The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cell

• Publication date

  2006-02-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CELL.2006.01.021PMID 16469705
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reactive Oxygen Species Promote TNF -Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

  2005cited by this paper
• c-FLIPR, a New Regulator of Death Receptor-induced Apoptosis*

  2005cited by this paper
• Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.

  2005cited by this paper
• Linking JNK signaling to NF-κB: a key to survival

  2004cited by this paper
• Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation.

  2004cited by this paper
• Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch

  2004cited by this paper
• The proteasome: a suitable antineoplastic target

  2004cited by this paper
• Tumor necrosis factor: an apoptosis JuNKie?

  2004cited by this paper
• Linking JNK signaling to NF-kappaB: a key to survival.

  2004cited by this paper
• Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species.

  2004cited by this paper
• Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction.

  2004cited by this paper
• Ferritin Heavy Chain Upregulation by NF- B Inhibits TNF -Induced Apoptosis by Suppressing Reactive Oxygen Species

  2004cited by this paper
• The ubiquitin system: pathogenesis of human diseases and drug targeting.

  2004cited by this paper
• c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis

  2004cited by this paper
• IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha.

  2003cited by this paper
• JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.

  2003cited by this paper
• Tumor necrosis factor signaling

  2003cited by this paper
• Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.

  2003cited by this paper
• A JNK-dependent pathway is required for TNFalpha-induced apoptosis.

  2003cited by this paper
• A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

  2003cited by this paper
• IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

  2003cited by this paper
• Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

  2002cited by this paper
• Macrophage Apoptosis by Anthrax Lethal Factor Through p38 MAP Kinase Inhibition

  2002cited by this paper
• Polymorphisms of tumour necrosis factors A and B in breast cancer.

  2002cited by this paper
• NF-kappaB at the crossroads of life and death.

  2002cited by this paper
• NF-κB at the crossroads of life and death

  2002cited by this paper
• Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

  2001cited by this paper
• Inhibition of JNK activation through NF-kappaB target genes.

  2001cited by this paper
• Regulation of lymphocyte proliferation and death by flip

  2001cited by this paper
• NF-κB Signals Induce the Expression of c-FLIP

  2001cited by this paper
• FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis

  2001cited by this paper
• Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

  2001cited by this paper
• Inhibition of JNK activation through NF-κB target genes

  2001cited by this paper
• Cellular FLICE-inhibitory Protein Splice Variants Inhibit Different Steps of Caspase-8 Activation at the CD95 Death-inducing Signaling Complex*

  2001cited by this paper
• Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.

  2000cited by this paper
• CD95's deadly mission in the immune system

  2000cited by this paper
• Up‐regulation of c‐FLIPshort and reduction of activation‐induced cell death in CD28‐co‐stimulated human T cells

  2000cited by this paper
• TCR-Mediated Up-Regulation of c-FLIPshort Correlates with Resistance Toward CD95-Mediated Apoptosis by Blocking Death-Inducing Signaling Complex Activity1

  2000cited by this paper
• Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.

  2000cited by this paper
• Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.

  2000cited by this paper
• The JNKK2-JNK1 Fusion Protein Acts As a Constitutively Active c-Jun Kinase That Stimulates c-Jun Transcription Activity*

  1999cited by this paper
• A Third-Generation Lentivirus Vector with a Conditional Packaging System

  1998cited by this paper
• NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

  1998cited by this paper
• Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.

  1998cited by this paper
• Inhibition of death receptor signals by cellular FLIP

  1997cited by this paper
• Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

  1996cited by this paper
• Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death.

  1996cited by this paper
• Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.

  1994cited by this paper
• A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

  1992cited by this paper
• Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death.

  1974cited by this paper

• Review Article: Efficacy and Safety of JNK Inhibitors in Cancer Therapy.

  2025cites this paper
• The Role of Post-Translational Modifications in Necroptosis

  2025cites this paper
• Role and therapeutic potential of the NEDD4 family in breast cancer

  2025cites this paper
• The Association Between Serum Gamma‐Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systematic Review and Meta‐Analysis

  2025cites this paper
• Selective genetic inactivation of Caspase 8 in hepatocytes ameliorates progression of MASH following Jnk deficiency.

  2025cites this paper
• Biological Functions and Clinical Implications of CFLAR: From Cell Death Mechanisms to Therapeutic Targeting in Immune Regulation

  2025cites this paper
• Oxidative complexity: The role of ROS in the tumor environment and therapeutic implications.

