insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neuron

• Publication date

  2011-12-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuron.2011.12.003PMID 22196332PMCID PMC3244879
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.

  2011cited by this paper
• Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.

  2010cited by this paper
• Clocks not winding down: unravelling circadian networks

  2010cited by this paper
• Genetic analysis of sleep.

  2010cited by this paper
• Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

  2010cited by this paper
• Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior.

  2010cited by this paper
• The Developmental Transcriptome of Drosophila melanogaster

  2010cited by this paper
• Sleep, aging, and lifespan in Drosophila

  2010cited by this paper
• The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila.

  2009cited by this paper
• Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits.

  2009cited by this paper
• Pentameric assembly of potassium channel tetramerization domain-containing protein 5.

  2009cited by this paper
• SLEEPLESS, a Ly–6/Neurotoxin Family Member, Regulates Levels, Localization, and Activity of Shaker

  2009cited by this paper
• Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.

  2009cited by this paper
• Octopamine Regulates Sleep in Drosophila through Protein Kinase A-Dependent Mechanisms

  2008cited by this paper
• Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila

  2008cited by this paper
• Identification of SLEEPLESS, a Sleep-Promoting Factor

  2008cited by this paper
• Genetics of sleep.

  2008cited by this paper
• PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit.

  2008cited by this paper
• Unearthing the phylogenetic roots of sleep.

  2008cited by this paper
• KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases

  2008cited by this paper
• Using FlyAtlas to identify better Drosophila melanogaster models of human disease

  2007cited by this paper
• A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

  2007cited by this paper
• A Ubiquitin Ligase Complex Regulates Caspase Activation During Sperm Differentiation in Drosophila

  2007cited by this paper
• Correction: A Ubiquitin Ligase Complex Regulates Caspase Activation During Sperm Differentiation in Drosophila

  2007cited by this paper
• Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila

  2007cited by this paper
• Drosophila Hyperkinetic Mutants Have Reduced Sleep and Impaired Memory

  2007cited by this paper
• A sleep-promoting role for the Drosophila serotonin receptor 1A.

  2006cited by this paper
• Sleep in Drosophila is regulated by adult mushroom bodies

  2006cited by this paper
• A dynamic role for the mushroom bodies in promoting sleep in Drosophila

  2006cited by this paper
• Prevalence of off-target effects in Drosophila RNA interference screens

  2006cited by this paper
• Drosophila melanogaster: an insect model for fundamental studies of sleep.

  2005cited by this paper
• Reduced sleep in Drosophila Shaker mutants

  2005cited by this paper
• Chapter 1 – History of Sleep Physiology and Medicine

  2005cited by this paper
• Dopaminergic modulation of arousal in Drosophila.

  2005cited by this paper
• Requirement of Cul3 for Axonal Arborization and Dendritic Elaboration in Drosophila Mushroom Body Neurons

  2005cited by this paper
• Function and regulation of cullin–RING ubiquitin ligases

  2005cited by this paper
• Dopamine Is a Regulator of Arousal in the Fruit Fly

  2005cited by this paper
• Hypothalamic regulation of sleep and circadian rhythms

  2005cited by this paper
• Sequence and structural analysis of BTB domain proteins

  2005cited by this paper
• Sleep deprivation in honey bees 1

  2004cited by this paper
• The DrosDel Collection

  2004cited by this paper
• Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

  2004cited by this paper
• Slow wave sleep in crayfish.

  2004cited by this paper
• Cullin-3 regulates pattern formation, external sensory organ development and cell survival during Drosophila development.

  2004cited by this paper
• Uncoupling of brain activity from movement defines arousal States in Drosophila.

  2004cited by this paper
• Sleep homeostasis in Drosophila melanogaster.

  2004cited by this paper
• BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases.

  2003cited by this paper
• BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3

  2003cited by this paper
• The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase

  2003cited by this paper
• Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms.

  2003cited by this paper
• Electrophysiological correlates of rest and activity in Drosophila melanogaster.

  2002cited by this paper
• Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

  2002cited by this paper
• Stress response genes protect against lethal effects of sleep deprivation in Drosophila

  2002cited by this paper
• A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis

  2001cited by this paper
• Correlates of sleep and waking in Drosophila melanogaster.

  2000cited by this paper
• Rest in Drosophila is a sleep-like state.

  2000cited by this paper
• Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance.

  1994cited by this paper
• Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins.

  1993cited by this paper
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

  1993cited by this paper
• Deletion analysis of K+ channel assembly.

  1993cited by this paper
• Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel.

  1992cited by this paper
• 24‐h variation of vigilance in the cockroach Blaberus giganteus

  1992cited by this paper
• Rest in the scorpion — a sleep-like state?

  1988cited by this paper
• Busy bees need rest, too

  1988cited by this paper
• Animal sleep: a review of sleep duration across phylogeny.

