Binding to F-actin guides cadherin cluster assembly, stability, and movement

Binding of cadherin to F-actin cooperates with the cadherin cis-interface to stabilize cadherin adhesion clusters and is required for their directional movement.

• Publication year

  2013

• Venue

  Journal of Cell Biology

• Publication date

  2013-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201211054PMID 23547031PMCID 3613698
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dimer asymmetry defines α-catenin interactions

  2013cited by this paper
• Adherens junction assembly.

  2012cited by this paper
• Thinking outside the cell: how cadherins drive adhesion.

  2012cited by this paper
• Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping

  2011cited by this paper
• Cadherin-actin interactions at adherens junctions.

  2011cited by this paper
• The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins.

  2011influential reference
• Cadherin exits the junction by switching its adhesive bond

  2011influential reference
• Ajuba is required for Rac activation and maintenance of E-cadherin adhesion

  2011cited by this paper
• Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation.

  2011cited by this paper
• Large-scale opening of utrophin’s tandem calponin homology (CH) domains upon actin binding by an induced-fit mechanism

  2011cited by this paper
• In vitro and in vivo reconstitution of the cadherin–catenin–actin complex from Caenorhabditis elegans

  2010cited by this paper
• Two-step adhesive binding by classical cadherins

  2010cited by this paper
• Spontaneous assembly and active disassembly balance adherens junction homeostasis

  2010influential reference
• Cooperativity between trans and cis interactions in cadherin-mediated junction formation

  2010influential reference
• Integrins in cell migration – the actin connection

  2009cited by this paper
• Endocytosis is required for E-cadherin redistribution at mature adherens junctions

  2009cited by this paper
• A two-tiered mechanism for stabilization and immobilization of E-cadherin

  2008cited by this paper
• Regulation of cell-cell adhesion by the cadherin-catenin complex.

  2008cited by this paper
• Inaugural Article: EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt

  2008cited by this paper
• Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions

  2007cited by this paper
• Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion.

  2007cited by this paper
• Basal-to-apical cadherin flow at cell junctions

  2007cited by this paper
• Nucleation and growth of cadherin adhesions.

  2007cited by this paper
• Regulation of cell-cell junctions by the cytoskeleton.

  2006influential reference
• Direct Interaction of the C-Terminal Domain of α-Catenin and F-Actin is Necessary for Stabilized Cell-Cell Adhesion

  2006influential reference
• Endocytosis of cadherin from intracellular junctions is the driving force for cadherin adhesive dimer disassembly.

  2006cited by this paper
• Regulation of cadherin-mediated adhesion in morphogenesis

  2005cited by this paper
• Actin at cell-cell junctions is composed of two dynamic and functional populations

  2005cited by this paper
• Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex.

  2005cited by this paper
• Crystal structure of human vinculin.

  2004cited by this paper
• Force measurements in E-cadherin–mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42

  2004cited by this paper
• Structural basis for vinculin activation at sites of cell adhesion

  2004cited by this paper
• Cadherin function probed by laser tweezer and single molecule fluorescence in vascular endothelial cells

  2003cited by this paper
• Both the dimerization and immunochemical properties of E-cadherin EC1 domain depend on Trp(156) residue.

  2002cited by this paper
• Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton

  2002influential reference
• Biochemical and Structural Definition of the l-Afadin- and Actin-binding Sites of α-Catenin*

  2002influential reference
• The Actin-Driven Movement and Formation of Acetylcholine Receptor Clusters

  2000cited by this paper
• Directed actin polymerization is the driving force for epithelial cell-cell adhesion.

  2000cited by this paper
• Structural comparison of actin binding in utrophin and dystrophin

  2000influential reference
• Functional Domains of α-Catenin Required for the Strong State of Cadherin-based Cell Adhesion

  1999cited by this paper
• Mobility and cytoskeletal interactions of cell adhesion receptors.

  1999cited by this paper
• Cytoplasmic Regulation of the Movement of E-Cadherin on the Free Cell Surface as Studied by Optical Tweezers and Single Particle Tracking: Corralling and Tethering by the Membrane Skeleton

  1998cited by this paper
• Mechanisms of Epithelial Cell–Cell Adhesion and Cell Compaction Revealed by High-resolution Tracking of E-Cadherin– Green Fluorescent Protein

  1998cited by this paper
• Identification of the Region of α-Catenin That Plays an Essential Role in Cadherin-mediated Cell Adhesion*

  1998cited by this paper
• α-Catenin-Vinculin Interaction Functions to Organize the Apical Junctional Complex in Epithelial Cells

  1998cited by this paper
• An alpha-E-catenin gene trap mutation defines its function in preimplantation development.

  1997cited by this paper
• Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function.

