Acid Phosphatases of Budding Yeast as a Model of Choice for Transcription Regulation Research

Acid phosphatases of budding yeast have been studied for more than forty years. This paper covers biochemical characteristics of acid phosphatases and different aspects in expression regulation of eukaryotic genes, which were researched using acid phosphatases model. A special focus is devoted to cyclin-dependent kinase Pho85p, a negative transcriptional regulator, and its role in maintaining mitochondrial genome stability and to pleiotropic effects of pho85 mutations.

• Publication year

  2011

• Venue

  Enzyme Research

• Publication date

  2011-07-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4061/2011/356093PMID 21785706PMCID 3137970
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
• Inorganic polyphosphates in mitochondria

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• Morphology and protein composition of the mitochondrial nucleoids in yeast cells lacking Abf2p, a high mobility group protein.

  2010cited by this paper
• The absence of cyclin-dependent protein kinase Pho85 affects stability of mitochondrial DNA in yeast Saccharomyces cerevisiae

  2009cited by this paper
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  2009cited by this paper
• Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways.

  2009cited by this paper
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  2008cited by this paper
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  2007influential reference
• Redundancy of Chromatin Remodeling Pathways for the Induction of the Yeast PHO5 Promoter in Vivo*

  2007cited by this paper
• Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiae.

  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007influential reference
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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• Inositol pyrophosphates: metabolism and signaling

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• [The lack of cyclin-dependent phosphoprotein kinase Pho85p leads to defects in mitochondrial nucleoid transmission in yeast Saccharomyces cerevisiae].

  2005cited by this paper
• A Systematic High-Throughput Screen of a Yeast Deletion Collection for Mutants Defective in PHO5 Regulation

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• Plc1p, Arg82p, and Kcs1p, Enzymes Involved in Inositol Pyrophosphate Synthesis, Are Essential for Phosphate Regulation and Polyphosphate Accumulation in Saccharomyces cerevisiae*

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  2004cited by this paper
• Phosphorylation of Proteins by Inositol Pyrophosphates

  2004cited by this paper
• [Involvement of PHO80 and PHO85 genes in Saccharomyces cerevisiae ion tolerance].

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002influential reference
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  2002influential reference
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
• Genomic expression programs in the response of yeast cells to environmental changes.

  2000influential reference
• New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis.

  2000influential reference
• Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p.

  2000cited by this paper
• Maintenance and Integrity of the Mitochondrial Genome: a Plethora of Nuclear Genes in the Budding Yeast

  2000cited by this paper
• [Effect of mutations in PHO85 and PHO4 genes on utilization of proline in Saccharomyces cerevisiae yeasts].

  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999influential reference
• Phosphate permeases of Saccharomyces cerevisiae: structure, function and regulation.

  1999cited by this paper
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  1999influential reference
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  1999influential reference
• Substrate Targeting of the Yeast Cyclin-Dependent Kinase Pho85p by the Cyclin Pcl10p

  1999cited by this paper
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  1996cited by this paper
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