Clinical application of genetics to guide prevention and treatment of oral diseases

Dental care costs in the United States exceed $100 billion annually. Personalized medicine efforts in dentistry are driven by potentially compelling clinical utility and cost‐effectiveness prospects in the major diseases of periodontitis, caries, and oral cancers. This review discusses progress and challenges identifying genetic markers and showing clinical utility in dentistry. Genome‐wide association studies (GWAS) of chronic periodontitis (CP) identified no significant variants, but CDKN2BAS variants on chromosome 9 were significantly associated with aggressive periodontitis. Stratifying patients by interleukin (IL)‐1 gene variants, smoking and diabetes differentiated CP prevention outcomes. Dental caries' GWAS identified significant signals in LYZL2, AJAp1, and KPNA4; and efforts are ongoing to identify genetic factors for multiple caries phenotypes. Trials of molecularly targeted therapies are in progress for oral, head, and neck squamous cell carcinomas (OHNSCC) and results have been promising but limited in their effectiveness. Current opportunities and challenges for molecular targeting for OHNSCC are discussed.

• Publication year

  2014

• Venue

  Clinical Genetics

• Publication date

  2014-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/cge.12396PMID 24702466PMCID 4233973
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chronic Disease Prevention and Health Promotion

  2016cited by this paper
• Genome-Wide Association Study of Primary Dentition Pit-and-Fissure and Smooth Surface Caries

  2014cited by this paper
• Improving the efficacy of chemoradiation with targeted agents.

  2014cited by this paper
• Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities

  2014cited by this paper
• The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10.

  2013cited by this paper
• Vascular Endothelial Growth Factor 936 C>T Polymorphism Increased Oral Cancer Risk: Evidence from a Meta-Analysis

  2013influential reference
• Recall intervals for oral health in primary care patients.

  2013cited by this paper
• A review of oral toxicity associated with mTOR inhibitor therapy in cancer patients.

  2013cited by this paper
• Companion Diagnostics in Oncology - Current Status and Future Aspects

  2013cited by this paper
• Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers.

  2013cited by this paper
• Promising New Molecular Targeted Therapies in Head and Neck Cancer

  2013cited by this paper
• Genome-wide association study of chronic periodontitis in a general German population.

  2013cited by this paper
• Validation of reported genetic risk factors for periodontitis in a large-scale replication study.

  2013cited by this paper
• Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence

  2013cited by this paper
• Personalized oncology: recent advances and future challenges.

  2013cited by this paper
• Factors contributing to severe early childhood caries in south-west Germany

  2013cited by this paper
• Patient Stratification for Preventive Care in Dentistry

  2013cited by this paper
• Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

  2013cited by this paper
• Exploring the genetic basis of chronic periodontitis: a genome-wide association study

  2013influential reference
• GSTM1 null polymorphisms and oral cancer risk: a meta-analysis

  2013influential reference
• GWAS of Dental Caries Patterns in the Permanent Dentition

  2013cited by this paper
• Cancer statistics, 2013

  2013cited by this paper
• Prevalence of Periodontitis in Adults in the United States: 2009 and 2010

  2012cited by this paper
• Targeted therapy in head and neck cancer

  2012cited by this paper
• Genome-wide association Scan of dental caries in the permanent dentition

  2012cited by this paper
• Making Personalized Cancer Medicine a Reality: Challenges and Opportunities in the Development of Biomarkers and Companion Diagnostics

  2012cited by this paper
• Promising Newer Molecular-Targeted Therapies in Head and Neck Cancer

  2012cited by this paper
• Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis.

  2012cited by this paper
• MMP13 Polymorphism Decreases Risk for Dental Caries

  2012cited by this paper
• The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway.

  2012cited by this paper
• Cancer biomarkers, companion diagnostics and personalized oncology.

  2011cited by this paper
• Association between AMELX polymorphisms and dental caries in Koreans.

  2011cited by this paper
• Genome-wide Association Scan for Childhood Caries Implicates Novel Genes

  2011cited by this paper
• The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

  2011cited by this paper
• Dental caries pathogenicity: a genomic and metagenomic perspective.

  2011cited by this paper
• Review of osteoimmunology and the host response in endodontic and periodontal lesions

  2011cited by this paper
• Molecular-targeted therapy of head and neck squamous cell carcinoma: beyond cetuximab-based therapy

  2011cited by this paper
• Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

  2011cited by this paper
• A randomized phase II study of 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy compared with bevacizumab plus 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy for intermediate-stage and T4N0-1 head and neck cancers.

  2011cited by this paper
• Genes and Their Effects on Dental Caries May Differ between Primary and Permanent Dentitions

  2010cited by this paper
• Inhibition of mutated, activated BRAF in metastatic melanoma.

  2010cited by this paper
• A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis.

  2010cited by this paper
• Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01.

