Systematic evaluation of the dependence of deoxyribozyme catalysis on random region length.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  ACS Combinatorial Science

• Publication date

  2012-12-10

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/co300111fPMID 23088677PMCID PMC3518697
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA-catalyzed reactivity of a phosphoramidate functional group and formation of an unusual pyrophosphoramidate linkage.

  2012cited by this paper
• Lanthanide ions as required cofactors for DNA catalysts.

  2012cited by this paper
• Covalent Tagging of Phosphorylated Peptides by Phosphate‐Specific Deoxyribozymes

  2012cited by this paper
• The mechanism of peptidyl transfer catalysis by the ribosome.

  2011cited by this paper
• DNA-catalyzed covalent modification of amino acid side chains in tethered and free peptide substrates.

  2011cited by this paper
• Establishing broad generality of DNA catalysts for site-specific hydrolysis of single-stranded DNA

  2011cited by this paper
• DNA-catalyzed reductive amination.

  2011cited by this paper
• Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior.

  2011cited by this paper
• DNA-catalyzed serine side chain reactivity and selectivity.

  2010cited by this paper
• Functional compromises among pH tolerance, site specificity, and sequence tolerance for a DNA-hydrolyzing deoxyribozyme.

  2010cited by this paper
• Computational generation and screening of RNA motifs in large nucleotide sequence pools

  2010cited by this paper
• DNA as a versatile chemical component for catalysis, encoding, and stereocontrol.

  2010cited by this paper
• In silico selection of RNA aptamers

  2009cited by this paper
• Biologically inspired synthetic enzymes made from DNA.

  2009cited by this paper
• DNA-catalyzed sequence-specific hydrolysis of DNA

  2009cited by this paper
• The structural and functional diversity of metabolite-binding riboswitches.

  2009cited by this paper
• Artificial Functional Nucleic Acids: Aptamers, Ribozymes, and Deoxyribozymes Identified by In Vitro Selection

  2009cited by this paper
• Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2',3'-cyclic phosphate RNA substrates.

  2008cited by this paper
• Catalytic DNA (deoxyribozymes) for synthetic applications-current abilities and future prospects.

  2008cited by this paper
• DNA-catalyzed formation of nucleopeptide linkages.

  2008cited by this paper
• A mathematical analysis of SELEX

  2007cited by this paper
• Forty years of in vitro evolution.

  2007cited by this paper
• Optimal Random Libraries for the Isolation of Catalytic RNA

  2005cited by this paper
• In vitro RNA random pools are not structurally diverse: a computational analysis.

  2005cited by this paper
• Size, constant sequences, and optimal selection.

  2005cited by this paper
• Directed evolution of nucleic acid enzymes.

  2003cited by this paper
• Deoxyribozymes with 2'-5' RNA ligase activity.

  2003cited by this paper
• The chemical repertoire of natural ribozymes

  2002cited by this paper
• RNA-catalyzed thioester synthesis.

  2002cited by this paper
• RNA-Catalyzed CoA, NAD, and FAD synthesis from phosphopantetheine, NMN, and FMN.

  2000cited by this paper
• A DNA enzyme with N-glycosylase activity.

  2000cited by this paper
• Accessing rare activities from random RNA sequences: the importance of the length of molecules in the starting pool.

  1997cited by this paper
• A mathematical analysis of in vitro molecular selection-amplification.

  1996cited by this paper
• A Mathematical Analysis ofin VitroMolecular Selection – Amplification

  1996cited by this paper
• Recognition of anionic porphyrins by DNA aptamers.

  1996cited by this paper
• A DNA enzyme that cleaves RNA.

  1994cited by this paper
• Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures

  1992cited by this paper
• Selection of single-stranded DNA molecules that bind and inhibit human thrombin

  1992cited by this paper
• SELEXION. Systematic evolution of ligands by exponential enrichment with integrated optimization by non-linear analysis.

  1991cited by this paper
• Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

  1990cited by this paper
• In vitro selection of RNA molecules that bind specific ligands

  1990cited by this paper
• Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.

