Pax2 contributes to inner ear patterning and optic nerve trajectory.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Development

• Publication date

  1996-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8951055
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multiple functions for Pax6 in mouse eye and nasal development.

  1996cited by this paper
• Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation.

  1996cited by this paper
• Pax-2 controls multiple steps of urogenital development.

  1995cited by this paper
• The first retinal axon growth in the mouse optic chiasm: axon patterning and the cellular environment

  1995influential reference
• Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox genes during brain and ear development.

  1995cited by this paper
• Patterning activities of vertebrate hedgehog proteins in the developing eye and brain.

  1995cited by this paper
• Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux

  1995influential reference
• Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila.

  1995cited by this paper
• Midline signalling is required for Pax gene regulation and patterning of the eyes.

  1995cited by this paper
• Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1.

  1995cited by this paper
• Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum.

  1994cited by this paper
• Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP.

  1994influential reference
• Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus.

  1994influential reference
• Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth.

  1994cited by this paper
• The hedgehog gene family in Drosophila and vertebrate development.

  1994cited by this paper
• PAX genes.

  1994cited by this paper
• Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells.

  1994cited by this paper
• Asymmetric expression of a novel homeobox gene in vertebrate sensory organs

  1994cited by this paper
• Anterior mesendoderm induces mouse Engrailed genes in explant cultures.

  1993cited by this paper
• Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

  1993cited by this paper
• Wholemount in situ hybridization of vertebrate embryos

  1992cited by this paper
• Regional expression of three homeobox transcripts in the inner ear of zebrafish embryos.

  1992cited by this paper
• Pax genes, mutants and molecular function

  1992cited by this paper
• Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development.

  1992cited by this paper
• Vertebrate eye development.

  1992cited by this paper
• Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

  1992cited by this paper
• Pax in development.

  1992cited by this paper
• Comparative analysis of Pax-2 protein distributions during neurulation in mice and zebrafish.

  1992cited by this paper
• Mouse Small eye results from mutations in a paired-like homeobox-containing gene

  1991cited by this paper
• Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region.

  1991cited by this paper
• Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox.

  1991cited by this paper
• Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3.

  1991cited by this paper
• Pax-6, a murine paired box gene, is expressed in the developing CNS.

  1991cited by this paper
• Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system.

  1990cited by this paper
• Retinal axon pathfinding in the optic chiasm: divergence of crossed and uncrossed fibers.

  1990cited by this paper
• Spatially and temporally restricted expression of Pax2 during murine neurogenesis.

  1990cited by this paper
• Local positional cues in the neuroepithelium guide retinal axons in embryonic Xenopus brain

  1989cited by this paper
• undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax 1.

  1988cited by this paper
• Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.

  1988influential reference
• Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo.

  1987influential reference
• Origins and patterning of craniofacial mesenchymal tissues.

  1986cited by this paper
• The early development of the optic nerve and chiasm in embryonic rat

  1986cited by this paper
• Axonal guidance during development of the optic nerve: The role of pigmented epithelia and other extrinsic factors

  1981cited by this paper
• The fate mapping of the eleventh and twelfth day mouse otocyst: An in vitro study of the sites of origin of the embryonic inner ear sensory structures

  1978cited by this paper
• Development of the optic nerve of the rat.

  1975cited by this paper
• Experimental evidence concerning the determination of posture of the membranous labyrinth in amphibian embryos

  year unknowncited by this paper

• Arrayed single-gene perturbations identify drivers of human anterior neural tube closure

  2025cites this paper
• Novel Roles of Sonic Hedgehog Signaling in Retinal Patterning and Neurogenesis During Mammalian Eye Development

  2025cites this paper
• An atypical basement membrane forms a midline barrier during left-right asymmetric gut development in the chicken embryo

  2025cites this paper
• A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate

  2025cites this paper
• The multifaceted links between hearing loss and chronic kidney disease

  2024cites this paper
• Shared features in ear and kidney development – implications for oto-renal syndromes

  2024cites this paper
• Pax2a, Pax5 and Cdh1-β-catenin, but not Wnt, protect sensory hair cells from destabilizing effects of Fgf signaling on cell adhesion.

  2024cites this paper
• PAX3 mutation suppress otic progenitors proliferation and induce apoptosis by inhibiting WNT1/β-catenin signaling pathway in WS1 patient iPSC-derived inner ear organoids.