  2010cited by this paper
• Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group Study S0420.

  2010cited by this paper
• COX-2 Is Associated with Periodontitis in Europeans

  2010cited by this paper
• Integration of Biomarkers Including Molecular Targeted Therapies in Head and Neck Cancer

  2010cited by this paper
• CDKN2BAS is associated with periodontitis in different European populations and is activated by bacterial infection

  2010cited by this paper
• Overview of current and future biologically based targeted therapies in head and neck squamous cell carcinoma

  2009cited by this paper
• Applying the molecular biology and epigenetics of head and neck cancer in everyday clinical practice.

  2009influential reference
• UvA-DARE ( Digital Academic Repository ) Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis

  2009cited by this paper
• Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma

  2009cited by this paper
• Head & Neck Oncology: purpose, scope and goals-charting the future

  2009cited by this paper
• Gene-expression signatures in breast cancer.

  2009cited by this paper
• A systematic review and meta-analyses on C-reactive protein in relation to periodontitis.

  2008cited by this paper
• Drug Insight: cetuximab in the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck

  2008cited by this paper
• Salivary Proteomics for Oral Cancer Biomarker Discovery

  2008cited by this paper
• Children's school performance: impact of general and oral health.

  2008cited by this paper
• IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1β and C-reactive protein

  2008cited by this paper
• Platinum-based chemotherapy plus cetuximab in head and neck cancer.

  2008cited by this paper
• Tooth loss after active periodontal therapy. 1: patient-related factors for risk, prognosis, and quality of outcome.

  2008cited by this paper
• Recent advances in Oral Oncology 2007: imaging, treatment and treatment outcomes.

  2008cited by this paper
• Molecular Targets in Squamous Cell Carcinoma of the Head and Neck

  2007influential reference
• Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy

  2007cited by this paper
• Recall intervals for oral health in primary care patients.

  2007cited by this paper
• Medicaid costs associated with the hospitalization of young children for restorative dental treatment under general anesthesia.

  2007cited by this paper
• Radiation-induced EGFR-signaling and control of DNA-damage repair

  2007cited by this paper
• Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma.

  2007cited by this paper
• Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer.

  2007cited by this paper
• Primary and acquired resistance to anti-EGFR targeted drugs in cancer therapy.

  2007cited by this paper
• VEGF receptor signalling ? in control of vascular function

  2006cited by this paper
• Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context.

  2006cited by this paper
• Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: a pilot phase II study of a new combined-modality paradigm.

  2006cited by this paper
• Advances in molecular diagnostics and therapeutics in head and neck cancer

  2006cited by this paper
• Signaling via ErbB2 and ErbB3 Associates with Resistance and Epidermal Growth Factor Receptor (EGFR) Amplification with Sensitivity to EGFR Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cells

  2006cited by this paper
• Longitudinal Analysis of Heritability for Dental Caries Traits

  2005cited by this paper
• Combination treatment significantly enhances the efficacy of antitumor therapy by preferentially targeting angiogenesis

  2005cited by this paper
• Recall intervals for oral health in primary care patients.

  2005cited by this paper
• Epidermal growth factor receptor and response of head-and-neck carcinoma to therapy.

  2004influential reference
• Polymorphisms of the Interleukin-1&bgr; Gene Affect the Risk of Myocardial Infarction and Ischemic Stroke at Young Age and the Response of Mononuclear Cells to Stimulation In Vitro

  2004cited by this paper
• Diagnosis and risk prediction of periodontal diseases

  2003cited by this paper
• The Interleukin-1 Polymorphism, Smoking, and the Risk of Periodontal Disease in the Population-based SHIP Study

  2003cited by this paper
• Gene-expression signatures in breast cancer.

  2003cited by this paper
• Current status of gene therapy for lung cancer and head and neck cancer.

  2003cited by this paper
• Recent trends in dental visits and private dental insurance, 1989 and 1999.

  2003cited by this paper
• GCF IL-1beta profiles in periodontal disease.

  2002cited by this paper
• Prevalence of aggressive periodontitis in school attendees in Uganda.

  2002cited by this paper
• Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists.

  2002cited by this paper
• GCF IL-1β profiles in periodontal disease

  2002cited by this paper
• Inherited risks for susceptibility to dental caries.

  2001cited by this paper
• Retrospective evaluation of the influence of the interleukin-1 genotype on radiographic bone levels in treated periodontal patients over 10 years.

  2001cited by this paper
• Retrospective Evaluation of the Influence the Interleukin-1 Genotype on Radiographic Bone Levels in Treated Periodontal Patients Over 10 Years.

  2001cited by this paper
• Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

  2001cited by this paper
• Evidence of a substantial genetic basis for risk of adult periodontitis.