  1997cited by this paper
• Mechanism for transition from initial to stable cell-cell adhesion: kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay

  1996cited by this paper
• The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules

  1994cited by this paper
• Effects of cytochalasin and phalloidin on actin

  1987cited by this paper

• Ground-state pluripotent stem cells are characterized by Rac1-dependent Cadherin-enriched F-actin Complexes.

  2025cites this paper
• The role of aging on endothelial cell–cell junctions and pulmonary microvascular permeability in male mice

  2025cites this paper
• Paths to stability – actin regulation of adherens junction mechanics

  2025cites this paper
• Heterotypic intercellular adhesion tunes efficiency of cell-on-cell migration

  2025cites this paper
• β-catenin condensation facilitates clustering of the cadherin/catenin complex and formation of nascent cell-cell junctions

  2025cites this paper
• Actin-dependent α-catenin oligomerization contributes to adherens junction assembly

  2025cites this paper
• Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery

  2024cites this paper
• Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature

  2024cites this paper
• Characterization of early and late events of adherens junction assembly

  2024cites this paper
• Steroid hormone signaling synchronizes cell migration machinery, adhesion, and polarity to direct collective movement.

  2024cites this paper
• Computational and Experimental Approaches to Quantify Protein Binding Interactions Under Confinement.

  2024cites this paper
• Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts

  2023cites this paper
• Localization of Cadherins in the postnatal cochlear epithelium and their relation to space formation

  2023cites this paper
• Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation

  2023cites this paper
• Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea.

  2023cites this paper
• Actin polymerization and depolymerization in developing vertebrates

  2023cites this paper
• Push-pull mechanics of E-cadherin ectodomains in biomimetic adhesions.

  2023cites this paper
• Mechanics of cell-cell junctions

  2023cites this paper
• Ground-state pluripotent stem cells are characterized by Rac1-dependent Cadherin-enriched F-actin protrusions

  2023cites this paper
• APC-driven actin nucleation powers collective cell dynamics in colorectal cancer cells

  2023cites this paper
• Force-dependent intercellular adhesion strengthening underlies asymmetric adherens junction contraction.

  2022cites this paper
• Adherens junction: the ensemble of specialized cadherin clusters.

  2022cites this paper
• Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion

  2022cites this paper
• E-cadherin/HMR-1 and PAR-3 break symmetry at stable cell contacts in a developing epithelium

  2022cites this paper
• Respiratory syncytial virus disrupts the airway epithelial barrier by decreasing cortactin and destabilizing F-actin

  2022cites this paper
• Role of actin filaments and cis binding in cadherin clustering and patterning

  2022influential citation
• Force-dependent intercellular adhesion strengthening underlies asymmetric adherens junction contraction.

  2022cites this paper
• Organoid‐Based Human Stomach Micro‐Physiological System to Recapitulate the Dynamic Mucosal Defense Mechanism

  2022cites this paper
• Cortical Tension Initiates the Positive Feedback Loop between Cadherin and F-actin.

  2022cites this paper
• Tension-dependent stabilization of E-cadherin limits cell–cell contact expansion in zebrafish germ-layer progenitor cells

  2022cites this paper
• Direct interaction of Sox10 with cadherin-19 mediates early sacral neural crest cell migration: implications for enteric nervous system development defects.

  2021cites this paper
• Sorting of cadherin–catenin-associated proteins into individual clusters

  2021cites this paper
• Mechanical processes underlying precise and robust cell matching.

  2021cites this paper
• P120 catenin potentiates constitutive E-cadherin dimerization at the plasma membrane and regulates trans binding.

  2021cites this paper
• Vascular Dysfunction after Modeled Traumatic Brain Injury Is Preserved with Administration of Umbilical Cord Derived Mesenchymal Stromal Cells and Is Associated with Modulation of the Angiogenic Response

  2021cites this paper
• Cadherin cis and trans interactions are mutually cooperative

  2021cites this paper
• Cortical Tension Initiates the Positive Feedback Loop Between E-cadherin and F-actin

  2021influential citation
• Asymmetric Contraction of Adherens Junctions arises through RhoA and E-cadherin feedback

  2021cites this paper
• The Adaptor Protein Lurap1 Is Required for Cell Cohesion during Epiboly Movement in Zebrafish

  2021cites this paper
• Immunolocalization of protease-activated receptors in endothelial cells of splenic sinuses

  2021cites this paper
• Influence of Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 on Epithelial Differentiation and Organization During Lung Development.