  2024cites this paper
• Retained PAX2 expression associated with DNA mismatch repair deficiency in endometrial endometrioid adenocarcinoma

  2024cites this paper
• A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate

  2024cites this paper
• Morphogenesis-coupled DNA repair - in mammalian embryogenesis, morphogenesis and DNA double strand break (DSB) repair are carried out simultaneously to ensure normal development

  2024cites this paper
• Signaling – transcription interactions in mouse retinal ganglion cells early axon pathfinding –a literature review

  2023influential citation
• Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons

  2023cites this paper
• Bop1 is required to establish precursor domains of craniofacial tissues

  2023cites this paper
• GC-biased gene conversion drives accelerated evolution of ultraconserved elements in mammalian and avian genomes

  2023cites this paper
• An atypical basement membrane forms a midline barrier during left-right asymmetric gut development in the chicken embryo

  2023cites this paper
• The sulfotransferase XB5850668.L is required to apportion embryonic ectodermal domains

  2023cites this paper
• Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons

  2023cites this paper
• Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis

  2023cites this paper
• Eye Morphogenesis in Vertebrates.

  2023cites this paper
• It takes Two: Discovery of Spider Pax2 Duplicates Indicates Prominent Role in Chelicerate Central Nervous System, Eye, as Well as External Sense Organ Precursor Formation and Diversification After Neo- and Subfunctionalization

  2022cites this paper
• Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear.

  2022cites this paper
• The impact of modifier genes on cone-rod dystrophy heterogeneity: An explorative familial pilot study and a hypothesis on neurotransmission impairment

  2022cites this paper
• De Novo PAX2 Mutation With Associated Papillorenal Syndrome: A Case Report and Literature Review of Penetrance and Expressivity

  2022cites this paper
• Sox8 remodels the cranial ectoderm to generate the ear

  2022cites this paper
• Mcrs1 is required for branchial arch and cranial cartilage development.

  2022cites this paper
• A possible origin of the inverted vertebrate retina revealed by physical modeling

  2022cites this paper
• BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish

  2021influential citation
• Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse.

  2021cites this paper
• Comparative assessment of Fgf's diverse roles in inner ear development: A zebrafish perspective

  2021cites this paper
• Multiple roles for Pax2 in the embryonic mouse eye.

  2021cites this paper
• Pax2a, but not pax2b, influences cell survival and periocular mesenchyme localization to facilitate zebrafish optic fissure closure

  2021cites this paper
• Semper's cells in the insect compound eye: Insights into ocular form and function.

  2021cites this paper
• Sox8 is sufficient to reprogram ectoderm into ear vesicles and associated neurons

  2021cites this paper
• Ocular coloboma: Genetic variants reveal a dynamic model of eye development

  2020cites this paper
• Emerging Therapies and Approaches to Treat and Prevent Hearing Loss

  2020cites this paper
• Evolution of Hair Cells

  2020cites this paper
• A molecular and cellular analysis of human embryonic optic fissure closure related to the eye malformation coloboma

  2020cites this paper
• Cell fate decisions during the development of the peripheral nervous system in the vertebrate head.

  2020cites this paper
• Generation of Third Dimension: Axial Patterning in the Developing Drosophila Eye

  2020cites this paper
• Hyaloid vasculature and mmp2 activity play a role during optic fissure fusion in zebrafish

  2020cites this paper
• Pax2a is expressed in oocytes and is responsible for early development and oogenesis in zebrafish.

  2020cites this paper
• Inherited Eye Diseases with Retinal Manifestations through the Eyes of Homeobox Genes

  2020cites this paper
• Increased repetitive self-grooming occurs in Pax2 mutant mice generated using CRISPR/Cas9.

  2020cites this paper
• Isolation and Characterization of Mammalian Otic Progenitor Cells that Can Differentiate into Both Sensory Epithelial and Neuronal Cell Lineages

  2020cites this paper
• In Vivo Analysis of Optic Fissure Fusion in Zebrafish: Pioneer Cells, Basal Lamina, Hyaloid Vessels, and How Fissure Fusion is Affected by BMP

  2020cites this paper
• Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup–Stalk Boundary Maintenance

  2020cites this paper
• Transcriptome profiles of sturgeon lateral line electroreceptor and mechanoreceptor during regeneration

  2020cites this paper
• A new mutation in the PAX2 gene in a Papillorenal Syndrome patient

  2019cites this paper
• Sensory Placode Formation in Vertebrates

  2019cites this paper
• The biological strategies for hearing re-establishment based on the stem/progenitor cells.