  2000cited by this paper
• Prognostic value of vascular endothelial growth factor (VEGF) in head and neck squamous cell carcinomas

  2000cited by this paper
• Prognosis versus actual outcome. IV. The effectiveness of clinical parameters and IL-1 genotype in accurately predicting prognoses and tooth survival.

  1999cited by this paper
• Development of a classification system for periodontal diseases and conditions.

  1999cited by this paper
• The interleukin-1 genotype as a severity factor in adult periodontal disease.

  1997cited by this paper
• Primary incisor decay before age 4 as a risk factor for future dental caries.

  1997cited by this paper
• The effect of nursing or rampant caries on height, body weight and head circumference.

  1996cited by this paper
• Early onset periodontitis in the United States of America.

  1991cited by this paper

• Genome-wide association studies on dental caries: A systematic review.

  2025cites this paper
• Personalized approaches to oral health and disease management

  2024cites this paper
• Periodontitis-resistant and -susceptible matriline regulation of gingival transcriptome in nonhuman primates.

  2023cites this paper
• Dermatoglyphic Study: A Diagnostic Tool for Predicting Oral Submucous Fibrosis

  2023cites this paper
• Precision Medicine in Oral Health and Diseases: A Systematic Review

  2023influential citation
• Shooting at Moving and Hidden Targets—Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas

  2021cites this paper
• Amylase Alpha 1 Gene (AMY1) Copy Number Variation and Dental Caries Experience: A Pilot Study among Adults in Lithuania

  2021cites this paper
• Gene therapy and its applicability in Dentistry

  2020cites this paper
• The Importance of Research in Dental Education and Practice

  2020cites this paper
• Evolving Paradigms in the Pathogenesis and Management of Periodontitis

  2020cites this paper
• Genetics and oral health

  2020cites this paper
• Emerging Therapies in Periodontics

  2020cites this paper
• Biologically informed stratification of periodontal disease holds the key to achieving precision oral health.

  2020cites this paper
• Using big data to promote precision oral health in the context of a learning healthcare system

  2020cites this paper
• Down-regulation of long non-coding RNA MEG3 suppresses osteogenic differentiation of periodontal ligament stem cells (PDLSCs) through miR-27a-3p/IGF1 axis in periodontitis

  2019cites this paper
• Knockdown of lncRNA LEF1-AS1 inhibited the progression of oral squamous cell carcinoma (OSCC) via Hippo signaling pathway

  2019cites this paper
• Embracing Personalized Medicine in Dentistry

  2019cites this paper
• Identification of Periopathogenes from Dental Plaque in Periodontal Patients with PCR Technique and Their Association with Composite Interleukin-1 Genotype

  2019cites this paper
• Searching Deep and Wide: Advances in the Molecular Understanding of Dental Caries and Periodontal Disease

  2019cites this paper
• The present, past and future of orthodontic research

  2019cites this paper
• Genomics of periodontal disease and tooth morbidity

  2019cites this paper
• Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease

  2018cites this paper
• Molecular-Genetic Mechanisms of Caries Development

  2018cites this paper
• Periodontal disease susceptible matrilines in the Cayo Santiago Macaca mulatta macaques

  2018cites this paper
• Prospective evaluation of periodontally diseased molars in smokers using the Miller–McEntire Periodontal Prognostic Index

  2018cites this paper
• Systematic review of cyclosporin A-induced gingival overgrowth and genetic predisposition.

  2017cites this paper
• Expanding the Research Capacity of Dental Schools: Are We There Yet?

  2017cites this paper
• Oral microbiota as a key point for understanding the carious process (current state in 2016)

  2017cites this paper
• Biomarkers in molecular epidemiology study of oral squamous cell carcinoma in the era of precision medicine

  2017cites this paper
• Immunological Variation Due to Genetics of Inflammatory SNPs and Age and Impact on Disease Manifestation

  2017cites this paper
• An Exploratory Statistical Method For Finding Interactions In A Large Dataset With An Application Toward Periodontal Diseases

  2017cites this paper
• Antimicrobials in caries prevention

  2017cites this paper
• Research and Discovery Science and the Future of Dental Education and Practice.

  2017cites this paper
• Familial periodontal disease in the cayo santiago rhesus macaques

  2016cites this paper
• The “New” Genetics and Its Impact on Oral Care Delivery

  2016cites this paper
• Pathogenesis of Periodontal Diseases

  2016cites this paper
• Oral squamous cell carcinoma: Key clinical questions, biomarker discovery, and the role of proteomics.

  2016cites this paper
• Gene polymorphisms in periodontitis. Overview

  2015cites this paper
• The Oral Microbiome and Its Relationship to Genomics and Oral Disease

  2015cites this paper
• Pharmacogenomics for Oral Disease

  2015cites this paper
• PREDISPOSITION FOR CARIES IN PERMANENT DENTITION. REVIEW

  year unknowncites this paper