A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Drug Metabolism And Disposition

• Publication date

  2004-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/DMD.32.6.603PMID 15155551
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacokinetics of droloxifene in mice, rats, monkeys, premenopausal and postmenopausal patients

  2010cited by this paper
• Dose-dependent kinetics of the enantiomers of MK-571, an LTD4-receptor antagonist

  2005cited by this paper
• Pharmacokinetics and hemostasis following administration of a new, injectable oxacephem (6315-S, flomoxef) in volunteers and in patients with renal insufficiency

  2005cited by this paper
• Pharmacokinetics of vincristine, vinblastine, and vindesine in rhesus monkeys

  2004cited by this paper
• Pharmacokinetics of ketorolac tromethamine in humans after intravenous, intramuscular and oral administration

  2004cited by this paper
• Pharmacokinetics and tolerance of a new penem antibiotic, FCE 22101, in healthy volunteers after a single intravenous dose

  2004cited by this paper
• Influence of the cardioprotective agent dexrazoxane on doxorubicin pharmacokinetics in the dog

  2004cited by this paper
• Interspecies scaling of biliary excreted drugs.

  2002cited by this paper
• Comparison of Oral Absorption and Bioavailability of Drugs Between Monkey and Human

  2002cited by this paper
• SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: In vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man

  2002cited by this paper
• Clinical Pharmacokinetics of Fluvastatin

  2001cited by this paper
• Comparison of cefepime pharmacokinetics in neonatal foals and adult dogs.

  2001cited by this paper
• Pharmacokinetics and interspecies scaling of a novel VEGF receptor inhibitor, SU5416

  2001cited by this paper
• Disposition of radiolabeled ifetroban in rats, dogs, monkeys, and humans.

  2000cited by this paper
• Evaluation of Using Dog as an Animal Model to Study the Fraction of Oral Dose Absorbed of 43 Drugs in Humans

  2000cited by this paper
• Effect of streptozotocin-induced hyperglycaemia on intravenous pharmacokinetics and acute cardiotoxicity of doxorubicin in rats.

  2000cited by this paper
• Pharmacokinetics and cardiopulmonary effects of fentanyl in isoflurane-anesthetized rhesus monkeys (Macaca mulatta).

  2000cited by this paper
• Effect of Fluconazole on the Pharmacokinetics of Doxorubicin in Nonhuman Primates

  2000cited by this paper
• Critique of Prospective Allometric Scaling: Does the Emperor Have Clothes?

  2000cited by this paper
• Species differences in oral bioavailability of methotrexate between rats and monkeys.

  2000cited by this paper
• Pharmacokinetics of Intravenous Trovafloxacin in Critically Ill Adults

  2000cited by this paper
• First Time in Human for GV196771: Interspecies Scaling Applied on Dose Selection

  1999cited by this paper
• In vivo and in vitro trimethadione oxidation activity of the liver from various animal species including mouse, hamster, rat, rabbit, dog, monkey and human

  1999cited by this paper
• Allometric issues in drug development.

  1999cited by this paper
• Pharmacokinetics of the 8-methoxyquinolone, moxifloxacin: a comparison in humans and other mammalian species.

  1999cited by this paper
• Interspecies Pharmacokinetic Comparisons and Allometric Scaling of Napsagatran, a Low Molecular Weight Thrombin Inhibitor

  1999cited by this paper
• Pharmacokinetics of ketorolac after intravenous and oral single dose administration in dogs.

  1999cited by this paper
• Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist.

  1999cited by this paper
• Disposition of tiludronate (Skelid) in animals.

  1999cited by this paper
• Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism.

  1999cited by this paper
• The Pharmacokinetics, Safety, and Tolerance of Cefepime Administered as an Intravenous Bolus or as a Rapid Infusion

  1999cited by this paper
• Interspecies pharmacokinetic scaling of a new carbapenem, DA‐1131, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics

  1998cited by this paper
• Pharmacokinetics of Susalimod, a Highly Biliary‐excreted Sulphasalazine Analogue, in Various Species. Nonpredictable Human Clearance by Allometric Scaling

  1998cited by this paper
• Elucidation of Human Amphotericin B Pharmacokinetics: Identification of a New Potential Factor Affecting Interspecies Pharmacokinetic Scaling

  1998cited by this paper
• Correlation of Plasma Clearance of 54 Extensively Metabolized Drugs Between Humans and Rats: Mean Allometric Coefficient of 0.66

  1998cited by this paper
• Animal pharmacokinetics and interspecies scaling of Ro 25-6833 and related (lactamylvinyl)cephalosporins.

