Low mitochondrial DNA and ATP contents contribute to the absence of birefringent spindle imaged with PolScope in in vitro matured human oocytes.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Human Reproduction

• Publication date

  2007-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HUMREP/DEM070PMID 17449512
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial content reflects oocyte variability and fertilization outcome.

  2006influential reference
• Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes.

  2005cited by this paper
• In Vitro Maturation of Oocytes

  2005cited by this paper
• The increase of mitochondrial DNA content in endometrial adenocarcinoma cells: a quantitative study using laser-captured microdissected tissues.

  2005cited by this paper
• Polar body morphology and spindle imaging as predictors of oocyte quality.

  2005cited by this paper
• Spindle imaging: a new marker for optimal timing of ICSI?

  2004influential reference
• Visualization and Examination of the Meiotic Spindle in Human Oocytes with Polscope

  2004influential reference
• Spindles, mitochondria and redox potential in ageing oocytes.

  2004cited by this paper
• Occurrence of maternal and paternal spindles in unfertilized human oocytes: possible relationship to nucleation defects after silent fertilization.

  2004influential reference
• Relationship between meiotic spindle location with regard to the polar body position and oocyte developmental potential after ICSI.

  2003influential reference
• Visualization of the metaphase II meiotic spindle in living human oocytes using the Polscope enables the prediction of embryonic developmental competence after ICSI.

  2003influential reference
• Meiotic spindle location and identification and its effect on embryonic cleavage plane and early development.

  2003influential reference
• Chaotic mosaicism in human preimplantation embryos is correlated with a low mitochondrial membrane potential.

  2003cited by this paper
• Day 3 embryo transfer with combined evaluation at the pronuclear and cleavage stages compares favourably with day 5 blastocyst transfer.

  2002cited by this paper
• Maturational and developmental competence of cumulus-free immature human oocytes derived from stimulated and intracytoplasmic sperm injection cycles.

  2002cited by this paper
• Consequences of bovine oocyte maturation, fertilization or early embryo development in vitro versus in vivo: Implications for blastocyst yield and blastocyst quality

  2002cited by this paper
• The role of maternal mitochondria during oogenesis, fertilization and embryogenesis.

  2002influential reference
• Mitochondrial DNA content affects the fertilizability of human oocytes.

  2001cited by this paper
• Limited recovery of meiotic spindles in living human oocytes after cooling-rewarming observed using polarized light microscopy.

  2001influential reference
• Mitochondrial aggregation patterns and activity in human oocytes and preimplantation embryos.

  2001cited by this paper
• Maturation of human oocytes in vitro and their developmental competence.

  2001cited by this paper
• The spindle observation and its relationship with fertilization after intracytoplasmic sperm injection in living human oocytes.

  2001influential reference
• Developmental ability of human oocytes with or without birefringent spindles imaged by Polscope before insemination.

  2000influential reference
• Increased Birefringence in the Meiotic Spindle Provides a New Marker for the Onset of Activation in Living Oocytes1

  2000cited by this paper
• In vitro maturation, fertilization, and development of human germinal vesicle oocytes collected from stimulated cycles.

  2000cited by this paper
• Polarized light microscopy of spindles.

  1999cited by this paper
• Maturation in vitro of immature human oocytes for clinical use.

  1998cited by this paper
• Oocyte polarity and cell determination in early mammalian embryos.

  1997cited by this paper
• Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography.

  1997cited by this paper
• ATP content of human oocytes and developmental potential and outcome after in-vitro fertilization and embryo transfer.

  1995cited by this paper
• New polarized light microscope with precision universal compensator

  1995cited by this paper
• Uncouplers of oxidative phosphorylation.

  1990cited by this paper
• Amounts of mitochondrial DNA and abundance of some mitochondrial gene transcripts in early mouse embryos.

  1987cited by this paper
• Mitochondrial reorganization during resumption of arrested meiosis in the mouse oocyte.

  1984cited by this paper
• Uncouplers of oxidative phosphorylation.

  1980cited by this paper
• Uncouplers of oxidative phosphorylation.