  1984cited by this paper
• Neuronal correlates of sleep, wakefulness and arousal in a diurnal insect

  1983cited by this paper
• Effect of forced locomotion on the rest-activity cycle of the cockroach.

  1983cited by this paper
• Physiological correlates of prolonged sleep deprivation in rats.

  1983cited by this paper
• A two process model of sleep regulation.

  1982cited by this paper

• Inferring the genetic basis of sleep states in Drosophila melanogaster using hidden Markov models

  2026cites this paper
• Sleep regulation in Drosophila: a review of neural circuits and genetics

  2026cites this paper
• The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis

  2025cites this paper
• Early life sleep is associated with longevity in Drosophila

  2025cites this paper
• A switch in arousal circuit architecture shapes sleep across the lifespan

  2025cites this paper
• KCTD Family: Emerging Regulators of GPCR Biased Signaling.

  2025cites this paper
• FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep in Drosophila

  2025cites this paper
• Enhanced memory despite severe sleep loss in Drosophila insomniac mutants

  2025influential citation
• 25 years of Drosophila “Sleep genes”

  2025influential citation
• Sleep Deprivation Primes Synaptic Vulnerability Without Inducing Oxidative Damage: A Mechanistic Reappraisal

  2025cites this paper
• Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches.

  2024cites this paper
• Ubiquitin system mutations in neurological diseases.

  2024cites this paper
• Drosophila Sleep Homeostasis in Sickness and in Health.

  2024cites this paper
• Targeted single cell expression profiling identifies integrators of sleep and metabolic state

  2024cites this paper
• Cognitive hyperplasticity drives insomnia

  2024cites this paper
• BDNF-TrkB signaling orchestrates the buildup process of local sleep.

  2024cites this paper
• Altered Metabolism during the Dark Period in Drosophila Short Sleep Mutants.

  2024cites this paper
• Sleep deprivation drives brain-wide changes in cholinergic presynapse abundance in Drosophila melanogaster

  2024cites this paper
• Neuronal knockdown of Cullin3 as a Drosophila model of autism spectrum disorder

  2024cites this paper
• Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach.

  2024cites this paper
• Gut AstA mediates sleep deprivation-induced energy wasting in Drosophila

  2023cites this paper
• Neurofibromin 1 regulates early developmental sleep in Drosophila

  2023cites this paper
• Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase

  2023cites this paper
• The Drosophila blood–brain barrier regulates sleep via Moody G protein-coupled receptor signaling

  2023cites this paper
• FlyVISTA, an Integrated Machine Learning Platform for Deep Phenotyping of Sleep in Drosophila

  2023cites this paper
• Altered Metabolism During the Dark Period in Drosophila Short Sleep Mutants

  2023cites this paper
• Mild sleep restriction increases endothelial oxidative stress in female persons

  2023cites this paper
• Ubiquitin proteasome system in circadian rhythm and sleep homeostasis: Lessons from Drosophila

  2022cites this paper
• Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms.

  2022cites this paper
• Glial control of sphingolipid levels sculpts diurnal remodeling of circadian circuits

  2022cites this paper
• Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit.

  2022cites this paper
• Integrative Proteome and Ubiquitinome Analyses Reveal the Substrates of BTBD9 and Its Underlying Mechanism in Sleep Regulation

  2022cites this paper
• Degradation of STK16 via KCTD17 with Ubiquitin–Proteasome System in Relation to Sleep–Wake Cycle

  2022cites this paper
• Chronic sleep loss disrupts rhythmic gene expression in Drosophila

  2022influential citation
• Neurofibromin 1 mediates sleep depth in Drosophila

  2022cites this paper
• What have we learned about sleep from selective breeding strategies?

  2022cites this paper
• The need for unbiased genetic screens to dissect aggression in Drosophila melanogaster

  2022cites this paper
• A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila

  2022cites this paper
• Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension

  2022cites this paper
• Whole blood transcriptome analysis using RNA sequencing in individuals with insomnia disorder and good sleepers: a pilot study.

  2021cites this paper
• insomniac links the development and function of a sleep-regulatory circuit

  2021influential citation
• Regulation of sleep in Drosophila melanogaster

  2021cites this paper
• Chronic social isolation signals starvation and reduces sleep in Drosophila

  2021cites this paper
• Sleep Modulates Alcohol Toxicity in Drosophila

  2021cites this paper
• Molecular resolution of a behavioral paradox: sleep and arousal are regulated by distinct acetylcholine receptors in different neuronal types in Drosophila.

  2021cites this paper
• The 2020 Pittendrigh/Aschoff Lecture: My Circadian Journey

  2021influential citation
• Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut.

  2020influential citation
• Bidirectional Regulation of Sleep and Synapse Pruning after Neural Injury.

  2020cites this paper
• Presynaptic and postsynaptic long-term plasticity in sleep homeostasis.