  1990cited by this paper
• Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates.

  1987cited by this paper

• Recent Advances in DNAzyme Systems for Disease Diagnosis and Therapy

  2025cites this paper
• DNA Catalysis: Design, Function, and Optimization

  2024cites this paper
• Sequence‐Dependent Acylation of Peptide Lysine Residues by DNAzymes

  2024cites this paper
• Defining the substrate scope of DNAzyme catalysis for reductive amination with aliphatic amines.

  2023cites this paper
• Pushing the Limits of Nucleic Acid Function

  2022cites this paper
• The Chemical Repertoire of DNA Enzymes

  2021cites this paper
• Investigating the Influences of Random-Region Length on Aptamer Selection Efficiency Based on Capillary Electrophoresis-SELEX and High-Throughput Sequencing.

  2021cites this paper
• New DNA-hydrolyzing DNAs isolated from an ssDNA library carrying a terminal hybridization stem

  2021cites this paper
• Riboswitches for Controlled Expression of Therapeutic Transgenes Delivered by Adeno-Associated Viral Vectors

  2021cites this paper
• Screening Aptamer of Apo-transferrin via Capillary Electrophoresis-Systematic Evolution of Ligands by Exponential Enrichment and Environmental Factors Analysis

  2020cites this paper
• DNAmoreDB, a database of DNAzymes

  2020cites this paper
• Generation of single stranded DNA with selective affinity to bovine spermatozoa

  2020cites this paper
• Development of Aptamer Screening against Proteins and Its Applications

  2020cites this paper
• Chemical methods for the modification of RNA.

  2019cites this paper
• Targeting a viral DNA sequence with a deoxyribozyme in a preparative scale.

  2019cites this paper
• Nucleic acid enzymes based on functionalized nucleosides.

  2019cites this paper
• Tissue-Specific Delivery of Oligonucleotides.

  2019cites this paper
• Multi-metal-dependent nucleic acid enzymes.

  2018cites this paper
• Aptamer chemistry

  2018cites this paper
• Aptamer–field-effect transistors overcome Debye length limitations for small-molecule sensing

  2018cites this paper
• Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

  2018cites this paper
• Innate potential of random genetic oligomer pools for recombination

  2018cites this paper
• Preparation of MetalloDNAzymes

  2018cites this paper
• Functional Nucleic Acid Based Biosensors for Post-transition Metal Ion Detection

  2018cites this paper
• DNA-Catalyzed DNA Cleavage by a Radical Pathway with Well-Defined Products.

  2017cites this paper
• Metal Sensing by DNA.

  2017cites this paper
• Characterization of Highly Efficient RNA‐Cleaving DNAzymes that Function at Acidic pH with No Divalent Metal‐Ion Cofactors

  2016cites this paper
• DNA Oligonucleotide 3'-Phosphorylation by a DNA Enzyme.

  2016cites this paper
• Analysis of In Vitro Aptamer Selection Parameters

  2015cites this paper
• Identification of Sequence-Selective Tyrosine Kinase Deoxyribozymes

  2015cites this paper
• Pursuing DNA catalysts for protein modification.

  2015cites this paper
• DNA Catalysis: The Chemical Repertoire of DNAzymes

  2015cites this paper
• A Generalizable DNA‐Catalyzed Approach to Peptide–Nucleic Acid Conjugation

  2014cites this paper
• Catalysis by DNA enzymes: Roles of lanthanide(III) ions and DNA aptamer modules

  2014cites this paper
• Simulation and Automatic Design of Nucleic Acid Reaction System

  2014cites this paper
• In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity

  2014cites this paper
• DNA catalysts with tyrosine kinase activity.

  2013cites this paper
• DNA-catalyzed hydrolysis of esters and aromatic amides.

  2013cites this paper
• Combinatorial nucleoside-deletion-scanning mutagenesis of functional DNA.

  2013cites this paper
• Small, highly active DNAs that hydrolyze DNA.

  2013cites this paper
• Mutationsanalyse funktionaler DNA durch statistische Nucleosiddeletion

  2013cites this paper