  1979cited by this paper
• [58] Uncouplers of oxidative phosphorylation

  1979cited by this paper

• MITOCHONDRIA IN MAMMALIAN OOCYTES AND EARLY EMBRYOS. A REVIEW ON MORPHOLOGICAL AND FUNCTIONAL STUDIES

  2026cites this paper
• Proline improves the developmental competence of in vitro matured porcine oocytes by enhancing mitochondrial function.

  2025cites this paper
• Mitochondrial DNA in day 3 culture medium as a molecular biomarker of human embryo fragmentation, aneuploidy, and implantation competency

  2025cites this paper
• Incidence and Pattern of Congenital Malformations: An Observational Study in Northeastern Rajasthan, India

  2025cites this paper
• Impaired Mitochondrial Biogenesis Inhibits Epithelial-Mesenchymal Transition in Villi of PCOS Patients.

  2025cites this paper
• Mitochondrial morphology, distribution and activity during oocyte development.

  2024cites this paper
• Excess Weight Impairs Oocyte Quality, as Reflected by mtDNA and BMP-15

  2024cites this paper
• Mitochondria-Targeted Antioxidant MitoQ Improves In Vitro Maturation and Subsequent Embryonic Development from Culled Cows

  2024cites this paper
• Mitochondria of Porcine Oocytes Synthesize Melatonin, Which Improves Their In Vitro Maturation and Embryonic Development

  2024cites this paper
• A strategy for the investigation of toxic mechanisms and protection by efflux pumps using Schizosaccharomyces pombe strains: Application to rotenone.

  2024cites this paper
• Aging and oocyte competence: A molecular cell perspective.

  2023cites this paper
• A comprehensive characterization of cell-free RNA in spent blastocyst medium and quality prediction for blastocyst.

  2023cites this paper
• Leonurine improves bovine oocyte maturation and subsequent embryonic development by reducing oxidative stress and improving mitochondrial function.

  2023cites this paper
• Beneficial Effect of Polysaccharide Gel Made of Xanthan Gum and Locust Bean Gum on Bovine Oocytes

  2023cites this paper
• Effects of adverse fertility-related factors on mitochondrial DNA in the oocyte: a comprehensive review

  2023cites this paper
• Knock-down of YME1L1 induces mitochondrial dysfunction during early porcine embryonic development

  2023cites this paper
• Comparative Biochemistry and Physiology-Part A: Molecular & Integrative Physiology Special Issue: Comparative Models in Biomedical Research Invited Review C. elegans as a model organism to study female reproductive health

  2023cites this paper
• Epicatechin promotes oocyte quality in mice during repeated superovulation.

  2023cites this paper
• The Role of Lifestyle and Dietary Factors in the Development of Premature Ovarian Insufficiency

  2023cites this paper
• The Molecular Quality and Mitochondrial Activity of Porcine Cumulus–Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds under 3D In Vitro Maturation Conditions

  2022cites this paper
• Germline-soma Supply Mitochondria for mtDNA Inheritance in Mouse Oogenesis

  2022cites this paper
• C. elegans as a model organism to study female reproductive health.

  2022cites this paper
• Total And Mitochondrial Cell Free DNA Quantification in Day 5 Embryos Culture Media Reflect Embryos Quality

  2022cites this paper
• Noninvasive autologous mitochondria transport improves the quality and developmental potential of oocytes from aged mice.

  2022cites this paper
• The effect of ovarian stimulation on aneuploidy of early aborted tissues and preimplantation blastocysts: comparison of the GnRH agonist long protocol with the GnRH antagonist protocol

  2022cites this paper
• Quality Evaluation of Gilts and Sow’s Oocytes During In Vitro Maturation Based on Mitochondria Distribution

  2022cites this paper
• DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies

  2022cites this paper
• Reproductive senescence impairs the energy metabolism of human luteinized granulosa cells.