  2020cites this paper
• Identification of Genes Contributing to a Long Circadian Period in Drosophila Melanogaster

  2020cites this paper
• The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation

  2020cites this paper
• K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca2+ Signaling and Rac1 Activity

  2020cites this paper
• Presynaptic Active Zone Plasticity Encodes Sleep Need in Drosophila.

  2020cites this paper
• Excessive daytime sleepiness is associated with altered gene expression in military personnel and veterans with posttraumatic stress disorder: An RNA sequencing study.

  2020cites this paper
• Phosphorylation Hypothesis of Sleep

  2020cites this paper
• KCTD5, a novel TRPM4‐regulatory protein required for cell migration as a new predictor for breast cancer prognosis

  2020cites this paper
• Covert sleep-related biological processes are revealed by probabilistic analysis in Drosophila

  2020cites this paper
• Time-restricted feeding prolongs lifespan in Drosophila in a peripheral clock-dependent manner

  2020cites this paper
• Forward genetic approach for behavioral neuroscience using animal models

  2020cites this paper
• Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway

  2020cites this paper
• Cullin-3: Renal and Vascular Mechanisms Regulating Blood Pressure

  2020cites this paper
• Circadian and Sleep Metabolomics Across Species.

  2020cites this paper
• Quantitative imaging of sleep behavior in Caenorhabditis elegans and larval Drosophila melanogaster

  2019cites this paper
• Genetic Mechanisms Underlying Sleep.

  2019cites this paper
• A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila

  2019cites this paper
• Molecular mechanisms and physiological importance of circadian rhythms

  2019cites this paper
• A Drosophila Model Of Sleep Restriction Therapy For Insomnia And Neurodegenerative Disease

  2019cites this paper
• A Drosophila Model of Sleep Restriction Therapy for Insomnia

  2019cites this paper
• Biological and clinical insights from genetics of insomnia symptoms

  2019cites this paper
• Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control

  2019influential citation
• The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis

  2019cites this paper
• Sleep, Immunity, and Stress: Novel Insights From Drosophila

  2019cites this paper
• Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling

  2019cites this paper
• State-Switching Probability Reveals Sleep-Related Biological Drives in Drosophila

  2019cites this paper
• Genetic sleep deprivation: using sleep mutants to study sleep functions

  2019cites this paper
• Neurocalcin regulates nighttime sleep and arousal in Drosophila

  2019influential citation
• Reise durch die Zeit: 40 Jahre Forschung von den Clock-Mutanten in Drosophila zu Störungen des zirkadianen Rhythmus beim Menschen (Nobel-Vortrag)

  2018cites this paper
• The neurobiological basis of sleep: Insights from Drosophila

  2018cites this paper
• Behavioral and genetic features of sleep ontogeny in Drosophila

  2018cites this paper
• A bidirectional relationship between sleep and oxidative stress in Drosophila

  2018cites this paper
• The Sleep Inbred Panel, a Collection of Inbred Drosophila melanogaster with Extreme Long and Short Sleep Duration

  2018cites this paper
• Time Travels: A 40-Year Journey from Drosophila's Clock Mutants to Human Circadian Disorders (Nobel Lecture).

  2018cites this paper
• The Neurobiological Basis of Sleep and Sleep Disorders.

  2018cites this paper
• Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

  2018cites this paper
• Whi2 is a conserved negative regulator of TORC1 in response to low amino acids

  2018cites this paper
• Tired and stressed: Examining the need for sleep

  2018influential citation
• Most sleep does not serve a vital function: Evidence from Drosophila melanogaster

  2018cites this paper
• Decoding the Sleep Homeostat Architecture

  2018cites this paper
• A probabilistic model of sleep structure suggests a primary role for wake probability in overall sleep in Drosophila melanogaster

  2018cites this paper
• A Drosophila Model for Behavioral Sleep Modification

  2018cites this paper
• Long term impact of intensive post graduate laboratory training at the Cold Spring Harbor Neurobiology of Drosophila summer course

  2018cites this paper
• The sleep gene insomniac ubiquitinates targets at postsynaptic densities and is required for retrograde homeostatic signaling

  2018cites this paper
• Sleep structure and quantity are determined by behavioral transition probability in Drosophila melanogaster

  2018cites this paper
• A mathematical model describes Drosophila sleep behavior in w 1118 2 controls and in a hyposomnolent insomniac line 3 Running title : A Model for Drosophila Sleep 4

  2018cites this paper
• Biological and clinical insights from genetics of insomnia symptoms

  2018cites this paper
• Identification of Genes that Maintain Behavioral and Structural Plasticity during Sleep Loss

  2017cites this paper
• Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep

  2017cites this paper
• Isolation of Aggressive Behavior Mutants in Drosophila Using a Screen for Wing Damage

  2017cites this paper
• Fast and slow Ca2+-dependent hyperpolarization mechanisms connect membrane potential and sleep homeostasis.

  2017cites this paper
• Unraveling the Neurobiology of Sleep and Sleep Disorders Using Drosophila.

  2017cites this paper