Zebrafish mab21l2 mutants possess severe defects in optic cup morphogenesis, lens and cornea development

Mutations in MAB21L2 result in severe ocular defects including microphthalmia, anophthalmia, coloboma, microcornea, and cataracts. The molecular and cellular underpinnings of these defects are unknown, as is the normal cellular function of MAB21L2. Zebrafish mab21l2 au10 mutants possess ocular defects resembling those in humans with MAB21L2 mutations, providing an excellent model to characterize mab21l2 functions during eye development.

• Publication year

  2019

• Venue

  Developmental Dynamics

• Publication date

  2019-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/dvdy.44PMID 31037784PMCID PMC6602828
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Issue Information

  2019cites this paper