  1998cited by this paper
• Interspecies scaling of renally secreted drugs.

  1998cited by this paper
• Animal pharmacokinetics of inogatran, a low‐molecular‐weight thrombin inhibitor with potential use as an antithrombotic drug

  1998cited by this paper
• Disposition of the antipsychotic agent CI-1007 in rats, monkeys, dogs, and human cytochrome P450 2D6 extensive metabolizers. Species comparison and allometric scaling.

  1998cited by this paper
• Prediction of the pharmacokinetic parameters of reduced-dolasetron in man using in vitro-in vivo and interspecies allometric scaling.

  1997cited by this paper
• Pharmacokinetics of CPT-11 in rhesus monkeys

  1997cited by this paper
• Evaluation of dose-dependent pharmacokinetics of cocaethylene and cocaine in conscious dogs.

  1997cited by this paper
• Physiological Parameter Values for Physiologically Based Pharmacokinetic Models

  1997cited by this paper
• The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

  1997cited by this paper
• The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine.

  1996cited by this paper
• Animal Pharmacokinetics and Interspecies Scaling from Animals to Man of Lamifiban, a New Platelet Aggregation Inhibitor

  1996cited by this paper
• Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach.

  1996cited by this paper
• Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin, in rat, dog and primates.

  1996cited by this paper
• Pharmacokinetics of trovafloxacin (CP-99,219), a new quinolone, in rats, dogs, and monkeys

  1996cited by this paper
• Interspecies scaling: predicting clearance of drugs in humans. Three different approaches.

  1996cited by this paper
• Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat.

  1995cited by this paper
• Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates

  1995cited by this paper
• 1-Aminocyclopropanecarboxylic acid: mouse to man interspecies pharmacokinetic comparisons and allometric relationships.

  1995cited by this paper
• Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys.

  1995cited by this paper
• 931-115 Phase I Studies on Inogatran, a New Selective Thrombin Inhibitor

  1995cited by this paper
• The Role of Drug Metabolism in Drug Discovery: A Case Study in the Selection of an Oxytocin Receptor Antagonist for Development

  1995cited by this paper
• Human pharmacokinetics of tiludronate.

  1995cited by this paper
• Interspecies Scaling of Tebufelone Pharmacokinetic Data and Application to Preclinical Toxicology

  1995cited by this paper
• Disposition of ciprofloxacin following intravenous administration in dogs.

  1994cited by this paper
• Pharmacokinetic study of biapenem.

  1994cited by this paper
• Clinical pharmacokinetics of gabapentin.

  1994cited by this paper
• Interspecies Scaling and Pharmacokinetic Parameters of 3TC in Humans

  1994cited by this paper
• Clinical pharmacokinetics of gabapentin

  1994cited by this paper
• Can Allometric Interspecies Scaling be Used to Predict Human Kinetics?

  1994cited by this paper
• Inter-species extrapolation of pharmacokinetic data of three prostacyclin-mimetics.

  1994cited by this paper
• Application of interspecies scaling to the bispyridinium oxime HI-6.

  1994cited by this paper
• Antipyrine and caffeine dispositions in clinically normal dogs and dogs with progressive liver disease.

  1994cited by this paper
• Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat.

  1993cited by this paper
• Pharmacokinetics of a Novel Antiarrhythmic Drug, Actisomide

  1993cited by this paper
• Hemodynamics, biochemical effects, and pharmacokinetics of the renin inhibitor remikiren in healthy human subjects

  1993cited by this paper
• Physiological Parameters in Laboratory Animals and Humans

  1993cited by this paper
• Pharmacokinetics of cocaine in pregnant and nonpregnant rhesus monkeys.

  1993cited by this paper
• Pharmacodynamics and pharmacokinetics of intravenously administered morphine in spontaneously hypertensive and normotensive Wistar-Kyoto rats.

  1992cited by this paper
• Pharmacokinetics of the organic nitrates trans-2-amino-2-methyl-N-(4- nitroxycyclohexylmethyl)-propionamide in dogs, and of 4-(2-nitroxyethyl)-piperidine in dogs and in monkeys.

  1992cited by this paper
• Pharmacokinetic/pharmacodynamic relationship of the duration of vasodilating action of organic mononitrates in rats.

  1992cited by this paper
• High-performance liquid chromatographic determination of the calcium channel blocker nimodipine in monkey plasma.

  1992cited by this paper
• Iloprost. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischaemia and extracorporeal circulation procedures.

