nigriventer, induces peripheral antinociception involving neprilysin, opioid and cannabinoid systems

  2024cites this paper
• A review of dorsal root ganglia and primary sensory neuron plasticity mediating inflammatory and chronic neuropathic pain

  2024cites this paper
• LmNaTx15, a novel scorpion toxin, enhances the activity of Nav channels and induces pain in mice.

  2023cites this paper
• Peripheral mechanisms of peripheral neuropathic pain

  2023cites this paper
• Voltage-gated sodium channels (NaV) in GtoPdb v.2023.1

  2023cites this paper
• Depolarizing NaV and Hyperpolarizing KV Channels Are Co-Trafficked in Sensory Neurons

  2022cites this paper
• Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain.

  2022cites this paper
• Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2

  2022cites this paper
• Familial Episodic Pain Syndromes

  2022cites this paper
• Inhibition of the human neuronal sodium channel Nav1.9 by ACEA (arachidonyl-2-chloroethylamide), an analogue of anandamide in a hNav1.9/rNav1.4 chimera, an experimental and in silico study.

  2022cites this paper
• Voltage-gated sodium channels in diabetic sensory neuropathy: Function, modulation, and therapeutic potential

  2022cites this paper
• NaV1.9 current in muscle afferent neurons is enhanced by substances released during muscle activity.

  2022cites this paper
• A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors

  2021cites this paper
• Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets

  2021cites this paper
• Non‐length‐dependent small fiber neuropathy: Not a matter of stockings and gloves

  2021cites this paper
• Neuropathic pain: Spotlighting anatomy, experimental models, mechanisms, and therapeutic aspects

  2021cites this paper
• Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins

  2021cites this paper
• Tetrodotoxin: A New Strategy to Treat Visceral Pain?

  2021cites this paper
• Development of a (cid:2) O-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel Na V 1.8 *

  2020cites this paper
• Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits

  2020cites this paper
• L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats In Vivo

  2020cites this paper
• Status of peripheral sodium channel blockers for non-addictive pain treatment

  2020cites this paper
• Joint Pain

  2020cites this paper
• Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons

  2020cites this paper
• Sodium Channels

  2020cites this paper
• Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe

  2020cites this paper
• Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways

  2019cites this paper
• Cadmium versus Lanthanum Effects on Spontaneous Electrical Activity and Expression of Connexin Isoforms Cx26, Cx36, and Cx45 in the Human Fetal Cortex.

  2019cites this paper
• A 49-residue sequence motif in the C terminus of Nav1.9 regulates trafficking of the channel to the plasma membrane

  2019cites this paper
• Anti-Nociceptive and Anti-Inflammation Effect Mechanisms of Mutants of Syb-prII, a Recombinant Neurotoxic Polypeptide

  2019cites this paper
• A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain

  2019cites this paper
• Voltage-gated sodium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Small Fiber Neuropathy

  2019cites this paper
• Neural mechanisms of thermoregulation.

  2019cites this paper
• The Genetics of Neuropathic Pain from Model Organisms to Clinical Application

  2019cites this paper
• Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions.

  2019cites this paper
• Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

  2019cites this paper
• Identification and characterisation of sodium channel Nav1.7 protein-protein interactions using an epitope-tagged gene-targeted mouse

  2019cites this paper
• The Role of Voltage-Gated Sodium Channels in Pain Signaling.

  2019cites this paper
• Ion Channels Involved in Tooth Pain

  2019cites this paper
• Synthesis of C12-keto saxitoxin derivatives with unusual inhibitory activity against voltage-gated sodium channels.

  2019cites this paper
• A 39-Year-Old Woman with Intermittent Bilateral Foot and Leg Pain since Childhood

  2019cites this paper
• Heat-resistant action potentials require TTX-resistant sodium channels NaV1.8 and NaV1.9

  2018cites this paper
• Somatosensory Neurons Enter a State of Altered Excitability during Hibernation.

  2018cites this paper
• The effect of acute dissociation on the electrophysiological properties of rat dorsal root ganglion neurons

  2018cites this paper
• Modulation of sodium channels as pharmacological tool for pain therapy—highlights and gaps

  2018cites this paper
• Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7.