  2025cites this paper
• Linear ubiquitination of p31comet by HOIP couples cytokine response with mitotic regulation

  2025cites this paper
• Significance of Necroptosis in Cartilage Degeneration

  2024cites this paper
• The Identification of New c-FLIP Inhibitors for Restoring Apoptosis in TRAIL-Resistant Cancer Cells

  2024cites this paper
• Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death

  2024cites this paper
• The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation

  2024cites this paper
• The Crosstalk of Apoptotic and Non-Apoptotic Signaling in CD95 System

  2024cites this paper
• A matter of new life and cell death: programmed cell death in the mammalian ovary

  2024cites this paper
• Ubiquitination and Metabolic Disease.

  2024cites this paper
• Parkinson’s disease models and death signaling: what do we know until now?

  2024cites this paper
• Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity

  2024cites this paper
• Hepatocyte programmed cell death: the trigger for inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis

  2024cites this paper
• Mechanisms of Cytotoxicity in Six Classes of Ionic Liquids: Evaluating Cell Cycle Impact and Genotoxic and Apoptotic Effects.

  2024cites this paper
• Adaptor protein Abelson interactor 1 in homeostasis and disease

  2024cites this paper
• Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis.

  2023cites this paper
• Chirality-Dependent Reprogramming of Macrophages by Chiral Nanozymes.

  2023cites this paper
• GSK3β/ITCH/c-FLIP Axis Counteracts TRAIL-induced Apoptosis in Human Lung Adenocarcinoma Cells.

  2023cites this paper
• The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis

  2023cites this paper
• JNK Cascade-Induced Apoptosis—A Unique Role in GqPCR Signaling

  2023cites this paper
• UBE4B interacts with the ITCH E3 ubiquitin ligase to induce Ku70 and c-FLIPL polyubiquitination and enhanced neuroblastoma apoptosis

  2023cites this paper
• JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1.

  2023cites this paper
• Regulation of apoptosis by ubiquitination in liver cancer.

  2023cites this paper
• Entanglement of MAPK pathways with gene expression and its omnipresence in the etiology for cancer and neurodegenerative disorders.

  2023cites this paper
• Titanium dioxide nanoparticles: revealing the mechanisms underlying hepatotoxicity and effects in the gut microbiota

  2023cites this paper
• The roles of E3 ubiquitin ligases in cancer progression and targeted therapy

  2023cites this paper
• Role of Necroptosis in Intervertebral Disc Degeneration

  2023cites this paper
• Roles of immune dysregulation in MASLD.

  2023cites this paper
• Genome-wide characterization of the U-box gene in Camellia sinensis and functional analysis in transgenic tobacco under abiotic stresses.

  2023cites this paper
• Necroptosis in the pathophysiology of preeclampsia

  2023cites this paper
• Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation

  2023cites this paper
• Role of Oxidative Stress in Liver Disorders

  2022cites this paper
• Triptolide-mediated downregulation of FLIPS in hepatoma cells occurs at the post-transcriptional level independently of proteasome-mediated pathways

  2022cites this paper
• The Emerging Role of Deubiquitinases in Cell Death

  2022cites this paper
• The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response

  2022cites this paper
• Crystallographic mining of ASK1 regulators to unravel the intricate PPI interfaces for the discovery of small molecule

  2022cites this paper
• Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1

  2022cites this paper
• Re-establishing the comprehension of phytomedicine and nanomedicine in inflammation-mediated cancer signaling.

  2022cites this paper
• The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis

  2022cites this paper
• H5N1 infection impairs the alveolar epithelial barrier through intercellular junction proteins via Itch-mediated proteasomal degradation

  2022cites this paper
• Osteocalcin reduces fat accumulation and inflammatory reaction by inhibiting ROS-JNK signal pathway in chicken embryonic hepatocytes

  2022cites this paper
• Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors

  2022cites this paper
• Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer

  2022cites this paper
• cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells

  2022cites this paper
• Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition

  2022cites this paper
• The emerging roles of E3 ubiquitin ligases in ovarian cancer chemoresistance

  2021cites this paper
• Analysis of miRNAs Profiles in Serum of Patients With Steatosis and Steatohepatitis

  2021cites this paper
• IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1+/- mice display increases atherosclerotic plaque stability

  2021cites this paper
• Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells

  2021cites this paper
• LUBAC Suppresses IL-21-Induced Apoptosis in CD40-Activated Murine B Cells and Promotes Germinal Center B Cell Survival and the T-Dependent Antibody Response

  2021cites this paper
• ADVANCED PRECLINICAL MODELS FOR EVALUATION OF DRUG INDUCED LIVER INJURY - CONSENSUS STATEMENT BY THE EUROPEAN DRUG-INDUCED LIVER INJURY NETWORK [PRO-EURO-DILI-NET].

