An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold

M. Gómez-Gonzalo,G. Losi,A. Chiavegato,Micaela Zonta,Mario Cammarota,M. Brondi,Francesco Vetri,L. Uva,T. Pozzan,M. de Curtis,G. Ratto,G. Carmignoto

Published 2010 in PLoS Biology

ABSTRACT

Studies in rodent brain slices suggest that seizures in focal epilepsies are sustained and propagated by the reciprocal interaction between neurons and astroglial cells

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