  2021cites this paper
• Resveratrol enhanced mitochondrial recovery from cryopreservation‐induced damages in oocytes and embryos

  2021cites this paper
• Seasonal Effect on Developmental Competence, Oxidative Status and Tubulin Assessment of Prepubertal Ovine Oocyte

  2021cites this paper
• Integrated analysis of transcriptome and histone modifications in granulosa cells during ovulation in female mice.

  2021cites this paper
• The Molecular Regulation in the Pathophysiology in Ovarian Aging

  2021cites this paper
• REPRODUCTIVE SENESCENCE IMPAIRS THE ENERGY METABOLISM OF HUMAN GRANULOSA CELLS

  2021cites this paper
• Mitochondrial reactive oxygen species regulate mitochondrial biogenesis in porcine embryos

  2021cites this paper
• Effect of melatonin addition in ovulation induction protocols with clomiphene citrate in management of infertility

  2021cites this paper
• Transcriptome and epigenome analysis of porcine embryos from non-esterified fatty acid-exposed oocytes.

  2021cites this paper
• Autologous mitochondria transport via transzonal filopodia rejuvenates aged oocytes by UC-MSCs derived granulosa cells-oocyte aggregation

  2021cites this paper
• Intracellular oxygen metabolism during bovine oocyte and preimplantation embryo development

  2021cites this paper
• Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence.

  2020cites this paper
• Journal of Reproduction and Development

  2020cites this paper
• Journal of Reproduction and Development

  2020cites this paper
• Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes

  2020cites this paper
• Abundance of cell‐free mitochondrial DNA in spent culture medium associated with morphokinetics and blastocyst collapse of expanded blastocysts

  2020cites this paper
• Mitochondrial Genetic Drift after Nuclear Transfer in Oocytes

  2020cites this paper
• Aging-related mitochondrial alterations in bovine oocytes.

  2020cites this paper
• Microinjection induces changes in the transcriptome of bovine oocytes

  2020cites this paper
• Xanthan gum and locust bean gum substrate improves bovine embryo development.

  2020cites this paper
• Mechanistic insights into the reduced developmental capacity of in vitro matured oocytes and importance of cumulus cells in oocyte quality determination

  2020cites this paper
• Mitochondrial dynamics and metabolism in induced pluripotency.

  2020cites this paper
• Egg maturity assessment prior to ICSI prevents premature fertilization of late-maturing oocytes

  2019cites this paper
• Mitochondrial DNA copy number as a predictor of embryo viability.

  2019cites this paper
• Mitochondria as a tool for oocyte rejuvenation.

  2019cites this paper
• The Role of Mitochondria in the Establishment of Developmental Competence in Early Human Development

  2019cites this paper
• Autologous mitochondrial microinjection; a strategy to improve the oocyte quality and subsequent reproductive outcome during aging

  2019cites this paper
• Comparison of gene expression and mitochondria number between bovine blastocysts obtained in vitro and in vivo

  2019cites this paper
• Melatonin rescues the aneuploidy in mice vitrified oocytes by regulating mitochondrial heat product.

  2019cites this paper
• Novel aspects of mitochondrial biology in early embryos

  2019cites this paper
• Mitochondrial function in vitrified versus slow-frozen murine embryos

  2019cites this paper
• Differential impacts of gonadotropins, IVF and embryo culture on mouse blastocyst development.

  2019cites this paper
• Participation of the adenosine salvage pathway and cyclic AMP modulation in oocyte energy metabolism

  2019cites this paper
• N-acetyl-L-cysteine (NAC) delays post-ovulatory oocyte aging in mouse

  2019cites this paper
• Combined noninvasive metabolic and spindle imaging as potential tools for embryo and oocyte assessment.

  2019cites this paper
• Autologous mitochondrial transfer as a complementary technique to intracytoplasmic sperm injection to improve embryo quality in patients undergoing in vitro fertilization-a randomized pilot study.

  2019cites this paper
• Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans†.

  2018cites this paper
• Palmitic acid induces ceramide accumulation, mitochondrial protein hyperacetylation, and mitochondrial dysfunction in porcine oocytes†

  2018cites this paper
• The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights.

