Expression and functional characterization of ABCG2 in brain endothelial cells and vessels

No abstract is available for this paper.

• Publication year

  2003

• Venue

  The FASEB Journal

• Publication date

  2003-11-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1096/fj.02-1131fje
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Drug efflux transporters in the CNS.

  2003cited by this paper
• Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier.

  2003cited by this paper
• A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

  2003cited by this paper
• A new multidrug resistance protein at the blood-brain barrier.

  2002influential reference
• Expression and Functional Activity of the ABC-transporter Proteins P-glycoprotein and Multidrug-resistance Protein 1 in Human Brain Tumor Cells and Astrocytes

  2002cited by this paper
• Localisation of breast cancer resistance protein in microvessel endothelium of human brain

  2002cited by this paper
• Mammalian ABC transporters in health and disease.

  2002influential reference
• Molecular and functional MDR1‐Pgp and MRPs expression in human glioblastoma multiforme cell lines

  2002cited by this paper
• The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

  2002cited by this paper
• C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

  2002cited by this paper
• Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier.

  2002cited by this paper
• Selection of phage‐displayed llama single‐domain antibodies that transmigrate across human blood‐brain barrier endothelium

  2002cited by this paper
• From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance

  2001influential reference
• Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations.

  2001cited by this paper
• P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

  2001cited by this paper
• The human ATP-binding cassette (ABC) transporter superfamily.

  2001cited by this paper
• Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

  2001cited by this paper
• A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).

  2001cited by this paper
• An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domain

  2001cited by this paper
• The roles of P-glycoprotein and MRP1 in the blood-brain and blood-cerebrospinal fluid barriers.

  2001influential reference
• Overexpression of Multiple Drug Resistance Genes in Endothelial Cells from Patients with Refractory Epilepsy

  2001cited by this paper
• Drug delivery to tumors of the central nervous system

  2001cited by this paper
• Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice.

  2001cited by this paper
• Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood‐brain barrier for the treatment of patients with malignant brain tumors

  2000cited by this paper
• P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs.

  2000cited by this paper
• Differential transport of rat and human interleukin-1alpha across the blood-brain barrier and blood-testis barrier in rats.

  2000cited by this paper
• Transporter-mediated permeation of drugs across the blood-brain barrier.

  2000cited by this paper
• Inflammatory Activation of Human Brain Endothelial Cells by Hypoxic Astrocytes In Vitro is Mediated by IL-1β

  2000influential reference
• The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.

  1999cited by this paper
• Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

  1999cited by this paper
• The cell biology of the blood-brain barrier.

  1999cited by this paper
• Multidrug resistance mediated by the ATP‐binding cassette transporter protein MRP

  1998cited by this paper
• Multidrug Resistance‐Related Transport Proteins in Isolated Human Brain Microvessels and in Cells Cultured from These Isolates

  1998cited by this paper
• Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells.

  1998cited by this paper
• A multidrug resistance transporter from human MCF-7 breast cancer cells.

  1998cited by this paper
• Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood–brain barrier

  1997influential reference
• Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P‐glycoprotein or MRP overexpression

  1997cited by this paper
• A novel method for real time quantitative RT-PCR.

  1996cited by this paper
• Angiotensin II‐induced fluid phase endocytosis in human cerebromicrovascular endothelial cells is regulated by the inositol‐phosphate signaling pathway

  1996influential reference
• Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.

  1996cited by this paper
• P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

  1996influential reference
• One-hour downward alkaline capillary transfer for blotting of DNA and RNA.

  1992cited by this paper
• Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.

  1992cited by this paper
• Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

  1992influential reference
• Differential proliferative response of human and mouse astrocytes to gamma‐interferon

  1992cited by this paper
• The biochemistry of P-glycoprotein-mediated multidrug resistance.

  1989cited by this paper
• Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs.

  1988cited by this paper
• Cultured human and canine endothelial cells from brain microvessels.

  1988cited by this paper
• Ultrastructural localization of lectin receptors on the luminal and abluminal aspects of brain micro-blood vessels.

  1986cited by this paper
• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method

  year unknowncited by this paper

• IFN-γ protects the human blood-brain barrier from Toxoplasma gondii-mediated dysfunction via CCL2 suppression

  2026cites this paper
• Adaptation of ACMG/AMP Guidelines for Clinical Classification of BMPR2 Variants in Pulmonary Arterial Hypertension Resolves Variants of Unclear Pathogenicity in ClinVar

  2025cites this paper
• Visualization-based evaluation of short-chain PFAS effects on ABCG2 in human cell models: A preliminary study

  2025cites this paper
• Alcohol Diminishes Barrier Integrity in Human Stem Cell-Derived Brain Microvascular Endothelial Cells: Role of Reactive Oxygen Species.