  2020cites this paper
• Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions

  2020cites this paper
• Cadherin clustering controls heterogeneous, asymmetric junction dynamics during vertebrate axis elongation

  2020cites this paper
• EGF and a GSK3 Inhibitor Deplete Junctional E-cadherin and Stimulate Proliferation in the Mature Mammalian Ear

  2020cites this paper
• Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function

  2020cites this paper
• The multifarious regulation of the apical junctional complex

  2020cites this paper
• Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity

  2020cites this paper
• Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion

  2020cites this paper
• Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

  2020cites this paper
• Estrogens Determine Adherens Junction Organization and E-Cadherin Clustering in Breast Cancer Cells via Amphiregulin

  2020cites this paper
• Dimerization mechanism and structural features of human LI-cadherin

  2020cites this paper
• Actin protrusions push on E-cadherin to maintain epithelial cell-cell adhesion

  2019cites this paper
• mDia2 formin selectively interacts with catenins and not E-cadherin to regulate Adherens Junction formation

  2019cites this paper
• Cadherin Extracellular Domain Clustering in the Absence of Trans-Interactions.

  2019cites this paper
• DISTINCT ACTIN-DEPENDENT NANOSCALE ASSEMBLIES UNDERLIE THE DYNAMIC AND HIERARCHICAL ORGANIZATION OF E-CADHERIN

  2019cites this paper
• Vinculin anchors contractile actin to the cardiomyocyte adherens junction

  2019cites this paper
• The Adherens Junction Interactome and the Role of Vinculin in Cytoskeletal Integration at the Cardiomyocyte ICD

  2019cites this paper
• Actin protrusions push at apical junctions to maintain E-cadherin adhesion

  2019cites this paper
• Purinergic receptor (P2X7) activation reduces cell-cell adhesion between tubular epithelial cells of the proximal kidney.

  2019cites this paper
• Dose and Timing of N‐Cadherin Mimetic Peptides Regulate MSC Chondrogenesis within Hydrogels

  2018cites this paper
• Spatial and temporal organization of cadherin in punctate adherens junctions

  2018cites this paper
• Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers

  2018cites this paper
• Persistent disruption of lateral junctional complexes and actin cytoskeleton in parotid salivary glands following radiation treatment

  2018cites this paper
• Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin

  2018cites this paper
• Mechanical forces in cell monolayers

  2018cites this paper
• Adhesion of Biological Membranes

  2018cites this paper
• Spatial and Mechanical Aspects of Signal Transduction in the Cell Membrane

  2018cites this paper
• Evaluating Mechanisms of Metastasis of Prostate Cancer to Bone Using 3D Bone-Mimetic Tissue Engineered Scaffolds

  2018cites this paper
• Myosin Light Chain Phosphatase regulates the transcription of Wingless target genes in Drosophila

  2017cites this paper
• Integrating regulatory mechanisms of Wnt signaling in development and tissue homeostasis

  2017influential citation
• Actomyosin contractility modulates Wnt signaling through adherens junction stability

  2017cites this paper
• Corrigendum: Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions

  2017cites this paper
• CD82 membrane scaffolding regulates hematopoietic cell functions

  2017influential citation
• Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability.

  2017cites this paper
• Cadherin-mediated cell-cell interactions in normal and cancer cells

  2017cites this paper
• Mechanobiology of collective cell behaviours

  2017cites this paper
• WAVE regulates Cadherin junction assembly and turnover during epithelial polarization.

  2017cites this paper
• The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids.

  2017cites this paper
• Tension (re)builds: Biophysical mechanisms of embryonic wound repair.

  2017cites this paper
• Corrigendum: Defining functional interactions during biogenesis of epithelial junctions

  2017cites this paper
• Emerging Mechanisms and Roles for Asymmetric Cytokinesis.

  2017cites this paper
• Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin

  2017cites this paper
• Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions.

  2017influential citation
• E‐cadherin expression increases cell proliferation by regulating energy metabolism through nuclear factor‐κB in AGS cells

  2017cites this paper
• Cadherin de-adhesion: consequences and mechanisms

  2017influential citation
• Membrane fluctuations mediate lateral interaction between cadherin bonds

  2017cites this paper
• Understanding the mechanisms underlying force transmission during epithelial cell division

  2016cites this paper
• Correction to Supporting Information for Biswas et al., E-cadherin junction formation involves an active kinetic nucleation process

  2016cites this paper
• Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions

  2016cites this paper
• Defining functional interactions during biogenesis of epithelial junctions

  2016cites this paper
• Analysis of DDR1 function at epithelial cell contacts

  2016cites this paper
• Chapter 11 – Signal Transduction to and from Adhesion Molecules

  2016cites this paper
• Regulation of Cadherin–Catenin Biology by Mechanical Force and Phosphorylation

  2016cites this paper
• The Molecular Architecture of Cell–Cell Adhesions

  2016cites this paper
• Cell-cell adhesion and the cytoskeleton

  2016cites this paper
• Analyse fonctionnelle de la protéine CRB3 in vivo

  2016cites this paper
• CDH1/E-cadherin and solid tumors. An updated gene-disease association analysis using bioinformatics tools

  2016cites this paper
• Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation.

  2016cites this paper
• Actin Rings of Power.

  2016cites this paper
• A phenomenological model of cell–cell adhesion mediated by cadherins

  2016cites this paper