  1992cited by this paper
• Prediction of human pharmacokinetics of panipenem-betamipron, a new carbapenem, from animal data

  1992cited by this paper
• Pharmacokinetics of iododoxorubicin in the rat, dog, and monkey.

  1991cited by this paper
• Comparative study of the pharmacokinetics of alfentanil in rabbits, sheep, and dogs.

  1991cited by this paper
• Goodman and Gilman's The Pharmacological Basis of Therapeutics

  1991cited by this paper
• Peripheral Pharmacokinetic Handling and Metabolism of L‐Dopa in the Rat: The Effect of Route of Administration and Carbidopa Pretreatment

  1991cited by this paper
• Animal pharmacokinetics and interspecies scaling of FCE 22101, a penem antibiotic.

  1991cited by this paper
• Pharmacokinetic studies and renal dehydropeptidase stability of the new beta-lactamase inhibitor BRL 42715 in animals

  1991cited by this paper
• Pharmacokinetic interaction between verapamil and metoprolol in the dog. Stereochemical aspects.

  1991cited by this paper
• Pharmacokinetics of 2',3'-dideoxyinosine in monkeys

  1991cited by this paper
• Effect of Age on the Gastrointestinal Absorption of Acyclovir in Rats

  1991cited by this paper
• Interspecies scaling of the pharmacokinetic parameters of coumarin among six different mammalian species.

  1991cited by this paper
• Cocaine inhalation in the rat: pharmacokinetics and cardiovascular response.

  1991cited by this paper
• Pharmacokinetics of 2',3'-dideoxyinosine (BMY-40900), a new anti-human immunodeficiency virus agent, after administration of single intravenous doses to beagle dogs

  1991cited by this paper
• Uptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats: intravenous infusion studies.

  1990cited by this paper
• Nonlinear pharmacokinetics and interconversion of prednisolone and prednisone in rats

  1990cited by this paper
• Prediction of the pharmacokinetics of cefodizime and cefotetan in humans from pharmacokinetic parameters in animals.

  1990cited by this paper
• Comparative pharmacokinetics and interspecies scaling of 3'-azido-3'-deoxythymidine (AZT) in several mammalian species.

  1990cited by this paper
• Species differences in the pharmacokinetics of recainam, a new anti‐arrhythmic drug

  1990cited by this paper
• Interspecies scaling and comparisons in drug development and toxicokinetics.

  1990influential reference
• Interspecies comparison of the pharmacokinetics of aldose reductase inhibitors.

  1990cited by this paper
• Interspecies differences in stereoselective protein binding and clearance of MK-571.

  1990cited by this paper
• Pharmacology and clinical toxicity of 4'-iodo-4'-deoxydoxorubicin: an example of successful application of pharmacokinetics to dose escalation in phase I trials.

  1990cited by this paper
• L‐Dopa pharmacokinetics in plasma and cisternal and lumbar cerebrospinal fluid of monkeys

  1990cited by this paper

• In Vitro Antioxidant Properties of Mitratonic Remedy in Tea Form and In Vivo Protection Against Methanol-Induced Oxidative Stress in Wistar Rats

  2025cites this paper
• Lenacapavir Exhibits Atropisomerism—Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway

  2024cites this paper
• Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: A possible GABAergic transmission intervention

  2024cites this paper
• Prediction of Human Clearance Using In Silico Models with Reduced Bias.

  2024cites this paper
• Combined translational pharmacometrics approach to support the design and conduct of the first‐in‐human study of DWP16001

  2023cites this paper
• Application of the Population Pharmacokinetics Model-Based Approach to the Prediction of Drug–Drug Interaction between Rivaroxaban and Carbamazepine in Humans

  2023influential citation
• In Vivo Pharmacokinetic Analyses of Placental Transfer of Three Drugs of Different Physicochemical Properties in Pregnant Rats.

  2022cites this paper
• A Single Animal Species-Based Prediction of Human Clearance and First-in-Human Dose of Monoclonal Antibodies: Beyond Monkey

  2021cites this paper
• Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19

  2021cites this paper
• Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans

  2021cites this paper
• Interspecies Scaling of Human Clearance and Plasma Trough Exposure for Antisense Oligonucleotides: A Retrospective Analysis of GalNAc3-Conjugated and Unconjugated-Antisense Oligonucleotides

  2021cites this paper
• Toxicokinetics of U-47700, tramadol, and their main metabolites in pigs following intravenous administration: is a multiple species allometric scaling approach useful for the extrapolation of toxicokinetic parameters to humans?