  2018cites this paper
• Novel Sodium Channel Inhibitor From Leeches

  2018cites this paper
• Voltage‐gated sodium channels: (NaV)igating the field to determine their contribution to visceral nociception

  2018cites this paper
• The NaV1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons

  2018cites this paper
• Characterization of dural afferent neurons innervating cranial blood vessels within the dura in rats.

  2018cites this paper
• TRPs et al.: a molecular toolkit for thermosensory adaptations

  2018cites this paper
• Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain?

  2018cites this paper
• Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain

  2018cites this paper
• Difference of acute dissociation and 1-day culture on the electrophysiological properties of rat dorsal root ganglion neurons

  2018cites this paper
• NaV1.9 channels in muscle afferent neurons and axons.

  2018cites this paper
• NaV Channels: Assaying Biosynthesis, Trafficking, Function.

  2018cites this paper
• Sodium channels and pain: from toxins to therapies

  2018influential citation
• Alabama to Beijing… and Back: The Search for a Pain Gene

  2018cites this paper
• Sodium Channel Blockers for the Treatment of Pain

  2017cites this paper
• Chronic exposure to tumor necrosis factor in vivo induces hyperalgesia, upregulates sodium channel gene expression and alters the cellular electrophysiology of dorsal root ganglion neurons

  2017cites this paper
• Title: Age-dependent expression of Nav1.9 channels in medial prefrontal cortex (mPFC) pyramidal neurons in rats Running title: Nav1.9 channels in pyramidal neurons

  2017influential citation
• Ultrafast optical recording reveals distinct capsaicin-induced ion dynamics along single nociceptive neurite terminals in vitro

  2017cites this paper
• Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis

  2017cites this paper
• Selective Voltage-Gated Sodium Channel Peptide Toxins from Animal Venom: Pharmacological Probes and Analgesic Drug Development.

  2017cites this paper
• Associated conditions in small fiber neuropathy – a large cohort study and review of the literature

  2017cites this paper
• Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models

  2017cites this paper
• Interleukin-8 levels in rat models of nerve damage and neuropathic pain.

  2017cites this paper
• SCN11A variants may influence postoperative pain sensitivity after gynecological surgery in Chinese Han female patients

  2017cites this paper
• Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability

  2017cites this paper
• Age‐dependent expression of Nav1.9 channels in medial prefrontal cortex pyramidal neurons in rats

  2017influential citation
• Transcriptionally Defined Subpopulations of Cutaneous Neurons: Effects of Nerve Injury and Regeneration

  2016cites this paper
• Familial gain-of-function Nav1.9 mutation in a painful channelopathy

  2016cites this paper
• Ion channelopathies in functional GI disorders.

  2016cites this paper
• Voltage-gated sodium channels and pain-related disorders.

  2016cites this paper
• Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9.

  2016cites this paper
• Sodium Channels, Mitochondria, and Axonal Degeneration in Peripheral Neuropathy.

  2016cites this paper
• [Patterns of action potential firing in cortical neurons of neonatal mice and their electrophysiological property].

  2016cites this paper
• Physiology and Pathophysiology of Sodium Channel Inactivation.

  2016cites this paper
• Unusual Voltage-Gated Sodium Currents as Targets for Pain.

  2016cites this paper
• Antinociceptive Effects of AGAP, a Recombinant Neurotoxic Polypeptide: Possible Involvement of the Tetrodotoxin-Resistant Sodium Channels in Small Dorsal Root Ganglia Neurons

  2016cites this paper
• Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli

  2016cites this paper
• Sodium Channels in Pain and Cancer: New Therapeutic Opportunities.

  2016cites this paper
• Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells

  2016cites this paper
• Nociceptor-enriched genes required for normal thermal nociception

  2016cites this paper
• The voltage‐gated sodium channel NaV1.9 in visceral pain

  2016cites this paper
• Development of a O-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8

  2016cites this paper
• Neurocutaneous disease: Cutaneous neuroanatomy and mechanisms of itch and pain.

  2016cites this paper
• Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target Na V 1.8

  2016cites this paper
• Acid modulation of tetrodotoxin-sensitive Na+ channels in large-sized trigeminal ganglion neurons.

  2016cites this paper
• Nociceptor-Enriched Genes Required for Normal Thermal Nociception.

  2016cites this paper