  2025cites this paper
• Hopping the Hurdle: Strategies to Enhance the Molecular Delivery to the Brain through the Blood–Brain Barrier

  2024cites this paper
• The pathogenic germline ETV4 P433L mutation identified in multiple primary lung cancer affect tumor stem-like property by Wnt/β-catenin pathway

  2024cites this paper
• Enhancing of cerebral Abeta clearance by modulation of ABC transporter expression: a review of experimental approaches

  2024cites this paper
• Exploring Bile Acid Transporters As Key Players In Cancer Development And Treatment: Evidence From Preclinical And Clinical Studies.

  2024cites this paper
• The impact of ATP-binding cassette transporters in the diseased brain: Context matters

  2024cites this paper
• Adaptation of ACMG/AMP guidelines for clinical classification of BMPR2 variants in Pulmonary Arterial Hypertension resolves variants of unclear pathogenicity in ClinVar.

  2024cites this paper
• Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model

  2024cites this paper
• Understanding the impact of ABCG2 polymorphisms on drug pharmacokinetics: focus on rosuvastatin and allopurinol

  2024cites this paper
• Fluorescence-based methods for studying activity and drug-drug interactions of hepatic solute carrier and ATP binding cassette proteins involved in ADME-Tox.

  2023cites this paper
• Universal method for the isolation of microvessels from frozen brain tissue: A proof-of-concept multiomic investigation of the neurovasculature

  2023cites this paper
• In Vitro Blood-Brain Barrier Models for Neuroinfectious Diseases: A Narrative Review

  2023cites this paper
• Differential Expression of ABC Transporter Genes in Brain Vessels vs. Peripheral Tissues and Vessels from Human, Mouse and Rat

  2023cites this paper
• ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery

  2023cites this paper
• Evaluation of Dimercaptosuccinic Acid-Coated Iron Nanoparticles Immunotargeted to Amyloid Beta as MRI Contrast Agents for the Diagnosis of Alzheimer’s Disease

  2023cites this paper
• CPEB2 m6A methylation regulates blood–tumor barrier permeability by regulating splicing factor SRSF5 stability

  2022cites this paper
• Functional Expression of Multidrug-Resistance (MDR) Transporters in Developing Human Fetal Brain Endothelial Cells

  2022cites this paper
• Quantitative Comparison of Breast Cancer Resistance Protein (BCRP/ABCG2) Expression and Function Between Maternal Blood-Brain Barrier and Placental Barrier in Mice at Different Gestational Ages

  2022cites this paper
• Transport Mechanisms at the Blood–Brain Barrier and in Cellular Compartments of the Neurovascular Unit: Focus on CNS Delivery of Small Molecule Drugs

  2022cites this paper
• Multidrug efflux transporter ABCG2: expression and regulation

  2021cites this paper
• Distinctive Properties of Endothelial Cells from Tumor and Normal Tissue in Human Breast Cancer

  2021cites this paper
• Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord.

  2021cites this paper
• The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

  2021cites this paper
• Medically Important Alterations in Transport Function and Trafficking of ABCG2

  2021cites this paper
• Brain metastases in patients with oncogenic-driven non-small cell lung cancer: Pros and cons for early radiotherapy.

  2021cites this paper
• RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway

  2020cites this paper
• Efflux transporters in cancer resistance: Molecular and functional characterization of breast cancer resistance protein

  2020cites this paper
• ABCG2 transports anticancer drugs via a closed-to-open switch

  2020cites this paper
• 3D structure of the transporter ABCG2—What's new?

  2020cites this paper
• Extracellular and intracellular tumor necrosis factor alpha modulates cytosolic and nuclear calcium in human cardiovascular cells 1.

  2019cites this paper
• Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models.

  2019cites this paper
• Cell-type specific differences in antiretroviral penetration and the effects of HIV-1 Tat and morphine among primary human brain endothelial cells, astrocytes, pericytes, and microglia.

  2019cites this paper
• Targeting the Genetic and Molecular Role of ABCG2 Following Traumatic Brain Injury

  2018cites this paper
• Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies

  2018cites this paper
• Transcellular transport of cobalamin in aortic endothelial cells

  2018cites this paper
• Association of ABCG2 polymorphisms with ischemic stroke in a Chinese population

  2018cites this paper
• Effects of HIV-1 Tat and drugs of abuse on antiretroviral penetration inside different CNS cell types

  2018cites this paper
• Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

  2018cites this paper
• Fasudil increases temozolomide sensitivity and suppresses temozolomide-resistant glioma growth via inhibiting ROCK2/ABCG2

  2018cites this paper
• ABC Transporters Are Key Players in Alzheimer’s Disease

  2017cites this paper
• Iron uptake and transport

  2017cites this paper
• Metabolite transport across the mammalian and insect brain diffusion barriers.

  2017cites this paper
• Brain and the Drug Transporters

  2017cites this paper
• Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig.

  2017cites this paper
• circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways

  2017cites this paper
• Role and modulation of drug transporters in HIV-1 therapy.