  2021cites this paper
• MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates.

  2021cites this paper
• Humans are animals, but are animals human enough? A systematic review and meta-analysis on interspecies differences in renal drug clearance.

  2020cites this paper
• Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs.

  2020cites this paper
• Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades.

  2020cites this paper
• Dose Finding in Single Dose Studies by Allometric Scaling

  2020cites this paper
• Cocaine vaccine dAd5GNE protects against moderate daily and high-dose “binge” cocaine use

  2020cites this paper
• Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases

  2020cites this paper
• Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source

  2020cites this paper
• A sensitive in vitro performance assay reveals the in vivo drug release mechanisms of long-acting medroxyprogesterone acetate microparticles.

  2020cites this paper
• Application of an Inter-Species Extrapolation Method for the Prediction of Drug Interactions between Propolis and Duloxetine in Humans

  2020cites this paper
• Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs

  2019cites this paper
• In Silico Prediction of Human Intravenous Pharmacokinetic Parameters with Improved Accuracy

  2019cites this paper
• Novel risk assessment of reactive metabolites from discovery to clinical stage.

  2019cites this paper
• Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4).

  2019cites this paper
• Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3

  2019cites this paper
• Animal to human translation: a systematic scoping review of reported concordance rates

  2019cites this paper
• Evaluation of mifepristone effects on alcohol-seeking and self-administration in baboons.

  2019cites this paper
• Development of a novel alcohol and nicotine concurrent access (ANCA) self-administration procedure in baboons.

  2019cites this paper
• The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor

  2019cites this paper
• Prospects and limitations of physiologically-based pharmacokinetic modelling for cross-species extrapolation

  2019cites this paper
• Discovery of GSK3527497: A candidate for the inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).

  2019cites this paper
• Estimating human ADME properties, pharmacokinetic parameters and likely clinical dose in drug discovery

  2019cites this paper
• Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery: Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling.

  2019cites this paper
• The Journal of Toxicological Sciences

  2019cites this paper
• Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease.

  2019cites this paper
• Prediction of Human Pharmacokinetics of Bendamustine from Preclinical Species Pharmacokinetics Based on Normalizing Time Course Profiles

  2018cites this paper
• High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human.

  2018cites this paper
• Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4).

  2018cites this paper
• Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds

  2018cites this paper
• Differences in nonclinical pharmacokinetics between species and prediction of human pharmacokinetics of TAK‐272 (SCO‐272), a novel orally active renin inhibitor

  2018cites this paper
• In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development.

  2017cites this paper
• Preclinical Pharmacokinetics, Pharmacodynamics, Tissue Distribution, and Interspecies Scaling of Recombinant Human Coagulation Factor XaI16L.

  2017cites this paper
• ADME Optimization in Drug Discovery

  2017cites this paper
• Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates

  2017cites this paper
• Integrated Lead Optimization: Translational Models as We Advance Toward the Clinic

  2017cites this paper
• Inhibiting Kinases in the CNS

  2017cites this paper
• Baclofen and naltrexone effects on alcohol self-administration: Comparison of treatment initiated during abstinence or ongoing alcohol access in baboons.

  2017cites this paper
• Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

  2017cites this paper
• Towards knowledge-driven cross-species extrapolation

  2016cites this paper
• A unified strategy in selection of the best allometric scaling methods to predict human clearance based on drug disposition pathway

  2016cites this paper
• Extinction of Conditioned Responses to Methamphetamine-Associated Stimuli in Healthy Humans

  2016cites this paper
• Systematic Evaluation of Wajima Superposition (Steady-State Concentration to Mean Residence Time) in the Estimation of Human Intravenous Pharmacokinetic Profile.

  2016cites this paper
• Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels

  2016cites this paper
• Nonhuman Primate Self-Administration in Assessments of Abuse Potential

  2015cites this paper
• Pharmacokinetics and allometric scaling of antimalarial drugs

  2015cites this paper
• Pharmacokinetics of Human Therapeutics Characterized in Nonhuman Primates

  2015cites this paper
• Interspecies allometric meta-analysis of the comparative pharmacokinetics of 85 drugs across veterinary and laboratory animal species.

  2015cites this paper
• Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction

  2015cites this paper
• Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.

  2015cites this paper
• Prediction of Human Clearance Based on Animal Data and Molecular Properties

  2015cites this paper
• Compound Attrition at the Preclinical Phase

  2015cites this paper
• Prediction of Human Pharmacokineticsfor Protein‐Based Biologic Therapeutics

  2015cites this paper
• Prospective Predictions of Human Pharmacokinetics for Eighteen Compounds.