  2021cites this paper
• Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins

  2021cites this paper
• The E3 protein ubiquitin ligase Itch is a potential target in myeloid malignancies with marrow fibrosis

  2021cites this paper
• Hydrogen gas alleviates acute alcohol-induced liver injury by inhibiting JNK activation

  2021cites this paper
• Emerging roles of the HECT-type E3 ubiquitin ligases in hematological malignancies

  2021cites this paper
• MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL

  2021cites this paper
• Complement-5 Inhibition Deters Progression of Fulminant Hepatitis to Acute Liver Failure in Murine Models

  2021cites this paper
• Protein Kinase-Mediated Decision Between the Life and Death.

  2021cites this paper
• Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks.

  2021cites this paper
• Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma

  2021cites this paper
• JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin–Proteasome–Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells

  2021cites this paper
• The role of necroptosis in disease and treatment

  2021cites this paper
• Preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer

  2021cites this paper
• TAK1: A Molecular Link Between Liver Inflammation, Fibrosis, Steatosis, and Carcinogenesis

  2021cites this paper
• Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury

  2021cites this paper
• H2O2 mediated FLIP and XIAP down-regulation involves increased ITCH expression and ERK-Akt crosstalk in Imatinib resistant Chronic Myeloid Leukemia cell line K562.

  2021cites this paper
• RORγt protein modifications and IL-17-mediated inflammation.

  2021cites this paper
• Impact of Acute Inflammation on the Survival Outcomes of Patients with Resected Pancreatic Ductal Adenocarcinoma

  2021cites this paper
• Prognostic Impact of Pre- and Post-operative P-CRP Levels in Pancreatic Cancer Patients.

  2020cites this paper
• ITCH as a potential therapeutic target in human cancers.

  2020cites this paper
• Hepatocyte Apoptosis

  2020cites this paper
• JNK/p66Shc/ITCH Signaling Pathway Mediates Angiotensin II-induced Ferritin Degradation and Labile Iron Pool Increase

  2020cites this paper
• Hormones of Programmed Cell Death

  2020cites this paper
• ASK1 inhibition: a therapeutic strategy with multi-system benefits

  2020cites this paper
• Targeting apoptotic caspases in cancer.

  2020cites this paper
• Understanding MAPK Signaling Pathways in Apoptosis

  2020cites this paper
• Hypo-Expression of Flice-Inhibitory Protein and Activation of the Caspase-8 Apoptotic Pathways in the Death-Inducing Signaling Complex Due to Ischemia Induced by the Compression of the Asphyxiogenic Tool on the Skin in Hanging Cases

  2020cites this paper
• Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

  2020cites this paper
• Functional and molecular effects of TNF-α on human iPSC-derived cardiomyocytes

  2020cites this paper
• CCT128930 induces G1-phase arrest and apoptosis and synergistically enhances the anticancer efficiency of VS5584 in human osteosarcoma cells.

  2020cites this paper
• Si-Wu-Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4-JNK and Caspase-8-GSDMD Signaling Pathways

  2020cites this paper
• Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

  2020cites this paper
• The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

  2020cites this paper
• Cracking the Monoubiquitin Code of Genetic Diseases

  2020cites this paper
• Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells

  2020cites this paper
• Suppression of TRPM7 enhances TRAIL‐induced apoptosis in triple‐negative breast cancer cells

  2020cites this paper
• Controlling Cell Death through Post-translational Modifications of DED Proteins.

  2020cites this paper
• NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX

  2020cites this paper
• Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors

  2019cites this paper
• Chapter 4 Linking Obesity and Pancreatic Cancer

  2019cites this paper
• Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation

  2019cites this paper
• WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP

  2019cites this paper
• The many faces of tumor necrosis factor signaling in the intestinal epithelium

  2019cites this paper
• HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

  2019cites this paper
• HECT-Type E3 Ubiquitin Ligases in Cancer.

  2019cites this paper