  2018cites this paper
• SIRT7 functions in redox homeostasis and cytoskeletal organization during oocyte maturation

  2018cites this paper
• Respirometric reserve capacity of cumulus cell mitochondria correlates with oocyte maturity

  2018cites this paper
• Dehydroepiandrosterone Ameliorates Abnormal Mitochondrial Dynamics and Mitophagy of Cumulus Cells in Poor Ovarian Responders

  2018cites this paper
• Updating the markers for oocyte quality evaluation: intracellular temperature as a new index

  2018cites this paper
• Maternal age affects oocyte developmental potential at both ends of the age spectrum.

  2018cites this paper
• SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation

  2018cites this paper
• The Effects of Sodium Selenite on Mitochondrial DNA Copy Number and Reactive Oxygen Species Levels of In Vitro Matured Mouse Oocytes

  2018cites this paper
• Will noninvasive methods surpass invasive for assessing gametes and embryos?

  2017cites this paper
• RNA-Seq transcriptome profiling of mouse oocytes after in vitro maturation and/or vitrification

  2017cites this paper
• A Double-Blind, Randomized Prospective Study to Evaluate the Efficacy of Previous Therapy With Melatonin, Myo-inositol, Folic Acid, and Selenium in Improving the Results of an Assisted Reproductive Treatment:

  2017cites this paper
• Effect of Heat Stress on Reproduction in Dairy Cows: Insights into the Cellular and Molecular Responses of the Oocyte.

  2017cites this paper
• DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells.

  2017cites this paper
• The Application of Dehydroepiandrosterone on Improving Mitochondrial Function and Reducing Apoptosis of Cumulus Cells in Poor Ovarian Responders

  2017cites this paper
• Mitochondria in oocyte aging: current understanding

  2017cites this paper
• Protection of cumulus cells following dehydroepiandrosterone supplementation

  2017cites this paper
• Expression patterns of mitochondrial OXPHOS components, mitofusin 1 and dynamin-related protein 1 are associated with human embryo fragmentation.

  2016cites this paper
• Effects of ovarian hyperstimulation on mitochondria in oocytes and early embryos.

  2016cites this paper
• Ultrastructure and mitochondrial numbers in pre- and postpubertal pig oocytes.

  2016cites this paper
• Una mirada retrospectiva de la influencia de la aplicación de los sistemas de imagen en los resultados de las técnicas de inyección intracitoplasmática (ICSI)

  2016cites this paper
• Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells.

  2015cites this paper
• Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation

  2015cites this paper
• Mcl-1 is a key regulator of the ovarian reserve

  2015cites this paper
• Porcine oocyte mtDNA copy number is high or low depending on the donor

  2015cites this paper
• Maternal age and in vitro culture affect mitochondrial number and function in equine oocytes and embryos.

  2015cites this paper
• Targeting oocyte maturation to improve fertility in older women

  2015cites this paper
• Resveratrol improves the quality of pig oocytes derived from early antral follicles through sirtuin 1 activation.

  2015cites this paper
• Measurement of ATP in Single Oocytes: Impact of Maturation and Cumulus Cells on Levels and Consumption

  2014cites this paper
• A pilot double-blind randomised placebo-controlled dose–response trial assessing the effects of melatonin on infertility treatment (MIART): study protocol

  2014cites this paper
• Behaviour of cytoplasmic organelles and cytoskeleton during oocyte maturation.

  2014cites this paper
• Reduced uterine receptivity for mouse embryos developed from in-vitro matured oocytes

  2014cites this paper
• Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.

  2014cites this paper
• Prematuration with Cyclic Adenosine Monophosphate Modulators Alters Cumulus Cell and Oocyte Metabolism and Enhances Developmental Competence of In Vitro-Matured Mouse Oocytes1

  2014cites this paper
• The Association of Mitochondrial Potential and Copy Number with Pig Oocyte Maturation and Developmental Potential

  2014cites this paper
• Bi-directional communication with the cumulus cells is involved in the deficiency of XY oocytes in the components essential for proper second meiotic spindle assembly.

  2014cites this paper