  2015cites this paper
• Utility of Intracranial Self-Stimulation in the Assessment of the Abuse Liability of New Pharmaceuticals

  2015cites this paper
• Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice

  2015cites this paper
• The application of allometric scaling principles to predict pharmacokinetic parameters across species

  2014cites this paper
• Evaluation of the Usefulness of Breast Cancer Resistance Protein (BCRP) Knockout Mice and BCRP Inhibitor-Treated Monkeys to Estimate the Clinical Impact of BCRP Modulation on the Pharmacokinetics of BCRP Substrates

  2014cites this paper
• Mechanistic prediction of intestinal first-pass metabolism using in vitro data in preclinical species and in man

  2014cites this paper
• Genetic substructure in cynomolgus macaques (Macaca fascicularis) on the island of Mauritius

  2014cites this paper
• The effect of the Pheroid delivery system on the in vitro metabolism and in vivo pharmacokinetics of artemisone

  2014cites this paper
• Predicting In Vivo Caffeine/ Angelica dahurica and Caffeine/ Salvia miltiorrhiza Pharmacokinetic Interactions in Humans with In Vitro CYP1A2 Inhibition Data

  2014cites this paper
• Expression and Characterization of Cynomolgus Monkey Cytochrome CYP 3 A 4 in a Novel Human Embryonic Kidney Cell – Based Mammalian System s

  2014cites this paper
• Clearance mechanism assignment and total clearance prediction in human based upon in silico models.

  2014cites this paper
• Expression and Characterization of Cynomolgus Monkey Cytochrome CYP3A4 in a Novel Human Embryonic Kidney Cell–Based Mammalian System

  2014cites this paper
• Interspecies Pharmacokinetics. 1. Allometric Scaling of Pharmacokinetic Parameters (a Review)

  2014cites this paper
• A Comparative Pharmacokinetic Estimate of Mercury in U.S. Infants Following Yearly Exposures to Inactivated Influenza Vaccines Containing Thimerosal

  2014cites this paper
• Comparison of the InVivo Distribution of Four Different Annexin A 5 Adducts in

  2014cites this paper
• Effects of amphetamine, diazepam and caffeine on polysomnography (EEG, EMG, EOG)-derived variables measured using telemetry in Cynomolgus monkeys.

  2014cites this paper
• Evaluation of the Allometric Exponents in Prediction of Human Drug Clearance

  2014cites this paper
• Integrated Assessment of Drug Clearance and Cross‐Species Scalability

  2014cites this paper
• Integration and analysis of protein evolutionary relationships and small molecule bioactivity data

  2014cites this paper
• Prediction of human systemic, biologically relevant pharmacokinetic (PK) properties using quantitative structure pharmacokinetic relationships (QSPKR) and interspecies pharmacokinetic allometric scaling (PK-AS) approaches for four different pharmacological classes of compounds

  2014cites this paper
• In Vitro Models for Metabolism: Applicability for Research on Food Bioactives

  2014cites this paper
• Investigation of the Pharmacokinetic Interaction between Ritonavir and CMDCK, a New Non-nucleoside Reverse Transcriptase Inhibitor

  2013cites this paper
• Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

  2013cites this paper
• Adenovirus Capsid-Based Anti-Cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter

  2013cites this paper
• A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development

  2013cites this paper
• A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data

  2013cites this paper
• Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing

  2013cites this paper
• Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance

  2013cites this paper
• Translation of Central Nervous System Occupancy from Animal Models: Application of Pharmacokinetic/Pharmacodynamic Modeling

  2013cites this paper
• In silico categorization of in vivo intrinsic clearance using machine learning.

  2013cites this paper
• Comparison of p450 enzymes between cynomolgus monkeys and humans: p450 identities, protein contents, kinetic parameters, and potential for inhibitory profiles.

  2013cites this paper
• Pharmacokinetic profile of spectinomycin in rats.

  2013cites this paper
• The usefulness of non-human primates in central nervous system safety pharmacology.

  2013cites this paper
• Application of in silico, in vitro and preclinical pharmacokinetic data for the effective and efficient prediction of human pharmacokinetics.

  2013cites this paper
• The Use of the African Green Monkey as a Preclinical Model for Ocular Pharmacokinetic Studies

  2012cites this paper
• Prediction of volume of distribution at steady state in humans: comparison of different approaches

  2012cites this paper