  2016cites this paper
• The multidrug transporter ABCG2: still more questions than answers

  2016cites this paper
• Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock

  2016cites this paper
• Human Platelet Lysate as a Replacement for Fetal Bovine Serum in Limbal Stem Cell Therapy

  2016cites this paper
• Long non-coding RNA H19 regulates glioma angiogenesis and the biological behavior of glioma-associated endothelial cells by inhibiting microRNA-29a.

  2016cites this paper
• The multidrug transporter ABCG 2 : still more questions than answers

  2016cites this paper
• In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

  2016cites this paper
• ABCG2 inhibition as a therapeutic approach for overcoming multidrug resistance in cancer

  2016cites this paper
• Knockdown of long non-coding RNA MALAT1 increases the blood-tumor barrier permeability by up-regulating miR-140.

  2016cites this paper
• Regulation of Multidrug Resistance P‐Glycoprotein in the Developing Blood–Brain Barrier: Interplay between Glucocorticoids and Cytokines

  2016cites this paper
• Design and development of new ligands of ABCG2 and MRP1 transporters targeting the Multidrug Resistance (MDR).

  2015cites this paper
• The Expression and Function of ABC Transporters at the Blood-Brain Barrier

  2015cites this paper
• Genetic and/or non-genetic causes for inter-individual and inter-cellular variability in transporter protein expression: implications for understanding drug efficacy and toxicity

  2015cites this paper
• In Vitro and In Vivo Regulation of Pro-inflammatory Cytokines and Drug Efflux Transporters by Signal Transduction Pathways in Glial Cells: Implications in HIV-1 Neuropathogenesis and its Treatment

  2015cites this paper
• Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders.

  2015cites this paper
• In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator‐activated receptor alpha (Pparα) at the blood–brain barrier

  2015cites this paper
• The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144

  2015cites this paper
• Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

  2015cites this paper
• Mechanisms of regulation of P-glycoprotein and breast cancer resistance protein at the blood-brain barrier : focus on the role of morphine, and P-glycoprotein activation

  2015cites this paper
• Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics.

  2015cites this paper
• Drug Resistance of Endocardial Endothelial Cells is Related to Higher Endogenous ABCG2

  2015cites this paper
• Blood-brain barrier proteomics: towards the understanding of neurodegenerative diseases.

  2014cites this paper
• Regulation of ABCG2 Expression in the Lactating Mammary Gland

  2014cites this paper
• Inputs drive cell phenotype variability

  2014cites this paper
• Imaging of cerebrovascular pathology in animal models of Alzheimer's disease

  2014cites this paper
• Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics

  2014cites this paper
• Biology and Regulation of Blood-Tissue Barriers

  2014cites this paper
• Drug Access to the Central Nervous System in Alzheimer’s Disease: Preclinical and Clinical Insights

  2014cites this paper
• Functional expression of drug transporters in glial cells: potential role on drug delivery to the CNS.

  2014cites this paper
• TITLE : Inputs Drive Cell Phenotype Variability

  2014cites this paper
• Bioavailability of Flavonoids

  2014cites this paper
• Pathological Angiogenesis: An Overview

  2014cites this paper
• Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness

  2014cites this paper
• Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?

  2014cites this paper
• Analysis of expression of microRNAs and genes involved in the control of key signaling mechanisms that support or inhibit development of brain tumors of different grades.

  2014cites this paper
• PET Imaging of ABC Transporters in the BBB

  2014cites this paper
• Impact of Drug Size on Brain Tumor and Brain Parenchyma Delivery after a Blood–Brain Barrier Disruption

  2014cites this paper
• Changes in the ATP-binding cassette efflux transporters of the blood-brain barrier in glioma challenge

  2014influential citation
• The glioblastoma vasculature as a target for cancer therapy.

  2014cites this paper
• Drug Transporters At Brain Barriers

  2013cites this paper
• Blood-brain barrier transport of amyloid beta peptides in efflux pump knock-out animals evaluated by in vivo optical imaging

  2013cites this paper
• Breast cancer resistance protein (BCRP)/ABCG2

  2013cites this paper
• NSAIDs Modulate Morphine Transport at the Blood-Brain Barrier: A Role for P-glycoprotein

  2013cites this paper
• Protein tyrosine phosphatase inhibition down-regulates ligand-induced ABCA1 expression.

  2013cites this paper
• Expressed in Human Heart The ATP-binding Cassette Transporter ABCG2 (BCRP), a Marker for Side Population Stem Cells, Is

  2013cites this paper
• Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro

  2013cites this paper
• Therapy Resistance in Prostate Cancer: A Stem Cell Perspective

  2013cites this paper
• Effect of the ATP-binding cassette transporter ABCG2 on pharmacokinetics: experimental findings and clinical implications

  2013cites this paper
• Implications of Glioblastoma Stem Cells in Chemoresistance

  2013cites this paper
• Utilisation de modèles in vitro de la barrière hémato-encéphalique dans les phases précoces du développement de médicaments

  2013cites this paper
• ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate.

  2013cites this paper
• Adenosine triphosphate-binding cassette transporter G2 expression in endometriosis and in endometrium from patients with and without endometriosis.

  2012cites this paper