  2019cites this paper
• Pax2a regulates angiogenesis to facilitate mmp2-dependent basement membrane remodeling of the optic fissure

  2019cites this paper
• The Molecular Basis of Human Anophthalmia and Microphthalmia

  2019cites this paper
• An update on the genetics of ocular coloboma

  2019cites this paper
• Cochlear Implantation Outcomes in Children with Agenesis of the Corpus Callosum: A Retrospective Study and A Review of the Literature.

  2019cites this paper
• Zebrafish mab21l2 mutants possess severe defects in optic cup morphogenesis, lens and cornea development

  2019cites this paper
• Pax2a regulates angiogenesis to facilitate fusion of the optic fissure

  2019cites this paper
• Development of Neurogenic Placodes in Vertebrates

  2019cites this paper
• Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm

  2019cites this paper
• Genetic Control of Inner Ear Development in Xenopus Laevis

  2018cites this paper
• The cellular bases of choroid fissure formation and closure.

  2018cites this paper
• TGFβ-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism

  2018cites this paper
• Unilateral Optic Nerve Aplasia In An Otherwise Normally Developed Eye

  2018cites this paper
• Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure.

  2018cites this paper
• Sonic Hedgehog Is a Remotely Produced Cue that Controls Axon Guidance Trans-axonally at a Midline Choice Point.

  2018cites this paper
• The origins of the circumventricular organs

  2018influential citation
• Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells

  2018cites this paper
• Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis

  2018cites this paper
• Otic Regeneration and Development: Advancement of Stem Cell-Based Methodology for In Vitro Modeling of Mammalian Inner Ear Sensory Epithelia

  2018cites this paper
• The role of the zebrafish tbx5 paralogues during eye, pectoral fin and heart development

  2018cites this paper
• Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure.

  2018cites this paper
• Cranial Pair II: The Optic Nerves

  2018cites this paper
• Independent erosion of conserved transcription factor binding sites points to shared hindlimb, vision and external testes loss in different mammals

  2018cites this paper
• PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells

  2017cites this paper
• VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels

  2017cites this paper
• Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid–Independent Pathway

  2017cites this paper
• Genetic causes of optic nerve hypoplasia

  2017cites this paper
• Retinal axon guidance at the midline: Chiasmatic misrouting and consequences

  2017cites this paper
• Genes and pathways in optic fissure closure.

  2017cites this paper
• From Otic Induction to Hair Cell Production: Pax2EGFP Cell Line Illuminates Key Stages of Development in Mouse Inner Ear Organoid Model

  2017cites this paper
• Complement component C3aR constitutes a novel regulator for chick eye morphogenesis

  2017cites this paper
• Multifunctional glial support by Semper cells in the Drosophila retina

  2017cites this paper
• A Study of Effect of Consanguinity on Cochlear Morphology in Patients with Congenital Bilateral Profound Sensorineural Hearing Loss

  2017cites this paper
• The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk

  2017cites this paper
• Molecular guidance cues in the development of visual pathway

  2017cites this paper
• Deep Homology?: Uncanny Similarities of Humans and Flies Uncovered by Evo-Devo

  2017cites this paper
• A systems-level approach reveals new gene regulatory modules in the developing ear

  2017cites this paper
• Pax2/Pax8-defined subdomains and the occurrence of apoptosis in the posterior placodal area of mice

  2017cites this paper
• TGFβ mediated structural remodeling facilitates optic fissure fusion and the necessity of BMP antagonism in this process

  2017cites this paper
• Frizzled 3 acts upstream of Alcam during embryonic eye development.

  2017cites this paper
• Optic fissure margin morphogenesis sets the stage for consecutive optic fissure fusion, pioneered by a distinct subset of margin cells using a hyaloid vessel as scaffold

  2017cites this paper
• Independent erosion of conserved transcription factor binding sites points to shared hindlimb, vision, and scrotum loss in different mammals

  2017cites this paper
• Understanding the Structural and Developmental Aspect of Simple Eye of Drosophila: The Ocelli

  2017cites this paper
• The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.

  2016cites this paper
• Pet-1 Switches Transcriptional Targets Postnatally to Regulate Maturation of Serotonin Neuron Excitability

  2016cites this paper
• Involvement of pax2 in ovarian development and recrudescence of catfish: a role in steroidogenesis.

  2016cites this paper
• Characterizing the Structure and Function of the Cytoplasmic Domains of Ptch1

  2016cites this paper
• The role of Gata3 in the functional development of cochlear hair cells

  2016cites this paper
• Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling

  2016influential citation
• Sox2 in the differentiation of cochlear progenitor cells

  2016cites this paper