Structure and Function of SLC4 Family HCO3- Transporters

The solute carrier SLC4 family consists of 10 members, nine of which are HCO3- transporters, including three Na+-independent Cl−/HCO3- exchangers AE1, AE2, and AE3, five Na+-coupled HCO3- transporters NBCe1, NBCe2, NBCn1, NBCn2, and NDCBE, as well as “AE4” whose Na+-dependence remains controversial. The SLC4 HCO3- transporters play critical roles in pH regulation and transepithelial movement of electrolytes with a broad range of demonstrated physiological relevances. Dysfunctions of these transporters are associated with a series of human diseases. During the past decades, tremendous amount of effort has been undertaken to investigate the topological organization of the SLC4 transporters in the plasma membrane. Based upon the proposed topology models, mutational and functional studies have identified important structural elements likely involved in the ion translocation by the SLC4 transporters. In the present article, we review the advances during the past decades in understanding the structure and function of the SLC4 transporters.

• Publication year

  2015

• Venue

  Frontiers in Physiology

• Publication date

  2015-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3389/fphys.2015.00355PMID 26648873PMCID 4664831
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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