Utility of Intracranial Self-Stimulation in the Assessment of the Abuse Liability of New Pharmaceuticals

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/B978-0-12-420172-9.00008-4
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Intracranial Self-Stimulation to Evaluate Abuse Potential of Drugs

  2014cited by this paper
• Tramadol acts as a weak reinforcer in the rat self-administration model, consistent with its low abuse liability in humans.

  2010cited by this paper
• Using a rate-frequency curve method to assess the rewarding properties of morphine in the intracranial self-stimulation paradigm in rats.

  2010cited by this paper
• Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation

  2007cited by this paper
• Lack of evidence for appetitive effects of Δ9-tetrahydrocannabinol in the intracranial self-stimulation and conditioned place preference procedures in rodents

  2007cited by this paper
• Relative Reinforcing Effects of Cocaine, Remifentanil, and Their Combination in Rhesus Monkeys

  2006cited by this paper
• Facilitation of brain stimulation reward byΔ9-tetrahydrocannabinol

  2006cited by this paper
• Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human

  2005cited by this paper
• Phencyclidine-induced potentiation of brain stimulation reward: acute effects are not altered by repeated administration

  2005cited by this paper
• Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats

  2004cited by this paper
• A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time.

  2004cited by this paper
• A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.

  2004cited by this paper
• Neuroadaptive effects of active versus passive drug administration in addiction research.

  2003cited by this paper
• Incorporating the assessment of abuse liability into the drug discovery and development process.

  2003cited by this paper
• Facilitation of electrical brain self-stimulation behavior by abused solvents.

  2003cited by this paper
• Guidelines and methodological reviews concerning drug abuse liability assessment.

  2003cited by this paper
• Abuse liability assessment of CNS drugs: conclusions, recommendations, and research priorities.

  2003cited by this paper
• Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat

  2003cited by this paper
• Principles of drug abuse liability assessment in laboratory animals.

  2003cited by this paper
• Repeated Exposure to Rewarding Brain Stimulation Downregulates GluR1 Expression in the Ventral Tegmental Area

  2001cited by this paper
• Effects of abused drugs on thresholds and breaking points of intracranial self-stimulation in rats.

  1999cited by this paper
• Memantine does not substantially affect brain stimulation reward: comparison with MK-801.

  1999cited by this paper
• Evaluation of the reinforcing properties and phencyclidine-like discriminative stimulus effects of dextromethorphan and dextrorphan in rats and rhesus monkeys

  1999cited by this paper
• Drug-activation of brain reward pathways.

  1998cited by this paper
• Effect of chronic nicotine on brain stimulation reward. I. Effect of daily injections.

  1998cited by this paper
• Evaluation of the reinforcing and discriminative stimulus properties of the low-affinity N-methyl-D-aspartate channel blocker memantine.

  1998cited by this paper
• Addictive drugs and brain stimulation reward.

  1996cited by this paper
• Butorphanol: characterization of agonist and antagonist effects in rhesus monkeys.

  1995cited by this paper
• Brain-stimulation reward: a model for the study of the rewarding effects of abused drugs.

  1992cited by this paper
• Effects of nicotine on the threshold for rewarding brain stimulation in rats.

  1992cited by this paper
• Bromocriptine reverses the elevation in intracranial self-stimulation thresholds observed in a rat model of cocaine withdrawal.

  1992cited by this paper
• Schedule-controlled brain self-stimulation: has it utility for behavioral pharmacology?

  1992cited by this paper
• The intravenous self-administration of antihistamines by rhesus monkeys.

  1992cited by this paper
• "Temporal summation decay" in hypothalamic self-stimulation: threshold changes at long intrapair intervals due to axonal subnormal periods.

  1990cited by this paper
• The self-administration of MK-801 can depend upon drug-reinforcement history, and its discriminative stimulus properties are phencyclidine-like in rhesus monkeys.

  1990cited by this paper
• Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.

  1989cited by this paper
• Two substrates for medial forebrain bundle self-stimulation: myelinated axons and dopamine axons.

  1989cited by this paper
• The discovery of self-stimulation and other stories.

  1989cited by this paper
• Caffeine elevates reinforcement threshold for electrical brain stimulation: tolerance and withdrawal changes.

  1988cited by this paper
• Brain stimulation reward: effects of ethanol.

  1988cited by this paper
• Ethanol and current thresholds for brain self-stimulation in the lateral hypothalamus of the rat.

  1987cited by this paper
• Fitting intracranial self-stimulation data with growth models.

  1987cited by this paper
• Some behavioral effects of histamine H1 antagonists in squirrel monkeys.

  1986cited by this paper
• The Neurobiology of Motivation and Reward

  1985cited by this paper
• Auto-titration technique using intracranial self-stimulation and effects of antianxiety drugs.

  1985cited by this paper
• Review of self-administration.

  1985cited by this paper
• Brain-stimulation reward: a model for the neuronal bases for drug-induced euphoria.

  1985cited by this paper
• Tripelennamine: enhancement of brain-stimulation reward.

  1984cited by this paper
• Effects of peripheral and central dopamine blockade on lateral hypothalamic self-stimulation: evidence for both reward and motor deficits.

  1983cited by this paper
• Discriminating between reward and performance: a critical review of intracranial self-stimulation methodology.

  1983cited by this paper
• Self-administration of nalbuphine, butorphanol and pentazocine by morphine post-addict rats.

  1982cited by this paper
• Behavioral pharmacology of local anesthetics: reinforcing and discriminative stimulus effects.

  1982cited by this paper
• Euphorigenic drugs: effects on the reward pathways of the brain.

  1979cited by this paper
• Free-operant and auto-titration brain self-stimulation procedures in the rat: a comparison of drug effects.

  1979cited by this paper
• A summary of the results of a drug self-administration study using substitution procedures in rhesus monkeys.

  1978cited by this paper
• The search for a nonaddicting analgesic: has it been worth it? The twenty-third Oscar B. Hunter Memorial Award in Therapeutics lecture.

  1977cited by this paper
• Catecholamines and self-stimulation: evidence suggesting a reinforcing role for noradrenaline and a motivating role for dopamine.

  1976cited by this paper
• Mazindol self-administration in the rhesus monkey.

  1976cited by this paper
• Parametric analysis of brain stimulation reward in the rat: III. Effect of performance variables on the reward summation function.

  1974cited by this paper
• Self-Stimulation of the Brain

  1958cited by this paper
• Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.

  1954cited by this paper

• NLX-112, a highly selective 5-HT1A receptor biased agonist, does not exhibit misuse potential in male rats or macaques.

  2022cites this paper
• Effects of Acute and Repeated Administration of Oxycodone and Naloxone-Precipitated Withdrawal on Intracranial Self-Stimulation in Rats

  2016cites this paper